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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Obox1

Z-value: 1.15

Motif logo

Transcription factors associated with Obox1

Gene Symbol Gene ID Gene Info
ENSMUSG00000054310.10 oocyte specific homeobox 1

Activity profile of Obox1 motif

Sorted Z-values of Obox1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Obox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:1902617 response to fluoride(GO:1902617)
1.1 5.7 GO:0006572 tyrosine catabolic process(GO:0006572)
1.1 7.9 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 4.2 GO:0034031 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.9 4.3 GO:0001692 histamine metabolic process(GO:0001692)
0.8 2.5 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.8 4.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.7 8.0 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.7 3.3 GO:0014016 neuroblast differentiation(GO:0014016)
0.6 1.9 GO:0070947 neutrophil mediated killing of fungus(GO:0070947) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.6 8.4 GO:0015747 urate transport(GO:0015747)
0.5 2.5 GO:0072181 mesonephric duct formation(GO:0072181)
0.5 1.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.5 4.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.4 2.4 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.4 1.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.4 1.2 GO:0048338 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414)
0.4 1.1 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.4 2.6 GO:0006108 malate metabolic process(GO:0006108) regulation of NADP metabolic process(GO:1902031)
0.4 1.5 GO:0090472 dibasic protein processing(GO:0090472)
0.3 2.1 GO:0003383 apical constriction(GO:0003383)
0.3 1.0 GO:0060336 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.3 1.9 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) MDA-5 signaling pathway(GO:0039530)
0.3 1.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 0.8 GO:0046104 thymidine metabolic process(GO:0046104)
0.3 5.7 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 0.8 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.3 0.8 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.3 1.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 1.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 0.7 GO:0010446 response to alkaline pH(GO:0010446)
0.2 0.6 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.2 0.8 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 1.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.2 0.8 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.2 1.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.2 1.0 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 2.7 GO:0070842 aggresome assembly(GO:0070842)
0.2 0.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 0.5 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.2 0.6 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 1.3 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.2 0.3 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.1 0.9 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 1.2 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.1 1.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 1.1 GO:0070813 hydrogen sulfide metabolic process(GO:0070813)
0.1 0.7 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.1 1.0 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.5 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.5 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.1 0.8 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.8 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.3 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.4 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 4.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.6 GO:0042776 response to glucagon(GO:0033762) mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.4 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 3.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.7 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 6.3 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 0.3 GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.1 0.8 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.4 GO:0034769 basement membrane disassembly(GO:0034769)
0.1 0.7 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.1 0.6 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.8 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 1.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 0.5 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.8 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.5 GO:0035865 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 0.2 GO:0052203 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 0.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 1.2 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 0.8 GO:0070166 enamel mineralization(GO:0070166)
0.1 1.0 GO:0032096 negative regulation of response to food(GO:0032096)
0.1 0.3 GO:1901642 purine nucleoside transmembrane transport(GO:0015860) nucleoside transmembrane transport(GO:1901642)
0.1 0.4 GO:0021539 subthalamus development(GO:0021539)
0.1 0.2 GO:0070537 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537)
0.1 0.2 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.1 1.8 GO:0048240 sperm capacitation(GO:0048240)
0.1 7.2 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 0.9 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.7 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 1.2 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.3 GO:0008228 opsonization(GO:0008228)
0.1 1.0 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.1 0.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.8 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.7 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 0.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.6 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.4 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
0.0 3.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.5 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 2.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.7 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.1 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
0.0 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0 0.6 GO:0008272 sulfate transport(GO:0008272)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.8 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.5 GO:0030223 neutrophil differentiation(GO:0030223) negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 1.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:2000864 estradiol secretion(GO:0035938) regulation of estradiol secretion(GO:2000864)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0072053 renal inner medulla development(GO:0072053)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0009223 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.4 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.0 0.6 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 1.6 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.0 GO:0034475 U4 snRNA 3'-end processing(GO:0034475) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.8 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.4 GO:0003229 ventricular cardiac muscle tissue development(GO:0003229)
0.0 0.8 GO:0032355 response to estradiol(GO:0032355)
0.0 0.9 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.7 GO:0050919 negative chemotaxis(GO:0050919)
0.0 4.0 GO:0015833 peptide transport(GO:0015833)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.0 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.6 2.5 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.6 9.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.5 1.4 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.3 0.8 GO:0031533 mRNA cap methyltransferase complex(GO:0031533)
0.3 2.1 GO:0033269 internode region of axon(GO:0033269)
0.2 1.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 0.5 GO:0043159 acrosomal matrix(GO:0043159)
0.2 3.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.6 GO:0036128 CatSper complex(GO:0036128)
0.1 0.8 GO:0098536 deuterosome(GO:0098536)
0.1 0.8 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 5.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.9 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.8 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.7 GO:0042101 T cell receptor complex(GO:0042101)
0.1 11.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.7 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 3.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 1.5 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.3 GO:0042825 MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.1 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908) mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.0 GO:1990696 USH2 complex(GO:1990696)
0.0 0.3 GO:0042588 zymogen granule(GO:0042588)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 1.4 GO:0031526 brush border membrane(GO:0031526)
0.0 19.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.2 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0004063 aryldialkylphosphatase activity(GO:0004063)
2.0 8.0 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
1.9 5.7 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.0 4.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.9 2.6 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.8 4.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.8 3.3 GO:0004104 cholinesterase activity(GO:0004104)
0.6 8.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.5 3.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.5 4.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.5 1.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.5 1.4 GO:0019981 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.4 1.7 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.4 1.2 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.3 2.9 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.3 1.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.3 0.8 GO:0004482 mRNA (guanine-N7-)-methyltransferase activity(GO:0004482)
0.3 2.5 GO:0039706 co-receptor binding(GO:0039706)
0.2 5.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 1.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.2 0.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 0.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 0.8 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.2 0.6 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.2 1.0 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 0.6 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.6 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 1.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 2.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 25.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.9 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 2.7 GO:0070628 proteasome binding(GO:0070628)
0.1 2.4 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 0.3 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 1.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.2 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.4 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 2.7 GO:0070330 aromatase activity(GO:0070330)
0.1 5.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 7.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 0.7 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.9 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.1 1.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 1.0 GO:0050542 icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.1 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 1.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.3 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 2.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.7 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.6 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 5.0 GO:0004497 monooxygenase activity(GO:0004497)
0.0 1.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 2.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 3.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.7 GO:0005537 mannose binding(GO:0005537)
0.0 1.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.8 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 0.8 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0016933 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.2 GO:0003727 single-stranded RNA binding(GO:0003727)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 16.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.9 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 2.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.4 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 5.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 2.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 3.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 5.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 0.7 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 4.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.9 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 0.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 4.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 0.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 4.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 3.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.2 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 2.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.3 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import