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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Ikzf2

Z-value: 0.67

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Transcription factors associated with Ikzf2

Gene Symbol Gene ID Gene Info
ENSMUSG00000025997.7 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ikzf2mm10_v2_chr1_-_69685937_696859660.492.4e-03Click!

Activity profile of Ikzf2 motif

Sorted Z-values of Ikzf2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Ikzf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0002436 immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
0.6 1.9 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.5 4.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.4 1.1 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.3 1.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.8 GO:0002632 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.2 0.6 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.2 0.8 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.2 1.3 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.2 0.6 GO:0007521 muscle cell fate determination(GO:0007521) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 1.0 GO:0036394 amylase secretion(GO:0036394)
0.1 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 1.9 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 0.2 GO:0035481 Notch signaling pathway involved in heart induction(GO:0003137) regulation of Notch signaling pathway involved in heart induction(GO:0035480) positive regulation of Notch signaling pathway involved in heart induction(GO:0035481)
0.1 1.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 0.5 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 0.9 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1 0.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 1.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 1.5 GO:0015809 arginine transport(GO:0015809)
0.1 3.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.1 0.2 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.1 0.9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.0 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 1.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 2.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0021558 oculomotor nerve development(GO:0021557) trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.0 1.1 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 1.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.1 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.9 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.5 GO:0046855 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) inositol phosphate dephosphorylation(GO:0046855)
0.0 2.0 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773)
0.0 0.2 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.6 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.9 GO:0008623 CHRAC(GO:0008623)
0.1 0.9 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 1.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.9 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.9 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 1.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.8 GO:0032982 myosin filament(GO:0032982)
0.1 2.7 GO:0002102 podosome(GO:0002102)
0.1 1.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 2.2 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
0.2 1.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.5 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.2 0.9 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 0.5 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 1.1 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 2.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0071820 N-box binding(GO:0071820)
0.0 3.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.2 GO:0070888 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 1.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 3.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.0 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.2 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 3.8 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions