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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Irx4

Z-value: 0.44

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Transcription factors associated with Irx4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021604.9 Iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx4mm10_v2_chr13_+_73260473_732604970.281.0e-01Click!

Activity profile of Irx4 motif

Sorted Z-values of Irx4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 2.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 1.3 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.4 GO:0007130 synaptonemal complex assembly(GO:0007130)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.4 1.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 PID IGF1 PATHWAY IGF1 pathway
0.0 1.5 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling