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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxd3

Z-value: 0.43

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Transcription factors associated with Foxd3

Gene Symbol Gene ID Gene Info
ENSMUSG00000067261.3 forkhead box D3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxd3mm10_v2_chr4_+_99656299_99656340-0.144.2e-01Click!

Activity profile of Foxd3 motif

Sorted Z-values of Foxd3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0006548 histidine catabolic process(GO:0006548)
0.1 0.6 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.1 1.0 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.3 GO:0006041 glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.4 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.2 GO:0060279 positive regulation of ovulation(GO:0060279)
0.0 0.6 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.1 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.2 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 3.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.3 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 0.2 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.4 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.0 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.3 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.2 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.6 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.1 GO:0099530 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 4.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol