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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxd10

Z-value: 0.32

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Transcription factors associated with Hoxd10

Gene Symbol Gene ID Gene Info
ENSMUSG00000050368.3 homeobox D10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd10mm10_v2_chr2_+_74691090_74691090-0.251.4e-01Click!

Activity profile of Hoxd10 motif

Sorted Z-values of Hoxd10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.6 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.3 GO:0061010 gall bladder development(GO:0061010)
0.1 0.3 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.1 GO:0060197 cloacal septation(GO:0060197)
0.0 0.6 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 1.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0030035 microspike assembly(GO:0030035)
0.0 0.3 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0060912 cardiac cell fate specification(GO:0060912)
0.0 0.2 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:1904882 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 1.0 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.0 0.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.7 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway