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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rxra

Z-value: 1.40

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Transcription factors associated with Rxra

Gene Symbol Gene ID Gene Info
ENSMUSG00000015846.8 retinoid X receptor alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rxramm10_v2_chr2_+_27677201_276772290.124.9e-01Click!

Activity profile of Rxra motif

Sorted Z-values of Rxra motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rxra

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
1.0 3.9 GO:0006069 ethanol oxidation(GO:0006069)
0.8 5.0 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.4 1.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.4 1.7 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.4 2.6 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.3 4.9 GO:0043589 Notch receptor processing(GO:0007220) skin morphogenesis(GO:0043589)
0.3 10.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.3 0.9 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.3 0.9 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 0.9 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 1.3 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.3 2.3 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 0.6 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.2 1.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 1.7 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.7 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.2 1.1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 0.5 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 1.6 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.2 GO:0072602 interleukin-4 secretion(GO:0072602) positive regulation of interleukin-2 secretion(GO:1900042)
0.1 1.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.2 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.1 1.3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 0.3 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.1 1.2 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.1 1.8 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.2 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.2 GO:0046618 drug export(GO:0046618)
0.1 0.3 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 2.0 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 1.7 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 8.4 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.6 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.0 0.7 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.8 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 1.3 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.8 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.7 GO:0090201 negative regulation of release of cytochrome c from mitochondria(GO:0090201)
0.0 0.9 GO:0019236 response to pheromone(GO:0019236)
0.0 1.3 GO:0006953 acute-phase response(GO:0006953)
0.0 0.5 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.2 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:1904717 regulation of AMPA glutamate receptor clustering(GO:1904717)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:2001179 regulation of interleukin-10 secretion(GO:2001179)
0.0 0.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 5.2 GO:0051321 meiotic cell cycle(GO:0051321)
0.0 0.5 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.1 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 1.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 1.3 GO:0035725 sodium ion transmembrane transport(GO:0035725)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 4.9 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.6 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.1 1.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 4.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.6 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.0 GO:0055087 Ski complex(GO:0055087)
0.0 0.5 GO:0051233 desmosome(GO:0030057) spindle midzone(GO:0051233)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 1.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
1.3 5.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.3 3.9 GO:0003960 NADPH:quinone reductase activity(GO:0003960) alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.8 5.0 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.6 4.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.5 1.6 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.4 1.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 1.6 GO:0016726 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.3 1.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 0.8 GO:0070401 NADP+ binding(GO:0070401) lithocholic acid binding(GO:1902121)
0.2 1.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 1.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 0.5 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.2 0.7 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 1.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 1.6 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 1.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 1.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 3.6 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391)
0.1 1.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.6 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466) very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.6 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.7 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 9.8 GO:0015293 symporter activity(GO:0015293)
0.0 1.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.2 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.6 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.9 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 3.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 3.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 4.9 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 5.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 5.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 2.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.7 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 2.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling