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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hivep1

Z-value: 0.93

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Transcription factors associated with Hivep1

Gene Symbol Gene ID Gene Info
ENSMUSG00000021366.7 human immunodeficiency virus type I enhancer binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hivep1mm10_v2_chr13_+_42052015_420520720.153.8e-01Click!

Activity profile of Hivep1 motif

Sorted Z-values of Hivep1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hivep1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.5 1.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.5 4.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 1.8 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.5 2.7 GO:0060931 sinoatrial node cell development(GO:0060931)
0.5 2.7 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.4 2.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.3 1.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.3 1.3 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.3 3.2 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.3 1.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.3 5.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 1.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 1.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 0.6 GO:0071288 cellular response to mercury ion(GO:0071288)
0.2 0.8 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.2 1.0 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 0.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 2.6 GO:0051601 exocyst localization(GO:0051601)
0.1 0.4 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.1 2.1 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.5 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.8 GO:1990573 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) potassium ion import across plasma membrane(GO:1990573)
0.1 0.5 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.1 0.3 GO:0072573 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.1 0.4 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.1 0.3 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.1 1.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.4 GO:0030070 insulin processing(GO:0030070)
0.1 1.2 GO:0070269 pyroptosis(GO:0070269)
0.1 0.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.4 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1 0.2 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.1 1.0 GO:0015747 urate transport(GO:0015747)
0.1 0.6 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 0.2 GO:0000239 pachytene(GO:0000239)
0.1 1.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 0.6 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.3 GO:0032329 serine transport(GO:0032329)
0.1 3.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.0 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.0 0.7 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.5 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.8 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.2 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.3 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.6 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.1 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.2 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 1.0 GO:0045730 respiratory burst(GO:0045730)
0.0 0.4 GO:0070571 negative regulation of neuron projection regeneration(GO:0070571)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.0 0.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.2 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 1.4 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.1 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.5 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.4 GO:0048535 lymph node development(GO:0048535)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.0 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.0 0.5 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0002829 negative regulation of type 2 immune response(GO:0002829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0033193 Lsd1/2 complex(GO:0033193)
0.4 1.5 GO:0045160 myosin I complex(GO:0045160)
0.3 4.7 GO:0042555 MCM complex(GO:0042555)
0.3 1.0 GO:0071953 elastic fiber(GO:0071953)
0.2 5.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 0.8 GO:0000802 transverse filament(GO:0000802)
0.2 2.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 3.0 GO:0042581 specific granule(GO:0042581)
0.2 2.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 1.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.2 2.7 GO:0031143 pseudopodium(GO:0031143)
0.1 0.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 2.6 GO:0000145 exocyst(GO:0000145)
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.2 GO:0032127 dense core granule membrane(GO:0032127)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.8 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0071546 pi-body(GO:0071546)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 1.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 3.9 GO:0042383 sarcolemma(GO:0042383)
0.0 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.1 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.6 1.8 GO:0045159 myosin II binding(GO:0045159)
0.4 4.6 GO:0038064 collagen receptor activity(GO:0038064)
0.3 0.8 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.2 0.8 GO:0004096 catalase activity(GO:0004096)
0.2 0.5 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.2 5.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.8 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.4 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 3.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 4.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.2 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
0.1 0.2 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.4 GO:0045340 mercury ion binding(GO:0045340)
0.1 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.0 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 2.7 GO:0030552 cAMP binding(GO:0030552)
0.1 0.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 1.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0034584 piRNA binding(GO:0034584)
0.0 1.0 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 2.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 1.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 3.2 GO:0000149 SNARE binding(GO:0000149)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID ATR PATHWAY ATR signaling pathway
0.1 2.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 5.0 REACTOME KINESINS Genes involved in Kinesins
0.1 2.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.0 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 1.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 2.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins