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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Scrt2

Z-value: 0.64

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Transcription factors associated with Scrt2

Gene Symbol Gene ID Gene Info
ENSMUSG00000060257.2 scratch family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_1520816240.124.7e-01Click!

Activity profile of Scrt2 motif

Sorted Z-values of Scrt2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Scrt2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.2 0.7 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.2 2.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.2 0.5 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.6 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.3 GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) negative regulation of metalloendopeptidase activity(GO:1904684) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 0.4 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.1 0.2 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.1 0.3 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.1 0.3 GO:0015822 lysine transport(GO:0015819) ornithine transport(GO:0015822)
0.1 0.2 GO:0007308 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.1 0.2 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.5 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.9 GO:0001967 suckling behavior(GO:0001967)
0.0 0.2 GO:1901908 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.5 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.7 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.0 0.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.6 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.4 GO:0008105 asymmetric protein localization(GO:0008105)
0.0 0.6 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.2 GO:0060174 limb bud formation(GO:0060174)
0.0 0.3 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.3 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.1 GO:0032349 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0032807 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.8 GO:0097546 ciliary base(GO:0097546)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0071546 pi-body(GO:0071546)
0.0 0.7 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.2 0.5 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.2 0.5 GO:0019002 GMP binding(GO:0019002)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.2 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 1.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064) L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.7 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 2.9 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.5 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.3 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 1.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane