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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxa1

Z-value: 0.49

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Transcription factors associated with Hoxa1

Gene Symbol Gene ID Gene Info
ENSMUSG00000029844.9 homeobox A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa1mm10_v2_chr6_-_52158292_521583240.335.1e-02Click!

Activity profile of Hoxa1 motif

Sorted Z-values of Hoxa1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.3 1.0 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.3 1.0 GO:0060032 notochord regression(GO:0060032)
0.2 1.0 GO:1904799 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.1 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.7 GO:0035989 tendon development(GO:0035989)
0.1 1.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.3 GO:1990869 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 0.4 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.3 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.6 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.5 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 0.3 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.4 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.4 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 0.4 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 2.0 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 0.3 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.4 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.6 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.1 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 1.0 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.3 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0035633 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.0 0.2 GO:0043084 penile erection(GO:0043084)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.0 GO:0097542 ciliary tip(GO:0097542)
0.1 0.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 2.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0051373 FATZ binding(GO:0051373)
0.3 0.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 2.0 GO:0032052 bile acid binding(GO:0032052)
0.1 1.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.0 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids