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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Dbp
Z-value: 0.87
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Transcription factors associated with Dbp
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dbp | rn6_v1_chr1_+_101688297_101688297 | -0.38 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_40009691 Show fit | 0.45 |
ENSRNOT00000042679
|
V-set and immunoglobulin domain containing 2 |
|
| chr12_-_40822159 Show fit | 0.42 |
ENSRNOT00000001826
|
HECT domain E3 ubiquitin protein ligase 4 |
|
| chr13_-_111948753 Show fit | 0.42 |
ENSRNOT00000048074
|
hydroxysteroid 11-beta dehydrogenase 1 |
|
| chr20_-_22459025 Show fit | 0.42 |
ENSRNOT00000000792
|
early growth response 2 |
|
| chr9_-_28732919 Show fit | 0.41 |
ENSRNOT00000083915
|
regulating synaptic membrane exocytosis 1 |
|
| chr6_+_52631092 Show fit | 0.39 |
ENSRNOT00000014054
|
ataxin 7-like 1 |
|
| chr10_-_90240509 Show fit | 0.36 |
ENSRNOT00000028407
|
ataxin 7-like 3 |
|
| chr17_+_43632397 Show fit | 0.32 |
ENSRNOT00000013790
|
histone cluster 1, H2ah |
|
| chr7_+_99954492 Show fit | 0.30 |
ENSRNOT00000005885
|
tribbles pseudokinase 1 |
|
| chr15_+_51756978 Show fit | 0.30 |
ENSRNOT00000024067
|
early growth response 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Dbp
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.1 | 0.5 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.1 | 0.4 | GO:0006713 | glucocorticoid catabolic process(GO:0006713) |
| 0.1 | 0.4 | GO:0031632 | positive regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031632) |
| 0.0 | 0.4 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 0.4 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.1 | 0.3 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) |
| 0.1 | 0.3 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.3 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.0 | 0.3 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.0 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.3 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 0.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 0.2 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 0.2 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.2 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.1 | GO:0031592 | centrosomal corona(GO:0031592) |
| 0.0 | 0.1 | GO:0098855 | HCN channel complex(GO:0098855) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.4 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.0 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.3 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 0.3 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.3 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.0 | 0.3 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 0.2 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.4 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.3 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.2 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |