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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zkscan3

Z-value: 1.19

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Transcription factors associated with Zkscan3

Gene Symbol Gene ID Gene Info
ENSMUSG00000021327.12 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_214027550.154.0e-01Click!

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 15.9 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.5 4.6 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.1 3.4 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.8 3.2 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.7 2.1 GO:0009233 menaquinone metabolic process(GO:0009233) phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.6 10.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.5 1.5 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.5 1.9 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.4 2.6 GO:0002835 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.3 2.8 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.3 0.8 GO:0055130 D-serine catabolic process(GO:0036088) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.2 0.9 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 5.8 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 1.3 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.4 GO:1904170 positive regulation of interleukin-1 alpha secretion(GO:0050717) regulation of bleb assembly(GO:1904170)
0.1 0.6 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.4 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 1.4 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.4 GO:0071051 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 1.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.4 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 2.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.8 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.0 6.2 GO:0007586 digestion(GO:0007586)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 2.3 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.0 1.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 1.0 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of hemostasis(GO:1900048)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.3 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.2 GO:0006968 cellular defense response(GO:0006968)
0.0 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.2 GO:0030168 platelet activation(GO:0030168)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.3 0.8 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.2 0.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.4 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.6 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 5.9 GO:0014704 intercalated disc(GO:0014704)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 15.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
1.2 4.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.1 3.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.7 2.1 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
0.7 2.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.5 1.5 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.4 2.3 GO:0004111 creatine kinase activity(GO:0004111)
0.4 10.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.3 5.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 0.9 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.3 1.9 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.3 3.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 0.9 GO:0038100 nodal binding(GO:0038100)
0.2 0.8 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.2 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.0 GO:0004954 prostanoid receptor activity(GO:0004954)
0.1 1.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 7.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0004890 GABA-A receptor activity(GO:0004890)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.4 15.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 7.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.0 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.1 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 5.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 1.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism