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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Stat6

Z-value: 1.84

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Transcription factors associated with Stat6

Gene Symbol Gene ID Gene Info
ENSMUSG00000002147.12 signal transducer and activator of transcription 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.221.9e-01Click!

Activity profile of Stat6 motif

Sorted Z-values of Stat6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.9 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
4.9 14.8 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
2.0 6.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
1.8 7.0 GO:0045575 basophil activation(GO:0045575)
1.7 6.9 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
1.4 6.9 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.2 12.3 GO:0030916 otic vesicle formation(GO:0030916)
0.7 3.7 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.7 2.8 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.6 1.9 GO:2000349 negative regulation of CD40 signaling pathway(GO:2000349)
0.6 1.7 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.5 3.8 GO:0006561 proline biosynthetic process(GO:0006561)
0.5 1.6 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.5 1.4 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.5 1.4 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.4 1.2 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3 1.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.3 1.3 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.3 5.1 GO:0015809 arginine transport(GO:0015809)
0.3 4.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 1.9 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.3 1.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.3 1.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 0.9 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.2 0.7 GO:0060399 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 1.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2 1.3 GO:0001757 somite specification(GO:0001757)
0.2 0.9 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.2 0.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.1 GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.1 0.4 GO:0032954 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 1.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.1 0.4 GO:0001805 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 0.8 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 0.6 GO:0035026 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)
0.1 0.4 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 5.6 GO:0043029 T cell homeostasis(GO:0043029)
0.1 0.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 2.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 2.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 8.2 GO:0043627 response to estrogen(GO:0043627)
0.1 0.4 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1 0.7 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.1 0.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 2.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0051715 cytolysis in other organism(GO:0051715)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 4.0 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.0 2.2 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 1.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.9 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 1.0 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.8 GO:0010575 positive regulation of vascular endothelial growth factor production(GO:0010575)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 2.2 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 1.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.9 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 1.7 GO:0043200 response to amino acid(GO:0043200)
0.0 0.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.2 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 25.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.9 3.7 GO:0044194 cytolytic granule(GO:0044194)
0.4 1.6 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.3 0.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 4.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 16.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 0.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.8 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.4 GO:0005922 connexon complex(GO:0005922)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 1.0 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 7.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 7.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.2 GO:0016528 sarcoplasm(GO:0016528)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 2.2 GO:0000776 kinetochore(GO:0000776)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
2.3 6.9 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.9 3.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.6 1.9 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.6 5.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.5 4.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 3.3 GO:0001515 opioid peptide activity(GO:0001515)
0.4 25.9 GO:0004601 peroxidase activity(GO:0004601)
0.4 2.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.4 2.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 3.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 1.4 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.3 0.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 6.1 GO:0030275 LRR domain binding(GO:0030275)
0.2 1.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 0.7 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 9.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.9 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.0 GO:0019534 toxin transporter activity(GO:0019534)
0.1 1.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 4.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 14.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 1.5 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 2.4 GO:0030276 clathrin binding(GO:0030276)
0.0 1.0 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.5 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 1.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.6 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 1.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 14.7 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 1.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 25.8 PID IL23 PATHWAY IL23-mediated signaling events
0.2 8.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 7.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 6.9 PID IL1 PATHWAY IL1-mediated signaling events
0.1 0.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.6 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 4.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.5 PID FGF PATHWAY FGF signaling pathway
0.0 7.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 2.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 6.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 6.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 6.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 4.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 4.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 0.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.9 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.0 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.6 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.0 5.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 4.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery