avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Hoxd12
|
ENSMUSG00000001823.4 | homeobox D12 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hoxd12 | mm10_v2_chr2_+_74674929_74675032 | -0.34 | 4.1e-02 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 3.8 | GO:0006069 | ethanol oxidation(GO:0006069) |
0.9 | 2.6 | GO:0006583 | melanin biosynthetic process from tyrosine(GO:0006583) |
0.4 | 5.9 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.3 | 3.8 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
0.3 | 1.2 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
0.3 | 1.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.3 | 0.8 | GO:0002344 | peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344) |
0.3 | 1.0 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.3 | 0.8 | GO:0006507 | GPI anchor release(GO:0006507) |
0.2 | 1.0 | GO:0036367 | adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367) |
0.2 | 0.7 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
0.2 | 1.1 | GO:0021764 | amygdala development(GO:0021764) |
0.2 | 0.6 | GO:0046101 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
0.2 | 2.5 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
0.2 | 3.0 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
0.2 | 1.2 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
0.2 | 4.9 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.2 | 3.1 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.2 | 1.5 | GO:0061042 | vascular wound healing(GO:0061042) |
0.1 | 0.7 | GO:2000327 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
0.1 | 1.5 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.1 | 0.6 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
0.1 | 0.4 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.1 | 0.7 | GO:0042706 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.1 | 1.5 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.1 | 0.6 | GO:0061056 | sclerotome development(GO:0061056) |
0.1 | 0.6 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.1 | 1.8 | GO:0030828 | positive regulation of cGMP biosynthetic process(GO:0030828) |
0.1 | 1.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
0.1 | 0.4 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
0.1 | 0.6 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
0.1 | 0.3 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.1 | 0.5 | GO:0072675 | osteoclast fusion(GO:0072675) |
0.1 | 0.5 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.1 | 0.9 | GO:0007320 | insemination(GO:0007320) |
0.1 | 1.0 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 0.5 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
0.0 | 0.3 | GO:0030910 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.0 | 0.1 | GO:0060769 | negative regulation of mitotic cell cycle, embryonic(GO:0045976) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173) |
0.0 | 0.3 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.0 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.3 | GO:0019856 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
0.0 | 0.4 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
0.0 | 0.1 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
0.0 | 1.0 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.0 | 0.4 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.0 | 0.1 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
0.0 | 1.5 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 1.7 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
0.0 | 0.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
0.0 | 0.5 | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
0.0 | 0.9 | GO:0046677 | response to antibiotic(GO:0046677) |
0.0 | 0.1 | GO:0097283 | keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) |
0.0 | 0.4 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
0.0 | 0.4 | GO:0086069 | bundle of His cell to Purkinje myocyte communication(GO:0086069) |
0.0 | 0.5 | GO:0002076 | osteoblast development(GO:0002076) |
0.0 | 2.7 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
0.0 | 0.3 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
0.0 | 0.1 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.0 | 0.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.0 | 0.4 | GO:0044062 | regulation of excretion(GO:0044062) |
0.0 | 0.5 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.3 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
0.0 | 0.3 | GO:0006828 | manganese ion transport(GO:0006828) |
0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
0.0 | 0.1 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
0.0 | 0.3 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
0.0 | 0.3 | GO:0097286 | iron ion import(GO:0097286) |
0.0 | 0.1 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
0.0 | 0.7 | GO:0055010 | ventricular cardiac muscle tissue morphogenesis(GO:0055010) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 3.0 | GO:0045179 | apical cortex(GO:0045179) |
0.2 | 0.6 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
0.1 | 0.7 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.1 | 2.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.1 | 1.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 0.6 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.1 | 2.6 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.1 | 0.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.1 | 1.4 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.1 | 0.2 | GO:0071942 | XPC complex(GO:0071942) |
0.1 | 0.3 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.1 | 1.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 4.9 | GO:0000502 | proteasome complex(GO:0000502) |
0.0 | 1.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.0 | 1.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 0.7 | GO:0070469 | respiratory chain(GO:0070469) |
0.0 | 0.3 | GO:0036156 | inner dynein arm(GO:0036156) |
0.0 | 0.1 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
0.0 | 0.2 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 0.6 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.3 | GO:0030057 | desmosome(GO:0030057) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.8 | GO:0004024 | NADPH:quinone reductase activity(GO:0003960) alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
0.9 | 3.8 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
0.8 | 5.4 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.7 | 4.9 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.4 | 3.0 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.4 | 1.8 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.3 | 1.5 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.3 | 1.1 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
0.2 | 0.6 | GO:0038052 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.2 | 0.6 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
0.1 | 2.6 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.1 | 0.4 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.1 | 0.3 | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
0.1 | 0.4 | GO:0031699 | beta-3 adrenergic receptor binding(GO:0031699) |
0.1 | 1.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.1 | 1.0 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
0.1 | 0.8 | GO:0004630 | phospholipase D activity(GO:0004630) |
0.1 | 0.7 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.1 | 0.5 | GO:0005113 | patched binding(GO:0005113) |
0.1 | 2.3 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 0.3 | GO:0070287 | ferritin receptor activity(GO:0070287) |
0.1 | 0.8 | GO:1990405 | protein antigen binding(GO:1990405) |
0.1 | 0.5 | GO:0032564 | dATP binding(GO:0032564) |
0.1 | 0.4 | GO:0031013 | troponin I binding(GO:0031013) |
0.1 | 0.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.1 | 0.5 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
0.0 | 2.7 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.0 | 0.4 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
0.0 | 2.5 | GO:0004521 | endoribonuclease activity(GO:0004521) |
0.0 | 1.0 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
0.0 | 1.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
0.0 | 1.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 1.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.4 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
0.0 | 0.2 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
0.0 | 0.7 | GO:0032183 | SUMO binding(GO:0032183) |
0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.0 | 0.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 0.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.0 | 0.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.0 | 0.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.0 | 1.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.0 | 0.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
0.0 | 0.4 | GO:0022829 | wide pore channel activity(GO:0022829) |
0.0 | 3.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 1.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 1.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.0 | 0.1 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 3.2 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 0.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.1 | 5.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 2.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 1.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
0.0 | 0.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
0.0 | 1.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
0.0 | 0.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
0.0 | 1.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 0.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.0 | 0.6 | PID ARF6 PATHWAY | Arf6 signaling events |
0.0 | 1.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
0.5 | 4.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
0.2 | 2.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.0 | 0.4 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
0.0 | 0.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
0.0 | 1.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.0 | 0.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.0 | 4.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.3 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 0.4 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 1.3 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.0 | 1.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
0.0 | 1.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
0.0 | 2.5 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
0.0 | 0.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.0 | 1.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.4 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |