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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Aire

Z-value: 0.87

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Transcription factors associated with Aire

Gene Symbol Gene ID Gene Info
ENSMUSG00000000731.9 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Airemm10_v2_chr10_-_78043580_78043611-0.048.3e-01Click!

Activity profile of Aire motif

Sorted Z-values of Aire motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0042853 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853)
0.4 1.5 GO:0032789 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.3 1.3 GO:0061625 fructose catabolic process(GO:0006001) response to sucrose(GO:0009744) response to disaccharide(GO:0034285) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.3 0.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.6 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.2 0.5 GO:0006550 isoleucine catabolic process(GO:0006550)
0.2 0.7 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 0.9 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
0.1 1.5 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.5 GO:0006742 NADP catabolic process(GO:0006742)
0.1 1.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.3 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.1 1.5 GO:0009437 carnitine metabolic process(GO:0009437)
0.1 0.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.5 GO:0061056 sclerotome development(GO:0061056)
0.1 0.5 GO:0033762 response to glucagon(GO:0033762)
0.1 2.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 0.7 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.1 0.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.5 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:1902572 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 1.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.6 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.6 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.1 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.0 1.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.1 GO:0035553 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.5 GO:2000398 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0036128 CatSper complex(GO:0036128)
0.1 0.7 GO:0016011 dystroglycan complex(GO:0016011)
0.1 2.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 1.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 4.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0033647 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0004454 ketohexokinase activity(GO:0004454)
0.4 2.6 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.4 1.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 1.3 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.1 0.6 GO:0031711 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.1 0.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 1.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.4 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
0.1 0.5 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 0.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 3.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.5 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.3 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466) palmitoyl-CoA oxidase activity(GO:0016401)
0.1 1.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.4 GO:0016726 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 0.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 1.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.3 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.8 GO:0048038 quinone binding(GO:0048038)
0.0 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.7 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC