avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Atf4
|
ENSMUSG00000042406.7 | activating transcription factor 4 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Atf4 | mm10_v2_chr15_+_80255184_80255263 | 0.47 | 3.7e-03 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
5.7 | 28.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
3.9 | 11.7 | GO:0006592 | ornithine biosynthetic process(GO:0006592) |
1.2 | 6.0 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
1.1 | 4.6 | GO:0006561 | proline biosynthetic process(GO:0006561) |
1.0 | 9.4 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.9 | 2.6 | GO:0061536 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
0.8 | 3.2 | GO:0015825 | L-serine transport(GO:0015825) |
0.7 | 6.6 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.7 | 4.2 | GO:0006116 | NADH oxidation(GO:0006116) |
0.7 | 10.7 | GO:0015809 | arginine transport(GO:0015809) |
0.6 | 1.9 | GO:0034395 | regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) |
0.6 | 1.8 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
0.5 | 1.5 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
0.4 | 1.3 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
0.4 | 1.1 | GO:0009258 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
0.4 | 4.4 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.3 | 2.6 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
0.3 | 1.4 | GO:0015960 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
0.2 | 0.2 | GO:0072368 | regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368) |
0.2 | 2.1 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
0.2 | 0.8 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
0.2 | 1.4 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
0.2 | 2.8 | GO:0001778 | plasma membrane repair(GO:0001778) |
0.2 | 3.6 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.2 | 5.2 | GO:0031065 | positive regulation of histone deacetylation(GO:0031065) |
0.2 | 3.4 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
0.2 | 4.0 | GO:0043486 | histone exchange(GO:0043486) |
0.2 | 0.6 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
0.2 | 3.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.2 | 0.6 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
0.1 | 0.5 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
0.1 | 0.8 | GO:1904252 | negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252) |
0.1 | 0.4 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
0.1 | 2.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
0.1 | 5.7 | GO:0006826 | iron ion transport(GO:0006826) |
0.1 | 6.3 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
0.1 | 5.4 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
0.1 | 0.3 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
0.1 | 10.4 | GO:0016579 | protein deubiquitination(GO:0016579) |
0.1 | 1.6 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.1 | 0.6 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
0.1 | 0.9 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
0.0 | 5.7 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity(GO:2000117) |
0.0 | 0.4 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.0 | 1.3 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
0.0 | 1.5 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.0 | 0.5 | GO:2000194 | regulation of female gonad development(GO:2000194) |
0.0 | 1.9 | GO:0034605 | cellular response to heat(GO:0034605) |
0.0 | 0.4 | GO:0006825 | copper ion transport(GO:0006825) |
0.0 | 3.2 | GO:0046330 | positive regulation of JNK cascade(GO:0046330) |
0.0 | 0.7 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
0.0 | 0.1 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 28.3 | GO:0015030 | Cajal body(GO:0015030) |
0.4 | 1.3 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
0.4 | 2.8 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
0.3 | 1.5 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
0.2 | 3.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
0.2 | 0.5 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
0.2 | 1.4 | GO:0042382 | paraspeckles(GO:0042382) |
0.2 | 1.3 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
0.1 | 10.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.1 | 2.1 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.1 | 6.6 | GO:0031430 | M band(GO:0031430) |
0.1 | 3.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 2.6 | GO:0002102 | podosome(GO:0002102) |
0.1 | 0.4 | GO:0070187 | telosome(GO:0070187) |
0.0 | 0.2 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.0 | 6.0 | GO:0000793 | condensed chromosome(GO:0000793) |
0.0 | 3.2 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 1.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 9.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 4.0 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
0.0 | 1.9 | GO:0005901 | caveola(GO:0005901) |
0.0 | 5.4 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 10.1 | GO:0009986 | cell surface(GO:0009986) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.1 | 28.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
3.9 | 11.7 | GO:0017084 | glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202) |
1.3 | 10.7 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
1.1 | 4.6 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
1.1 | 3.4 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
0.7 | 4.4 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.6 | 1.8 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
0.5 | 1.5 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
0.5 | 1.9 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
0.5 | 5.7 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
0.4 | 1.1 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
0.3 | 3.2 | GO:0022858 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
0.3 | 4.0 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
0.3 | 2.6 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.2 | 0.7 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
0.2 | 0.8 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
0.1 | 1.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.1 | 0.3 | GO:0004816 | asparagine-tRNA ligase activity(GO:0004816) |
0.1 | 10.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
0.1 | 0.5 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
0.1 | 6.6 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 0.1 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
0.1 | 0.4 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
0.1 | 1.4 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
0.1 | 3.3 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 4.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
0.0 | 9.0 | GO:0008201 | heparin binding(GO:0008201) |
0.0 | 0.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 1.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.0 | 4.9 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.4 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.0 | 6.8 | GO:0042393 | histone binding(GO:0042393) |
0.0 | 6.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 2.8 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
0.0 | 1.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 1.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
0.0 | 0.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 1.4 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.0 | 0.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
0.0 | 0.1 | GO:0050815 | phosphoserine binding(GO:0050815) |
0.0 | 0.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 1.6 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 9.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.1 | 7.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
0.1 | 2.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
0.1 | 2.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
0.1 | 1.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 2.0 | PID REELIN PATHWAY | Reelin signaling pathway |
0.0 | 4.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
0.0 | 1.8 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
0.0 | 1.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
0.0 | 1.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
0.0 | 0.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 29.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.5 | 13.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.4 | 9.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.3 | 14.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.3 | 6.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.2 | 2.6 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.1 | 1.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.1 | 3.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
0.1 | 7.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.1 | 1.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.1 | 4.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.1 | 0.4 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
0.1 | 6.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.6 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
0.0 | 1.3 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
0.0 | 3.0 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
0.0 | 1.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |