avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Plagl1
|
ENSMUSG00000019817.12 | pleiomorphic adenoma gene-like 1 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Plagl1 | mm10_v2_chr10_+_13090788_13090843 | -0.82 | 8.2e-10 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.3 | 9.9 | GO:0060752 | negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730) |
1.5 | 6.0 | GO:0071718 | sodium-independent icosanoid transport(GO:0071718) |
1.0 | 3.0 | GO:0042732 | D-xylose metabolic process(GO:0042732) |
0.8 | 3.4 | GO:0030091 | protein repair(GO:0030091) |
0.4 | 2.2 | GO:0006068 | ethanol catabolic process(GO:0006068) |
0.3 | 1.0 | GO:0021759 | globus pallidus development(GO:0021759) |
0.3 | 5.8 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
0.2 | 1.0 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
0.2 | 2.1 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
0.2 | 1.6 | GO:0032377 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
0.2 | 0.9 | GO:0014734 | skeletal muscle hypertrophy(GO:0014734) |
0.2 | 1.4 | GO:1904219 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
0.2 | 0.6 | GO:0070904 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
0.2 | 3.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.2 | 0.7 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.2 | 0.9 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
0.1 | 4.2 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
0.1 | 1.3 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
0.1 | 1.8 | GO:0070842 | aggresome assembly(GO:0070842) |
0.1 | 3.5 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
0.1 | 0.4 | GO:0003218 | cardiac left ventricle formation(GO:0003218) |
0.1 | 2.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.1 | 0.6 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
0.1 | 1.3 | GO:0014824 | artery smooth muscle contraction(GO:0014824) |
0.1 | 2.9 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.1 | 0.8 | GO:0045341 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) |
0.1 | 2.3 | GO:0051639 | actin filament network formation(GO:0051639) |
0.1 | 2.2 | GO:0098596 | vocal learning(GO:0042297) imitative learning(GO:0098596) |
0.1 | 2.2 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
0.1 | 1.6 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.1 | 0.8 | GO:0015879 | carnitine transport(GO:0015879) |
0.1 | 0.5 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.1 | 1.5 | GO:0034063 | stress granule assembly(GO:0034063) |
0.1 | 0.7 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.1 | 0.9 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.1 | 0.8 | GO:1990035 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
0.1 | 0.3 | GO:0001661 | conditioned taste aversion(GO:0001661) |
0.1 | 1.1 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
0.0 | 1.1 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
0.0 | 1.4 | GO:0031639 | plasminogen activation(GO:0031639) |
0.0 | 0.4 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
0.0 | 0.9 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
0.0 | 0.3 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
0.0 | 0.2 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
0.0 | 1.0 | GO:0010884 | positive regulation of lipid storage(GO:0010884) |
0.0 | 0.2 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
0.0 | 0.3 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.0 | 0.2 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
0.0 | 0.3 | GO:0014850 | response to muscle activity(GO:0014850) |
0.0 | 1.0 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
0.0 | 0.1 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) |
0.0 | 0.2 | GO:0007000 | nucleolus organization(GO:0007000) |
0.0 | 1.9 | GO:0007584 | response to nutrient(GO:0007584) |
0.0 | 4.1 | GO:0051321 | meiotic cell cycle(GO:0051321) |
0.0 | 0.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 0.4 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
0.0 | 1.0 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
0.0 | 0.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 0.6 | GO:0007528 | neuromuscular junction development(GO:0007528) |
0.0 | 1.4 | GO:0051781 | positive regulation of cell division(GO:0051781) |
0.0 | 0.5 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.3 | 9.9 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
0.5 | 3.5 | GO:0008091 | spectrin(GO:0008091) |
0.4 | 1.6 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
0.3 | 3.1 | GO:0005579 | membrane attack complex(GO:0005579) |
0.2 | 1.0 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
0.1 | 0.2 | GO:0097232 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
0.1 | 6.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.1 | 0.9 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
0.1 | 0.5 | GO:0097413 | Lewy body(GO:0097413) |
0.1 | 1.8 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.1 | 0.2 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
0.1 | 0.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.1 | 6.3 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.7 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.0 | 3.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 1.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 1.8 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 2.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 1.9 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 1.0 | GO:0016592 | mediator complex(GO:0016592) |
0.0 | 1.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
0.0 | 1.2 | GO:0044295 | axonal growth cone(GO:0044295) |
0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.0 | 0.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.0 | 0.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 1.3 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 2.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.0 | 0.2 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 0.9 | GO:0031519 | PcG protein complex(GO:0031519) |
0.0 | 0.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 4.0 | GO:0005667 | transcription factor complex(GO:0005667) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.4 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.5 | 5.8 | GO:0016151 | nickel cation binding(GO:0016151) |
0.5 | 1.4 | GO:0004794 | L-threonine ammonia-lyase activity(GO:0004794) |
0.4 | 2.2 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.4 | 2.2 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
0.3 | 9.9 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
0.3 | 1.0 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
0.3 | 6.0 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
0.3 | 1.1 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
0.3 | 0.8 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
0.2 | 1.9 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
0.2 | 1.1 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
0.2 | 4.2 | GO:0004707 | MAP kinase activity(GO:0004707) |
0.2 | 1.0 | GO:0008384 | NF-kappaB-inducing kinase activity(GO:0004704) IkappaB kinase activity(GO:0008384) |
0.2 | 1.0 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
0.2 | 0.6 | GO:0015229 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
0.2 | 0.6 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
0.1 | 0.8 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
0.1 | 0.5 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.1 | 0.9 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.1 | 3.1 | GO:0001848 | complement binding(GO:0001848) |
0.1 | 0.3 | GO:0070905 | serine binding(GO:0070905) |
0.1 | 1.4 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.1 | 1.8 | GO:0070628 | proteasome binding(GO:0070628) |
0.1 | 1.0 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.1 | 3.0 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) |
0.1 | 1.6 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
0.1 | 0.3 | GO:0005042 | netrin receptor activity(GO:0005042) |
0.0 | 0.1 | GO:0001729 | ceramide kinase activity(GO:0001729) |
0.0 | 0.9 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
0.0 | 2.2 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 1.0 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
0.0 | 0.7 | GO:0031402 | sodium ion binding(GO:0031402) |
0.0 | 1.1 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 5.1 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
0.0 | 0.9 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 2.9 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
0.0 | 0.8 | GO:0033613 | activating transcription factor binding(GO:0033613) |
0.0 | 1.1 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 1.0 | GO:0030546 | receptor activator activity(GO:0030546) |
0.0 | 0.2 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
0.0 | 1.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 0.4 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.0 | 0.5 | GO:0070182 | DNA polymerase binding(GO:0070182) |
0.0 | 1.2 | GO:0043621 | protein self-association(GO:0043621) |
0.0 | 0.3 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 2.9 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 6.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
0.0 | 4.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
0.0 | 1.1 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
0.0 | 0.7 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
0.0 | 1.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 0.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
0.0 | 1.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
0.0 | 0.7 | PID IL2 1PATHWAY | IL2-mediated signaling events |
0.0 | 1.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 0.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 6.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
0.5 | 11.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.2 | 2.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
0.1 | 6.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
0.1 | 3.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
0.1 | 6.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
0.1 | 3.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.1 | 1.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
0.1 | 1.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.0 | 2.2 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
0.0 | 1.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.0 | 1.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 1.0 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
0.0 | 0.6 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 0.8 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.0 | 0.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
0.0 | 1.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
0.0 | 0.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
0.0 | 0.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
0.0 | 0.3 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.0 | 0.4 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
0.0 | 1.4 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
0.0 | 1.1 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
0.0 | 1.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |