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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gsx1_Alx1_Mixl1_Lbx2

Z-value: 1.05

Motif logo

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000053129.5 GS homeobox 1
ENSMUSG00000036602.7 ALX homeobox 1
ENSMUSG00000026497.7 Mix1 homeobox-like 1 (Xenopus laevis)
ENSMUSG00000034968.2 ladybird homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lbx2mm10_v2_chr6_+_83086365_83086365-0.643.0e-05Click!
Alx1mm10_v2_chr10_-_103029043_103029054-0.455.3e-03Click!
Mixl1mm10_v2_chr1_-_180697034_1806970340.057.6e-01Click!

Activity profile of Gsx1_Alx1_Mixl1_Lbx2 motif

Sorted Z-values of Gsx1_Alx1_Mixl1_Lbx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.4 1.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 1.6 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.4 3.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 1.1 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 1.4 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.3 2.6 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.3 0.8 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343)
0.3 2.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.3 3.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.3 0.8 GO:1902605 heterotrimeric G-protein complex assembly(GO:1902605)
0.2 1.0 GO:0032468 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.2 1.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 1.8 GO:0019532 oxalate transport(GO:0019532)
0.2 4.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.0 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 0.7 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.2 0.5 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.2 0.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 0.5 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.2 0.5 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.2 0.6 GO:0061743 motor learning(GO:0061743)
0.1 0.6 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 2.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.4 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 0.4 GO:0002194 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 1.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 1.8 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 1.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.1 0.3 GO:2000584 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.4 GO:0036233 glycine import(GO:0036233)
0.1 0.3 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.1 0.4 GO:0050975 sensory perception of touch(GO:0050975)
0.1 0.3 GO:1903774 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.4 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 2.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.2 GO:0015755 fructose transport(GO:0015755)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.3 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.4 GO:0070459 prolactin secretion(GO:0070459) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 0.2 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.7 GO:0018158 protein oxidation(GO:0018158)
0.1 0.2 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.1 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 1.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.3 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.1 1.4 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.1 GO:0009946 proximal/distal axis specification(GO:0009946)
0.1 0.8 GO:0007320 insemination(GO:0007320)
0.1 0.2 GO:2000292 negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.1 0.4 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.1 0.1 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.1 0.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.3 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.8 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.0 0.2 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 1.4 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.3 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 0.2 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.6 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.1 GO:1904732 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.0 0.2 GO:0009115 xanthine catabolic process(GO:0009115)
0.0 0.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 2.4 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.2 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 0.6 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:1903690 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.7 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.0 0.4 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.2 GO:0021853 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 1.1 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.2 GO:0043504 mitochondrial DNA repair(GO:0043504) negative regulation of mitochondrial DNA replication(GO:0090298)
0.0 0.8 GO:0044062 regulation of excretion(GO:0044062)
0.0 0.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.2 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.3 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 4.9 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.2 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.4 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 0.2 GO:2000510 negative regulation of trophoblast cell migration(GO:1901164) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 0.1 GO:0021553 olfactory nerve development(GO:0021553)
0.0 0.1 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.5 GO:0007602 phototransduction(GO:0007602)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.7 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.5 GO:0046688 response to copper ion(GO:0046688)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0009624 response to nematode(GO:0009624)
0.0 0.2 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.8 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0 0.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584) histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.2 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0051610 serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.2 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.0 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.2 GO:0010225 response to UV-C(GO:0010225)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.0 GO:1903632 positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.0 1.9 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.3 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0001834 trophectodermal cellular morphogenesis(GO:0001831) trophectodermal cell proliferation(GO:0001834) positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.0 3.6 GO:0015833 peptide transport(GO:0015833)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.0 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:1904016 positive regulation of female receptivity(GO:0045925) response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 1.6 GO:0071438 invadopodium membrane(GO:0071438)
0.2 3.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.6 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.3 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.1 0.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.7 GO:0097413 Lewy body(GO:0097413)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.1 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.5 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.1 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.2 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0097441 basilar dendrite(GO:0097441)
0.0 1.6 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.4 3.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 3.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.3 1.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 1.6 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.3 0.8 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.2 1.0 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.2 1.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 0.6 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 0.6 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.2 0.7 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.2 0.5 GO:0046911 metal chelating activity(GO:0046911)
0.2 0.7 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 1.0 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.9 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.4 GO:0048408 epidermal growth factor-activated receptor activity(GO:0005006) epidermal growth factor binding(GO:0048408)
0.1 1.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.3 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 0.6 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.8 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.5 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.7 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.2 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.2 GO:0003681 bent DNA binding(GO:0003681)
0.1 1.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 2.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.2 GO:0016726 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0019825 oxygen binding(GO:0019825)
0.0 1.1 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.2 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0050693 LBD domain binding(GO:0050693)
0.0 5.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0019809 spermidine binding(GO:0019809)
0.0 0.1 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.0 1.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.1 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.5 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.2 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 6.8 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.1 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 2.6 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.1 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) NADPH binding(GO:0070402)
0.0 0.1 GO:0051575 double-stranded telomeric DNA binding(GO:0003691) 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 2.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.7 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 ST ADRENERGIC Adrenergic Pathway
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 3.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 3.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 1.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 0.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 4.1 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell