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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for UUGUUCG

Z-value: 0.54

Motif logo

miRNA associated with seed UUGUUCG

NamemiRBASE accession
MIMAT0000739

Activity profile of UUGUUCG motif

Sorted Z-values of UUGUUCG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UUGUUCG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0007529 establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.2 0.9 GO:0043379 memory T cell differentiation(GO:0043379)
0.2 0.5 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.4 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.6 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.3 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.1 0.3 GO:0060300 regulation of cytokine activity(GO:0060300)
0.1 0.2 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.3 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
0.1 0.3 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.1 GO:0009826 unidimensional cell growth(GO:0009826)
0.1 0.2 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.5 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.2 GO:0007493 endodermal cell fate determination(GO:0007493)
0.1 0.3 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.3 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.0 0.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:2000793 negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793)
0.0 0.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.2 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0 0.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.6 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.0 0.2 GO:0007343 egg activation(GO:0007343)
0.0 0.2 GO:0060242 contact inhibition(GO:0060242)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.4 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.0 0.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.3 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0008940 nitrate reductase activity(GO:0008940)
0.1 0.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.3 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0009374 biotin binding(GO:0009374)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.7 PID FOXO PATHWAY FoxO family signaling
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.8 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development