Project

avrg: GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Hoxa10

Z-value: 1.51

Motif logo

Transcription factors associated with Hoxa10

Gene Symbol Gene ID Gene Info
ENSMUSG00000000938.11 homeobox A10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa10mm10_v2_chr6_-_52234902_52234960-0.391.9e-02Click!

Activity profile of Hoxa10 motif

Sorted Z-values of Hoxa10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa10

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.9 6.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.6 5.5 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.5 4.8 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4 2.2 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.4 1.5 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.3 2.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.3 1.8 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 1.2 GO:1903383 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.3 1.3 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.3 2.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 0.7 GO:0002358 B cell homeostatic proliferation(GO:0002358)
0.2 1.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 3.3 GO:0015747 urate transport(GO:0015747)
0.2 1.4 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.2 1.3 GO:0033762 response to glucagon(GO:0033762)
0.2 1.0 GO:0009446 spermidine biosynthetic process(GO:0008295) putrescine biosynthetic process(GO:0009446)
0.2 0.9 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 0.6 GO:1902047 polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 3.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 4.1 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1 0.7 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 1.1 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1 1.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.4 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 0.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 4.0 GO:0019236 response to pheromone(GO:0019236)
0.1 1.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 5.8 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 0.7 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.8 GO:0008228 opsonization(GO:0008228)
0.1 1.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.7 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 0.7 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.4 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.4 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 2.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.2 GO:0010705 meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705)
0.1 2.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.3 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 1.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.7 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.2 GO:1903999 negative regulation of eating behavior(GO:1903999)
0.0 2.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.6 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 2.2 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.8 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.8 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.5 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.9 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 2.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.5 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 2.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 3.5 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0008091 spectrin(GO:0008091)
0.2 1.4 GO:0032807 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.2 1.5 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 1.3 GO:0045293 mRNA editing complex(GO:0045293)
0.2 2.2 GO:0005579 membrane attack complex(GO:0005579)
0.2 6.1 GO:0030673 axolemma(GO:0030673)
0.1 1.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 2.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:0097227 sperm annulus(GO:0097227)
0.1 0.5 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 0.4 GO:0033263 CORVET complex(GO:0033263)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.0 3.5 GO:0070469 respiratory chain(GO:0070469)
0.0 6.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 1.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 2.4 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 1.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 6.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 5.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0002079 inner acrosomal membrane(GO:0002079) outer acrosomal membrane(GO:0002081)
0.0 1.9 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.1 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
1.0 6.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 3.7 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.8 4.1 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.8 5.5 GO:0001851 complement component C3b binding(GO:0001851)
0.4 3.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.4 2.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.4 2.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.4 2.6 GO:0005534 galactose binding(GO:0005534)
0.3 2.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 1.4 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 3.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.4 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.2 0.9 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.2 8.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 0.7 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.2 1.2 GO:0008312 7S RNA binding(GO:0008312)
0.2 1.3 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 4.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 1.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 1.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.9 GO:0016936 galactoside binding(GO:0016936)
0.1 0.5 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 3.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.4 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.7 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.7 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.1 2.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.3 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 2.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 1.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0023023 MHC protein complex binding(GO:0023023)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 1.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.8 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 3.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 2.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 2.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 2.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 0.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 6.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.4 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 2.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 4.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 3.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis