avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
E2f8
|
ENSMUSG00000046179.11 | E2F transcription factor 8 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
E2f8 | mm10_v2_chr7_-_48881596_48881619 | 0.77 | 4.3e-08 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.1 | 18.2 | GO:0070488 | neutrophil aggregation(GO:0070488) |
2.7 | 8.2 | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
2.2 | 8.8 | GO:0090095 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
2.1 | 20.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
2.0 | 30.6 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
1.6 | 4.8 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of sodium-dependent phosphate transport(GO:2000118) |
1.6 | 6.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
1.4 | 4.3 | GO:0045004 | DNA replication proofreading(GO:0045004) |
1.2 | 4.8 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
1.2 | 2.4 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
1.2 | 5.9 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
1.2 | 17.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
1.1 | 6.7 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
1.0 | 24.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.9 | 16.9 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
0.8 | 5.9 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
0.8 | 7.1 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
0.6 | 4.4 | GO:0060762 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
0.5 | 1.6 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
0.5 | 7.3 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
0.5 | 5.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
0.4 | 12.6 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.4 | 1.7 | GO:0072737 | response to diamide(GO:0072737) cellular response to diamide(GO:0072738) |
0.4 | 3.9 | GO:0019336 | phenol-containing compound catabolic process(GO:0019336) |
0.4 | 3.2 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.3 | 2.1 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.3 | 1.6 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
0.3 | 3.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.3 | 9.1 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.2 | 1.2 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
0.2 | 1.4 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.2 | 11.4 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
0.2 | 3.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.2 | 1.0 | GO:0002326 | B cell lineage commitment(GO:0002326) |
0.2 | 3.0 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.1 | 0.7 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
0.1 | 10.9 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
0.1 | 1.2 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.1 | 0.7 | GO:0045631 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
0.1 | 2.3 | GO:0033045 | regulation of sister chromatid segregation(GO:0033045) |
0.0 | 0.2 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
0.0 | 0.1 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
0.0 | 0.4 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
0.0 | 0.3 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
0.0 | 1.2 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
0.0 | 0.1 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.6 | 10.9 | GO:1990423 | RZZ complex(GO:1990423) |
3.4 | 16.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
3.0 | 9.1 | GO:0033186 | CAF-1 complex(GO:0033186) |
2.7 | 8.2 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
2.3 | 11.4 | GO:0031523 | Myb complex(GO:0031523) |
1.9 | 28.2 | GO:0042555 | MCM complex(GO:0042555) |
1.5 | 7.3 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
1.4 | 4.3 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
1.2 | 6.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
1.0 | 4.8 | GO:0035189 | Rb-E2F complex(GO:0035189) |
0.7 | 5.1 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
0.5 | 34.6 | GO:0005657 | replication fork(GO:0005657) |
0.5 | 1.4 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
0.4 | 1.2 | GO:0048179 | activin receptor complex(GO:0048179) |
0.4 | 9.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.3 | 10.5 | GO:0051233 | spindle midzone(GO:0051233) |
0.3 | 8.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
0.2 | 8.8 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.2 | 3.0 | GO:0001673 | male germ cell nucleus(GO:0001673) |
0.2 | 1.0 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
0.1 | 5.9 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 1.9 | GO:0044232 | organelle membrane contact site(GO:0044232) |
0.1 | 0.8 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.1 | 1.7 | GO:0001741 | XY body(GO:0001741) |
0.1 | 3.2 | GO:0031430 | M band(GO:0031430) |
0.0 | 0.7 | GO:0070822 | Sin3-type complex(GO:0070822) |
0.0 | 0.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
0.0 | 0.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
0.0 | 0.2 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.0 | 14.6 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 3.1 | GO:0043204 | perikaryon(GO:0043204) |
0.0 | 17.2 | GO:0005730 | nucleolus(GO:0005730) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.7 | 21.9 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
3.7 | 14.6 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
3.4 | 16.9 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
2.4 | 7.1 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
2.3 | 18.2 | GO:0050786 | Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786) |
1.9 | 26.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
1.7 | 5.1 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
1.3 | 3.9 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
1.3 | 11.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
1.1 | 9.1 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.7 | 2.1 | GO:0048030 | disaccharide binding(GO:0048030) |
0.5 | 5.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.4 | 3.1 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
0.3 | 1.0 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
0.3 | 12.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.3 | 4.3 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
0.3 | 7.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.2 | 1.4 | GO:0070883 | pre-miRNA binding(GO:0070883) |
0.2 | 3.0 | GO:0098505 | single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505) |
0.2 | 0.7 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
0.2 | 4.8 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.2 | 1.2 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
0.2 | 6.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.2 | 8.8 | GO:0070888 | E-box binding(GO:0070888) |
0.1 | 6.2 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
0.1 | 1.4 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.1 | 6.0 | GO:0035064 | methylated histone binding(GO:0035064) |
0.1 | 3.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.1 | 1.7 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.1 | 4.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.1 | 8.7 | GO:0004386 | helicase activity(GO:0004386) |
0.0 | 3.2 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 1.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 7.2 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 3.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.7 | GO:0004407 | histone deacetylase activity(GO:0004407) |
0.0 | 4.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 10.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.6 | 57.3 | PID E2F PATHWAY | E2F transcription factor network |
0.5 | 18.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
0.3 | 11.5 | PID ATR PATHWAY | ATR signaling pathway |
0.3 | 14.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
0.2 | 8.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 1.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
0.1 | 1.8 | PID BARD1 PATHWAY | BARD1 signaling events |
0.1 | 2.1 | PID RAS PATHWAY | Regulation of Ras family activation |
0.1 | 5.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
0.0 | 1.7 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
0.0 | 4.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 1.4 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
0.0 | 2.7 | PID LKB1 PATHWAY | LKB1 signaling events |
0.0 | 0.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.5 | 39.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
1.9 | 33.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
1.1 | 10.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
1.0 | 13.5 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
0.7 | 11.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
0.4 | 5.1 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
0.3 | 8.7 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
0.3 | 8.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
0.2 | 3.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
0.1 | 14.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.1 | 3.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
0.1 | 1.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
0.0 | 0.8 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
0.0 | 1.0 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
0.0 | 4.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 0.4 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |