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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Mef2c

Z-value: 0.56

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Transcription factors associated with Mef2c

Gene Symbol Gene ID Gene Info
ENSMUSG00000005583.10 myocyte enhancer factor 2C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83573577_835736070.411.4e-02Click!

Activity profile of Mef2c motif

Sorted Z-values of Mef2c motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
1.2 3.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.1 7.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.9 4.3 GO:0071313 cellular response to caffeine(GO:0071313)
0.8 2.5 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.8 3.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.7 7.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.5 2.6 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 4.6 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.5 5.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.4 2.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.4 3.7 GO:0032264 IMP salvage(GO:0032264)
0.4 19.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.3 0.9 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 0.9 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521)
0.3 0.5 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.3 1.5 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 6.8 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.2 14.3 GO:0030239 myofibril assembly(GO:0030239)
0.2 0.8 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.2 0.6 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 4.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.2 0.6 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.4 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.3 GO:0014900 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.3 GO:0070543 response to linoleic acid(GO:0070543)
0.1 0.3 GO:0070256 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 3.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.9 GO:0014823 response to activity(GO:0014823)
0.1 1.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.4 GO:0045994 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 0.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 1.2 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 4.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.9 GO:0007614 short-term memory(GO:0007614)
0.0 0.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 4.7 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.5 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0045168 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) cell-cell signaling involved in cell fate commitment(GO:0045168) negative regulation of forebrain neuron differentiation(GO:2000978)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.1 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.2 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.4 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.0 0.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.0 0.9 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 1.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.7 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.7 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.8 GO:0003012 muscle system process(GO:0003012)
0.0 3.2 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.1 20.6 GO:0005861 troponin complex(GO:0005861)
0.8 7.3 GO:0097512 cardiac myofibril(GO:0097512)
0.8 2.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.4 10.4 GO:0005859 muscle myosin complex(GO:0005859)
0.4 3.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 5.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 3.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.2 1.9 GO:0032982 myosin filament(GO:0032982)
0.2 32.3 GO:0031674 I band(GO:0031674)
0.2 0.8 GO:0044316 cone cell pedicle(GO:0044316)
0.1 1.0 GO:0031430 M band(GO:0031430)
0.1 0.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.2 GO:0005916 fascia adherens(GO:0005916)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.5 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 6.0 GO:0016528 sarcoplasm(GO:0016528)
0.1 7.1 GO:0030016 myofibril(GO:0030016)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.3 GO:0016460 myosin II complex(GO:0016460)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 3.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.5 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.0 GO:0090537 CERF complex(GO:0090537)
0.0 0.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.0 GO:0051373 FATZ binding(GO:0051373)
1.3 7.8 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
1.1 10.9 GO:0031014 troponin T binding(GO:0031014)
0.6 15.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.4 3.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 3.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 3.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 2.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.3 11.8 GO:0003785 actin monomer binding(GO:0003785)
0.3 0.5 GO:0030172 troponin C binding(GO:0030172)
0.3 3.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2 0.6 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 0.9 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.7 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 2.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 2.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.3 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 1.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.0 GO:0031005 filamin binding(GO:0031005)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 2.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 4.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.7 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0071820 N-box binding(GO:0071820)
0.0 1.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.5 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 14.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 8.8 GO:0003779 actin binding(GO:0003779)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.7 GO:0044325 ion channel binding(GO:0044325)
0.0 0.0 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.0 7.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.8 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 ST ADRENERGIC Adrenergic Pathway
0.0 0.7 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 43.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.7 REACTOME DEFENSINS Genes involved in Defensins
0.2 3.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.4 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)