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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for E2f1
Z-value: 1.00
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Transcription factors associated with E2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f1 | rn6_v1_chr3_-_150062311_150062311 | -0.37 | 5.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_33885495 Show fit | 1.43 |
ENSRNOT00000086633
|
syndecan 1 |
|
| chr7_-_12221330 Show fit | 1.02 |
ENSRNOT00000042204
|
polo-like kinase 5 |
|
| chr2_+_155555840 Show fit | 0.48 |
ENSRNOT00000080951
|
|
|
| chr1_-_184188911 Show fit | 0.47 |
ENSRNOT00000055124
ENSRNOT00000014948 |
calcitonin-related polypeptide alpha |
|
| chr2_+_27107318 Show fit | 0.44 |
ENSRNOT00000019553
|
Rho guanine nucleotide exchange factor 26 |
|
| chr18_-_63394690 Show fit | 0.44 |
ENSRNOT00000090078
ENSRNOT00000029431 |
centrosomal protein 76 |
|
| chr11_+_89511191 Show fit | 0.43 |
ENSRNOT00000002510
|
minichromosome maintenance complex component 4 |
|
| chr16_+_7303578 Show fit | 0.39 |
ENSRNOT00000025656
|
semaphorin 3G |
|
| chr16_-_73827488 Show fit | 0.38 |
ENSRNOT00000064070
|
ankyrin 1 |
|
| chr10_-_56558487 Show fit | 0.38 |
ENSRNOT00000023256
|
solute carrier family 2 member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.4 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.1 | 1.0 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.1 | 0.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.6 | GO:2000344 | positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 0.6 | GO:0046599 | regulation of centriole replication(GO:0046599) |
| 0.0 | 0.6 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 0.2 | 0.5 | GO:0001983 | baroreceptor response to increased systemic arterial blood pressure(GO:0001983) |
| 0.0 | 0.5 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
| 0.1 | 0.4 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.0 | 0.4 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 0.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.6 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.4 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.4 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.3 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 0.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.3 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.3 | GO:0001940 | male pronucleus(GO:0001940) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.2 | 0.6 | GO:0030977 | taurine binding(GO:0030977) |
| 0.0 | 0.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 0.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.4 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.1 | 0.3 | GO:0042895 | antibiotic transporter activity(GO:0042895) |
| 0.1 | 0.3 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.0 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.8 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 0.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.0 | 0.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.2 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |