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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox14

Z-value: 1.73

Motif logo

Transcription factors associated with Sox14

Gene Symbol Gene ID Gene Info
ENSMUSG00000053747.8 SRY (sex determining region Y)-box 14

Activity profile of Sox14 motif

Sorted Z-values of Sox14 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
1.9 5.7 GO:0060369 positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.4 10.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.2 3.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
1.0 3.0 GO:0034147 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.9 2.6 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
0.8 24.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.8 6.5 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.8 4.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.8 3.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.7 2.7 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.6 2.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.6 6.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.6 2.5 GO:0051944 positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.5 1.6 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.5 1.5 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.5 2.5 GO:1904925 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.5 3.5 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.5 2.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.5 2.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.5 1.8 GO:0015825 L-serine transport(GO:0015825)
0.5 2.3 GO:0006868 glutamine transport(GO:0006868)
0.4 2.7 GO:0030421 defecation(GO:0030421)
0.4 1.9 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.4 1.8 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.4 1.1 GO:2000458 immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
0.3 2.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.3 1.6 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.3 1.0 GO:2000978 auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.3 1.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) negative regulation of neutrophil activation(GO:1902564)
0.3 2.5 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.3 0.9 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.3 5.1 GO:0070307 lens fiber cell development(GO:0070307)
0.3 4.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 1.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 0.7 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.2 3.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.2 2.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 0.8 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.2 0.8 GO:0030070 insulin processing(GO:0030070)
0.2 1.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.2 1.9 GO:0006527 arginine catabolic process(GO:0006527)
0.2 3.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.2 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 0.6 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 3.9 GO:0014823 response to activity(GO:0014823)
0.2 0.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.7 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.7 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.8 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 1.9 GO:0032808 lacrimal gland development(GO:0032808)
0.1 0.7 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.1 0.7 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 2.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 1.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.4 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 3.8 GO:0097435 fibril organization(GO:0097435)
0.1 1.6 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 2.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.3 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.3 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.5 GO:0060279 positive regulation of ovulation(GO:0060279)
0.1 0.5 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 2.6 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.7 GO:0051013 microtubule severing(GO:0051013)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.3 GO:1903898 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 1.6 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 1.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.2 GO:0033189 response to vitamin A(GO:0033189)
0.1 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 1.0 GO:0032274 gonadotropin secretion(GO:0032274)
0.1 0.1 GO:1902022 L-lysine transport(GO:1902022)
0.1 0.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.7 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.1 4.6 GO:0001541 ovarian follicle development(GO:0001541)
0.1 1.0 GO:0051601 exocyst localization(GO:0051601)
0.1 0.3 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.2 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.1 1.8 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 5.8 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 2.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 1.4 GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 0.7 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 2.3 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 3.0 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.7 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.9 GO:0006379 mRNA cleavage(GO:0006379)
0.0 4.1 GO:0051225 spindle assembly(GO:0051225)
0.0 0.6 GO:0032570 response to progesterone(GO:0032570)
0.0 0.2 GO:0031296 B cell costimulation(GO:0031296)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.8 GO:0008585 female gonad development(GO:0008585)
0.0 0.4 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.9 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 1.8 GO:0008347 glial cell migration(GO:0008347)
0.0 1.3 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 1.5 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.5 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.6 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.2 GO:0010288 response to lead ion(GO:0010288)
0.0 0.6 GO:0015858 nucleoside transport(GO:0015858)
0.0 2.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 2.0 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 0.5 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 2.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.3 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.5 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.8 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.9 3.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.8 2.5 GO:0005607 laminin-2 complex(GO:0005607)
0.6 2.4 GO:0014802 terminal cisterna(GO:0014802)
0.6 2.3 GO:0008623 CHRAC(GO:0008623)
0.5 3.8 GO:0042382 paraspeckles(GO:0042382)
0.4 1.8 GO:0005594 collagen type IX trimer(GO:0005594)
0.4 2.7 GO:0001740 Barr body(GO:0001740)
0.4 4.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 3.5 GO:0045298 tubulin complex(GO:0045298)
0.3 0.6 GO:0042585 germinal vesicle(GO:0042585)
0.3 2.5 GO:0000796 condensin complex(GO:0000796)
0.3 1.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 1.3 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.2 3.8 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 3.1 GO:0070938 contractile ring(GO:0070938)
0.2 2.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.4 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 2.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.1 GO:0010369 chromocenter(GO:0010369)
0.1 1.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 3.4 GO:0031430 M band(GO:0031430)
0.1 0.7 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.7 GO:0005861 troponin complex(GO:0005861)
0.1 6.7 GO:0005882 intermediate filament(GO:0005882)
0.1 0.3 GO:0097443 sorting endosome(GO:0097443)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 5.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.6 GO:0030315 T-tubule(GO:0030315)
0.0 2.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 3.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 3.8 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 1.0 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.3 GO:0031672 A band(GO:0031672)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 7.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.9 4.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.8 2.4 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.8 3.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.7 4.7 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.5 2.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.4 4.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 1.6 GO:0003883 CTP synthase activity(GO:0003883)
0.4 3.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 1.8 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.4 1.1 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
0.3 1.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 5.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 3.5 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3 18.5 GO:0005158 insulin receptor binding(GO:0005158)
0.3 0.9 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.3 5.8 GO:0005523 tropomyosin binding(GO:0005523)
0.3 5.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 2.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.3 2.5 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 1.8 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.3 1.5 GO:0042731 PH domain binding(GO:0042731)
0.3 0.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 4.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 1.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 0.9 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.2 1.5 GO:0034056 estrogen response element binding(GO:0034056)
0.2 6.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 2.6 GO:0031432 titin binding(GO:0031432)
0.1 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 7.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.8 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.1 2.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.4 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.7 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 4.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 2.5 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 0.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 2.5 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.1 0.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 1.4 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 3.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 3.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.7 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.4 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 2.5 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.0 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 2.7 GO:0008083 growth factor activity(GO:0008083)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 2.1 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 4.7 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 10.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 6.4 PID AURORA B PATHWAY Aurora B signaling
0.1 6.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 4.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 2.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 2.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 4.4 PID NOTCH PATHWAY Notch signaling pathway
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 2.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 6.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.3 3.0 REACTOME DEFENSINS Genes involved in Defensins
0.2 0.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 4.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 6.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 5.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 4.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 5.2 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 3.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 1.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 2.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.5 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA