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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Klf13

Z-value: 0.73

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Transcription factors associated with Klf13

Gene Symbol Gene ID Gene Info
ENSMUSG00000052040.9 Kruppel-like factor 13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf13mm10_v2_chr7_-_63938862_63938933-0.456.3e-03Click!

Activity profile of Klf13 motif

Sorted Z-values of Klf13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0018894 coumarin metabolic process(GO:0009804) dibenzo-p-dioxin metabolic process(GO:0018894)
0.4 1.4 GO:0014916 regulation of lung blood pressure(GO:0014916)
0.3 1.3 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.3 1.2 GO:0090346 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.2 3.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 2.1 GO:0090166 Golgi disassembly(GO:0090166)
0.2 0.9 GO:0006788 heme oxidation(GO:0006788)
0.2 1.9 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.2 1.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 1.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.5 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.6 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 0.5 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.3 GO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451)
0.1 1.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 4.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.8 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 1.3 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 0.4 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 2.3 GO:0030903 notochord development(GO:0030903)
0.1 1.2 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.1 0.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.7 GO:0045176 apical protein localization(GO:0045176)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.8 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.4 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 0.2 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0 0.9 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 2.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.2 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 1.2 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 2.9 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.3 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.6 GO:1901264 carbohydrate derivative transport(GO:1901264)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0097441 basilar dendrite(GO:0097441)
0.2 0.7 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.6 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.8 GO:0042587 glycogen granule(GO:0042587)
0.1 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.2 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.7 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.4 GO:0089701 U2AF(GO:0089701)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 1.7 GO:0005795 Golgi stack(GO:0005795)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0047936 glucose 1-dehydrogenase [NAD(P)] activity(GO:0047936)
0.4 1.3 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.4 1.5 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.3 1.0 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.3 1.9 GO:0035529 phosphodiesterase I activity(GO:0004528) NADH pyrophosphatase activity(GO:0035529)
0.3 4.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.2 GO:0047726 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.2 1.4 GO:0019238 cyclohydrolase activity(GO:0019238)
0.2 0.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 1.9 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.2 1.0 GO:0070404 NADH binding(GO:0070404)
0.2 0.8 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.1 1.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.6 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 0.3 GO:0035877 death effector domain binding(GO:0035877)
0.1 1.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.7 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.7 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.6 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.9 PID P73PATHWAY p73 transcription factor network
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 1.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.0 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway