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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Plagl1

Z-value: 1.12

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Transcription factors associated with Plagl1

Gene Symbol Gene ID Gene Info
ENSMUSG00000019817.12 pleiomorphic adenoma gene-like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.828.2e-10Click!

Activity profile of Plagl1 motif

Sorted Z-values of Plagl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Plagl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0060752 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
1.5 6.0 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
1.0 3.0 GO:0042732 D-xylose metabolic process(GO:0042732)
0.8 3.4 GO:0030091 protein repair(GO:0030091)
0.4 2.2 GO:0006068 ethanol catabolic process(GO:0006068)
0.3 1.0 GO:0021759 globus pallidus development(GO:0021759)
0.3 5.8 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.2 1.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.2 2.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 1.6 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.2 0.9 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.2 1.4 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.6 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.2 3.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.7 GO:0046684 response to pyrethroid(GO:0046684)
0.2 0.9 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 4.2 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 1.3 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 1.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 3.5 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1 0.4 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.1 2.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 1.3 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.1 2.9 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.8 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.1 2.3 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.2 GO:0098596 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.1 2.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 1.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 0.8 GO:0015879 carnitine transport(GO:0015879)
0.1 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 1.5 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.9 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.8 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 1.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 1.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 1.4 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.4 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.9 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 1.0 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.0 0.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.3 GO:0014850 response to muscle activity(GO:0014850)
0.0 1.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 1.9 GO:0007584 response to nutrient(GO:0007584)
0.0 4.1 GO:0051321 meiotic cell cycle(GO:0051321)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.4 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 1.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 1.4 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.5 GO:0008333 endosome to lysosome transport(GO:0008333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.5 3.5 GO:0008091 spectrin(GO:0008091)
0.4 1.6 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.3 3.1 GO:0005579 membrane attack complex(GO:0005579)
0.2 1.0 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.2 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 6.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.1 0.5 GO:0097413 Lewy body(GO:0097413)
0.1 1.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 6.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 3.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.8 GO:0016235 aggresome(GO:0016235)
0.0 2.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.9 GO:0032420 stereocilium(GO:0032420)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.9 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 4.0 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 5.8 GO:0016151 nickel cation binding(GO:0016151)
0.5 1.4 GO:0004794 L-threonine ammonia-lyase activity(GO:0004794)
0.4 2.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 2.2 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.3 9.9 GO:0017127 cholesterol transporter activity(GO:0017127)
0.3 1.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.3 6.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 1.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.3 0.8 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.2 1.9 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.2 1.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 4.2 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.0 GO:0008384 NF-kappaB-inducing kinase activity(GO:0004704) IkappaB kinase activity(GO:0008384)
0.2 1.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.2 0.6 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.2 0.6 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 0.8 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.9 GO:0032027 myosin light chain binding(GO:0032027)
0.1 3.1 GO:0001848 complement binding(GO:0001848)
0.1 0.3 GO:0070905 serine binding(GO:0070905)
0.1 1.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.8 GO:0070628 proteasome binding(GO:0070628)
0.1 1.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 3.0 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 1.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0001729 ceramide kinase activity(GO:0001729)
0.0 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 2.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.1 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 5.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.8 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.0 GO:0030546 receptor activator activity(GO:0030546)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 1.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 4.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 1.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.5 11.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 2.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 6.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 6.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 2.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.1 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 1.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression