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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc10

Z-value: 1.20

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Transcription factors associated with Hoxc10

Gene Symbol Gene ID Gene Info
ENSMUSG00000022484.7 homeobox C10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc10mm10_v2_chr15_+_102966794_102966812-0.038.6e-01Click!

Activity profile of Hoxc10 motif

Sorted Z-values of Hoxc10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 11.0 GO:0034760 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.8 4.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.8 3.1 GO:0014916 regulation of lung blood pressure(GO:0014916)
0.7 2.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.6 4.5 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.6 2.4 GO:0043380 regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.5 1.6 GO:0006507 GPI anchor release(GO:0006507)
0.5 1.5 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.5 1.5 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.4 2.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.4 2.6 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.3 1.3 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.3 0.9 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.3 1.6 GO:0006083 acetate metabolic process(GO:0006083)
0.3 5.1 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.3 2.8 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.2 0.7 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.2 4.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2 0.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.7 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 2.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.4 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.1 2.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 2.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.3 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 1.8 GO:0000338 protein deneddylation(GO:0000338)
0.1 1.4 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 2.9 GO:0015813 L-glutamate transport(GO:0015813)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.6 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.3 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.4 GO:0021502 neural fold elevation formation(GO:0021502)
0.1 0.1 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.5 GO:0014823 response to activity(GO:0014823)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.5 GO:0007320 insemination(GO:0007320)
0.0 0.1 GO:0003274 endocardial cushion fusion(GO:0003274) positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 1.4 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 3.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.8 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.6 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 1.1 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.3 GO:0030057 desmosome(GO:0030057)
0.2 2.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.1 GO:0045179 apical cortex(GO:0045179)
0.1 0.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 2.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.8 GO:0097452 GAIT complex(GO:0097452)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.4 GO:0005657 replication fork(GO:0005657)
0.0 2.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 3.8 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 1.6 GO:0000502 proteasome complex(GO:0000502)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 5.4 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
1.1 4.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.0 4.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.5 1.6 GO:0019807 aspartoacylase activity(GO:0019807)
0.5 3.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.4 1.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 3.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 2.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 0.8 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.2 0.7 GO:0070540 stearic acid binding(GO:0070540)
0.2 1.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 2.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 1.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.5 GO:0038132 neuregulin binding(GO:0038132)
0.2 2.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.6 GO:0030977 taurine binding(GO:0030977)
0.2 1.6 GO:0004630 phospholipase D activity(GO:0004630)
0.2 4.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 2.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 0.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 1.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 2.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 9.6 GO:0005179 hormone activity(GO:0005179)
0.1 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 2.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 3.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.1 GO:0098918 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.0 0.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.7 GO:0004386 helicase activity(GO:0004386)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 4.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 4.0 PID FOXO PATHWAY FoxO family signaling
0.1 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.4 PID IFNG PATHWAY IFN-gamma pathway
0.0 1.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 3.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.3 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 3.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters