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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Onecut2_Onecut3

Z-value: 1.15

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Transcription factors associated with Onecut2_Onecut3

Gene Symbol Gene ID Gene Info
ENSMUSG00000045991.12 one cut domain, family member 2
ENSMUSG00000045518.8 one cut domain, family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut2mm10_v2_chr18_+_64340225_643403640.202.4e-01Click!
Onecut3mm10_v2_chr10_+_80494835_80494873-0.192.7e-01Click!

Activity profile of Onecut2_Onecut3 motif

Sorted Z-values of Onecut2_Onecut3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 GO:0008355 olfactory learning(GO:0008355)
0.3 2.0 GO:0006108 malate metabolic process(GO:0006108) regulation of NADP metabolic process(GO:1902031)
0.2 0.7 GO:0014901 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.1 0.6 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.3 GO:0070543 response to linoleic acid(GO:0070543)
0.1 0.6 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.3 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.6 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 1.4 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705)
0.1 0.8 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.1 0.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.6 GO:0051715 cytolysis in other organism(GO:0051715)
0.1 1.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.2 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.3 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0 0.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.3 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 1.0 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.4 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 1.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.6 GO:0001967 suckling behavior(GO:0001967)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0010979 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.0 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.9 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.1 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.4 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0090170 regulation of Golgi inheritance(GO:0090170) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.0 GO:0070836 caveola assembly(GO:0070836)
0.0 0.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.5 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0046691 intracellular canaliculus(GO:0046691)
0.1 1.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.6 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.0 0.5 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0000800 lateral element(GO:0000800)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0005186 pheromone activity(GO:0005186)
0.7 2.0 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.5 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.6 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 0.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0051430 G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.8 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis