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PRJEB1986: zebrafish developmental stages transcriptome
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Results for crx+otx1
Z-value: 1.17
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Transcription factors associated with crx+otx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| otx1 | dr11_v1_chr17_+_24320861_24320861 | -0.71 | 6.0e-04 | Click! |
| crx | dr11_v1_chr5_+_36932718_36932718 | 0.07 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_13366353 Show fit | 4.21 |
ENSDART00000151630
|
si:ch73-62l21.1 |
|
| chr4_+_68562464 Show fit | 3.41 |
ENSDART00000192954
|
|
|
| chr1_+_5576151 Show fit | 3.17 |
ENSDART00000109756
|
carboxypeptidase O |
|
| chr4_-_16853464 Show fit | 3.12 |
ENSDART00000125743
ENSDART00000164570 |
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a |
|
| chr6_+_54538948 Show fit | 3.10 |
ENSDART00000149270
|
tubby like protein 1b |
|
| chr1_-_58766424 Show fit | 2.56 |
ENSDART00000191010
|
|
|
| chr17_+_30448452 Show fit | 2.54 |
ENSDART00000153939
|
lipin 1 |
|
| chr19_-_5207361 Show fit | 2.53 |
ENSDART00000174611
|
syntaxin 1B |
|
| chr10_+_17026870 Show fit | 2.51 |
ENSDART00000184529
ENSDART00000157480 |
|
|
| chr6_-_16406210 Show fit | 2.46 |
ENSDART00000012023
|
Fas apoptotic inhibitory molecule b |
Network of associatons between targets according to the STRING database.
First level regulatory network of crx+otx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0030042 | actin filament depolymerization(GO:0030042) |
| 0.1 | 4.7 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.2 | 3.8 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.1 | 3.1 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.5 | 2.5 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.2 | 2.5 | GO:1902042 | regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.1 | 2.5 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.1 | 2.3 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 2.2 | GO:0006584 | catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712) |
| 0.0 | 2.1 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 2.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 2.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 2.1 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 2.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 2.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.1 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.3 | 1.9 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 1.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 3.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 3.1 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.0 | 2.7 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.1 | 2.5 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 2.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 2.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 2.2 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 2.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 2.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 0.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.6 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.5 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 2.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 1.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.0 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 0.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |