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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Fosb

Z-value: 0.58

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Transcription factors associated with Fosb

Gene Symbol Gene ID Gene Info
ENSMUSG00000003545.2 FBJ osteosarcoma oncogene B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.353.5e-02Click!

Activity profile of Fosb motif

Sorted Z-values of Fosb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Fosb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0044805 late nucleophagy(GO:0044805)
0.2 0.5 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 1.0 GO:0015862 uridine transport(GO:0015862)
0.1 0.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 1.3 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1 0.4 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.1 0.2 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.1 0.3 GO:0090472 dibasic protein processing(GO:0090472)
0.1 0.3 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
0.1 0.5 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.2 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.0 0.2 GO:0035938 estradiol secretion(GO:0035938) regulation of estradiol secretion(GO:2000864)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:1903027 regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028)
0.0 0.4 GO:1902572 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.3 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0009816 defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.0 0.2 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.2 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.3 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 0.3 GO:0005914 spot adherens junction(GO:0005914)
0.0 0.8 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.2 GO:0097447 dendritic tree(GO:0097447)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.4 GO:0042599 lamellar body(GO:0042599)
0.0 0.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.2 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling