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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Crem_Jdp2
Z-value: 0.82
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Transcription factors associated with Crem_Jdp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Crem | rn6_v1_chr17_+_57031766_57031766 | 0.94 | 1.7e-02 | Click! |
| Jdp2 | rn6_v1_chr6_+_109466060_109466060 | 0.91 | 3.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_9695292 Show fit | 1.55 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr7_+_120580743 Show fit | 0.52 |
ENSRNOT00000017181
|
MAF bZIP transcription factor F |
|
| chr12_-_13668515 Show fit | 0.51 |
ENSRNOT00000086847
|
fascin actin-bundling protein 1 |
|
| chr17_+_10463303 Show fit | 0.48 |
ENSRNOT00000060822
|
ring finger protein 44 |
|
| chr10_+_16970626 Show fit | 0.40 |
ENSRNOT00000005383
|
dual specificity phosphatase 1 |
|
| chr8_+_114866768 Show fit | 0.35 |
ENSRNOT00000076731
|
WD repeat domain 82 |
|
| chr17_+_57074525 Show fit | 0.33 |
ENSRNOT00000020012
ENSRNOT00000074146 |
cAMP responsive element modulator |
|
| chr11_+_88424414 Show fit | 0.30 |
ENSRNOT00000022328
|
sperm associated antigen 6-like |
|
| chr7_-_58587787 Show fit | 0.30 |
ENSRNOT00000005814
|
leucine rich repeat containing G protein coupled receptor 5 |
|
| chr5_-_152464850 Show fit | 0.28 |
ENSRNOT00000021937
|
zinc finger protein 593 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Crem_Jdp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 0.5 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.1 | 0.5 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.0 | 0.4 | GO:0090231 | regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 0.3 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 0.1 | 0.3 | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
| 0.0 | 0.3 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.0 | 0.3 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.1 | 0.2 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201) |
| 0.1 | 0.2 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0044393 | microspike(GO:0044393) |
| 0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.3 | GO:1990716 | axonemal central apparatus(GO:1990716) |
| 0.0 | 0.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 0.2 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 0.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.2 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.3 | GO:0031177 | phosphopantetheine binding(GO:0031177) |
| 0.1 | 0.3 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.0 | 0.3 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.2 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.2 | GO:0045340 | mercury ion binding(GO:0045340) |
| 0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.2 | GO:0016503 | pheromone receptor activity(GO:0016503) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |