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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pou3f4

Z-value: 2.53

Motif logo

Transcription factors associated with Pou3f4

Gene Symbol Gene ID Gene Info
ENSMUSG00000056854.3 POU domain, class 3, transcription factor 4

Activity profile of Pou3f4 motif

Sorted Z-values of Pou3f4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou3f4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.6 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
3.1 18.7 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
2.2 17.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
2.0 6.0 GO:0035700 immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
1.6 36.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
1.5 6.0 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
1.2 4.8 GO:0061743 motor learning(GO:0061743)
1.1 5.5 GO:0031860 telomeric 3' overhang formation(GO:0031860)
1.1 3.2 GO:1904431 positive regulation of t-circle formation(GO:1904431)
1.1 4.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 2.6 GO:0006714 sesquiterpenoid metabolic process(GO:0006714)
0.9 2.6 GO:0002632 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.8 6.7 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.7 5.7 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.6 5.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.6 1.8 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.6 3.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.6 2.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5 2.6 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.4 1.5 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.4 10.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 8.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.1 GO:0051464 positive regulation of cortisol secretion(GO:0051464) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.4 1.4 GO:0031296 B cell costimulation(GO:0031296)
0.3 0.9 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 4.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.3 3.8 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.3 1.1 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 2.0 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.3 1.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 16.2 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.2 9.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 0.9 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.2 0.6 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.2 4.9 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 1.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.2 1.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.0 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 1.6 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.2 1.0 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 0.7 GO:0043622 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660)
0.2 1.9 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.2 2.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 2.4 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 1.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 5.3 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.1 0.4 GO:0060197 cloacal septation(GO:0060197)
0.1 1.1 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.1 1.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 5.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.4 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.1 1.5 GO:0001778 plasma membrane repair(GO:0001778)
0.1 3.7 GO:0007616 long-term memory(GO:0007616)
0.1 2.7 GO:0006825 copper ion transport(GO:0006825)
0.1 2.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 0.5 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.3 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 7.8 GO:0007051 spindle organization(GO:0007051)
0.0 1.1 GO:0001553 luteinization(GO:0001553)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0040031 snRNA modification(GO:0040031)
0.0 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.2 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 0.4 GO:0001913 T cell mediated cytotoxicity(GO:0001913)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 36.0 GO:0071439 clathrin complex(GO:0071439)
0.9 5.5 GO:0030870 Mre11 complex(GO:0030870)
0.7 5.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.6 3.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.5 1.5 GO:0030312 external encapsulating structure(GO:0030312)
0.5 1.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 5.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.4 7.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 0.9 GO:0072534 perineuronal net(GO:0072534)
0.3 1.8 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.9 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.2 2.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 1.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 1.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 1.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 2.4 GO:0036157 outer dynein arm(GO:0036157)
0.2 8.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0000235 astral microtubule(GO:0000235)
0.1 10.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 7.8 GO:0000922 spindle pole(GO:0000922)
0.1 0.5 GO:0000322 storage vacuole(GO:0000322)
0.0 16.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 8.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 4.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 8.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0000346 transcription export complex(GO:0000346)
0.0 4.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 4.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 3.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 18.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.0 6.0 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
1.9 16.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.4 4.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.8 8.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.7 5.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.7 5.3 GO:0004064 arylesterase activity(GO:0004064)
0.6 3.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.6 9.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 6.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 5.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 1.5 GO:0004568 chitinase activity(GO:0004568)
0.4 2.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.4 1.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.3 4.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 5.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 2.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 2.9 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 1.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 3.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 0.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 0.9 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.2 1.1 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.0 GO:0045545 syndecan binding(GO:0045545)
0.1 2.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.9 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 3.1 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.1 GO:0051378 serotonin binding(GO:0051378)
0.1 1.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 36.0 GO:0005543 phospholipid binding(GO:0005543)
0.1 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 6.7 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.9 GO:0046625 sphingolipid binding(GO:0046625)
0.1 3.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 3.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.0 6.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 16.3 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 4.0 GO:0003774 motor activity(GO:0003774)
0.0 1.8 GO:0005549 odorant binding(GO:0005549)
0.0 2.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.6 GO:0016208 AMP binding(GO:0016208)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0042166 acetylcholine binding(GO:0042166)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 4.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 2.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 7.6 PID AURORA A PATHWAY Aurora A signaling
0.2 7.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 5.5 PID BARD1 PATHWAY BARD1 signaling events
0.1 10.6 PID E2F PATHWAY E2F transcription factor network
0.1 4.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 2.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.0 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 5.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.0 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.4 5.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.3 5.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 4.9 REACTOME KINESINS Genes involved in Kinesins
0.2 8.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 2.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 5.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 2.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 3.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism