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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Trp73

Z-value: 0.60

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Transcription factors associated with Trp73

Gene Symbol Gene ID Gene Info
ENSMUSG00000029026.10 transformation related protein 73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_154097173-0.029.3e-01Click!

Activity profile of Trp73 motif

Sorted Z-values of Trp73 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1904970 brush border assembly(GO:1904970)
0.1 2.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.8 GO:0015879 carnitine transport(GO:0015879)
0.1 0.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 0.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.6 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 0.3 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 1.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.3 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0 0.1 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.4 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.6 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.4 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.5 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.1 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.0 0.1 GO:0018992 germ-line sex determination(GO:0018992)
0.0 0.2 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.1 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.5 GO:0097435 fibril organization(GO:0097435)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331) protein localization to adherens junction(GO:0071896)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776) positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.0 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.2 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0044299 C-fiber(GO:0044299)
0.0 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)
0.1 0.8 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.0 0.4 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex