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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zfp652

Z-value: 0.98

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Transcription factors associated with Zfp652

Gene Symbol Gene ID Gene Info
ENSMUSG00000075595.3 zinc finger protein 652

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp652mm10_v2_chr11_+_95749067_957490670.411.3e-02Click!

Activity profile of Zfp652 motif

Sorted Z-values of Zfp652 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp652

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.8 2.4 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.6 1.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.5 1.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 1.2 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) response to mineralocorticoid(GO:0051385)
0.2 0.9 GO:1902303 negative regulation of potassium ion export(GO:1902303)
0.2 0.7 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.2 0.7 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466) regulation of G-protein coupled receptor internalization(GO:1904020)
0.2 0.8 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2 2.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 1.0 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 1.1 GO:0015074 DNA integration(GO:0015074)
0.1 0.9 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.4 GO:0042668 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 1.7 GO:0015747 urate transport(GO:0015747)
0.1 0.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.3 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.1 0.3 GO:0072720 response to sorbitol(GO:0072708) response to dithiothreitol(GO:0072720)
0.1 0.6 GO:0097350 neutrophil clearance(GO:0097350)
0.1 0.3 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443) multicellular organism lipid catabolic process(GO:0044240)
0.1 2.3 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 1.0 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 1.2 GO:0060159 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.8 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.2 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.1 0.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.4 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0046049 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.0 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 1.2 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 1.4 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.5 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 1.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 2.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.4 GO:0097435 fibril organization(GO:0097435)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0005588 collagen type V trimer(GO:0005588)
0.6 2.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.0 GO:0046691 intracellular canaliculus(GO:0046691)
0.3 1.0 GO:0043259 laminin-5 complex(GO:0005610) laminin-10 complex(GO:0043259)
0.2 0.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.0 GO:0002102 podosome(GO:0002102)
0.0 2.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.6 GO:0033643 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0042627 chylomicron(GO:0042627)
0.0 1.7 GO:0005882 intermediate filament(GO:0005882)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.3 2.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.8 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 1.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 1.7 GO:0031404 chloride ion binding(GO:0031404)
0.2 0.9 GO:0000155 phosphorelay sensor kinase activity(GO:0000155) voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 0.4 GO:0071820 N-box binding(GO:0071820)
0.1 0.4 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.9 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0034235 GPI anchor binding(GO:0034235)
0.1 1.0 GO:0015250 water channel activity(GO:0015250)
0.1 1.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.3 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.5 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.4 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 4.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.4 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.9 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 1.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 2.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development