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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax4

Z-value: 0.46

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Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
ENSMUSG00000029706.9 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4mm10_v2_chr6_-_28447180_284471800.048.3e-01Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:0051977 lysophospholipid transport(GO:0051977)
0.1 0.4 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.1 0.8 GO:0097264 self proteolysis(GO:0097264)
0.1 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.4 GO:0060022 hard palate development(GO:0060022)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.3 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326) somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.1 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:1990462 omegasome(GO:1990462)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.4 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 0.4 GO:0000010 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening