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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Lhx8

Z-value: 1.19

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Transcription factors associated with Lhx8

Gene Symbol Gene ID Gene Info
ENSMUSG00000096225.2 LIM homeobox protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.212.1e-01Click!

Activity profile of Lhx8 motif

Sorted Z-values of Lhx8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377)
0.7 2.2 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.6 2.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 1.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.3 1.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 0.9 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.2 2.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 2.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 0.7 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
0.1 2.1 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.4 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.6 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 3.8 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.3 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 4.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.9 GO:0050955 thermoception(GO:0050955)
0.1 0.7 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 0.2 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 1.0 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.4 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 0.2 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:0006296 base-excision repair, AP site formation(GO:0006285) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.1 0.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 3.0 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 3.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.0 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.4 GO:0046688 response to copper ion(GO:0046688)
0.0 1.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.3 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.7 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 1.2 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:2000595 optic nerve formation(GO:0021634) regulation of metanephros size(GO:0035566) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.6 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 0.4 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 1.1 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.7 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.0 0.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.4 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.3 GO:0030238 male sex determination(GO:0030238)
0.0 0.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.4 1.3 GO:0034657 GID complex(GO:0034657)
0.2 1.0 GO:0031673 H zone(GO:0031673)
0.1 0.4 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 1.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.8 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 2.8 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.7 2.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.4 1.2 GO:0008431 vitamin E binding(GO:0008431)
0.3 0.8 GO:1902121 NADP+ binding(GO:0070401) lithocholic acid binding(GO:1902121)
0.2 0.7 GO:0004948 calcitonin receptor activity(GO:0004948)
0.2 2.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 8.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 6.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.7 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.8 GO:0070330 aromatase activity(GO:0070330)
0.1 2.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.1 2.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.7 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 2.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 2.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 5.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 2.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification