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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Ppard

Z-value: 0.87

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Transcription factors associated with Ppard

Gene Symbol Gene ID Gene Info
ENSMUSG00000002250.9 peroxisome proliferator activator receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28272191_28272205-0.173.3e-01Click!

Activity profile of Ppard motif

Sorted Z-values of Ppard motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Ppard

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.6 1.8 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.4 2.3 GO:0006083 acetate metabolic process(GO:0006083)
0.4 1.1 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.3 1.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 5.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 5.9 GO:0035634 response to stilbenoid(GO:0035634)
0.2 0.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 1.4 GO:0015879 carnitine transport(GO:0015879)
0.1 0.5 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.5 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 0.7 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.1 0.4 GO:0046340 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.1 0.3 GO:0071661 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793) renal water absorption(GO:0070295)
0.1 1.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.2 GO:0045041 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 1.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 0.6 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to diacyl bacterial lipopeptide(GO:0071726) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0 1.1 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.2 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.2 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 1.1 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 1.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.7 GO:0070098 lymphocyte chemotaxis(GO:0048247) chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.6 1.8 GO:0032010 phagolysosome(GO:0032010)
0.4 4.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.3 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 2.3 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.8 2.3 GO:0019807 aspartoacylase activity(GO:0019807)
0.6 3.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.3 1.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 1.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.3 0.8 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.2 1.4 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.2 1.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 5.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.5 GO:0070404 NADH binding(GO:0070404)
0.1 0.3 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.5 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.0 GO:0070513 death domain binding(GO:0070513)
0.1 1.0 GO:0010181 FMN binding(GO:0010181)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.5 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0 0.2 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.1 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 4.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 4.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.9 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.1 1.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 0.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1