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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Osr2_Osr1

Z-value: 0.42

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Transcription factors associated with Osr2_Osr1

Gene Symbol Gene ID Gene Info
ENSMUSG00000022330.4 odd-skipped related 2
ENSMUSG00000048387.7 odd-skipped related transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Osr2mm10_v2_chr15_+_35296090_35296112-0.307.4e-02Click!
Osr1mm10_v2_chr12_+_9574437_9574448-0.182.9e-01Click!

Activity profile of Osr2_Osr1 motif

Sorted Z-values of Osr2_Osr1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Osr2_Osr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.1 1.0 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.7 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.5 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 0.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.1 0.4 GO:0061623 glycolytic process from galactose(GO:0061623)
0.1 0.4 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.1 0.4 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.1 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 0.2 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 0.2 GO:0021623 oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.1 0.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0015862 uridine transport(GO:0015862)
0.0 0.2 GO:0007227 signal transduction downstream of smoothened(GO:0007227) positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.1 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.2 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.1 GO:0009992 cellular water homeostasis(GO:0009992)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.4 GO:0034312 diol biosynthetic process(GO:0034312)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.0 0.0 GO:0044313 protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.3 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.0 GO:2000584 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.0 GO:0097447 dendritic tree(GO:0097447)
0.0 0.6 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.4 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.6 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.2 GO:0038052 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.1 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.0 0.2 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 0.3 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0051381 histamine binding(GO:0051381)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0005223 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0089720 caspase binding(GO:0089720)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)