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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Alx4

Z-value: 0.80

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Transcription factors associated with Alx4

Gene Symbol Gene ID Gene Info
ENSMUSG00000040310.6 aristaless-like homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_936423880.153.8e-01Click!

Activity profile of Alx4 motif

Sorted Z-values of Alx4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Alx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
1.1 3.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535)
0.8 3.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.7 2.0 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.5 5.9 GO:0002826 negative regulation of T-helper 1 type immune response(GO:0002826)
0.5 1.6 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.5 1.5 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.5 4.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 3.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.4 2.1 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.4 2.3 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.4 2.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.4 2.8 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.3 1.0 GO:0061743 motor learning(GO:0061743)
0.3 2.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 1.2 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.3 2.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.3 1.9 GO:0046208 spermine catabolic process(GO:0046208)
0.3 0.8 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.2 1.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 2.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.2 3.5 GO:0031000 response to caffeine(GO:0031000)
0.2 2.4 GO:0006020 inositol metabolic process(GO:0006020)
0.2 0.5 GO:0090265 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
0.2 1.4 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 0.5 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.5 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 1.6 GO:0030916 otic vesicle formation(GO:0030916)
0.2 0.8 GO:0021828 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 1.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.6 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.1 1.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 3.8 GO:0097435 fibril organization(GO:0097435)
0.1 1.3 GO:0036376 sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 1.7 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 0.4 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.1 1.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.5 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 0.3 GO:0090260 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 0.3 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.8 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.1 0.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.6 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.9 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.7 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 7.7 GO:0007586 digestion(GO:0007586)
0.1 0.6 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0090172 microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0021995 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.0 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.4 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.4 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.6 GO:0018126 protein hydroxylation(GO:0018126)
0.0 0.6 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.3 GO:1905050 positive regulation of metallopeptidase activity(GO:1905050)
0.0 0.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 2.7 GO:0042100 B cell proliferation(GO:0042100)
0.0 1.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 1.2 GO:0051693 actin filament capping(GO:0051693)
0.0 1.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.0 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.7 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.9 GO:0007566 embryo implantation(GO:0007566)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.5 GO:0021591 ventricular system development(GO:0021591)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:0001502 cartilage condensation(GO:0001502) negative regulation of astrocyte differentiation(GO:0048712)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.3 5.5 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.3 4.9 GO:0042555 MCM complex(GO:0042555)
0.2 3.8 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.0 GO:0044301 climbing fiber(GO:0044301)
0.2 1.4 GO:0019815 B cell receptor complex(GO:0019815)
0.2 0.8 GO:0043202 lysosomal lumen(GO:0043202)
0.1 1.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.1 3.3 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.2 GO:0070820 tertiary granule(GO:0070820)
0.1 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.5 GO:0001739 sex chromatin(GO:0001739)
0.0 0.7 GO:0045179 apical cortex(GO:0045179) ciliary transition fiber(GO:0097539)
0.0 0.8 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 1.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0034709 methylosome(GO:0034709)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 6.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 1.9 GO:0000776 kinetochore(GO:0000776)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 17.7 GO:0005615 extracellular space(GO:0005615)
0.0 1.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0002113 interleukin-33 binding(GO:0002113)
1.0 6.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.9 3.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.6 1.9 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.5 2.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 2.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 3.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 1.6 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 2.8 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 1.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 2.4 GO:0008199 ferric iron binding(GO:0008199)
0.2 6.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 0.5 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
0.2 1.4 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 0.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.2 0.8 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2 1.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.8 GO:0030492 hemoglobin binding(GO:0030492)
0.1 1.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.4 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 4.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.5 GO:0016726 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 0.5 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 5.1 GO:0004601 peroxidase activity(GO:0004601)
0.1 2.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 1.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.1 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 10.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 3.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.6 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.7 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 2.3 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.6 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.5 PID IL23 PATHWAY IL23-mediated signaling events
0.1 5.0 PID ATR PATHWAY ATR signaling pathway
0.1 2.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 4.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 3.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 6.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 0.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.9 REACTOME DEFENSINS Genes involved in Defensins
0.3 1.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 4.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 2.0 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 1.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 3.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 1.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.1 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome