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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pknox2_Pknox1

Z-value: 0.60

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Transcription factors associated with Pknox2_Pknox1

Gene Symbol Gene ID Gene Info
ENSMUSG00000035934.9 Pbx/knotted 1 homeobox 2
ENSMUSG00000006705.6 Pbx/knotted 1 homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pknox1mm10_v2_chr17_+_31564749_315648540.202.4e-01Click!
Pknox2mm10_v2_chr9_-_37147257_37147323-0.144.3e-01Click!

Activity profile of Pknox2_Pknox1 motif

Sorted Z-values of Pknox2_Pknox1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.4 1.7 GO:0043056 forward locomotion(GO:0043056)
0.3 0.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 1.0 GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.2 0.4 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157)
0.2 0.5 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.2 0.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.4 GO:0042637 catagen(GO:0042637)
0.1 1.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.3 GO:0097065 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.1 0.8 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.2 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 0.5 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.5 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 0.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.6 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.0 0.3 GO:1904923 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.0 0.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 8.6 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.4 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.6 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.0 0.3 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:2000327 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.0 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.0 0.2 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 1.3 GO:0032411 positive regulation of transporter activity(GO:0032411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 10.2 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.6 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.3 6.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 1.9 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 1.7 GO:0031433 telethonin binding(GO:0031433)
0.1 0.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.0 GO:0032027 myosin light chain kinase activity(GO:0004687) myosin light chain binding(GO:0032027)
0.1 0.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 1.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.5 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.6 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 9.1 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 6.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis