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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Brca1

Z-value: 0.60

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Transcription factors associated with Brca1

Gene Symbol Gene ID Gene Info
ENSMUSG00000017146.6 breast cancer 1, early onset

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_101551893-0.153.8e-01Click!

Activity profile of Brca1 motif

Sorted Z-values of Brca1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Brca1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:2000292 regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.2 1.1 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 0.4 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.4 GO:0009726 detection of nodal flow(GO:0003127) detection of endogenous stimulus(GO:0009726)
0.1 0.3 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.3 GO:0002436 immune complex clearance by monocytes and macrophages(GO:0002436) monocyte homeostasis(GO:0035702) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265)
0.1 0.3 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.3 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.1 0.5 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 0.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 2.3 GO:0035634 response to stilbenoid(GO:0035634)
0.1 0.4 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.3 GO:0021764 amygdala development(GO:0021764)
0.1 0.3 GO:0080154 regulation of fertilization(GO:0080154)
0.1 0.2 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 0.9 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.2 GO:0061193 taste bud development(GO:0061193)
0.1 0.3 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.2 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.3 GO:0045585 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0 0.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.5 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.4 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.4 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.1 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 0.2 GO:1903677 adenosine to inosine editing(GO:0006382) regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.1 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.0 0.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.1 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0006507 GPI anchor release(GO:0006507)
0.0 0.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.0 GO:0007493 endodermal cell fate determination(GO:0007493)
0.0 0.0 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.0 0.1 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.4 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.3 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.9 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.1 0.3 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 0.9 GO:0070852 cell body fiber(GO:0070852)
0.1 0.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.1 0.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.3 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 0.4 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
0.0 0.2 GO:0036396 MIS complex(GO:0036396)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:1990696 USH2 complex(GO:1990696)
0.0 0.1 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.0 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.6 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.6 GO:0004058 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 0.9 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.4 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 2.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.2 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 1.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.3 GO:0002135 CTP binding(GO:0002135)
0.0 0.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.2 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.0 0.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035) NADH binding(GO:0070404)
0.0 1.1 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.9 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.0 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.0 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID EPO PATHWAY EPO signaling pathway
0.0 0.4 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.3 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription