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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Atf5

Z-value: 0.49

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Transcription factors associated with Atf5

Gene Symbol Gene ID Gene Info
ENSMUSG00000038539.8 activating transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Atf5mm10_v2_chr7_-_44815658_44815682-0.115.2e-01Click!

Activity profile of Atf5 motif

Sorted Z-values of Atf5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.2 0.6 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.4 GO:0038190 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.1 0.4 GO:2000041 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 1.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.4 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.3 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 0.3 GO:0060618 nipple development(GO:0060618)
0.1 0.4 GO:0007113 endomitotic cell cycle(GO:0007113)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.7 GO:0030035 microspike assembly(GO:0030035)
0.1 0.6 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 0.1 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608)
0.1 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.6 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.4 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.1 0.5 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.1 0.2 GO:1990743 protein sialylation(GO:1990743)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.2 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.4 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.3 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.4 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 1.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0035989 tendon development(GO:0035989)
0.0 0.5 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0 0.1 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.4 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 2.7 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.2 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.4 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.1 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.0 0.1 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.6 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.6 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.1 GO:0071820 N-box binding(GO:0071820)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0042166 acetylcholine binding(GO:0042166)
0.0 0.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex