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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tfap2e

Z-value: 0.51

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Transcription factors associated with Tfap2e

Gene Symbol Gene ID Gene Info
ENSMUSG00000042477.7 transcription factor AP-2, epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_1267362450.067.4e-01Click!

Activity profile of Tfap2e motif

Sorted Z-values of Tfap2e motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.4 2.0 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4 1.2 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 0.7 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 0.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.6 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 0.3 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.1 0.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294) negative regulation of pancreatic juice secretion(GO:0090188)
0.1 1.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.2 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.1 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.1 GO:1903116 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) positive regulation of actin filament-based movement(GO:1903116)
0.0 0.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.3 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0048690 neuron cell-cell adhesion(GO:0007158) regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.6 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.0 0.2 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.6 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 1.0 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.1 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 2.0 GO:0042599 lamellar body(GO:0042599)
0.1 0.2 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.0 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.7 GO:0005859 muscle myosin complex(GO:0005859) myosin filament(GO:0032982)
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.7 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.7 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 0.2 GO:0000010 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.0 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport