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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Meox2

Z-value: 0.76

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Transcription factors associated with Meox2

Gene Symbol Gene ID Gene Info
ENSMUSG00000036144.5 mesenchyme homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Meox2mm10_v2_chr12_+_37108533_37108546-0.392.0e-02Click!

Activity profile of Meox2 motif

Sorted Z-values of Meox2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Meox2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.3 1.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.2 2.6 GO:0006569 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)
0.2 0.7 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.2 0.7 GO:0046968 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.2 1.3 GO:0033762 response to glucagon(GO:0033762)
0.2 0.6 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 2.1 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.2 0.5 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 1.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.4 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 0.5 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.1 0.5 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.1 0.4 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 0.4 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.4 GO:1903232 melanosome assembly(GO:1903232)
0.1 1.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.4 GO:0006548 histidine catabolic process(GO:0006548)
0.1 0.3 GO:0030091 protein repair(GO:0030091)
0.1 0.3 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 0.3 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.1 0.6 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.1 0.2 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.1 0.4 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.2 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.1 0.7 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.2 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.2 GO:0015755 fructose transport(GO:0015755)
0.0 0.1 GO:0033122 negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0 0.6 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.0 0.2 GO:0021764 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.1 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:1902530 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.0 1.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0009624 response to nematode(GO:0009624)
0.0 1.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 1.1 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.9 GO:0071385 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 3.8 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 1.3 GO:0022900 electron transport chain(GO:0022900)
0.0 0.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.1 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.3 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0 0.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.3 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.0 0.4 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.5 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.3 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.3 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.6 GO:0006953 acute-phase response(GO:0006953)
0.0 0.2 GO:0036159 inner dynein arm assembly(GO:0036159)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.4 GO:0070552 BRISC complex(GO:0070552)
0.1 0.6 GO:0044305 calyx of Held(GO:0044305)
0.1 0.7 GO:0042825 TAP complex(GO:0042825)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 3.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0033276 transcription factor TFTC complex(GO:0033276)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.7 2.1 GO:0005186 insulin-activated receptor activity(GO:0005009) pheromone activity(GO:0005186)
0.7 2.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.4 1.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 0.6 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.6 GO:0001566 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.2 0.5 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.7 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 1.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 0.4 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 3.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.9 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 2.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.4 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 2.6 GO:0005549 odorant binding(GO:0005549)
0.0 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 4.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.6 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0003681 bent DNA binding(GO:0003681)
0.0 0.1 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.7 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling