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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gli1

Z-value: 0.83

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Transcription factors associated with Gli1

Gene Symbol Gene ID Gene Info
ENSMUSG00000025407.6 GLI-Kruppel family member GLI1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_1273416140.029.1e-01Click!

Activity profile of Gli1 motif

Sorted Z-values of Gli1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gli1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.3 1.4 GO:0046898 response to cycloheximide(GO:0046898)
0.3 0.8 GO:1904980 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.2 0.8 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.2 0.6 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 1.4 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.2 0.5 GO:2000331 regulation of terminal button organization(GO:2000331)
0.2 0.6 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 0.8 GO:0002554 serotonin secretion by platelet(GO:0002554)
0.1 0.6 GO:0021941 negative regulation of cerebellar granule cell precursor proliferation(GO:0021941)
0.1 0.6 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.1 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.6 GO:0051697 protein delipidation(GO:0051697)
0.1 0.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 2.2 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.1 1.7 GO:0046541 saliva secretion(GO:0046541)
0.1 0.8 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.4 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.1 0.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.3 GO:2001074 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.1 0.7 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.4 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.1 0.3 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.1 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.4 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.6 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.3 GO:0043486 histone exchange(GO:0043486)
0.1 0.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.6 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.2 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 1.0 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 1.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.3 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.6 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 2.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0060709 glycogen cell differentiation involved in embryonic placenta development(GO:0060709)
0.0 0.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.2 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.6 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.2 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0042414 epinephrine metabolic process(GO:0042414)
0.0 0.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.4 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.7 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0030312 external encapsulating structure(GO:0030312)
0.2 2.7 GO:0097539 ciliary transition fiber(GO:0097539)
0.2 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 0.6 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.8 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 2.7 GO:0014704 intercalated disc(GO:0014704)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 0.6 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
0.2 0.7 GO:0070052 collagen V binding(GO:0070052)
0.2 0.8 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.2 0.5 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.2 0.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 0.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.8 GO:0004966 galanin receptor activity(GO:0004966)
0.1 1.4 GO:0051434 BH3 domain binding(GO:0051434)
0.1 2.0 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 0.8 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.6 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.0 0.1 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.7 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 4.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.8 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.5 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis