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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc9

Z-value: 0.78

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Transcription factors associated with Hoxc9

Gene Symbol Gene ID Gene Info
ENSMUSG00000036139.6 homeobox C9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.086.5e-01Click!

Activity profile of Hoxc9 motif

Sorted Z-values of Hoxc9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.5 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.2 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 0.6 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.2 1.1 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.2 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.9 GO:0060523 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523)
0.1 0.5 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.4 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 0.8 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.7 GO:0061042 vascular wound healing(GO:0061042)
0.1 2.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 1.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.7 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.2 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.1 0.3 GO:1901581 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 3.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.8 GO:0030903 notochord development(GO:0030903)
0.0 0.3 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 4.5 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0044308 axonal spine(GO:0044308)
0.1 1.2 GO:0005915 zonula adherens(GO:0005915)
0.1 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.3 GO:1990707 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.8 GO:0055100 adiponectin binding(GO:0055100)
0.3 0.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.4 GO:0047936 glucose 1-dehydrogenase [NAD(P)] activity(GO:0047936)
0.1 2.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035) testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 3.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides