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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc6

Z-value: 0.60

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Transcription factors associated with Hoxc6

Gene Symbol Gene ID Gene Info
ENSMUSG00000001661.4 homeobox C6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc6mm10_v2_chr15_+_103009479_1030095070.212.1e-01Click!

Activity profile of Hoxc6 motif

Sorted Z-values of Hoxc6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:2000473 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.5 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.5 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.2 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0051030 snRNA transport(GO:0051030)
0.0 0.8 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.1 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.2 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044753 amphisome(GO:0044753)
0.1 0.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 0.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 0.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.4 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.5 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors