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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gata6

Z-value: 0.70

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Transcription factors associated with Gata6

Gene Symbol Gene ID Gene Info
ENSMUSG00000005836.8 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata6mm10_v2_chr18_+_11052487_110525100.591.5e-04Click!

Activity profile of Gata6 motif

Sorted Z-values of Gata6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:1902896 terminal web assembly(GO:1902896)
0.3 2.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 0.9 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 2.4 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.5 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.3 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 1.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 0.5 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 2.5 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.3 GO:0060282 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 1.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 1.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 1.0 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 1.1 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.6 GO:0008203 cholesterol metabolic process(GO:0008203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1990357 terminal web(GO:1990357)
0.1 1.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 3.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.2 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 5.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.9 GO:0031433 telethonin binding(GO:0031433)
0.1 0.4 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.6 GO:0038064 collagen receptor activity(GO:0038064)
0.0 0.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 0.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.3 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 1.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 5.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.7 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression