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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tbx1_Eomes

Z-value: 0.94

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Transcription factors associated with Tbx1_Eomes

Gene Symbol Gene ID Gene Info
ENSMUSG00000009097.9 T-box 1
ENSMUSG00000032446.8 eomesodermin

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx1mm10_v2_chr16_-_18586959_185869700.325.9e-02Click!
Eomesmm10_v2_chr9_+_118478851_1184788660.281.0e-01Click!

Activity profile of Tbx1_Eomes motif

Sorted Z-values of Tbx1_Eomes motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx1_Eomes

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0051714 regulation of cytolysis in other organism(GO:0051710) positive regulation of cytolysis in other organism(GO:0051714)
0.4 1.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 1.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.3 0.8 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 2.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 0.7 GO:0002355 detection of tumor cell(GO:0002355)
0.2 2.4 GO:0048859 formation of anatomical boundary(GO:0048859)
0.2 1.9 GO:0090527 actin filament reorganization(GO:0090527)
0.2 0.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.9 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.2 0.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 0.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012) bud outgrowth involved in lung branching(GO:0060447)
0.1 0.4 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.8 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.4 GO:1902303 negative regulation of potassium ion export(GO:1902303)
0.1 0.4 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.9 GO:0036005 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.1 0.4 GO:0070889 platelet alpha granule organization(GO:0070889)
0.1 0.3 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.3 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.2 GO:0045226 hyaluranon cable assembly(GO:0036118) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.1 0.3 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.1 0.4 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.1 2.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.8 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1 0.4 GO:0048539 bone marrow development(GO:0048539)
0.1 0.3 GO:0051697 protein delipidation(GO:0051697)
0.1 0.4 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.3 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.0 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 2.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.4 GO:0021546 rhombomere development(GO:0021546)
0.0 2.1 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.3 GO:1903849 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.3 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.0 0.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.3 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.0 0.2 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 1.1 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.3 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.4 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562) snRNA modification(GO:0040031)
0.0 0.2 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.3 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 2.9 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.2 GO:0060159 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.8 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.5 GO:0019236 response to pheromone(GO:0019236)
0.0 0.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.1 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0030953 astral microtubule organization(GO:0030953)
0.0 0.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.4 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.3 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.1 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 1.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 2.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.3 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.6 1.9 GO:0071820 N-box binding(GO:0071820)
0.2 1.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 2.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.8 GO:0070728 leucine binding(GO:0070728)
0.1 1.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.9 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0038100 nodal binding(GO:0038100)
0.1 1.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 2.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.6 GO:0045545 syndecan binding(GO:0045545)
0.1 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155) voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 0.2 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 1.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.4 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 2.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0019808 polyamine binding(GO:0019808)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.5 GO:0008009 chemokine activity(GO:0008009)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 3.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.4 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID EPO PATHWAY EPO signaling pathway
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 3.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.0 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines