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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Otx1

Z-value: 1.13

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Transcription factors associated with Otx1

Gene Symbol Gene ID Gene Info
ENSMUSG00000005917.9 orthodenticle homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.096.1e-01Click!

Activity profile of Otx1 motif

Sorted Z-values of Otx1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Otx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.9 6.0 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.4 1.8 GO:0090472 dibasic protein processing(GO:0090472)
0.2 0.9 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 0.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 0.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.6 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.7 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 1.4 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 2.9 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.1 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.5 GO:0039019 pronephric nephron development(GO:0039019)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.7 GO:0050872 white fat cell differentiation(GO:0050872)
0.1 1.3 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 0.7 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.7 GO:0036315 cellular response to sterol(GO:0036315)
0.0 0.6 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.2 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.6 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.7 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.2 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 1.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 1.0 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.0 GO:0009268 response to pH(GO:0009268)
0.0 0.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 1.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.6 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.0 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.0 0.3 GO:1901798 positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 2.3 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0031983 vesicle lumen(GO:0031983)
0.1 6.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.8 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 6.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 7.4 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.5 1.6 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.5 1.9 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.3 6.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 7.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.7 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.7 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.7 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 2.9 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.7 GO:0005521 lamin binding(GO:0005521)
0.1 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 1.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.6 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 2.0 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 3.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0032029 myosin tail binding(GO:0032029)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 4.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 2.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 2.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.6 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.7 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 2.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.7 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.8 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC