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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr2e1

Z-value: 7.31

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Transcription factors associated with Nr2e1

Gene Symbol Gene ID Gene Info
ENSMUSG00000019803.5 nuclear receptor subfamily 2, group E, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2e1mm10_v2_chr10_-_42583628_425836390.029.0e-01Click!

Activity profile of Nr2e1 motif

Sorted Z-values of Nr2e1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.0 187.4 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
11.9 71.4 GO:0008355 olfactory learning(GO:0008355)
5.8 156.0 GO:0035634 response to stilbenoid(GO:0035634)
2.3 32.8 GO:0015747 urate transport(GO:0015747)
2.0 22.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
2.0 7.8 GO:0090472 dibasic protein processing(GO:0090472)
1.7 6.8 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
1.1 5.3 GO:0006572 tyrosine catabolic process(GO:0006572)
1.1 3.2 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.7 4.8 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.6 6.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.6 6.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.5 5.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.4 7.6 GO:0016540 protein autoprocessing(GO:0016540)
0.4 1.2 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.4 16.8 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.4 3.6 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.3 9.1 GO:0046325 negative regulation of glucose import(GO:0046325)
0.2 2.5 GO:0097475 motor neuron migration(GO:0097475)
0.2 19.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 7.0 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.2 4.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 6.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.3 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.1 1.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 12.7 GO:0050890 cognition(GO:0050890)
0.0 1.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 2.7 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.6 4.8 GO:0042825 TAP complex(GO:0042825)
0.5 7.0 GO:0031209 SCAR complex(GO:0031209)
0.5 7.8 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.4 5.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 6.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 6.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 9.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.2 GO:0071438 invadopodium membrane(GO:0071438)
0.2 2.2 GO:0036156 inner dynein arm(GO:0036156)
0.2 52.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 303.3 GO:0005615 extracellular space(GO:0005615)
0.1 49.6 GO:0045177 apical part of cell(GO:0045177)
0.1 4.1 GO:0002102 podosome(GO:0002102)
0.1 0.8 GO:0097255 R2TP complex(GO:0097255)
0.1 15.8 GO:0030133 transport vesicle(GO:0030133)
0.0 15.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.7 GO:0016528 sarcoplasm(GO:0016528)
0.0 57.8 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
59.4 178.3 GO:0005186 pheromone activity(GO:0005186)
6.0 144.0 GO:0005550 pheromone binding(GO:0005550)
4.1 32.8 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
3.7 22.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
1.4 51.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.4 6.8 GO:0015254 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
1.1 40.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
1.0 9.1 GO:0031419 cobalamin binding(GO:0031419)
0.8 15.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.7 7.6 GO:0036122 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.7 4.8 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.5 5.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.5 3.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.5 7.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.5 1.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.5 1.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.5 7.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 6.6 GO:0031996 thioesterase binding(GO:0031996)
0.2 1.2 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 6.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 22.9 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 19.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 5.3 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.1 16.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 3.6 GO:0031593 polyubiquitin binding(GO:0031593)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 7.6 PID BMP PATHWAY BMP receptor signaling
0.1 6.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 7.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.6 7.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4 6.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 5.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 5.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives