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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Irx5

Z-value: 1.01

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000031737.10 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_92357801-0.447.2e-03Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.7 6.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.6 1.9 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.5 1.8 GO:0051344 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) positive regulation of calcium-transporting ATPase activity(GO:1901896) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.3 1.0 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.3 5.1 GO:0006063 uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585) cellular glucuronidation(GO:0052695)
0.3 1.0 GO:0006507 GPI anchor release(GO:0006507)
0.3 1.0 GO:1990927 calcium ion regulated lysosome exocytosis(GO:1990927)
0.3 3.8 GO:0015747 urate transport(GO:0015747)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.6 GO:0060618 nipple development(GO:0060618)
0.2 0.5 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 4.5 GO:0046688 response to copper ion(GO:0046688)
0.1 0.4 GO:0042668 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 0.5 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 1.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 0.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.4 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.6 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.0 0.1 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.9 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 1.9 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.2 GO:1901979 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 1.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.8 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.3 GO:0032092 positive regulation of protein binding(GO:0032092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070939 Dsl1p complex(GO:0070939)
0.3 3.2 GO:0005579 membrane attack complex(GO:0005579)
0.2 5.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.7 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.9 GO:0071986 Ragulator complex(GO:0071986)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 4.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 5.5 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 4.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 16.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 0.8 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 3.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.9 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 0.5 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0071820 N-box binding(GO:0071820)
0.1 1.0 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.5 GO:0016623 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 0.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 2.1 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 4.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription