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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zbtb3

Z-value: 0.72

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Transcription factors associated with Zbtb3

Gene Symbol Gene ID Gene Info
ENSMUSG00000071661.6 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zbtb3mm10_v2_chr19_+_8802486_88025300.651.9e-05Click!

Activity profile of Zbtb3 motif

Sorted Z-values of Zbtb3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.9 GO:0015671 oxygen transport(GO:0015671)
0.2 1.2 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 0.9 GO:1904616 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.2 0.9 GO:0030070 insulin processing(GO:0030070)
0.2 0.9 GO:0050904 diapedesis(GO:0050904)
0.1 0.4 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 1.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 2.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.7 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.1 0.4 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.9 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.4 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.1 1.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 1.1 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 1.3 GO:0030953 astral microtubule organization(GO:0030953)
0.1 0.5 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.1 1.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.4 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.0 1.4 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 0.2 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.1 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.0 1.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 1.1 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0008358 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 0.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 1.2 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.7 GO:0045730 respiratory burst(GO:0045730)
0.0 1.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.2 GO:0015879 carnitine transport(GO:0015879)
0.0 0.1 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 2.6 GO:0030168 platelet activation(GO:0030168)
0.0 0.2 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0 0.1 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.8 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.4 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.1 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.9 GO:0005833 hemoglobin complex(GO:0005833)
0.1 3.1 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.6 GO:0097165 nuclear stress granule(GO:0097165)
0.1 3.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.3 GO:0071953 elastic fiber(GO:0071953)
0.1 0.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.4 GO:0097255 R2TP complex(GO:0097255)
0.1 1.2 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 2.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.7 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 1.7 GO:0016234 inclusion body(GO:0016234)
0.0 0.0 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.6 1.7 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.3 2.3 GO:0005499 vitamin D binding(GO:0005499)
0.2 1.2 GO:0043532 angiostatin binding(GO:0043532)
0.2 1.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.9 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 3.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.9 GO:0050897 serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897)
0.1 0.9 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 0.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.4 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.9 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 1.1 GO:0070330 aromatase activity(GO:0070330)
0.0 1.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.4 GO:0008097 5S rRNA binding(GO:0008097)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 1.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi