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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr2f6

Z-value: 1.70

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Transcription factors associated with Nr2f6

Gene Symbol Gene ID Gene Info
ENSMUSG00000002393.8 nuclear receptor subfamily 2, group F, member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_71381977-0.634.4e-05Click!

Activity profile of Nr2f6 motif

Sorted Z-values of Nr2f6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2f6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0036088 D-serine catabolic process(GO:0036088) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
1.1 18.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.8 3.4 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.8 3.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8 2.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.7 3.6 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.7 2.9 GO:1902896 terminal web assembly(GO:1902896)
0.6 2.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 2.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.5 4.6 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.4 2.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 1.7 GO:1904306 regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.4 4.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.4 2.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.4 1.4 GO:0046075 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.3 1.7 GO:0071105 response to interleukin-11(GO:0071105)
0.3 2.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 1.2 GO:0006014 D-ribose metabolic process(GO:0006014)
0.3 1.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 3.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 6.4 GO:0035634 response to stilbenoid(GO:0035634)
0.2 4.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 4.8 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.2 0.5 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.9 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.6 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 1.2 GO:0010757 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) negative regulation of plasminogen activation(GO:0010757)
0.1 3.5 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.4 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.1 0.1 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.1 2.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 8.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 2.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 1.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 5.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 2.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.4 GO:1901998 toxin transport(GO:1901998)
0.1 1.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 2.9 GO:0006414 translational elongation(GO:0006414)
0.1 4.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 2.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0032290 peripheral nervous system myelin formation(GO:0032290) regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 3.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 5.4 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0 1.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:0043928 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.6 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 3.2 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 2.7 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.0 0.9 GO:0003341 cilium movement(GO:0003341)
0.0 0.3 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
1.3 6.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 2.7 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.5 7.1 GO:0097512 cardiac myofibril(GO:0097512)
0.5 2.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5 4.8 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.3 4.2 GO:0005861 troponin complex(GO:0005861)
0.3 1.0 GO:0031251 PAN complex(GO:0031251)
0.2 0.2 GO:0055087 Ski complex(GO:0055087)
0.2 1.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 1.4 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 3.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 1.7 GO:0031931 TORC1 complex(GO:0031931)
0.1 2.9 GO:0032433 filopodium tip(GO:0032433)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.0 GO:0061574 ASAP complex(GO:0061574)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 4.5 GO:0097440 apical dendrite(GO:0097440)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.1 8.4 GO:0005643 nuclear pore(GO:0005643)
0.1 1.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 0.9 GO:0016342 catenin complex(GO:0016342)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 3.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.3 GO:0005914 spot adherens junction(GO:0005914)
0.0 1.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 13.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.6 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 4.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.9 GO:0030018 Z disc(GO:0030018)
0.0 0.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.0 1.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 1.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:0031720 haptoglobin binding(GO:0031720)
1.3 3.8 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
1.1 4.5 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.9 3.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.8 8.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.7 3.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 3.6 GO:0052851 ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.4 2.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 2.3 GO:0019808 polyamine binding(GO:0019808)
0.2 1.2 GO:0015288 porin activity(GO:0015288)
0.1 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 6.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 6.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 5.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 2.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 11.4 GO:0008201 heparin binding(GO:0008201)
0.1 9.4 GO:0003774 motor activity(GO:0003774)
0.1 1.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0070883 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
0.0 2.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 1.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 18.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 3.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 3.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 2.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 5.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 3.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 4.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 6.3 REACTOME TRANSLATION Genes involved in Translation
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 3.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives