avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Hes5
|
ENSMUSG00000048001.7 | hes family bHLH transcription factor 5 |
Hes7
|
ENSMUSG00000023781.2 | hes family bHLH transcription factor 7 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes5 | mm10_v2_chr4_+_154960915_154960930 | 0.77 | 2.9e-08 | Click! |
Hes7 | mm10_v2_chr11_+_69120404_69120404 | 0.58 | 2.0e-04 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
15.2 | 166.7 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
5.1 | 90.9 | GO:0015816 | glycine transport(GO:0015816) |
3.3 | 9.8 | GO:0045660 | positive regulation of neutrophil differentiation(GO:0045660) |
1.1 | 3.2 | GO:0050883 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
1.0 | 39.8 | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) |
0.9 | 6.6 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.9 | 26.7 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.8 | 4.0 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
0.8 | 4.6 | GO:0009082 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
0.7 | 4.3 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.7 | 4.8 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
0.7 | 10.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.5 | 15.8 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.5 | 6.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.5 | 3.0 | GO:1903182 | regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755) |
0.5 | 1.9 | GO:0021586 | pons maturation(GO:0021586) |
0.4 | 5.2 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.4 | 1.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.4 | 5.2 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
0.4 | 1.5 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
0.4 | 2.9 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
0.3 | 3.7 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
0.3 | 1.1 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
0.3 | 9.7 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
0.3 | 2.1 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091) |
0.2 | 1.2 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
0.2 | 1.7 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.2 | 3.7 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
0.2 | 3.5 | GO:0071360 | cellular response to exogenous dsRNA(GO:0071360) |
0.2 | 0.7 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
0.2 | 1.5 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.2 | 1.8 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
0.2 | 1.4 | GO:0007000 | nucleolus organization(GO:0007000) |
0.2 | 0.5 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
0.1 | 0.7 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
0.1 | 20.8 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
0.1 | 8.6 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.1 | 3.2 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
0.1 | 4.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.1 | 0.3 | GO:0007309 | oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719) |
0.1 | 0.8 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.1 | 0.6 | GO:0032383 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
0.1 | 6.1 | GO:0045214 | sarcomere organization(GO:0045214) |
0.1 | 1.7 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
0.1 | 1.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.1 | 6.3 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity(GO:2000117) |
0.0 | 0.3 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
0.0 | 1.3 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
0.0 | 2.5 | GO:0045471 | response to ethanol(GO:0045471) |
0.0 | 1.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 0.2 | GO:0038031 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.0 | 0.6 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.2 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
0.0 | 1.7 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
0.0 | 0.3 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
0.0 | 0.3 | GO:0097284 | hepatocyte apoptotic process(GO:0097284) |
0.0 | 3.2 | GO:0006906 | vesicle fusion(GO:0006906) |
0.0 | 0.5 | GO:0048148 | behavioral response to cocaine(GO:0048148) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 4.7 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.6 | 1.9 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
0.6 | 2.9 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.5 | 8.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
0.5 | 3.0 | GO:1990356 | sumoylated E2 ligase complex(GO:1990356) |
0.4 | 2.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.4 | 3.5 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
0.2 | 6.2 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
0.2 | 4.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
0.2 | 2.5 | GO:0005652 | nuclear lamina(GO:0005652) |
0.1 | 1.4 | GO:0070545 | PeBoW complex(GO:0070545) |
0.1 | 6.1 | GO:0043034 | costamere(GO:0043034) |
0.1 | 1.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.1 | 3.7 | GO:0097440 | apical dendrite(GO:0097440) |
0.1 | 1.2 | GO:0005869 | dynactin complex(GO:0005869) |
0.1 | 1.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.1 | 1.7 | GO:0097225 | sperm midpiece(GO:0097225) |
0.1 | 4.8 | GO:0005657 | replication fork(GO:0005657) |
0.1 | 5.4 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 84.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
0.1 | 0.7 | GO:0090543 | Flemming body(GO:0090543) |
0.1 | 1.9 | GO:0090544 | BAF-type complex(GO:0090544) |
0.1 | 5.2 | GO:0036126 | sperm flagellum(GO:0036126) |
0.0 | 4.1 | GO:0005903 | brush border(GO:0005903) |
0.0 | 9.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 140.8 | GO:0005829 | cytosol(GO:0005829) |
0.0 | 1.5 | GO:0031519 | PcG protein complex(GO:0031519) |
0.0 | 9.6 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 1.7 | GO:0001726 | ruffle(GO:0001726) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.5 | 90.9 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
3.9 | 43.2 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
3.4 | 166.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
1.6 | 4.8 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
1.3 | 4.0 | GO:0045353 | interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353) |
0.9 | 3.7 | GO:0031849 | olfactory receptor binding(GO:0031849) |
0.9 | 3.5 | GO:0035851 | histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851) |
0.8 | 4.6 | GO:0052655 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.7 | 2.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
0.7 | 4.1 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.5 | 3.0 | GO:0061656 | SUMO conjugating enzyme activity(GO:0061656) |
0.4 | 1.7 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
0.4 | 5.2 | GO:0003796 | lysozyme activity(GO:0003796) |
0.3 | 9.8 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
0.2 | 9.7 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
0.2 | 0.7 | GO:0019809 | spermidine binding(GO:0019809) |
0.2 | 5.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.2 | 0.8 | GO:0050816 | phosphothreonine binding(GO:0050816) |
0.1 | 0.7 | GO:0004661 | protein geranylgeranyltransferase activity(GO:0004661) |
0.1 | 1.7 | GO:0030274 | LIM domain binding(GO:0030274) |
0.1 | 3.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 4.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.1 | 1.5 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
0.1 | 1.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.1 | 2.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.1 | 2.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.1 | 10.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.1 | 3.7 | GO:0045182 | translation regulator activity(GO:0045182) |
0.1 | 7.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
0.1 | 0.3 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.1 | 3.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.1 | 1.9 | GO:0008373 | sialyltransferase activity(GO:0008373) |
0.1 | 3.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 1.2 | GO:0070840 | dynein complex binding(GO:0070840) |
0.0 | 1.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 15.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 4.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 2.1 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 3.5 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.0 | 0.8 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 6.6 | GO:0015631 | tubulin binding(GO:0015631) |
0.0 | 0.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.9 | 166.7 | PID IGF1 PATHWAY | IGF1 pathway |
0.5 | 4.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.4 | 41.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
0.4 | 6.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
0.3 | 4.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.2 | 12.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.2 | 3.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
0.2 | 5.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
0.2 | 16.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
0.1 | 9.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.1 | 6.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
0.1 | 15.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 1.9 | PID AURORA A PATHWAY | Aurora A signaling |
0.1 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
0.1 | 1.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
0.1 | 3.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.1 | 1.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.1 | 2.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
0.0 | 3.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.9 | 166.7 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
1.9 | 90.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.5 | 9.7 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
0.5 | 4.8 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.4 | 15.8 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.2 | 4.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.2 | 4.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
0.2 | 1.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.1 | 2.0 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.1 | 21.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
0.1 | 2.1 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
0.1 | 2.9 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
0.1 | 4.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
0.1 | 0.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.1 | 1.5 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
0.0 | 3.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
0.0 | 1.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 1.8 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
0.0 | 1.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 1.5 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
0.0 | 0.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
0.0 | 0.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |