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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Lhx4

Z-value: 0.43

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Transcription factors associated with Lhx4

Gene Symbol Gene ID Gene Info
ENSMUSG00000026468.8 LIM homeobox protein 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx4mm10_v2_chr1_-_155742120_1557421360.096.1e-01Click!

Activity profile of Lhx4 motif

Sorted Z-values of Lhx4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.2 0.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 1.2 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.6 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.1 0.4 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.4 GO:1901074 regulation of engulfment of apoptotic cell(GO:1901074)
0.1 0.9 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.5 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.2 GO:1904173 regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.1 0.4 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.1 0.3 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.3 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.3 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.2 GO:0061076 camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.1 0.4 GO:2000473 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 0.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.3 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.4 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.1 0.2 GO:0033375 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.1 0.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.6 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 0.6 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.2 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.2 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.1 GO:0060168 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.0 0.5 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:1904753 regulation of phenotypic switching(GO:1900239) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 4.0 GO:0007586 digestion(GO:0007586)
0.0 0.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.1 GO:2000849 glucocorticoid secretion(GO:0035933) regulation of glucocorticoid secretion(GO:2000849)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.4 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.8 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.4 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.1 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.3 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.3 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.5 GO:0016601 Rac protein signal transduction(GO:0016601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031523 Myb complex(GO:0031523)
0.1 1.7 GO:0042581 specific granule(GO:0042581)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071820 N-box binding(GO:0071820)
0.2 0.6 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 0.9 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.4 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.8 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 1.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.5 GO:0030275 LRR domain binding(GO:0030275)
0.0 2.1 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0070411 alpha-catenin binding(GO:0045294) I-SMAD binding(GO:0070411) histone methyltransferase binding(GO:1990226)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.9 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.7 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.6 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis