Project

avrg: GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Foxc1

Z-value: 0.96

Motif logo

Transcription factors associated with Foxc1

Gene Symbol Gene ID Gene Info
ENSMUSG00000050295.2 forkhead box C1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.048.2e-01Click!

Activity profile of Foxc1 motif

Sorted Z-values of Foxc1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0060220 camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.5 1.4 GO:0052203 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.4 1.2 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.3 1.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.3 1.6 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.3 1.2 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.2 0.6 GO:0071288 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) cellular response to mercury ion(GO:0071288)
0.2 1.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 1.4 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.2 0.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.6 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.1 1.0 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.4 GO:2001293 fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293)
0.1 0.8 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.7 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.9 GO:0034196 blood coagulation, intrinsic pathway(GO:0007597) acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.6 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 1.2 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 1.0 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.3 GO:0042335 cuticle development(GO:0042335)
0.1 0.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 2.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.4 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.9 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.3 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.1 0.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.9 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 0.8 GO:0010748 negative regulation of B cell apoptotic process(GO:0002903) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1 0.2 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
0.1 0.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 1.5 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.4 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.5 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.0 0.2 GO:0061743 motor learning(GO:0061743)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.0 0.1 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) regulation of enamel mineralization(GO:0070173)
0.0 1.0 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.0 0.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.7 GO:0014823 response to activity(GO:0014823)
0.0 0.2 GO:0032349 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)
0.0 0.7 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.0 0.3 GO:0031000 response to caffeine(GO:0031000)
0.0 0.3 GO:0071280 cellular response to copper ion(GO:0071280)
0.0 0.5 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.6 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 1.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.5 GO:0031424 keratinization(GO:0031424)
0.0 0.0 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.4 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.0 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.4 GO:0009166 nucleotide catabolic process(GO:0009166)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.4 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.1 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0031094 platelet dense tubular network(GO:0031094)
0.2 1.2 GO:0019815 B cell receptor complex(GO:0019815)
0.2 1.4 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.7 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 1.4 GO:0097433 dense body(GO:0097433)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.5 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.1 GO:0005861 troponin complex(GO:0005861)
0.1 1.4 GO:0005922 connexon complex(GO:0005922)
0.1 0.9 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.9 GO:0042627 chylomicron(GO:0042627)
0.0 0.7 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.7 GO:0032982 myosin filament(GO:0032982)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 1.9 GO:0030018 Z disc(GO:0030018)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0032190 acrosin binding(GO:0032190)
0.3 2.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 1.4 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 0.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 1.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 0.7 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.2 0.9 GO:0051373 FATZ binding(GO:0051373)
0.2 1.4 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.6 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0045340 mercury ion binding(GO:0045340)
0.1 0.9 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 1.1 GO:0031014 troponin T binding(GO:0031014)
0.1 1.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.3 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.4 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.4 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.4 GO:0004064 arylesterase activity(GO:0004064)
0.1 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 1.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.3 GO:0015265 urea channel activity(GO:0015265)
0.0 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 2.2 GO:0038024 cargo receptor activity(GO:0038024)
0.0 1.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.1 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 1.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs