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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx1-1_Nkx1-2

Z-value: 0.70

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Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
ENSMUSG00000029112.5 NK1 homeobox 1
ENSMUSG00000048528.7 NK1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx1-1mm10_v2_chr5_-_33433976_334339760.231.8e-01Click!
Nkx1-2mm10_v2_chr7_-_132599637_1325996370.019.8e-01Click!

Activity profile of Nkx1-1_Nkx1-2 motif

Sorted Z-values of Nkx1-1_Nkx1-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 GO:0015747 urate transport(GO:0015747)
0.3 0.9 GO:0000239 pachytene(GO:0000239)
0.3 2.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.2 0.7 GO:0019085 early viral transcription(GO:0019085)
0.2 0.7 GO:0015825 L-serine transport(GO:0015825)
0.1 0.4 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.3 GO:2000583 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.3 GO:0019255 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.3 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.2 GO:1901608 dense core granule localization(GO:0032253) positive regulation of histone H3-K9 trimethylation(GO:1900114) regulation of vesicle transport along microtubule(GO:1901608) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811)
0.1 0.2 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.1 0.3 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.0 0.5 GO:0072615 interleukin-17 secretion(GO:0072615)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.4 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.1 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.0 0.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.0 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1990923 PET complex(GO:1990923)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.9 GO:0034584 piRNA binding(GO:0034584)
0.1 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.7 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0019863 IgE binding(GO:0019863)
0.0 0.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.3 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions