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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Arid3a

Z-value: 1.15

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Transcription factors associated with Arid3a

Gene Symbol Gene ID Gene Info
ENSMUSG00000019564.6 AT rich interactive domain 3A (BRIGHT-like)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Arid3amm10_v2_chr10_+_79927039_79927139-0.791.1e-08Click!

Activity profile of Arid3a motif

Sorted Z-values of Arid3a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Arid3a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 22.1 GO:0046449 creatinine metabolic process(GO:0046449)
0.7 2.6 GO:0032379 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.5 6.7 GO:0015747 urate transport(GO:0015747)
0.3 1.9 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 1.5 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.3 0.9 GO:0015755 fructose transport(GO:0015755)
0.3 0.5 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.2 1.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 2.4 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 0.6 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.2 3.9 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.1 1.2 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.1 0.4 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 1.0 GO:0015671 oxygen transport(GO:0015671)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.4 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.4 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 0.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.5 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 2.5 GO:0097286 iron ion import(GO:0097286)
0.1 0.5 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.9 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.3 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.4 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.5 GO:0009249 protein lipoylation(GO:0009249)
0.1 3.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) tolerance induction dependent upon immune response(GO:0002461)
0.1 1.9 GO:0019236 response to pheromone(GO:0019236)
0.1 0.2 GO:1903416 response to glycoside(GO:1903416)
0.1 0.4 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.1 0.7 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.3 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.2 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.0 1.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 6.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.9 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 1.1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.1 GO:0060025 regulation of synaptic activity(GO:0060025)
0.0 0.7 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 1.1 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.5 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.3 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.4 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.0 0.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.2 0.6 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 2.6 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.5 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 1.1 GO:0045179 apical cortex(GO:0045179)
0.1 0.4 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.8 3.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.7 2.6 GO:1904121 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.5 2.5 GO:0070287 ferritin receptor activity(GO:0070287)
0.4 6.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.4 1.9 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 1.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.3 1.5 GO:0016019 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.3 0.9 GO:0031403 lithium ion binding(GO:0031403)
0.3 1.0 GO:0004096 catalase activity(GO:0004096)
0.2 1.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.4 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 1.9 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 2.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 2.4 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.4 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.4 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.9 GO:0005536 glucose binding(GO:0005536)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 6.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)
0.0 0.5 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 22.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 1.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 2.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 2.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.2 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 24.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 6.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 4.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation