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GSE80451: E.coli grown aerobically and anaerobically

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Results for SoxS

Z-value: 2.12

Transcription factors associated with SoxS

Gene Symbol Gene ID Gene Info
soxS
soxS SoxS DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
soxS1.004.0e-04Click!

Activity profile of SoxS motif

Sorted Z-values of SoxS motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
sodA 8.28
sodA
superoxide dismutase (Mn)
ptsG 5.71
ptsG
glucose PTS permease - PtsG subunit
soxS 5.53
soxS
SoxS DNA-binding transcriptional dual regulator
ydbK 4.31
ydbK
pyruvate:flavodoxin oxidoreductase
fumC 3.97
fumC
fumarase C
ribA 3.69
ribA
GTP cyclohydrolase II
acnA 3.58
acnA
aconitate hydratase 1
fldB 3.32
fldB
flavodoxin 2
ydbK-ompN 2.60
ydbK
ompN
pyruvate:flavodoxin oxidoreductase
outer membrane pore protein N, non-specific
zinT 2.45
zinT
cadmium-induced cadmium binding protein
acrZ 2.33
acrZ
small membrane protein that interacts with the AcrAB-TolC multidrug efflux pump
fpr 2.13
fpr
flavodoxin-NADP+ reductase/ferredoxin-NADP+ reductase
pgi 2.04
pgi
phosphoglucose isomerase
poxB 1.84
poxB
pyruvate oxidase
pqiAB 1.61
pqiB
pqiA
paraquat-inducible protein B
paraquat-inducible protein A
zwf 0.69
zwf
glucose-6-phosphate dehydrogenase (NADP+)
inaA 0.52
inaA
pH-inducible protein involved in stress response
nfsB 0.32
nfsB
NAD(P)H nitroreductase NfsB

Network of associatons between targets according to the STRING database.

First level regulatory network of SoxS

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.4 GO:0000303 response to superoxide(GO:0000303)
1.4 5.7 GO:0046323 glucose transport(GO:0015758) glucose import(GO:0046323)
1.3 4.0 GO:0006108 malate metabolic process(GO:0006108)
1.2 3.6 GO:0006097 glyoxylate cycle(GO:0006097)
0.9 3.7 GO:0042727 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231) flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.8 2.4 GO:0046686 response to cadmium ion(GO:0046686)
0.8 2.3 GO:0036460 cellular response to cell envelope stress(GO:0036460)
0.2 2.6 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.2 2.0 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.2 0.7 GO:0048872 homeostasis of number of cells(GO:0048872) homeostasis of number of cells in a free-living population(GO:0048874)
0.1 4.3 GO:0006979 response to oxidative stress(GO:0006979)
0.1 0.3 GO:0046260 trinitrotoluene metabolic process(GO:0018973) 2,4,6-trinitrotoluene metabolic process(GO:0018974) nitrotoluene metabolic process(GO:0019326) 2,4,6-trinitrotoluene catabolic process(GO:0046256) trinitrotoluene catabolic process(GO:0046260) nitrotoluene catabolic process(GO:0046263) toluene-containing compound metabolic process(GO:0072490) toluene-containing compound catabolic process(GO:0072491)
0.1 1.8 GO:0051262 pyruvate metabolic process(GO:0006090) protein tetramerization(GO:0051262) protein homotetramerization(GO:0051289)
0.0 3.4 GO:0006355 regulation of transcription, DNA-templated(GO:0006355) regulation of nucleic acid-templated transcription(GO:1903506) regulation of RNA biosynthetic process(GO:2001141)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 22.7 GO:0005829 cytosol(GO:0005829)
0.0 2.4 GO:0005737 cytoplasm(GO:0005737)
0.0 1.4 GO:0009279 cell outer membrane(GO:0009279)
0.0 3.8 GO:0016020 membrane(GO:0016020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.8 5.5 GO:0001098 basal transcription machinery binding(GO:0001098) bacterial-type RNA polymerase holo enzyme binding(GO:0001108)
0.9 3.7 GO:0019238 cyclohydrolase activity(GO:0019238)
0.8 4.0 GO:0004333 fumarate hydratase activity(GO:0004333)
0.4 5.7 GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity(GO:0090563)
0.3 8.8 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors(GO:0016903)
0.2 3.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 2.1 GO:0071949 FAD binding(GO:0071949)
0.1 1.9 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 2.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.6 GO:0010181 FMN binding(GO:0010181)
0.0 0.7 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)