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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Obox3

Z-value: 0.68

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Transcription factors associated with Obox3

Gene Symbol Gene ID Gene Info
ENSMUSG00000066772.6 oocyte specific homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Obox3mm10_v2_chr7_-_15627876_156278760.391.8e-02Click!

Activity profile of Obox3 motif

Sorted Z-values of Obox3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Obox3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 0.8 GO:0060032 notochord regression(GO:0060032)
0.6 5.1 GO:0015671 oxygen transport(GO:0015671)
0.3 4.6 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.2 3.3 GO:0033504 floor plate development(GO:0033504)
0.2 0.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 1.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.7 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 0.4 GO:2000668 dendritic cell apoptotic process(GO:0097048) neutrophil clearance(GO:0097350) regulation of dendritic cell apoptotic process(GO:2000668)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.7 GO:0015747 urate transport(GO:0015747)
0.0 0.5 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.4 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.0 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 2.5 GO:0007030 Golgi organization(GO:0007030)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 0.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.5 GO:0030517 negative regulation of axon extension(GO:0030517)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 2.5 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.5 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 4.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0097542 ciliary tip(GO:0097542)
0.0 4.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0034709 methylosome(GO:0034709)
0.0 3.3 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.4 GO:0018995 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.2 1.3 GO:0004359 glutaminase activity(GO:0004359)
0.2 0.6 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.2 4.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 0.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 1.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 2.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.7 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 4.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor