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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Msx2_Hoxd4

Z-value: 1.33

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Transcription factors associated with Msx2_Hoxd4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021469.8 msh homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_534730740.401.7e-02Click!

Activity profile of Msx2_Hoxd4 motif

Sorted Z-values of Msx2_Hoxd4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0035566 regulation of metanephros size(GO:0035566)
1.0 4.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.8 17.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.5 1.6 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.5 2.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.4 1.6 GO:0061743 motor learning(GO:0061743)
0.4 2.7 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.4 2.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.4 5.4 GO:0001778 plasma membrane repair(GO:0001778)
0.4 1.1 GO:0031283 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 0.9 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.3 0.9 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.3 1.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 0.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 1.3 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 0.6 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 1.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 1.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.4 GO:0090260 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 1.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.4 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 1.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 1.9 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.7 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 4.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.3 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.1 1.7 GO:0032060 bleb assembly(GO:0032060)
0.1 0.6 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 1.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 1.1 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.4 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 1.0 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 1.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 4.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 0.9 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 1.4 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 2.3 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0043622 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660)
0.0 1.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 1.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.6 GO:0060539 diaphragm development(GO:0060539)
0.0 1.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.0 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 1.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.6 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.1 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.9 GO:0019236 response to pheromone(GO:0019236)
0.0 0.4 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 1.2 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.7 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 1.9 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.2 GO:0002827 positive regulation of T-helper 1 type immune response(GO:0002827)
0.0 0.2 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 0.7 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 17.9 GO:0071439 clathrin complex(GO:0071439)
0.7 5.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.5 2.7 GO:0098536 deuterosome(GO:0098536)
0.4 1.6 GO:0031523 Myb complex(GO:0031523)
0.3 2.3 GO:0001940 male pronucleus(GO:0001940)
0.3 1.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0072534 perineuronal net(GO:0072534)
0.1 0.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.2 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.1 1.4 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 4.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0031091 platelet alpha granule(GO:0031091)
0.0 4.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.7 GO:0042588 zymogen granule(GO:0042588)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.2 4.7 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.4 1.6 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.4 1.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 1.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 1.7 GO:0005499 vitamin D binding(GO:0005499)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 2.1 GO:0030274 LIM domain binding(GO:0030274)
0.2 1.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 1.3 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.7 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 1.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.9 GO:0036122 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.3 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 2.5 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 1.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 15.2 GO:0005543 phospholipid binding(GO:0005543)
0.0 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 4.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.3 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.8 REACTOME KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 1.1 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 6.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases