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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxn1

Z-value: 0.65

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Transcription factors associated with Foxn1

Gene Symbol Gene ID Gene Info
ENSMUSG00000002057.4 forkhead box N1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxn1mm10_v2_chr11_-_78386558_78386598-0.105.8e-01Click!

Activity profile of Foxn1 motif

Sorted Z-values of Foxn1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxn1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 1.9 GO:1904668 mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 0.5 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.2 1.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.2 0.5 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.1 0.8 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 0.3 GO:2000229 negative regulation of NAD(P)H oxidase activity(GO:0033861) pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 1.0 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.2 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.1 0.1 GO:1990839 response to endothelin(GO:1990839)
0.0 0.1 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.0 0.8 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.0 0.2 GO:0035106 operant conditioning(GO:0035106)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0072181 mesonephric duct formation(GO:0072181)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.0 0.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.2 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 0.5 GO:0044753 amphisome(GO:0044753)
0.1 0.8 GO:0032437 cuticular plate(GO:0032437)
0.1 0.8 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.3 GO:0008091 spectrin(GO:0008091)
0.1 0.5 GO:0033647 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.6 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.7 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.7 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 0.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 0.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.3 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.3 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.1 0.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.9 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.2 GO:0010857 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6