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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Etv6
Z-value: 0.58
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Transcription factors associated with Etv6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv6 | rn6_v1_chr4_+_167754525_167754525 | 0.53 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_70522092 Show fit | 0.34 |
ENSRNOT00000025873
|
dipeptidylpeptidase 8 |
|
| chr4_-_63039422 Show fit | 0.33 |
ENSRNOT00000015808
|
myotrophin |
|
| chr6_-_108796124 Show fit | 0.27 |
ENSRNOT00000086545
|
apoptosis resistant E3 ubiquitin protein ligase 1 |
|
| chr5_-_137238354 Show fit | 0.22 |
ENSRNOT00000039235
|
seizure threshold 2 homolog (mouse) |
|
| chr7_-_121783435 Show fit | 0.19 |
ENSRNOT00000034912
|
ENTH domain containing 1 |
|
| chr7_+_144647587 Show fit | 0.17 |
ENSRNOT00000022398
|
homeo box C4 |
|
| chr2_-_189096785 Show fit | 0.17 |
ENSRNOT00000028200
|
cholinergic receptor nicotinic beta 2 subunit |
|
| chr8_+_49354115 Show fit | 0.17 |
ENSRNOT00000032837
|
myelin protein zero-like 3 |
|
| chr12_+_46316236 Show fit | 0.17 |
ENSRNOT00000001508
|
protein kinase AMP-activated non-catalytic subunit beta 1 |
|
| chr13_+_97838361 Show fit | 0.16 |
ENSRNOT00000003641
|
consortin, connexin sorting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.1 | 0.2 | GO:1990790 | response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792) |
| 0.1 | 0.2 | GO:0060084 | synaptic transmission involved in micturition(GO:0060084) |
| 0.0 | 0.2 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.0 | 0.2 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.0 | 0.2 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.0 | 0.2 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.2 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.1 | GO:0036451 | cap mRNA methylation(GO:0036451) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.1 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 0.0 | 0.1 | GO:0035101 | FACT complex(GO:0035101) |
| 0.0 | 0.1 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.1 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.1 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 0.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.1 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.0 | 0.2 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.2 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 0.0 | 0.2 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 0.2 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.1 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.0 | 0.1 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.0 | 0.1 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 0.2 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.2 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |