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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Prdm1

Z-value: 2.14

Motif logo

Transcription factors associated with Prdm1

Gene Symbol Gene ID Gene Info
ENSMUSG00000038151.6 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prdm1mm10_v2_chr10_-_44458715_44458751-0.564.1e-04Click!

Activity profile of Prdm1 motif

Sorted Z-values of Prdm1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Prdm1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.5 GO:0009744 fructose catabolic process(GO:0006001) response to sucrose(GO:0009744) response to disaccharide(GO:0034285) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
3.3 10.0 GO:1990166 protein localization to site of double-strand break(GO:1990166)
2.7 8.2 GO:2000547 regulation of dendritic cell dendrite assembly(GO:2000547)
1.7 5.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
1.6 4.7 GO:0018900 dichloromethane metabolic process(GO:0018900)
1.5 7.4 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
1.1 4.3 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.0 2.9 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.9 2.7 GO:2000485 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) regulation of glutamine transport(GO:2000485)
0.9 0.9 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.8 3.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.7 3.0 GO:0032379 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.7 2.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.7 4.1 GO:0003383 apical constriction(GO:0003383)
0.7 2.0 GO:0006553 lysine metabolic process(GO:0006553)
0.6 2.5 GO:1903416 response to glycoside(GO:1903416)
0.6 1.8 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.6 2.3 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.6 1.7 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.6 2.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.5 1.6 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.5 3.0 GO:0006083 acetate metabolic process(GO:0006083)
0.5 2.0 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.5 1.5 GO:0039521 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.4 3.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4 1.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.4 1.3 GO:0043181 vacuolar sequestering(GO:0043181)
0.4 2.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 1.5 GO:1901026 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.3 1.7 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 1.0 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.3 1.0 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.3 6.1 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 2.7 GO:0045345 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.3 3.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 3.5 GO:0005513 detection of calcium ion(GO:0005513)
0.3 2.5 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.3 0.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 2.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.3 1.6 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.3 5.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.3 1.3 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.3 2.0 GO:0060594 mammary gland specification(GO:0060594)
0.2 0.7 GO:0000966 RNA 5'-end processing(GO:0000966) mitochondrial tRNA processing(GO:0090646)
0.2 1.2 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.2 1.9 GO:0042126 nitrate metabolic process(GO:0042126)
0.2 1.2 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.2 5.1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.2 2.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.2 3.0 GO:0070842 aggresome assembly(GO:0070842)
0.2 2.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 3.0 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 1.7 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 1.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 0.7 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 7.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 11.8 GO:0071346 cellular response to interferon-gamma(GO:0071346)
0.2 0.7 GO:0070268 cornification(GO:0070268)
0.2 0.5 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.2 2.2 GO:0015747 urate transport(GO:0015747)
0.2 1.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 0.8 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.2 0.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.2 2.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.4 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 1.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 2.5 GO:0046519 sphingoid metabolic process(GO:0046519)
0.1 0.6 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.1 0.5 GO:0009992 cellular water homeostasis(GO:0009992)
0.1 1.2 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.1 0.9 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.1 0.5 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.5 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.1 0.4 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 0.4 GO:2000864 estradiol secretion(GO:0035938) regulation of estradiol secretion(GO:2000864)
0.1 0.4 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 3.3 GO:0050892 intestinal absorption(GO:0050892)
0.1 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.3 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.1 0.5 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.3 GO:2000836 epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) positive regulation of androgen secretion(GO:2000836)
0.1 1.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.4 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 2.6 GO:0035456 response to interferon-beta(GO:0035456)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 0.9 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 0.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.3 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.0 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.8 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.4 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 1.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 7.1 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.3 GO:0043974 histone H3-K27 acetylation(GO:0043974) leukemia inhibitory factor signaling pathway(GO:0048861) regulation of histone H3-K27 acetylation(GO:1901674)
0.0 1.4 GO:0003416 endochondral bone growth(GO:0003416)
0.0 8.1 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 1.2 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.7 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.1 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.0 0.8 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.9 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.8 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.6 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 2.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 2.8 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 1.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.8 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 0.3 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.1 GO:0042697 menopause(GO:0042697)
0.0 0.3 GO:0043368 positive T cell selection(GO:0043368)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 2.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 1.5 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 7.4 GO:0001501 skeletal system development(GO:0001501)
0.0 0.9 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 0.7 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.7 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0033269 internode region of axon(GO:0033269)
0.5 7.4 GO:0045180 basal cortex(GO:0045180)
0.4 2.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 3.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 2.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 9.9 GO:0035861 site of double-strand break(GO:0035861)
0.2 3.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 3.3 GO:0045179 apical cortex(GO:0045179)
0.2 1.7 GO:0042825 TAP complex(GO:0042825)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 3.5 GO:0031045 dense core granule(GO:0031045)
0.2 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.1 GO:0097542 ciliary tip(GO:0097542)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 2.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.3 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.6 GO:0097386 glial cell projection(GO:0097386)
0.1 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.5 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.0 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.9 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.5 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 1.5 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 28.7 GO:0005615 extracellular space(GO:0005615)
0.0 3.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 6.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.5 GO:0004454 ketohexokinase activity(GO:0004454)
1.6 6.3 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.6 4.7 GO:0047651 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
1.3 5.2 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.3 7.8 GO:0008172 S-methyltransferase activity(GO:0008172)
1.1 10.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
1.1 4.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
1.0 3.0 GO:0019807 aspartoacylase activity(GO:0019807)
1.0 3.0 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
0.9 2.7 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.9 3.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.7 3.0 GO:0050632 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.7 7.4 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.6 1.9 GO:0008940 nitrate reductase activity(GO:0008940)
0.5 3.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.5 1.6 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.5 2.0 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.5 2.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.5 1.5 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.5 3.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 1.3 GO:0038052 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 8.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 13.0 GO:0008009 chemokine activity(GO:0008009)
0.3 8.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 2.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.3 1.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.3 0.9 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.3 1.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 2.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 2.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 2.5 GO:1990239 steroid hormone binding(GO:1990239)
0.2 4.8 GO:0070628 proteasome binding(GO:0070628)
0.2 1.7 GO:0046979 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.2 1.7 GO:0001851 complement component C3b binding(GO:0001851)
0.2 5.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 3.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 2.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.8 GO:0008147 structural constituent of bone(GO:0008147)
0.2 2.7 GO:0070513 death domain binding(GO:0070513)
0.2 1.5 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.2 2.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 5.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 1.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.8 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.7 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 5.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 3.2 GO:0043531 ADP binding(GO:0043531)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.2 GO:0005123 death receptor binding(GO:0005123)
0.1 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 2.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.0 GO:0005537 mannose binding(GO:0005537)
0.0 1.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0071209 histone pre-mRNA DCP binding(GO:0071208) U7 snRNA binding(GO:0071209)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 1.6 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 3.8 GO:0008083 growth factor activity(GO:0008083)
0.0 1.4 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 1.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.2 GO:0000049 tRNA binding(GO:0000049)
0.0 4.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 2.5 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.3 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 8.4 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 2.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 2.7 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.5 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 2.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 1.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 2.0 PID ARF 3PATHWAY Arf1 pathway
0.1 4.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 1.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 7.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 2.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 5.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.4 7.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 3.5 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 7.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 9.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 8.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 4.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 4.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 2.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.2 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 23.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 4.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.0 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 2.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 2.1 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 2.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.3 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport