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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Isl2

Z-value: 1.92

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Transcription factors associated with Isl2

Gene Symbol Gene ID Gene Info
ENSMUSG00000032318.6 insulin related protein 2 (islet 2)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Isl2mm10_v2_chr9_+_55541148_55541209-0.692.6e-06Click!

Activity profile of Isl2 motif

Sorted Z-values of Isl2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Isl2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 25.1 GO:0034031 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
1.8 25.3 GO:0015747 urate transport(GO:0015747)
1.5 4.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.8 9.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.8 4.7 GO:0002317 plasma cell differentiation(GO:0002317)
0.8 2.3 GO:0061290 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 9.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.5 2.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.5 1.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.5 1.4 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.4 1.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.4 2.6 GO:0033762 response to glucagon(GO:0033762)
0.4 14.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.4 1.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.4 1.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.3 1.0 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.3 2.4 GO:0019695 choline metabolic process(GO:0019695)
0.3 1.5 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.3 0.9 GO:0015881 creatine transport(GO:0015881)
0.2 2.5 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.2 1.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 2.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 4.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 1.0 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 0.6 GO:1905223 epicardium morphogenesis(GO:1905223)
0.2 1.0 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 1.1 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.2 1.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 1.2 GO:0019532 oxalate transport(GO:0019532)
0.1 1.3 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 1.7 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 2.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.8 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.5 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.1 0.3 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.5 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 2.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.4 GO:0070268 cornification(GO:0070268)
0.1 0.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.3 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 0.7 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.1 0.5 GO:0019732 antifungal humoral response(GO:0019732)
0.1 0.8 GO:0050955 thermoception(GO:0050955)
0.1 2.8 GO:0008206 bile acid metabolic process(GO:0008206)
0.1 1.2 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.9 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.4 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.3 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 1.5 GO:0021854 hypothalamus development(GO:0021854)
0.1 0.3 GO:0002568 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 1.7 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 2.1 GO:0071385 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 2.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.2 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.2 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.9 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0002017 regulation of blood volume by renal aldosterone(GO:0002017)
0.0 2.8 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.7 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.7 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.3 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 4.6 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 3.9 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.1 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.4 GO:0001832 blastocyst growth(GO:0001832)
0.0 0.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 3.9 GO:0007568 aging(GO:0007568)
0.0 0.6 GO:0070266 necroptotic process(GO:0070266)
0.0 8.1 GO:0032259 methylation(GO:0032259)
0.0 1.6 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.4 GO:0001967 suckling behavior(GO:0001967)
0.0 0.8 GO:0007595 lactation(GO:0007595)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 2.2 GO:0006865 amino acid transport(GO:0006865)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.5 GO:0019915 lipid storage(GO:0019915)
0.0 1.1 GO:0071333 cellular response to glucose stimulus(GO:0071333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 9.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.6 1.7 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.4 1.2 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.3 4.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 2.6 GO:0045275 respiratory chain complex III(GO:0045275)
0.2 0.8 GO:0002079 inner acrosomal membrane(GO:0002079)
0.2 0.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 11.1 GO:0070469 respiratory chain(GO:0070469)
0.1 29.4 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.8 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 2.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.5 GO:0005922 connexon complex(GO:0005922)
0.1 1.4 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.3 GO:0032807 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.9 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.1 GO:0060473 cortical granule(GO:0060473)
0.0 1.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.0 GO:0042101 T cell receptor complex(GO:0042101)
0.0 6.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 4.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 1.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 25.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
1.8 5.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
1.7 25.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.5 8.9 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
1.2 4.9 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
1.1 6.9 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.6 2.4 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.5 3.8 GO:0004556 alpha-amylase activity(GO:0004556)
0.5 18.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.5 2.8 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) CoA-transferase activity(GO:0008410) palmitoyl-CoA oxidase activity(GO:0016401) C-acetyltransferase activity(GO:0016453)
0.4 2.8 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.4 10.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 0.9 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.3 1.4 GO:0000405 bubble DNA binding(GO:0000405)
0.3 7.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 1.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 2.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 14.1 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 2.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.7 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.8 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.5 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 3.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.4 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 1.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 2.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.3 GO:0019809 spermidine binding(GO:0019809)
0.1 1.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0008527 taste receptor activity(GO:0008527)
0.1 0.6 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 2.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0070002 glutamic-type peptidase activity(GO:0070002)
0.0 0.9 GO:0005521 lamin binding(GO:0005521)
0.0 1.0 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 2.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.6 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 4.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 3.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 3.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 17.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 2.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 4.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 0.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 2.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation