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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Ddit3

Z-value: 0.91

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Transcription factors associated with Ddit3

Gene Symbol Gene ID Gene Info
ENSMUSG00000025408.9 DNA-damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_127290803-0.751.2e-07Click!

Activity profile of Ddit3 motif

Sorted Z-values of Ddit3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Ddit3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.8 4.9 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.5 1.4 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.5 1.4 GO:0061144 alveolar secondary septum development(GO:0061144)
0.4 1.1 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.3 1.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.3 0.8 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 2.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.5 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 0.9 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 0.9 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 1.0 GO:0030242 pexophagy(GO:0030242)
0.1 0.4 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 1.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 1.0 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.1 0.4 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.6 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 0.4 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 0.4 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 0.4 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.1 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 1.7 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.1 0.3 GO:2001055 positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.1 0.3 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
0.1 0.1 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.5 GO:0015671 oxygen transport(GO:0015671)
0.1 0.3 GO:0060066 oviduct development(GO:0060066)
0.1 0.2 GO:0032468 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 0.6 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
0.1 0.4 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1 1.8 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 0.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 2.7 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.6 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.0 1.0 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.3 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 1.3 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0035481 Notch signaling pathway involved in heart induction(GO:0003137) regulation of Notch signaling pathway involved in heart induction(GO:0035480) positive regulation of Notch signaling pathway involved in heart induction(GO:0035481) regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0 0.5 GO:0015874 norepinephrine transport(GO:0015874)
0.0 1.0 GO:0006084 acetyl-CoA metabolic process(GO:0006084)
0.0 0.4 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.6 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.4 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.7 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.1 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.0 0.1 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.0 0.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.3 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 2.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.9 GO:0097418 neurofibrillary tangle(GO:0097418)
0.3 1.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.2 0.9 GO:1990037 Lewy body core(GO:1990037)
0.2 1.2 GO:0097452 GAIT complex(GO:0097452)
0.1 0.4 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.3 GO:0043196 varicosity(GO:0043196)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.5 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.3 GO:0016600 flotillin complex(GO:0016600)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.1 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 3.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 1.0 GO:0098791 Golgi subcompartment(GO:0098791)
0.0 0.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 2.7 GO:0032810 sterol response element binding(GO:0032810)
0.5 1.4 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.4 1.2 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.3 1.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 4.9 GO:0051787 misfolded protein binding(GO:0051787)
0.2 0.6 GO:0030614 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.2 1.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.2 0.5 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.2 1.1 GO:0016812 nucleobase binding(GO:0002054) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.2 0.9 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 1.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.6 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 0.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.3 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.2 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 5.7 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.7 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 2.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.6 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 1.0 GO:0043295 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 1.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.5 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.0 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 4.9 PID E2F PATHWAY E2F transcription factor network
0.0 1.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.6 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 5.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 1.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 5.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.9 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 3.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits