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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb4

Z-value: 0.69

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Transcription factors associated with Hoxb4

Gene Symbol Gene ID Gene Info
ENSMUSG00000038692.7 homeobox B4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb4mm10_v2_chr11_+_96316684_96316684-0.231.7e-01Click!

Activity profile of Hoxb4 motif

Sorted Z-values of Hoxb4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 1.1 GO:0001192 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.3 6.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.4 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.4 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 1.4 GO:0008091 spectrin(GO:0008091)
0.1 0.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 7.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 6.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.6 GO:0015288 porin activity(GO:0015288)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 1.8 GO:0001848 complement binding(GO:0001848)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 6.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway