avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Twist1
|
ENSMUSG00000035799.5 | twist basic helix-loop-helix transcription factor 1 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Twist1 | mm10_v2_chr12_+_33957645_33957671 | -0.28 | 9.3e-02 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 5.6 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535) |
1.1 | 13.8 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
1.0 | 5.2 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
1.0 | 2.9 | GO:0031335 | regulation of sulfur amino acid metabolic process(GO:0031335) |
0.9 | 3.8 | GO:0034769 | basement membrane disassembly(GO:0034769) |
0.9 | 9.7 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
0.9 | 2.6 | GO:0015755 | fructose transport(GO:0015755) |
0.8 | 5.3 | GO:1904222 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
0.8 | 0.8 | GO:0061324 | canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) |
0.7 | 2.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173) |
0.7 | 4.2 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
0.7 | 3.4 | GO:0007207 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
0.6 | 1.9 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) |
0.6 | 1.8 | GO:0036118 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.5 | 2.2 | GO:0090472 | dibasic protein processing(GO:0090472) |
0.5 | 1.5 | GO:0009750 | response to fructose(GO:0009750) |
0.5 | 1.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
0.4 | 3.8 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.4 | 4.1 | GO:0051596 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.4 | 3.5 | GO:0035754 | B cell chemotaxis(GO:0035754) |
0.4 | 1.1 | GO:1902809 | regulation of skeletal muscle fiber differentiation(GO:1902809) |
0.4 | 3.6 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
0.3 | 1.3 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
0.3 | 6.4 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
0.3 | 0.8 | GO:1900477 | negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477) |
0.2 | 1.2 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
0.2 | 0.7 | GO:1902460 | transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
0.2 | 6.8 | GO:0014002 | astrocyte development(GO:0014002) |
0.2 | 1.6 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.2 | 0.9 | GO:2000564 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
0.2 | 0.7 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
0.2 | 1.4 | GO:0051503 | adenine nucleotide transport(GO:0051503) |
0.2 | 0.9 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
0.1 | 2.2 | GO:0030223 | neutrophil differentiation(GO:0030223) |
0.1 | 1.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
0.1 | 0.6 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
0.1 | 1.5 | GO:0000050 | urea cycle(GO:0000050) |
0.1 | 1.2 | GO:0060019 | radial glial cell differentiation(GO:0060019) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
0.1 | 1.2 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
0.1 | 1.1 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.1 | 1.3 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
0.1 | 0.4 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
0.1 | 0.8 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
0.1 | 1.8 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
0.1 | 1.9 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
0.1 | 0.6 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
0.1 | 0.5 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway(GO:0002756) |
0.1 | 0.2 | GO:1901355 | response to rapamycin(GO:1901355) |
0.1 | 3.7 | GO:0007520 | myoblast fusion(GO:0007520) |
0.1 | 3.4 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
0.1 | 1.0 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
0.0 | 1.5 | GO:0031424 | keratinization(GO:0031424) |
0.0 | 0.8 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.0 | 0.3 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.0 | 1.6 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 0.4 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
0.0 | 0.8 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.1 | GO:0030070 | insulin processing(GO:0030070) |
0.0 | 0.4 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
0.0 | 0.4 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
0.0 | 0.7 | GO:0003299 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898) |
0.0 | 0.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.0 | 0.8 | GO:0060441 | epithelial tube branching involved in lung morphogenesis(GO:0060441) |
0.0 | 0.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
0.0 | 0.3 | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
0.0 | 0.7 | GO:0010524 | positive regulation of calcium ion transport into cytosol(GO:0010524) |
0.0 | 0.2 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
0.0 | 0.3 | GO:0060766 | negative regulation of androgen receptor signaling pathway(GO:0060766) |
0.0 | 1.5 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
0.0 | 1.0 | GO:0001541 | ovarian follicle development(GO:0001541) |
0.0 | 0.5 | GO:0032456 | endocytic recycling(GO:0032456) |
0.0 | 22.5 | GO:0006508 | proteolysis(GO:0006508) |
0.0 | 2.2 | GO:0006909 | phagocytosis(GO:0006909) |
0.0 | 0.7 | GO:0070527 | platelet aggregation(GO:0070527) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 13.8 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.6 | 3.6 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
0.6 | 5.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.6 | 2.9 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
0.5 | 1.5 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
0.4 | 1.8 | GO:0043293 | apoptosome(GO:0043293) |
0.4 | 0.8 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
0.3 | 4.2 | GO:0016342 | catenin complex(GO:0016342) |
0.2 | 1.0 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
0.2 | 5.6 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
0.2 | 3.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.2 | 1.3 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.1 | 0.9 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
0.1 | 2.2 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.1 | 2.2 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.1 | 0.5 | GO:1990745 | EARP complex(GO:1990745) |
0.1 | 1.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 0.9 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
0.0 | 0.8 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 4.2 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 1.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 32.8 | GO:0005615 | extracellular space(GO:0005615) |
0.0 | 0.2 | GO:0031931 | TORC1 complex(GO:0031931) |
0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.8 | GO:0031201 | SNARE complex(GO:0031201) |
0.0 | 4.1 | GO:0031965 | nuclear membrane(GO:0031965) |
0.0 | 3.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.0 | 2.9 | GO:0043197 | dendritic spine(GO:0043197) |
0.0 | 1.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 9.7 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
1.2 | 3.6 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
1.0 | 2.9 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.7 | 2.9 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
0.7 | 3.4 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
0.7 | 2.0 | GO:0071936 | coreceptor activity involved in Wnt signaling pathway(GO:0071936) |
0.5 | 1.4 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
0.5 | 4.1 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.4 | 5.3 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.3 | 10.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.3 | 3.8 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
0.3 | 4.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.2 | 3.5 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
0.2 | 13.8 | GO:0004521 | endoribonuclease activity(GO:0004521) |
0.2 | 1.1 | GO:0070012 | oligopeptidase activity(GO:0070012) |
0.2 | 2.2 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
0.2 | 1.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
0.2 | 1.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 5.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.1 | 2.2 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.1 | 2.6 | GO:0005536 | glucose binding(GO:0005536) |
0.1 | 1.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.1 | 25.3 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
0.1 | 6.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.1 | 2.8 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
0.1 | 1.5 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
0.1 | 3.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
0.1 | 0.4 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.1 | 1.0 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.3 | GO:0061665 | SUMO ligase activity(GO:0061665) |
0.0 | 0.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 0.8 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.0 | 0.6 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.0 | 0.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.0 | 0.4 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.0 | 0.7 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
0.0 | 0.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
0.0 | 1.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 5.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 0.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.7 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.0 | 1.9 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.0 | 0.2 | GO:0090079 | translation regulator activity, nucleic acid binding(GO:0090079) |
0.0 | 0.8 | GO:0004407 | histone deacetylase activity(GO:0004407) |
0.0 | 0.1 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
0.0 | 0.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.4 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 2.2 | GO:0005125 | cytokine activity(GO:0005125) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 6.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
0.1 | 1.8 | PID ALK2 PATHWAY | ALK2 signaling events |
0.1 | 5.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
0.1 | 4.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
0.0 | 4.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 4.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 1.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
0.0 | 1.9 | PID ARF6 PATHWAY | Arf6 signaling events |
0.0 | 4.1 | PID P73PATHWAY | p73 transcription factor network |
0.0 | 7.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 1.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
0.0 | 0.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
0.0 | 0.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
0.0 | 0.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 3.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.2 | 2.6 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.2 | 3.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.2 | 2.2 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.1 | 4.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 5.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.1 | 2.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
0.1 | 2.2 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
0.1 | 1.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 1.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 1.5 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 0.4 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.0 | 0.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 2.9 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
0.0 | 0.7 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 1.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 1.0 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
0.0 | 0.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.0 | 0.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
0.0 | 0.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |