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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Fosl2_Bach2
Z-value: 0.92
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Transcription factors associated with Fosl2_Bach2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bach2 | rn6_v1_chr5_+_47546014_47546014 | -0.72 | 1.7e-01 | Click! |
| Fosl2 | rn6_v1_chr6_-_25616995_25616995 | -0.62 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_187863503 Show fit | 0.85 |
ENSRNOT00000093036
ENSRNOT00000026705 ENSRNOT00000082174 |
lamin A/C |
|
| chr10_-_82229140 Show fit | 0.70 |
ENSRNOT00000004400
|
epsin 3 |
|
| chr10_-_90312386 Show fit | 0.65 |
ENSRNOT00000028445
|
solute carrier family 4 member 1 |
|
| chr7_+_28654733 Show fit | 0.55 |
ENSRNOT00000006174
|
pro-melanin-concentrating hormone |
|
| chr1_+_198690794 Show fit | 0.53 |
ENSRNOT00000023999
|
zinc finger protein 771 |
|
| chr1_-_24191908 Show fit | 0.51 |
ENSRNOT00000061157
|
serum/glucocorticoid regulated kinase 1 |
|
| chr10_-_104575890 Show fit | 0.50 |
ENSRNOT00000050223
|
H3 histone family member 3B |
|
| chr17_+_6909728 Show fit | 0.48 |
ENSRNOT00000061231
|
hypothetical protein LOC681410 |
|
| chr3_+_147609095 Show fit | 0.47 |
ENSRNOT00000041456
|
sulfiredoxin 1 |
|
| chr1_+_218466289 Show fit | 0.46 |
ENSRNOT00000017948
|
MAS related GPR family member F |
Network of associatons between targets according to the STRING database.
First level regulatory network of Fosl2_Bach2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:1904178 | sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178) |
| 0.1 | 0.6 | GO:0010037 | response to carbon dioxide(GO:0010037) |
| 0.1 | 0.5 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 0.1 | 0.5 | GO:0060623 | pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623) |
| 0.1 | 0.5 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 0.5 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 0.4 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.1 | 0.4 | GO:0009609 | response to symbiotic bacterium(GO:0009609) |
| 0.1 | 0.4 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.1 | 0.4 | GO:0007296 | vitellogenesis(GO:0007296) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.5 | GO:0097413 | Lewy body(GO:0097413) |
| 0.1 | 0.5 | GO:0001740 | Barr body(GO:0001740) |
| 0.0 | 0.5 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 0.3 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.2 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.2 | GO:0031094 | platelet dense tubular network(GO:0031094) |
| 0.0 | 0.2 | GO:0031932 | TORC2 complex(GO:0031932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 0.6 | GO:0015106 | bicarbonate transmembrane transporter activity(GO:0015106) |
| 0.1 | 0.5 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.5 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.4 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.3 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.7 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.7 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
| 0.0 | 0.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.4 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.1 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.0 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |