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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hmga2

Z-value: 1.31

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Transcription factors associated with Hmga2

Gene Symbol Gene ID Gene Info
ENSMUSG00000056758.8 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmga2mm10_v2_chr10_-_120476469_1204765270.057.7e-01Click!

Activity profile of Hmga2 motif

Sorted Z-values of Hmga2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmga2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.3 GO:0031000 response to caffeine(GO:0031000)
0.3 0.9 GO:0021558 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.3 1.1 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.2 2.2 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.2 1.2 GO:0042938 dipeptide transport(GO:0042938)
0.2 2.7 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.2 33.7 GO:0007586 digestion(GO:0007586)
0.2 0.9 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
0.1 0.7 GO:0006548 histidine catabolic process(GO:0006548)
0.1 1.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.5 GO:2001183 positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.3 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.6 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.3 GO:0016598 protein arginylation(GO:0016598)
0.1 0.5 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 0.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.3 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.1 0.7 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 0.9 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 2.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.8 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.1 0.4 GO:0044597 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.1 0.3 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.8 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.6 GO:0009133 nucleoside diphosphate biosynthetic process(GO:0009133)
0.0 0.3 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.0 0.6 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.5 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.4 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.0 0.2 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636) positive regulation of neuron maturation(GO:0014042)
0.0 0.4 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.3 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0072014 proximal tubule development(GO:0072014)
0.0 0.3 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.5 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 1.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.6 GO:1901998 toxin transport(GO:1901998)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.7 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.8 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.2 GO:0005940 septin ring(GO:0005940)
0.0 0.4 GO:0036128 CatSper complex(GO:0036128)
0.0 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.7 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 61.5 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.4 1.2 GO:0042936 dipeptide transporter activity(GO:0042936)
0.3 63.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 0.9 GO:0071820 N-box binding(GO:0071820)
0.2 1.1 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.2 0.5 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.1 0.5 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.1 0.3 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 0.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.7 GO:0051870 methotrexate binding(GO:0051870)
0.1 1.7 GO:0070330 aromatase activity(GO:0070330)
0.0 2.4 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.9 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.4 GO:0015923 mannosidase activity(GO:0015923)
0.0 0.1 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 0.6 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.4 GO:0048038 quinone binding(GO:0048038) NADPH binding(GO:0070402)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.7 GO:0043236 laminin binding(GO:0043236)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.0 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.0 0.1 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0015250 water channel activity(GO:0015250)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 24.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 3.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 12.8 REACTOME DEFENSINS Genes involved in Defensins
0.4 11.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 1.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes