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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nfe2l2

Z-value: 0.68

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Transcription factors associated with Nfe2l2

Gene Symbol Gene ID Gene Info
ENSMUSG00000015839.6 nuclear factor, erythroid derived 2, like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.009.8e-01Click!

Activity profile of Nfe2l2 motif

Sorted Z-values of Nfe2l2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.6 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.5 1.5 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.5 1.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.3 0.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.3 1.1 GO:0035524 proline transmembrane transport(GO:0035524) glycine import(GO:0036233)
0.3 0.8 GO:1904023 regulation of fermentation(GO:0043465) regulation of bone mineralization involved in bone maturation(GO:1900157) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.2 0.6 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.2 0.5 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.9 GO:0007412 axon target recognition(GO:0007412)
0.1 0.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 1.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.1 1.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.8 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.1 0.3 GO:0061153 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.2 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.1 0.2 GO:0072034 renal vesicle induction(GO:0072034)
0.1 0.6 GO:0009137 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 0.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.9 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion(GO:0010881)
0.1 2.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.5 GO:0038031 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 0.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:0070488 neutrophil aggregation(GO:0070488)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108) regulation of NADP metabolic process(GO:1902031)
0.0 0.4 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.0 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0072138 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.0 0.1 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.7 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.2 GO:0071543 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.7 GO:0071450 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 1.0 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.1 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.3 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.3 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.6 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.0 GO:0006222 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0034769 basement membrane disassembly(GO:0034769)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 0.7 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.3 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 1.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.2 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.6 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:1990462 omegasome(GO:1990462)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235)
0.0 2.3 GO:0005875 microtubule associated complex(GO:0005875)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.4 1.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
0.3 1.7 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.2 0.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 1.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.1 0.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 0.3 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.6 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 1.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 5.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 2.2 GO:0002020 protease binding(GO:0002020)
0.0 1.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 1.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA