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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxo4

Z-value: 0.46

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Transcription factors associated with Foxo4

Gene Symbol Gene ID Gene Info
ENSMUSG00000042903.7 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_101254574-0.163.6e-01Click!

Activity profile of Foxo4 motif

Sorted Z-values of Foxo4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 1.0 GO:0035063 nuclear speck organization(GO:0035063)
0.2 0.9 GO:0002282 microglial cell activation involved in immune response(GO:0002282) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.2 1.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.4 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.6 GO:0032096 negative regulation of response to food(GO:0032096)
0.1 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.7 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.6 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.1 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.5 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 0.2 GO:0006983 ER overload response(GO:0006983)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.0 GO:0030172 troponin C binding(GO:0030172)
0.1 1.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.7 GO:0005550 pheromone binding(GO:0005550)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0016594 glycine binding(GO:0016594)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.3 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 0.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 2.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events