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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Meox1

Z-value: 0.54

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Transcription factors associated with Meox1

Gene Symbol Gene ID Gene Info
ENSMUSG00000001493.9 mesenchyme homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Meox1mm10_v2_chr11_-_101894355_101894374-0.086.4e-01Click!

Activity profile of Meox1 motif

Sorted Z-values of Meox1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Meox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0045575 basophil activation(GO:0045575)
0.4 1.9 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.3 1.0 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 0.5 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.2 0.7 GO:0061743 motor learning(GO:0061743)
0.2 0.5 GO:0071661 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.1 0.6 GO:0033382 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.1 0.6 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 0.4 GO:0070340 detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 0.4 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 0.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.6 GO:1903336 endosome localization(GO:0032439) negative regulation of vacuolar transport(GO:1903336)
0.1 0.3 GO:1900135 positive regulation of eosinophil degranulation(GO:0043311) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) positive regulation of renin secretion into blood stream(GO:1900135) positive regulation of eosinophil activation(GO:1902568)
0.1 0.3 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.4 GO:2000471 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.3 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.2 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.3 GO:0015676 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 0.2 GO:1904732 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.1 1.1 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 1.3 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.2 GO:0060364 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.0 0.3 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.2 GO:1905154 negative regulation of membrane invagination(GO:1905154)
0.0 0.5 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0006059 hexitol metabolic process(GO:0006059)
0.0 0.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.1 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.4 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.5 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.4 GO:0046541 saliva secretion(GO:0046541)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.4 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.4 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.2 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.6 GO:0097435 fibril organization(GO:0097435)
0.0 0.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.1 GO:0015822 lysine transport(GO:0015819) ornithine transport(GO:0015822)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.0 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.8 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.1 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.0 GO:1900239 regulation of phenotypic switching(GO:1900239)
0.0 0.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071953 elastic fiber(GO:0071953)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.3 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004349 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.2 0.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.2 0.6 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.4 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.3 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0004064 arylesterase activity(GO:0004064)
0.1 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 0.4 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0023029 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding(GO:0023029) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 2.3 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 4.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.7 GO:0005549 odorant binding(GO:0005549)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends