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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tfap4

Z-value: 0.99

Motif logo

Transcription factors associated with Tfap4

Gene Symbol Gene ID Gene Info
ENSMUSG00000005718.7 transcription factor AP4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.382.4e-02Click!

Activity profile of Tfap4 motif

Sorted Z-values of Tfap4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:2000041 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.5 1.5 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.4 1.3 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.4 3.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 1.1 GO:0090076 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
0.4 1.1 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.3 1.0 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.3 0.9 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 0.8 GO:1902730 positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.3 2.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.3 0.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.3 1.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 1.2 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2 0.7 GO:0071873 response to norepinephrine(GO:0071873)
0.2 0.6 GO:0033577 protein glycosylation in endoplasmic reticulum(GO:0033577)
0.2 0.8 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.2 0.9 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.2 0.5 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.2 0.8 GO:0046133 pyrimidine ribonucleoside catabolic process(GO:0046133)
0.2 0.6 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.2 1.1 GO:0030638 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.2 6.0 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.2 1.9 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 0.6 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.2 0.5 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 1.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.7 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.1 0.4 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.4 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.1 4.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 1.5 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.1 1.0 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.7 GO:0001757 somite specification(GO:0001757)
0.1 0.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) negative regulation of membrane depolarization(GO:1904180)
0.1 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.1 2.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 1.0 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.1 0.4 GO:1903028 regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028)
0.1 1.9 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.1 0.5 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 1.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.5 GO:0048050 post-embryonic eye morphogenesis(GO:0048050) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1 1.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.3 GO:0090282 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 1.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.4 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 3.5 GO:0051642 centrosome localization(GO:0051642)
0.1 3.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.1 GO:0070949 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.1 1.0 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.1 0.4 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.4 GO:0072311 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.6 GO:0070244 negative regulation of thymocyte apoptotic process(GO:0070244)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671) enucleate erythrocyte differentiation(GO:0043353)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 3.1 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 1.8 GO:0015813 L-glutamate transport(GO:0015813)
0.1 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 1.9 GO:0010107 potassium ion import(GO:0010107)
0.1 0.3 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 0.4 GO:0016576 histone dephosphorylation(GO:0016576) positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 2.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 1.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.0 0.3 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.4 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.0 0.3 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.5 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 1.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.4 GO:0031179 peptide modification(GO:0031179)
0.0 0.1 GO:0003266 regulation of secondary heart field cardioblast proliferation(GO:0003266) visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.5 GO:0007320 insemination(GO:0007320)
0.0 1.0 GO:0007020 microtubule nucleation(GO:0007020)
0.0 1.2 GO:0090662 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 1.2 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.5 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 1.0 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 0.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 2.7 GO:0048663 neuron fate commitment(GO:0048663)
0.0 0.6 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.9 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 2.1 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.8 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:2000836 positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 1.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.0 2.0 GO:0000045 autophagosome assembly(GO:0000045)
0.0 0.3 GO:0021681 cerebellar granular layer development(GO:0021681)
0.0 0.1 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.0 0.2 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.2 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 1.3 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0 0.1 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.4 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.0 0.8 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 1.0 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.0 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.0 0.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.5 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.1 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.7 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.7 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.0 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0030239 myofibril assembly(GO:0030239)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.2 1.1 GO:0031673 H zone(GO:0031673)
0.2 0.5 GO:0044317 rod spherule(GO:0044317)
0.2 0.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.2 0.6 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 1.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.7 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 2.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.0 GO:0005883 neurofilament(GO:0005883)
0.1 0.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 1.2 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.7 GO:1990357 terminal web(GO:1990357)
0.1 0.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 1.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.5 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 0.2 GO:0098830 presynaptic endosome(GO:0098830)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.1 1.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0070820 tertiary granule(GO:0070820)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.4 GO:0005776 autophagosome(GO:0005776)
0.0 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0016342 catenin complex(GO:0016342)
0.0 0.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3 1.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.3 3.4 GO:0016151 nickel cation binding(GO:0016151)
0.3 1.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 1.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.2 2.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 0.6 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 0.8 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.2 0.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 1.0 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 0.8 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 0.8 GO:0051373 FATZ binding(GO:0051373)
0.1 1.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 1.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 2.4 GO:0042166 acetylcholine binding(GO:0042166)
0.1 0.5 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 2.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.7 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.4 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.6 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 1.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 2.1 GO:0005537 mannose binding(GO:0005537)
0.1 1.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.8 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 0.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.4 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.4 GO:0009374 biotin binding(GO:0009374)
0.0 1.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 4.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.0 2.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.0 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.5 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.2 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0050681 androgen receptor binding(GO:0050681)
0.0 2.0 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID FAS PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 2.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.7 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 1.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 2.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.7 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation