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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Twist1

Z-value: 1.64

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Transcription factors associated with Twist1

Gene Symbol Gene ID Gene Info
Twist1
ENSMUSG00000035799.5 twist basic helix-loop-helix transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.289.3e-02Click!

Activity profile of Twist1 motif

Sorted Z-values of Twist1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_36942910 16.51 ENSMUST00000040498.5
Rnf39
ring finger protein 39
chr17_+_36943025 11.98 ENSMUST00000173072.1
Rnf39
ring finger protein 39
chr6_-_41035501 10.82 ENSMUST00000031931.5
2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr6_+_30639218 10.07 ENSMUST00000031806.9
Cpa1
carboxypeptidase A1, pancreatic
chr8_-_105933832 9.70 ENSMUST00000034368.6
Ctrl
chymotrypsin-like
chr19_+_39007019 9.68 ENSMUST00000025966.4
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
chr11_-_113710017 7.47 ENSMUST00000018871.1
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr2_+_31887262 6.83 ENSMUST00000138325.1
ENSMUST00000028187.6
Lamc3
laminin gamma 3
chr7_+_44384803 6.45 ENSMUST00000120262.1
Syt3
synaptotagmin III
chr11_-_113709520 6.29 ENSMUST00000173655.1
ENSMUST00000100248.4
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr7_-_142679533 5.58 ENSMUST00000162317.1
ENSMUST00000125933.1
ENSMUST00000105931.1
ENSMUST00000105930.1
ENSMUST00000105933.1
ENSMUST00000105932.1
ENSMUST00000000220.2
Ins2
insulin II
chr9_-_45009590 5.24 ENSMUST00000102832.1
Cd3e
CD3 antigen, epsilon polypeptide
chr15_+_100304782 4.87 ENSMUST00000067752.3
Mettl7a1
methyltransferase like 7A1
chr18_-_16809233 4.21 ENSMUST00000025166.7
Cdh2
cadherin 2
chr15_+_100353149 4.07 ENSMUST00000075675.5
ENSMUST00000088142.5
ENSMUST00000176287.1
AB099516
Mettl7a2
cDNA sequence AB099516
methyltransferase like 7A2
chr12_-_4592927 4.01 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr9_+_65265173 3.81 ENSMUST00000048762.1
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_-_31115227 3.77 ENSMUST00000168884.1
ENSMUST00000108102.2
Hpn
hepsin
chr6_-_95718800 3.63 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr7_+_127800844 3.49 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr19_+_8664005 3.37 ENSMUST00000035444.3
ENSMUST00000163785.1
Chrm1
cholinergic receptor, muscarinic 1, CNS
chr16_-_18426372 2.95 ENSMUST00000000335.4
Comt
catechol-O-methyltransferase
chr7_-_4789541 2.86 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr5_-_34187670 2.83 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4
Max dimerization protein 4
chr1_-_15892657 2.82 ENSMUST00000040695.4
Sbspon
somatomedin B and thrombospondin, type 1 domain containing
chr4_-_57143437 2.73 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chr4_-_130275542 2.73 ENSMUST00000154846.1
ENSMUST00000105996.1
Serinc2
serine incorporator 2
chr4_-_130275523 2.61 ENSMUST00000146478.1
Serinc2
serine incorporator 2
chr2_-_32982007 2.55 ENSMUST00000028129.7
Slc2a8
solute carrier family 2, (facilitated glucose transporter), member 8
chr14_+_53676141 2.53 ENSMUST00000103662.4
Trav9-4
T cell receptor alpha variable 9-4
chr19_-_28963863 2.52 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr8_+_122422020 2.25 ENSMUST00000050963.3
Il17c
interleukin 17C
chr8_+_105305572 2.25 ENSMUST00000109375.2
Elmo3
engulfment and cell motility 3
chr13_+_104109752 2.22 ENSMUST00000160322.1
ENSMUST00000159574.1
Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr13_+_73626886 2.21 ENSMUST00000022104.7
Tert
telomerase reverse transcriptase
chr7_-_80401707 2.18 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr13_+_104109737 2.18 ENSMUST00000044385.7
Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr17_+_24850484 2.07 ENSMUST00000118788.1
Hagh
hydroxyacyl glutathione hydrolase
chr9_-_63602417 2.07 ENSMUST00000171243.1
ENSMUST00000163982.1
ENSMUST00000163624.1
Iqch
IQ motif containing H
chr17_+_24850654 2.02 ENSMUST00000130989.1
ENSMUST00000024974.9
Hagh
hydroxyacyl glutathione hydrolase
chr8_-_71381907 1.92 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_+_97663366 1.91 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr7_+_28180272 1.88 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_28180226 1.86 ENSMUST00000172467.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr2_-_172940299 1.81 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr9_+_60794468 1.77 ENSMUST00000050183.6
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr6_+_40964760 1.75 ENSMUST00000076638.5
1810009J06Rik
RIKEN cDNA 1810009J06 gene
chr7_+_4119556 1.69 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr3_+_90051630 1.66 ENSMUST00000159064.1
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr9_-_108567336 1.64 ENSMUST00000074208.4
Ndufaf3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr9_-_114844090 1.60 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chrX_-_18461371 1.58 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr15_+_100334929 1.57 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr5_+_31297551 1.55 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chr11_+_103103051 1.55 ENSMUST00000152971.1
Acbd4
acyl-Coenzyme A binding domain containing 4
chr2_+_139678178 1.53 ENSMUST00000184404.1
ENSMUST00000099307.3
Ism1
isthmin 1 homolog (zebrafish)
chr6_-_40999479 1.50 ENSMUST00000166306.1
Gm2663
predicted gene 2663
chr16_-_5132458 1.48 ENSMUST00000035672.3
Ppl
periplakin
chr7_+_35119285 1.47 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr17_+_45563928 1.44 ENSMUST00000041353.6
Slc35b2
solute carrier family 35, member B2
chr11_-_119355484 1.40 ENSMUST00000100172.2
ENSMUST00000005173.4
Sgsh
N-sulfoglucosamine sulfohydrolase (sulfamidase)
chr15_-_57892358 1.27 ENSMUST00000022993.5
Derl1
Der1-like domain family, member 1
chr19_-_3686549 1.26 ENSMUST00000025856.10
ENSMUST00000176867.1
Lrp5
low density lipoprotein receptor-related protein 5
chr1_-_172590463 1.25 ENSMUST00000065679.6
Slamf8
SLAM family member 8
chr7_+_4119525 1.22 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1
tweety homolog 1 (Drosophila)
chr1_+_171437535 1.22 ENSMUST00000043839.4
F11r
F11 receptor
chr13_-_58113592 1.20 ENSMUST00000160860.1
Klhl3
kelch-like 3
chr6_+_85187438 1.18 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr14_+_101729907 1.17 ENSMUST00000100337.3
Lmo7
LIM domain only 7
chr13_-_104109576 1.15 ENSMUST00000109315.3
Nln
neurolysin (metallopeptidase M3 family)
chr10_+_89873497 1.12 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr11_+_94741782 1.11 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr5_-_62766153 1.07 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_43309554 0.98 ENSMUST00000031749.9
Nobox
NOBOX oogenesis homeobox
chr6_-_83831736 0.97 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr11_+_53770458 0.94 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1
interferon regulatory factor 1
chr9_-_14903932 0.93 ENSMUST00000034409.7
ENSMUST00000117620.1
Folr4
folate receptor 4 (delta)
chr14_+_62760496 0.92 ENSMUST00000181344.1
4931440J10Rik
RIKEN cDNA 4931440J10 gene
chr4_+_149518216 0.91 ENSMUST00000030839.6
Ctnnbip1
catenin beta interacting protein 1
chr2_-_32784424 0.90 ENSMUST00000102813.1
1700019L03Rik
RIKEN cDNA 1700019L03 gene
chr15_-_53902472 0.89 ENSMUST00000078673.6
Samd12
sterile alpha motif domain containing 12
chr6_+_122874526 0.88 ENSMUST00000032477.4
Necap1
NECAP endocytosis associated 1
chr4_-_135494499 0.87 ENSMUST00000105856.2
Nipal3
NIPA-like domain containing 3
chr2_+_74668207 0.83 ENSMUST00000001872.4
Hoxd13
homeobox D13
chr10_+_61175206 0.83 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr5_-_8622855 0.82 ENSMUST00000047485.8
ENSMUST00000115378.1
Rundc3b
RUN domain containing 3B
chr6_-_90716489 0.82 ENSMUST00000101153.3
Iqsec1
IQ motif and Sec7 domain 1
chr2_-_26122769 0.79 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr6_-_134566913 0.76 ENSMUST00000032322.8
Lrp6
low density lipoprotein receptor-related protein 6
chr9_-_14903752 0.76 ENSMUST00000148155.1
ENSMUST00000121116.1
Folr4
folate receptor 4 (delta)
chr17_-_70990751 0.74 ENSMUST00000038446.8
Myl12b
myosin, light chain 12B, regulatory
chr7_-_30861470 0.69 ENSMUST00000052700.3
Ffar1
free fatty acid receptor 1
chr9_+_118478851 0.68 ENSMUST00000150633.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr19_-_11266122 0.67 ENSMUST00000169159.1
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chr19_+_5740885 0.67 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr11_-_70687917 0.66 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2
calmodulin binding transcription activator 2
chr4_-_11386757 0.65 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1
epithelial splicing regulatory protein 1
chr7_-_70360593 0.64 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr5_-_35729276 0.63 ENSMUST00000070203.7
Sh3tc1
SH3 domain and tetratricopeptide repeats 1
chr15_+_100227819 0.62 ENSMUST00000023769.4
Atf1
activating transcription factor 1
chr17_-_65613521 0.55 ENSMUST00000024897.8
Vapa
vesicle-associated membrane protein, associated protein A
chr4_-_148038769 0.53 ENSMUST00000030879.5
ENSMUST00000137724.1
Clcn6
chloride channel 6
chr9_-_14903866 0.51 ENSMUST00000069408.3
Folr4
folate receptor 4 (delta)
chr9_+_111118070 0.51 ENSMUST00000035078.6
ENSMUST00000098340.2
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr4_+_119539652 0.50 ENSMUST00000044564.8
ENSMUST00000162267.1
ENSMUST00000106310.2
ENSMUST00000138845.2
Foxj3
forkhead box J3
chr9_-_57467985 0.48 ENSMUST00000046587.6
Scamp5
secretory carrier membrane protein 5
chr11_-_76179499 0.47 ENSMUST00000167114.1
ENSMUST00000094015.4
ENSMUST00000108419.2
ENSMUST00000170730.1
ENSMUST00000129256.1
ENSMUST00000056601.4
Vps53
vacuolar protein sorting 53 (yeast)
chr2_+_85991819 0.45 ENSMUST00000050942.2
Olfr1031
olfactory receptor 1031
chrX_+_157818435 0.42 ENSMUST00000087157.4
Klhl34
kelch-like 34
chr18_+_40256960 0.42 ENSMUST00000096572.1
2900055J20Rik
RIKEN cDNA 2900055J20 gene
chr7_-_4844665 0.42 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7
shisa homolog 7 (Xenopus laevis)
chr2_-_137116624 0.42 ENSMUST00000028735.7
Jag1
jagged 1
chr11_+_109650574 0.42 ENSMUST00000106676.1
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
chr11_+_72207537 0.40 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr2_-_142901506 0.40 ENSMUST00000043589.7
Kif16b
kinesin family member 16B
chr19_+_25610533 0.40 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chr2_-_85519018 0.39 ENSMUST00000099923.1
4833423E24Rik
RIKEN cDNA 4833423E24 gene
chr6_-_29165003 0.36 ENSMUST00000007993.9
Rbm28
RNA binding motif protein 28
chr15_+_100227871 0.35 ENSMUST00000163855.1
Atf1
activating transcription factor 1
chr16_+_62814676 0.34 ENSMUST00000055557.5
Stx19
syntaxin 19
chr18_+_77065195 0.33 ENSMUST00000114777.2
Pias2
protein inhibitor of activated STAT 2
chr11_-_102406783 0.31 ENSMUST00000155104.1
ENSMUST00000130436.1
Slc25a39
solute carrier family 25, member 39
chr8_-_105413473 0.31 ENSMUST00000167294.1
ENSMUST00000063071.6
Kctd19
potassium channel tetramerisation domain containing 19
chr16_+_18811772 0.31 ENSMUST00000168822.1
ENSMUST00000115578.3
Ufd1l
ubiquitin fusion degradation 1 like
chr7_+_82867327 0.29 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr2_-_33942111 0.27 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403
predicted gene 13403
chr11_-_99851608 0.27 ENSMUST00000107437.1
Krtap4-16
keratin associated protein 4-16
chr3_-_86002491 0.23 ENSMUST00000061343.3
Prss48
protease, serine, 48
chr14_+_101653967 0.21 ENSMUST00000002289.6
Uchl3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr12_+_4592992 0.21 ENSMUST00000062580.7
Itsn2
intersectin 2
chr8_+_119910792 0.20 ENSMUST00000108988.2
ENSMUST00000108982.4
ENSMUST00000127664.1
Usp10
Gm20388
ubiquitin specific peptidase 10
predicted gene 20388
chr11_+_58009064 0.20 ENSMUST00000071487.6
ENSMUST00000178636.1
Larp1
La ribonucleoprotein domain family, member 1
chr8_-_117082449 0.17 ENSMUST00000098375.4
ENSMUST00000109093.2
Pkd1l2
polycystic kidney disease 1 like 2
chr13_-_98891036 0.13 ENSMUST00000109399.2
Tnpo1
transportin 1
chr4_-_11386679 0.12 ENSMUST00000043781.7
ENSMUST00000108310.1
Esrp1
epithelial splicing regulatory protein 1
chr14_-_50930803 0.10 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
Tmem55b
transmembrane protein 55b
chr8_-_64693027 0.10 ENSMUST00000048967.7
Cpe
carboxypeptidase E

Network of associatons between targets according to the STRING database.

First level regulatory network of Twist1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535)
1.1 13.8 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.0 5.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
1.0 2.9 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.9 3.8 GO:0034769 basement membrane disassembly(GO:0034769)
0.9 9.7 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.9 2.6 GO:0015755 fructose transport(GO:0015755)
0.8 5.3 GO:1904222 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.8 0.8 GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324)
0.7 2.2 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.7 4.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.7 3.4 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.6 1.9 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.6 1.8 GO:0036118 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.5 2.2 GO:0090472 dibasic protein processing(GO:0090472)
0.5 1.5 GO:0009750 response to fructose(GO:0009750)
0.5 1.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.4 3.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 4.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.4 3.5 GO:0035754 B cell chemotaxis(GO:0035754)
0.4 1.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.4 3.6 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.3 1.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 6.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 0.8 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.2 1.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.2 0.7 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 6.8 GO:0014002 astrocyte development(GO:0014002)
0.2 1.6 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 0.9 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 0.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 1.4 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 0.9 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 2.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 1.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.6 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.5 GO:0000050 urea cycle(GO:0000050)
0.1 1.2 GO:0060019 radial glial cell differentiation(GO:0060019) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 1.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.8 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 1.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 1.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.5 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 3.7 GO:0007520 myoblast fusion(GO:0007520)
0.1 3.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.5 GO:0031424 keratinization(GO:0031424)
0.0 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 1.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.7 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.8 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.0 0.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.3 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.7 GO:0010524 positive regulation of calcium ion transport into cytosol(GO:0010524)
0.0 0.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 1.5 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.0 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 22.5 GO:0006508 proteolysis(GO:0006508)
0.0 2.2 GO:0006909 phagocytosis(GO:0006909)
0.0 0.7 GO:0070527 platelet aggregation(GO:0070527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.6 3.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.6 5.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 2.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.5 1.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.4 1.8 GO:0043293 apoptosome(GO:0043293)
0.4 0.8 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.3 4.2 GO:0016342 catenin complex(GO:0016342)
0.2 1.0 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.2 5.6 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.2 3.4 GO:0032279 asymmetric synapse(GO:0032279)
0.2 1.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 0.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 2.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 2.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.5 GO:1990745 EARP complex(GO:1990745)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.9 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 4.2 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 32.8 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 4.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.9 GO:0043197 dendritic spine(GO:0043197)
0.0 1.2 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
1.2 3.6 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.0 2.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.7 2.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.7 3.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.7 2.0 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.5 1.4 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.5 4.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.4 5.3 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 10.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 3.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.3 4.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 3.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 13.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.2 1.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.2 2.2 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2 1.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 1.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 5.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 2.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 2.6 GO:0005536 glucose binding(GO:0005536)
0.1 1.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 25.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 6.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.8 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.5 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 3.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 1.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.7 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 5.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.2 GO:0090079 translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 2.2 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.8 PID ALK2 PATHWAY ALK2 signaling events
0.1 5.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 4.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 4.1 PID P73PATHWAY p73 transcription factor network
0.0 7.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.8 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 2.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 3.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 2.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 4.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.8 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.2 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 1.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 2.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.0 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis