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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hif1a

Z-value: 1.59

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Transcription factors associated with Hif1a

Gene Symbol Gene ID Gene Info
ENSMUSG00000021109.7 hypoxia inducible factor 1, alpha subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73901370_73901391-0.511.6e-03Click!

Activity profile of Hif1a motif

Sorted Z-values of Hif1a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.9 6.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.9 5.1 GO:0006083 acetate metabolic process(GO:0006083) short-chain fatty acid biosynthetic process(GO:0051790)
0.8 2.4 GO:0009153 purine deoxyribonucleotide biosynthetic process(GO:0009153)
0.7 2.8 GO:0048294 regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.7 2.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.6 1.9 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982)
0.6 1.7 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.5 2.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.4 3.4 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.3 2.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.3 1.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.3 1.1 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.3 0.8 GO:0032025 response to cobalt ion(GO:0032025)
0.3 1.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.3 1.3 GO:0015886 heme transport(GO:0015886)
0.3 19.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 2.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 2.4 GO:1904152 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) regulation of retrograde protein transport, ER to cytosol(GO:1904152) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2 0.7 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 0.6 GO:0006154 adenosine catabolic process(GO:0006154)
0.2 0.9 GO:0060025 regulation of synaptic activity(GO:0060025)
0.2 0.8 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.2 0.6 GO:0042117 monocyte activation(GO:0042117)
0.2 0.6 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.2 0.8 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.2 0.2 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.2 0.6 GO:0060300 regulation of cytokine activity(GO:0060300)
0.2 0.5 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.2 1.4 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.2 0.7 GO:0006244 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.2 0.5 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.2 2.4 GO:0043589 Notch receptor processing(GO:0007220) skin morphogenesis(GO:0043589)
0.2 0.5 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 1.0 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) eye pigmentation(GO:0048069)
0.1 0.4 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 1.6 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.4 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 1.0 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.5 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 3.6 GO:0014002 astrocyte development(GO:0014002)
0.1 0.9 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.5 GO:0061743 motor learning(GO:0061743)
0.1 1.8 GO:0032060 bleb assembly(GO:0032060)
0.1 5.2 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 0.9 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 2.7 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 1.1 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 2.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 0.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 0.5 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 1.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.8 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1 0.3 GO:0032439 endosome localization(GO:0032439)
0.0 1.2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 1.5 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.9 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.0 0.4 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.8 GO:0042487 ventral spinal cord interneuron specification(GO:0021521) regulation of odontogenesis of dentin-containing tooth(GO:0042487) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.8 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.7 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:0021660 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.0 0.4 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.0 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.7 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.1 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 1.2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 0.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.0 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.4 GO:0061689 tricellular tight junction(GO:0061689)
0.4 1.6 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.4 1.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.4 3.0 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.3 0.9 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.3 2.0 GO:0097452 GAIT complex(GO:0097452)
0.3 6.4 GO:0043196 varicosity(GO:0043196)
0.2 1.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.4 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 2.4 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 2.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.5 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 2.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 3.3 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 1.0 GO:0005771 multivesicular body(GO:0005771)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.6 GO:0005657 replication fork(GO:0005657)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.0 6.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0032592 integral component of mitochondrial membrane(GO:0032592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 20.9 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
1.7 5.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.7 2.0 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.5 1.9 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.5 1.4 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.5 2.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.4 6.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 1.5 GO:0047288 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) monosialoganglioside sialyltransferase activity(GO:0047288)
0.3 1.6 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.3 1.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3 1.3 GO:0015232 heme transporter activity(GO:0015232)
0.3 2.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.3 2.0 GO:0016812 nucleobase binding(GO:0002054) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 1.0 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.2 4.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.2 1.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 0.6 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.2 2.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 1.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 0.7 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.2 1.8 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.2 0.7 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 2.4 GO:0019206 nucleoside kinase activity(GO:0019206)
0.2 1.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.7 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.4 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 1.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 0.6 GO:0009374 biotin binding(GO:0009374)
0.1 0.5 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 4.3 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.8 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.3 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.6 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.4 GO:0000182 rDNA binding(GO:0000182)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.5 GO:0050693 LBD domain binding(GO:0050693)
0.0 6.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.6 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 2.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.6 GO:0000049 tRNA binding(GO:0000049)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 5.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.8 PID BMP PATHWAY BMP receptor signaling
0.0 3.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 3.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.9 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 6.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 25.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 2.4 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 3.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 2.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.5 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.8 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.1 0.9 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 0.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.4 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis