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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gsx2_Hoxd3_Vax1

Z-value: 1.28

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Transcription factors associated with Gsx2_Hoxd3_Vax1

Gene Symbol Gene ID Gene Info
ENSMUSG00000035946.6 GS homeobox 2
ENSMUSG00000079277.3 homeobox D3
ENSMUSG00000006270.6 ventral anterior homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Vax1mm10_v2_chr19_-_59170978_59170978-0.572.8e-04Click!
Hoxd3mm10_v2_chr2_+_74711911_74711939-0.391.8e-02Click!

Activity profile of Gsx2_Hoxd3_Vax1 motif

Sorted Z-values of Gsx2_Hoxd3_Vax1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.6 4.8 GO:1903919 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
1.3 3.8 GO:0060995 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.0 2.9 GO:0018879 biphenyl metabolic process(GO:0018879)
0.7 2.7 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.6 8.4 GO:0015747 urate transport(GO:0015747)
0.4 1.8 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.3 2.8 GO:0019532 oxalate transport(GO:0019532)
0.3 1.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 0.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 0.7 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 1.4 GO:0033762 response to glucagon(GO:0033762)
0.2 1.6 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 1.3 GO:0006083 acetate metabolic process(GO:0006083)
0.2 0.9 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 2.7 GO:0048733 sebaceous gland development(GO:0048733)
0.2 1.9 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 2.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 2.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.4 GO:1903189 enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 1.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.4 GO:0030091 protein repair(GO:0030091)
0.1 0.6 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.4 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.6 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.6 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.1 0.6 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 1.6 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.2 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.4 GO:0030035 microspike assembly(GO:0030035)
0.0 0.1 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.0 0.6 GO:0019321 pentose metabolic process(GO:0019321)
0.0 1.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.7 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 1.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0015888 thiamine transport(GO:0015888)
0.0 0.3 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.0 0.1 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.0 0.4 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.3 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.5 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.3 GO:0043029 T cell homeostasis(GO:0043029)
0.0 1.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 2.9 GO:0007601 visual perception(GO:0007601)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) recognition of apoptotic cell(GO:0043654)
0.0 1.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.5 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 14.0 GO:0055114 oxidation-reduction process(GO:0055114)
0.0 0.6 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.4 GO:0071801 regulation of podosome assembly(GO:0071801)
0.0 1.2 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.8 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 8.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.6 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.4 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 3.9 GO:0045095 keratin filament(GO:0045095)
0.1 0.8 GO:0033503 HULC complex(GO:0033503)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.6 GO:0070695 FHF complex(GO:0070695)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 0.9 GO:0016600 flotillin complex(GO:0016600)
0.1 0.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 3.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.4 GO:0070469 respiratory chain(GO:0070469)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 4.2 GO:0030018 Z disc(GO:0030018)
0.0 2.4 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 16.7 GO:0005730 nucleolus(GO:0005730)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0005118 sevenless binding(GO:0005118)
0.9 9.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.8 4.8 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.6 13.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.6 8.4 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.4 1.3 GO:0019807 aspartoacylase activity(GO:0019807)
0.4 1.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.3 1.6 GO:0043532 angiostatin binding(GO:0043532)
0.2 2.7 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 3.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 0.6 GO:0019150 D-ribulokinase activity(GO:0019150)
0.2 1.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 2.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 5.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.7 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 0.4 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.1 1.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 3.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.6 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.6 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.1 2.5 GO:0070330 aromatase activity(GO:0070330)
0.1 1.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 2.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.9 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 2.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403) uptake transmembrane transporter activity(GO:0015563)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 4.6 GO:0016853 isomerase activity(GO:0016853)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.9 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 9.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 2.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.5 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 1.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins