Project

avrg: GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 0.86

Motif logo

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000062175.7 TGFB-induced factor homeobox 2
ENSMUSG00000061283.4 TGFB-induced factor homeobox 2-like, X-linked 1
ENSMUSG00000063242.6 TGFB-induced factor homeobox 2-like, X-linked 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840077_1568401410.728.5e-07Click!

Activity profile of Tgif2_Tgif2lx1_Tgif2lx2 motif

Sorted Z-values of Tgif2_Tgif2lx1_Tgif2lx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.9 GO:0060242 contact inhibition(GO:0060242)
0.5 3.2 GO:1904180 negative regulation of membrane depolarization(GO:1904180)
0.4 1.1 GO:0071846 actin filament debranching(GO:0071846)
0.4 1.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.3 1.4 GO:0015744 succinate transport(GO:0015744)
0.3 1.0 GO:2000554 regulation of T-helper 1 cell cytokine production(GO:2000554) positive regulation of T-helper 1 cell cytokine production(GO:2000556)
0.3 1.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 0.9 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877) positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.2 2.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.2 0.6 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.2 0.8 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.2 2.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 0.8 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.2 1.3 GO:0048478 replication fork protection(GO:0048478)
0.2 0.6 GO:0045763 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.2 0.6 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.2 0.5 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.2 4.7 GO:0014823 response to activity(GO:0014823)
0.2 0.8 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 2.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.4 GO:0002441 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 3.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 1.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 2.0 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.3 GO:0071873 response to norepinephrine(GO:0071873)
0.1 1.3 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.1 6.1 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.1 0.3 GO:0015825 L-serine transport(GO:0015825)
0.1 0.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.3 GO:1902303 negative regulation of potassium ion export(GO:1902303)
0.1 1.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.5 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 0.2 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 0.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 0.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.5 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.7 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.1 GO:1900368 regulation of RNA interference(GO:1900368)
0.0 0.4 GO:0071494 pyrimidine dimer repair(GO:0006290) cellular response to UV-C(GO:0071494)
0.0 0.7 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 1.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 5.4 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.0 1.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 1.2 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.2 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0042697 menopause(GO:0042697)
0.0 0.1 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.2 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.0 0.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 3.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 1.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0030224 monocyte differentiation(GO:0030224)
0.0 1.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:0014831 intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831)
0.0 1.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 1.9 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.2 GO:0015816 glycine transport(GO:0015816)
0.0 1.1 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 2.1 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.0 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 0.2 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0031262 Ndc80 complex(GO:0031262)
0.2 1.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 1.3 GO:0031298 replication fork protection complex(GO:0031298)
0.1 1.2 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 4.7 GO:0031430 M band(GO:0031430)
0.1 2.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.2 GO:0030312 external encapsulating structure(GO:0030312)
0.1 0.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 0.3 GO:0098536 deuterosome(GO:0098536)
0.0 2.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074) nuclear RNA export factor complex(GO:0042272)
0.0 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 1.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.0 1.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0042599 lamellar body(GO:0042599)
0.0 2.3 GO:0005903 brush border(GO:0005903)
0.0 0.5 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:0004111 creatine kinase activity(GO:0004111)
0.5 1.4 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.4 1.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 3.2 GO:0071253 connexin binding(GO:0071253)
0.2 4.7 GO:0005523 tropomyosin binding(GO:0005523)
0.2 0.6 GO:0052594 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.2 0.8 GO:0031711 beta-adrenergic receptor activity(GO:0004939) bradykinin receptor binding(GO:0031711)
0.2 2.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 1.8 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 1.1 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.1 0.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.2 GO:0004568 chitinase activity(GO:0004568)
0.1 0.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.5 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155) voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 1.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.6 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 7.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0008009 chemokine activity(GO:0008009)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 6.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.8 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.3 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.3 PID ATR PATHWAY ATR signaling pathway
0.0 1.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 1.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.9 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 2.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 5.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 4.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family