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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rfx5

Z-value: 0.68

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Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000005774.6 regulatory factor X, 5 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.019.3e-01Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.0 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.8 2.3 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.6 1.9 GO:0018879 biphenyl metabolic process(GO:0018879)
0.6 0.6 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.6 3.0 GO:0046967 cytosol to ER transport(GO:0046967)
0.6 1.7 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.5 7.5 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.3 0.8 GO:0010899 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.2 2.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 0.7 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 1.0 GO:0051182 coenzyme transport(GO:0051182)
0.1 2.8 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 0.3 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 3.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.2 GO:2000847 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0006013 mannose metabolic process(GO:0006013)
0.1 2.9 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 2.7 GO:0007520 myoblast fusion(GO:0007520) adipose tissue development(GO:0060612)
0.0 1.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 3.7 GO:0006641 triglyceride metabolic process(GO:0006641)
0.0 0.1 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 11.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 2.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 5.5 GO:0042611 MHC protein complex(GO:0042611)
0.4 3.0 GO:0042825 TAP complex(GO:0042825)
0.1 3.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 1.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.6 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.5 1.6 GO:0050253 sterol esterase activity(GO:0004771) retinyl-palmitate esterase activity(GO:0050253)
0.4 2.8 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.3 6.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 2.7 GO:0046977 TAP binding(GO:0046977)
0.2 0.8 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.2 0.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 2.3 GO:1990405 protein antigen binding(GO:1990405)
0.2 1.0 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.2 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 2.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 1.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 3.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA