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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Xbp1_Creb3l1

Z-value: 0.83

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol Gene ID Gene Info
ENSMUSG00000020484.12 X-box binding protein 1
ENSMUSG00000027230.9 cAMP responsive element binding protein 3-like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3l1mm10_v2_chr2_-_92024502_920245290.539.3e-04Click!
Xbp1mm10_v2_chr11_+_5520652_55206590.096.0e-01Click!

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.3 3.5 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 1.7 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 1.8 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 1.0 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.2 0.6 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.4 GO:0060435 bronchiole development(GO:0060435) intestinal epithelial cell maturation(GO:0060574)
0.1 0.5 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 1.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.3 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.1 0.6 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 0.2 GO:1990523 bone regeneration(GO:1990523)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.4 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 0.3 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 0.2 GO:2000705 negative regulation of anion channel activity(GO:0010360) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.1 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.0 0.7 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:1901671 positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.0 0.2 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 0.7 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.0 1.1 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.1 GO:0036090 cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.2 GO:0070417 negative regulation of translation in response to stress(GO:0032055) cellular response to cold(GO:0070417)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.4 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.1 GO:0033577 protein glycosylation in endoplasmic reticulum(GO:0033577)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.3 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 1.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.3 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.3 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 0.6 GO:0043293 apoptosome(GO:0043293)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 3.4 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 1.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.5 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.4 GO:0004096 catalase activity(GO:0004096)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.3 GO:0004104 cholinesterase activity(GO:0004104)
0.1 0.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 0.6 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression