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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxd9

Z-value: 0.62

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Transcription factors associated with Hoxd9

Gene Symbol Gene ID Gene Info
ENSMUSG00000043342.8 homeobox D9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd9mm10_v2_chr2_+_74697663_746976800.096.2e-01Click!

Activity profile of Hoxd9 motif

Sorted Z-values of Hoxd9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 1.1 GO:2000473 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.2 0.6 GO:0002632 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.2 1.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 0.5 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.9 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 1.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.4 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.4 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 0.4 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.9 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1 0.4 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 0.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.3 GO:2000584 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.3 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.7 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.9 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.3 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.7 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.2 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.5 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 0.4 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 0.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.5 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.2 GO:1903978 regulation of microglial cell activation(GO:1903978)
0.0 0.1 GO:0035712 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.8 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0030450 regulation of complement activation, classical pathway(GO:0030450)
0.0 0.5 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 0.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.7 GO:0034363 vesicle lumen(GO:0031983) intermediate-density lipoprotein particle(GO:0034363)
0.1 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.9 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.6 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.2 GO:0042641 actomyosin(GO:0042641)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 0.9 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.4 GO:0003960 NADPH:quinone reductase activity(GO:0003960) alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 1.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.6 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 0.7 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.4 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.1 0.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.7 GO:0035473 lipase binding(GO:0035473)
0.1 1.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.5 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.4 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.0 0.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.8 GO:0070330 aromatase activity(GO:0070330)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.1 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 1.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.6 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors