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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pbx1_Pbx3

Z-value: 0.60

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Transcription factors associated with Pbx1_Pbx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000052534.9 pre B cell leukemia homeobox 1
ENSMUSG00000038718.9 pre B cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168431695_168431750-0.372.4e-02Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.019.7e-01Click!

Activity profile of Pbx1_Pbx3 motif

Sorted Z-values of Pbx1_Pbx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.4 1.5 GO:0043056 forward locomotion(GO:0043056)
0.3 1.0 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.2 1.0 GO:0048769 sarcomerogenesis(GO:0048769)
0.2 0.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 0.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.7 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 0.6 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 0.4 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.1 0.3 GO:0097402 neuroblast migration(GO:0097402)
0.1 0.6 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 0.3 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 0.4 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.8 GO:0042637 catagen(GO:0042637)
0.1 0.2 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.2 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.2 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 5.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229)
0.0 0.1 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.0 0.3 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.2 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.1 GO:0061360 optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.2 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
0.0 0.1 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 0.1 GO:0048880 sensory system development(GO:0048880)
0.0 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.1 GO:0035709 defense response to nematode(GO:0002215) memory T cell activation(GO:0035709) positive regulation of memory T cell differentiation(GO:0043382) negative regulation of T-helper 1 cell differentiation(GO:0045626) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.0 0.1 GO:0006548 histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548)
0.0 0.1 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.1 GO:0043519 myosin II filament organization(GO:0031038) regulation of myosin II filament organization(GO:0043519)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.0 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.0 0.4 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.0 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 0.1 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.0 GO:0070543 response to linoleic acid(GO:0070543)
0.0 0.0 GO:2000041 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.0 GO:0097298 regulation of nucleus size(GO:0097298)
0.0 0.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.1 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.4 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.0 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.0 0.0 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.0 0.3 GO:0006308 DNA catabolic process(GO:0006308)
0.0 0.3 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.1 GO:0043084 penile erection(GO:0043084)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.7 GO:0031673 H zone(GO:0031673)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 5.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.3 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0098642 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0016234 inclusion body(GO:0016234)
0.0 0.1 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 0.8 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 1.5 GO:0031433 telethonin binding(GO:0031433)
0.1 0.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 0.3 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.7 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.8 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0036004 GAF domain binding(GO:0036004)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.2 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.0 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones