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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hic1
Z-value: 1.82
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Transcription factors associated with Hic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hic1 | rn6_v1_chr10_-_62009582_62009582 | 0.61 | 2.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.2 | 1.9 | GO:2000969 | positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
| 0.5 | 1.6 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.0 | 1.6 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.0 | 1.6 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.5 | 1.5 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.2 | 1.2 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.2 | 1.1 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 1.1 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.3 | 1.0 | GO:0072054 | renal outer medulla development(GO:0072054) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.8 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 1.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 1.6 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 1.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.4 | 1.2 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149) |
| 0.0 | 1.1 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.0 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 1.0 | GO:0043196 | varicosity(GO:0043196) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.3 | 2.1 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.5 | 1.5 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.0 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.3 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 1.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 1.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 1.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 1.1 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 1.1 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.4 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 1.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 1.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.1 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.3 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.2 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |
| 0.0 | 1.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.9 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |