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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Ptf1a

Z-value: 1.75

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Transcription factors associated with Ptf1a

Gene Symbol Gene ID Gene Info
ENSMUSG00000026735.2 pancreas specific transcription factor, 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ptf1amm10_v2_chr2_+_19445632_194456630.782.7e-08Click!

Activity profile of Ptf1a motif

Sorted Z-values of Ptf1a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Ptf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
1.0 3.0 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.7 109.6 GO:0007586 digestion(GO:0007586)
0.6 1.9 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.5 1.4 GO:2000412 lymphocyte migration into lymphoid organs(GO:0097021) positive regulation of thymocyte migration(GO:2000412) regulation of dendritic cell dendrite assembly(GO:2000547)
0.5 1.4 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.4 0.8 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.4 1.5 GO:0006069 ethanol oxidation(GO:0006069)
0.3 1.0 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.3 1.2 GO:0034760 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.3 0.5 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.2 0.7 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.2 0.9 GO:0015886 heme transport(GO:0015886)
0.1 1.1 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.5 GO:0060857 establishment of glial blood-brain barrier(GO:0060857)
0.1 0.5 GO:0060447 peripheral nervous system axon regeneration(GO:0014012) bud outgrowth involved in lung branching(GO:0060447)
0.1 0.8 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 15.0 GO:0031638 zymogen activation(GO:0031638)
0.1 0.8 GO:0071569 protein ufmylation(GO:0071569)
0.1 0.3 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 0.4 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.2 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.1 0.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.2 GO:0046271 coumarin metabolic process(GO:0009804) phenylpropanoid catabolic process(GO:0046271)
0.1 0.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.4 GO:1905049 negative regulation of metallopeptidase activity(GO:1905049)
0.1 1.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 1.0 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.1 0.2 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 1.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 18.2 GO:0006887 exocytosis(GO:0006887)
0.0 3.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 6.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.2 GO:0009814 defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.0 0.4 GO:0033227 dsRNA transport(GO:0033227)
0.0 1.0 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.3 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.3 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.8 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.2 GO:0060174 limb bud formation(GO:0060174)
0.0 0.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 1.2 GO:0048663 neuron fate commitment(GO:0048663)
0.0 0.6 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 15.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 18.8 GO:0030667 secretory granule membrane(GO:0030667)
0.1 16.8 GO:0072562 blood microparticle(GO:0072562)
0.1 101.5 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 2.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.4 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.5 112.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 1.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 2.1 GO:0005499 vitamin D binding(GO:0005499)
0.3 1.1 GO:0042806 fucose binding(GO:0042806)
0.3 1.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 5.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 0.9 GO:0015232 heme transporter activity(GO:0015232)
0.2 0.8 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 1.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.3 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 0.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.2 GO:0004063 aryldialkylphosphatase activity(GO:0004063)
0.1 0.4 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.4 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.1 0.5 GO:0045545 syndecan binding(GO:0045545)
0.1 0.2 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 3.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.5 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.6 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 2.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 23.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.7 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 1.4 PID IL2 1PATHWAY IL2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 26.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 7.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 3.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.8 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP