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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for AGUGGUU

Z-value: 0.48

Motif logo

miRNA associated with seed AGUGGUU

NamemiRBASE accession
MIMAT0000151
MIMAT0004855

Activity profile of AGUGGUU motif

Sorted Z-values of AGUGGUU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AGUGGUU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042117 monocyte activation(GO:0042117)
0.1 0.4 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.3 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.1 0.3 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.3 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.1 0.3 GO:1905223 epicardium morphogenesis(GO:1905223)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.4 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.1 0.4 GO:0071694 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1 0.6 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.5 GO:0006265 DNA topological change(GO:0006265)
0.1 0.3 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.2 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) negative regulation of vascular associated smooth muscle cell migration(GO:1904753)
0.1 0.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.1 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.0 0.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.0 0.1 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.0 0.1 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.2 GO:0014854 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0003130 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) embryonic heart tube anterior/posterior pattern specification(GO:0035054) corticotropin hormone secreting cell differentiation(GO:0060128)
0.0 0.5 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.4 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0060031 mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775)
0.0 0.1 GO:0021763 subthalamic nucleus development(GO:0021763) superior vena cava morphogenesis(GO:0060578)
0.0 0.2 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.1 GO:0021666 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.0 0.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.0 0.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.0 0.2 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:1903918 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
0.0 0.2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.3 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0044849 estrous cycle(GO:0044849) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.3 GO:0031208 POZ domain binding(GO:0031208)
0.1 0.5 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.1 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0008536 Ran GTPase binding(GO:0008536)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets