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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-3

Z-value: 0.88

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Transcription factors associated with Nkx2-3

Gene Symbol Gene ID Gene Info
ENSMUSG00000044220.12 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.325.4e-02Click!

Activity profile of Nkx2-3 motif

Sorted Z-values of Nkx2-3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0030221 basophil differentiation(GO:0030221)
0.3 1.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.3 1.0 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.3 1.5 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.2 3.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.7 GO:1902867 camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.2 0.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 3.0 GO:0001778 plasma membrane repair(GO:0001778)
0.2 0.6 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 0.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.7 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
0.2 0.5 GO:0044240 negative regulation of lipoprotein oxidation(GO:0034443) multicellular organism lipid catabolic process(GO:0044240)
0.2 0.8 GO:0021993 fourth ventricle development(GO:0021592) initiation of neural tube closure(GO:0021993)
0.2 2.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.4 GO:0015881 creatine transport(GO:0015881)
0.1 0.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.3 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.4 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) regulation of cytokine activity(GO:0060300) negative regulation of sensory perception of pain(GO:1904057)
0.1 0.4 GO:0072720 response to sorbitol(GO:0072708) response to dithiothreitol(GO:0072720)
0.1 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.3 GO:0006714 sesquiterpenoid metabolic process(GO:0006714)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.4 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.1 0.8 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.3 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.1 0.3 GO:0035910 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.4 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.1 0.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.8 GO:0032264 IMP salvage(GO:0032264)
0.1 0.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.3 GO:2000979 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.3 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.4 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.4 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.1 1.1 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.2 GO:0021570 rhombomere 4 development(GO:0021570)
0.1 0.4 GO:0035865 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 0.6 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.7 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.5 GO:1903849 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 1.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.6 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.2 GO:0035552 tRNA wobble cytosine modification(GO:0002101) oxidative single-stranded DNA demethylation(GO:0035552)
0.1 0.5 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.8 GO:0097264 self proteolysis(GO:0097264)
0.1 0.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.2 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.3 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863)
0.1 0.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 1.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 1.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.7 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.4 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.1 GO:1903537 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.0 0.5 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.4 GO:0002826 negative regulation of T-helper 1 type immune response(GO:0002826)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.3 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.3 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.7 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0046601 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.0 0.8 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.7 GO:0097186 amelogenesis(GO:0097186)
0.0 0.1 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.3 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.2 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.4 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.3 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.2 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.0 0.2 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.8 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.6 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.3 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.3 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.3 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.2 GO:1900003 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.7 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.4 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0014029 neural crest formation(GO:0014029)
0.0 0.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.0 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.0 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 0.2 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 3.5 GO:0071439 clathrin complex(GO:0071439)
0.3 1.0 GO:0031523 Myb complex(GO:0031523)
0.2 1.5 GO:0005927 muscle tendon junction(GO:0005927)
0.2 0.8 GO:1990923 PET complex(GO:1990923)
0.1 0.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.6 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 2.4 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0001940 male pronucleus(GO:0001940)
0.1 0.6 GO:0005818 aster(GO:0005818)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684) integrin alphav-beta6 complex(GO:0034685)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0042588 zymogen granule(GO:0042588)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 3.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.2 1.0 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 0.6 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2 0.9 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.2 1.1 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 2.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.4 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.1 0.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.5 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.0 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.4 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.8 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.6 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.3 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.4 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.1 1.1 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.2 GO:0043734 DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.5 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.0 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.0 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0048185 activin binding(GO:0048185)
0.0 0.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.6 PID ARF6 PATHWAY Arf6 signaling events
0.1 4.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.8 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.5 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 2.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 2.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 2.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases