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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb3

Z-value: 0.86

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Transcription factors associated with Hoxb3

Gene Symbol Gene ID Gene Info
ENSMUSG00000048763.5 homeobox B3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb3mm10_v2_chr11_+_96323253_96323326-0.464.6e-03Click!

Activity profile of Hoxb3 motif

Sorted Z-values of Hoxb3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.5 5.3 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.4 3.5 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.4 1.6 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.4 1.1 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.3 2.3 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.3 1.5 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 0.7 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 0.8 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 0.6 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.2 0.8 GO:0030091 protein repair(GO:0030091)
0.2 0.5 GO:0019085 early viral transcription(GO:0019085)
0.1 2.1 GO:0015747 urate transport(GO:0015747)
0.1 1.4 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.5 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 1.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.5 GO:0070162 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 0.6 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 2.3 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.1 0.2 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 2.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.1 1.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.0 0.7 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.4 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 1.5 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 1.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.3 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.2 GO:0009946 proximal/distal axis specification(GO:0009946)
0.0 0.3 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.3 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.2 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 1.6 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0046037 GMP metabolic process(GO:0046037)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.6 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.1 GO:0040031 snRNA modification(GO:0040031)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.7 GO:0006805 xenobiotic metabolic process(GO:0006805)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0005608 laminin-3 complex(GO:0005608)
0.1 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0036128 CatSper complex(GO:0036128)
0.0 2.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0005009 insulin-activated receptor activity(GO:0005009) pheromone activity(GO:0005186)
0.4 1.3 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.3 1.5 GO:0008410 acetyl-CoA C-acetyltransferase activity(GO:0003985) CoA-transferase activity(GO:0008410) palmitoyl-CoA oxidase activity(GO:0016401) C-acetyltransferase activity(GO:0016453)
0.2 1.6 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 2.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.2 0.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 0.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 0.6 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.2 0.6 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.2 1.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 1.1 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.7 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 2.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 2.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 3.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.3 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.1 0.5 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.6 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 2.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.0 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.1 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization