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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox6_Sox9

Z-value: 0.72

Motif logo

Transcription factors associated with Sox6_Sox9

Gene Symbol Gene ID Gene Info
ENSMUSG00000051910.7 SRY (sex determining region Y)-box 6
ENSMUSG00000000567.5 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox6mm10_v2_chr7_-_116031047_1160311220.563.5e-04Click!
Sox9mm10_v2_chr11_+_112782182_1127822480.192.7e-01Click!

Activity profile of Sox6_Sox9 motif

Sorted Z-values of Sox6_Sox9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox6_Sox9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.6 1.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.5 3.3 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.4 1.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.4 4.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.4 1.1 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
0.3 0.9 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.3 0.8 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
0.3 2.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 0.8 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2 0.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 0.8 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.4 GO:0071395 sesquiterpenoid metabolic process(GO:0006714) response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 2.3 GO:0070307 lens fiber cell development(GO:0070307)
0.1 1.3 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 0.6 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1 0.8 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 1.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.3 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.6 GO:0010159 specification of organ position(GO:0010159)
0.1 1.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.3 GO:0070543 response to linoleic acid(GO:0070543)
0.1 0.3 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.1 0.6 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.3 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.8 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 2.2 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 0.2 GO:0050924 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 2.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 1.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 0.8 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.3 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.1 0.8 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.4 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953)
0.1 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.1 GO:0060197 cloacal septation(GO:0060197) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.1 1.6 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 0.3 GO:0009597 detection of virus(GO:0009597)
0.1 0.2 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.1 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 0.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.2 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 0.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.2 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.2 GO:0009397 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.2 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.3 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.5 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.0 0.3 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.4 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.4 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.0 0.2 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 1.7 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.6 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 0.0 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0033129 positive regulation of histone phosphorylation(GO:0033129)
0.0 0.1 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.0 0.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.9 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.0 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.2 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.1 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.3 GO:0048505 regulation of timing of cell differentiation(GO:0048505)
0.0 0.1 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.3 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.6 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 2.4 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.0 0.5 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0002026 regulation of the force of heart contraction(GO:0002026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0033193 Lsd1/2 complex(GO:0033193)
0.6 1.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.5 4.2 GO:0097165 nuclear stress granule(GO:0097165)
0.3 0.8 GO:0005607 laminin-2 complex(GO:0005607)
0.2 0.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.7 GO:0001739 sex chromatin(GO:0001739)
0.2 0.6 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 0.6 GO:0044307 dendritic branch(GO:0044307)
0.1 2.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.6 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.9 GO:0033269 internode region of axon(GO:0033269)
0.1 0.7 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.7 GO:0042382 paraspeckles(GO:0042382)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.0 4.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 1.3 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.6 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.3 GO:0031672 A band(GO:0031672)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.5 3.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 1.8 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.3 1.6 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.2 0.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.4 GO:0047787 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.1 0.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.6 GO:0051373 FATZ binding(GO:0051373)
0.1 1.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 4.0 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.4 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.5 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 2.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 1.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 2.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.3 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.8 GO:0031432 titin binding(GO:0031432)
0.1 1.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.6 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.2 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.1 0.2 GO:0036033 mediator complex binding(GO:0036033)
0.1 0.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.8 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 1.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 1.1 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.1 GO:0071633 dihydroceramidase activity(GO:0071633)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 3.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070) insulin receptor binding(GO:0005158)
0.0 0.1 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 2.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.0 1.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.1 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.4 GO:0008198 ferrous iron binding(GO:0008198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 2.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.6 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation