avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Nkx6-2
|
ENSMUSG00000041309.11 | NK6 homeobox 2 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx6-2 | mm10_v2_chr7_-_139582790_139582808 | -0.11 | 5.3e-01 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.4 | 17.6 | GO:0035524 | proline transmembrane transport(GO:0035524) |
3.5 | 28.1 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
1.2 | 7.2 | GO:0050916 | sensory perception of sweet taste(GO:0050916) |
1.2 | 6.0 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
1.2 | 3.5 | GO:0098763 | mitotic cell cycle phase(GO:0098763) |
1.1 | 6.6 | GO:0007412 | axon target recognition(GO:0007412) |
0.8 | 5.9 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
0.7 | 5.2 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
0.7 | 6.5 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.6 | 6.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.6 | 4.2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.6 | 3.5 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
0.5 | 1.9 | GO:2001183 | negative regulation of interleukin-12 secretion(GO:2001183) |
0.4 | 2.5 | GO:0098535 | de novo centriole assembly(GO:0098535) |
0.3 | 1.0 | GO:0072276 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
0.3 | 2.0 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
0.3 | 1.2 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
0.3 | 5.8 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
0.3 | 2.8 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
0.3 | 2.1 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.2 | 0.9 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
0.2 | 3.0 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.2 | 1.7 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
0.2 | 1.0 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
0.2 | 1.1 | GO:0061373 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748) |
0.2 | 1.4 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
0.2 | 1.6 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.2 | 3.6 | GO:0060736 | prostate gland growth(GO:0060736) |
0.2 | 1.4 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.2 | 0.5 | GO:0000915 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
0.2 | 0.6 | GO:0060376 | positive regulation of mast cell differentiation(GO:0060376) |
0.1 | 0.5 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
0.1 | 12.4 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
0.1 | 6.1 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
0.1 | 0.4 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.1 | 0.3 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
0.1 | 0.9 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
0.1 | 0.2 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
0.1 | 1.5 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.1 | 1.2 | GO:0033603 | positive regulation of dopamine secretion(GO:0033603) |
0.1 | 9.1 | GO:0051028 | mRNA transport(GO:0051028) |
0.1 | 2.6 | GO:0019731 | antibacterial humoral response(GO:0019731) |
0.1 | 3.0 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
0.1 | 0.5 | GO:0086028 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
0.1 | 1.6 | GO:0051764 | actin crosslink formation(GO:0051764) |
0.1 | 2.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
0.1 | 0.9 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.0 | 2.6 | GO:0006414 | translational elongation(GO:0006414) |
0.0 | 0.2 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
0.0 | 0.9 | GO:0001553 | luteinization(GO:0001553) |
0.0 | 0.7 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.0 | 2.9 | GO:0045576 | mast cell activation(GO:0045576) |
0.0 | 6.0 | GO:0042742 | defense response to bacterium(GO:0042742) |
0.0 | 1.8 | GO:0030819 | positive regulation of cAMP biosynthetic process(GO:0030819) |
0.0 | 0.2 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
0.0 | 0.1 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
0.0 | 0.7 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
0.0 | 1.5 | GO:0061726 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
0.0 | 1.5 | GO:0001889 | liver development(GO:0001889) |
0.0 | 1.4 | GO:0050684 | regulation of mRNA processing(GO:0050684) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 9.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.6 | 2.8 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.5 | 1.6 | GO:0042585 | germinal vesicle(GO:0042585) |
0.5 | 5.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.4 | 2.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.4 | 2.5 | GO:0098536 | deuterosome(GO:0098536) |
0.3 | 0.9 | GO:0071920 | cleavage body(GO:0071920) |
0.3 | 3.5 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.3 | 5.1 | GO:0005652 | nuclear lamina(GO:0005652) |
0.3 | 1.8 | GO:0005796 | Golgi lumen(GO:0005796) |
0.3 | 2.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.2 | 2.1 | GO:0005642 | annulate lamellae(GO:0005642) |
0.2 | 6.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.1 | 1.5 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 1.2 | GO:0005883 | neurofilament(GO:0005883) |
0.1 | 2.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.1 | 0.5 | GO:0044299 | C-fiber(GO:0044299) |
0.1 | 2.1 | GO:0033391 | chromatoid body(GO:0033391) |
0.1 | 7.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.1 | 2.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.1 | 5.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.1 | 1.4 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.1 | 2.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.1 | 1.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 2.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.1 | 1.0 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.1 | 1.0 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.1 | 5.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.1 | 3.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.1 | 3.4 | GO:0001772 | immunological synapse(GO:0001772) |
0.1 | 1.5 | GO:0043596 | nuclear replication fork(GO:0043596) |
0.0 | 9.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.0 | 0.3 | GO:0031673 | H zone(GO:0031673) |
0.0 | 0.5 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
0.0 | 0.9 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 3.5 | GO:0016605 | PML body(GO:0016605) |
0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 6.6 | GO:0044306 | neuron projection terminus(GO:0044306) |
0.0 | 0.4 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 1.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.7 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 2.6 | GO:0001650 | fibrillar center(GO:0001650) |
0.0 | 1.0 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 5.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
0.0 | 22.8 | GO:0005615 | extracellular space(GO:0005615) |
0.0 | 0.3 | GO:0043034 | costamere(GO:0043034) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 6.6 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
1.6 | 17.6 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
1.5 | 9.0 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.8 | 29.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.5 | 5.8 | GO:0038064 | collagen receptor activity(GO:0038064) |
0.4 | 3.0 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
0.4 | 6.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.4 | 6.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.3 | 1.8 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
0.3 | 2.3 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.2 | 7.0 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.2 | 1.7 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.2 | 2.1 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.2 | 1.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
0.2 | 1.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.2 | 0.5 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.1 | 2.0 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.1 | 6.1 | GO:0030295 | protein kinase activator activity(GO:0030295) |
0.1 | 2.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.1 | 1.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.1 | 2.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.1 | 4.2 | GO:0001671 | ATPase activator activity(GO:0001671) |
0.1 | 0.3 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
0.1 | 1.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.1 | 1.5 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.1 | 1.9 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.1 | 0.2 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
0.1 | 1.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 0.7 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
0.1 | 2.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.1 | 1.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 1.9 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.1 | 0.9 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.1 | 1.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.1 | 0.3 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
0.0 | 13.6 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 2.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 6.5 | GO:0047485 | protein N-terminus binding(GO:0047485) |
0.0 | 1.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 2.9 | GO:0019210 | kinase inhibitor activity(GO:0019210) |
0.0 | 2.1 | GO:0003724 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
0.0 | 1.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 1.9 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.0 | 0.5 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.0 | 1.6 | GO:0005080 | protein kinase C binding(GO:0005080) |
0.0 | 2.5 | GO:0004540 | ribonuclease activity(GO:0004540) |
0.0 | 1.2 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 11.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.0 | 6.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 2.4 | GO:0005178 | integrin binding(GO:0005178) |
0.0 | 4.3 | GO:0001664 | G-protein coupled receptor binding(GO:0001664) |
0.0 | 0.5 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
0.0 | 0.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
0.0 | 2.4 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
0.0 | 0.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 21.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.2 | 3.0 | PID S1P S1P4 PATHWAY | S1P4 pathway |
0.1 | 6.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
0.1 | 1.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
0.1 | 6.0 | PID AURORA B PATHWAY | Aurora B signaling |
0.1 | 2.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
0.1 | 8.3 | PID E2F PATHWAY | E2F transcription factor network |
0.1 | 3.5 | PID ATM PATHWAY | ATM pathway |
0.1 | 1.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 2.2 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
0.0 | 1.0 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
0.0 | 0.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
0.0 | 2.3 | PID LKB1 PATHWAY | LKB1 signaling events |
0.0 | 1.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.0 | 1.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
0.0 | 1.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.0 | 0.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
0.0 | 0.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 28.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.4 | 3.5 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.2 | 6.0 | REACTOME KINESINS | Genes involved in Kinesins |
0.2 | 2.1 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
0.1 | 1.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.1 | 13.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.1 | 2.1 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
0.1 | 1.0 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
0.1 | 1.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
0.1 | 3.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
0.1 | 3.0 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
0.1 | 3.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
0.1 | 0.9 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
0.1 | 3.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
0.1 | 7.0 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
0.0 | 1.2 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.0 | 1.4 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
0.0 | 0.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
0.0 | 1.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
0.0 | 1.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 4.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 2.8 | REACTOME TRANSLATION | Genes involved in Translation |
0.0 | 1.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
0.0 | 0.2 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |