avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Clock
|
ENSMUSG00000029238.8 | circadian locomotor output cycles kaput |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Clock | mm10_v2_chr5_-_76304474_76304548 | 0.50 | 2.1e-03 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 3.8 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.2 | 1.2 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.2 | 1.2 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
0.2 | 0.9 | GO:0097477 | lateral motor column neuron migration(GO:0097477) |
0.2 | 1.1 | GO:0006543 | glutamine catabolic process(GO:0006543) |
0.2 | 0.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.2 | 0.5 | GO:0045041 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041) |
0.2 | 0.5 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.1 | 1.3 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.1 | 0.6 | GO:0046654 | tetrahydrofolate biosynthetic process(GO:0046654) |
0.1 | 0.5 | GO:0021660 | rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666) |
0.1 | 0.5 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
0.1 | 1.7 | GO:0033572 | transferrin transport(GO:0033572) |
0.1 | 0.9 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
0.1 | 0.3 | GO:1902256 | endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.1 | 0.4 | GO:0050812 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
0.1 | 2.4 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
0.1 | 0.4 | GO:0060376 | positive regulation of mast cell differentiation(GO:0060376) |
0.1 | 0.3 | GO:0035973 | aggrephagy(GO:0035973) |
0.1 | 1.0 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
0.1 | 0.5 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.1 | 0.3 | GO:1903416 | response to glycoside(GO:1903416) |
0.1 | 0.5 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
0.1 | 0.2 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
0.1 | 0.4 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
0.1 | 0.6 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.1 | 0.3 | GO:0048254 | snoRNA localization(GO:0048254) |
0.0 | 0.5 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.0 | 0.2 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
0.0 | 0.1 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.0 | 1.3 | GO:0014002 | astrocyte development(GO:0014002) |
0.0 | 0.3 | GO:0061143 | alveolar primary septum development(GO:0061143) |
0.0 | 0.3 | GO:0006265 | DNA topological change(GO:0006265) |
0.0 | 0.3 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
0.0 | 1.5 | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) |
0.0 | 0.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.0 | 0.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.0 | 0.3 | GO:0006983 | ER overload response(GO:0006983) |
0.0 | 0.3 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
0.0 | 0.1 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
0.0 | 0.3 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
0.0 | 0.3 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
0.0 | 0.3 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
0.0 | 0.5 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
0.0 | 0.3 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
0.0 | 0.2 | GO:0048069 | sphingosine-1-phosphate signaling pathway(GO:0003376) eye pigmentation(GO:0048069) |
0.0 | 0.6 | GO:0015936 | coenzyme A metabolic process(GO:0015936) |
0.0 | 0.1 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
0.0 | 0.1 | GO:0072553 | terminal button organization(GO:0072553) |
0.0 | 0.1 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) |
0.0 | 0.1 | GO:0002003 | angiotensin maturation(GO:0002003) |
0.0 | 0.2 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
0.0 | 0.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.0 | 0.2 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.7 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
0.0 | 4.0 | GO:0008643 | carbohydrate transport(GO:0008643) |
0.0 | 0.7 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
0.0 | 0.3 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) |
0.0 | 0.1 | GO:0072161 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
0.0 | 0.3 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
0.0 | 0.4 | GO:0006991 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
0.0 | 0.5 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
0.0 | 0.0 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
0.0 | 0.0 | GO:0006222 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
0.0 | 0.2 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
0.0 | 0.1 | GO:0072189 | ureter development(GO:0072189) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.1 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.2 | 1.7 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
0.1 | 0.4 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
0.1 | 0.5 | GO:0097433 | dense body(GO:0097433) |
0.1 | 2.0 | GO:0071564 | npBAF complex(GO:0071564) |
0.1 | 0.3 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
0.1 | 0.9 | GO:0071141 | SMAD protein complex(GO:0071141) |
0.1 | 0.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.1 | 0.3 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
0.1 | 0.3 | GO:0005606 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
0.1 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
0.1 | 0.3 | GO:0001651 | dense fibrillar component(GO:0001651) |
0.1 | 4.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.0 | 0.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.0 | 0.4 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
0.0 | 0.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.0 | 0.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.0 | 0.5 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.0 | 0.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
0.0 | 0.1 | GO:0099522 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
0.0 | 0.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.3 | GO:0000153 | cytoplasmic ubiquitin ligase complex(GO:0000153) |
0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 0.3 | GO:0043203 | axon hillock(GO:0043203) |
0.0 | 0.2 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
0.0 | 1.6 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 4.1 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 0.1 | GO:0031983 | vesicle lumen(GO:0031983) |
0.0 | 0.1 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
0.0 | 0.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 3.8 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.6 | 1.7 | GO:0004998 | transferrin receptor activity(GO:0004998) |
0.3 | 1.0 | GO:0035500 | MH2 domain binding(GO:0035500) |
0.2 | 0.6 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
0.2 | 0.6 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
0.2 | 4.0 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.1 | 0.9 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
0.1 | 1.5 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.1 | 0.4 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
0.1 | 0.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851) |
0.1 | 0.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.1 | 0.5 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
0.1 | 0.3 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
0.1 | 0.2 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
0.1 | 0.2 | GO:0005118 | sevenless binding(GO:0005118) |
0.1 | 0.6 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
0.1 | 0.4 | GO:0008312 | signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312) |
0.1 | 0.2 | GO:2001069 | glycogen binding(GO:2001069) |
0.0 | 0.5 | GO:0043426 | MRF binding(GO:0043426) |
0.0 | 2.4 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.2 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
0.0 | 1.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
0.0 | 0.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.0 | 0.2 | GO:0031849 | olfactory receptor binding(GO:0031849) |
0.0 | 0.3 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
0.0 | 0.1 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
0.0 | 0.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.0 | 0.3 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
0.0 | 0.5 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
0.0 | 0.3 | GO:1990239 | sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239) |
0.0 | 0.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.3 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
0.0 | 1.2 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 1.2 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.0 | 1.2 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
0.0 | 0.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.2 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
0.0 | 0.2 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
0.0 | 0.1 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
0.0 | 0.1 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 0.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
0.1 | 3.7 | PID ARF6 PATHWAY | Arf6 signaling events |
0.0 | 1.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
0.0 | 0.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 0.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
0.0 | 1.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.0 | 1.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
0.0 | 1.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.0 | 0.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
0.1 | 3.8 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.0 | 1.7 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
0.0 | 0.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.0 | 0.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 1.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.0 | 0.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.0 | 0.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
0.0 | 0.5 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.0 | 0.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 0.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |