avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Nkx3-1
|
ENSMUSG00000022061.8 | NK3 homeobox 1 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx3-1 | mm10_v2_chr14_+_69190638_69190691 | 0.24 | 1.6e-01 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 36.6 | GO:0019377 | galactolipid metabolic process(GO:0019374) glycolipid catabolic process(GO:0019377) |
1.9 | 28.7 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.7 | 3.6 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
0.6 | 3.0 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.5 | 2.0 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
0.5 | 1.4 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
0.4 | 1.2 | GO:2000412 | lymphocyte migration into lymphoid organs(GO:0097021) positive regulation of thymocyte migration(GO:2000412) regulation of dendritic cell dendrite assembly(GO:2000547) |
0.4 | 2.1 | GO:0002838 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
0.4 | 1.8 | GO:0072386 | stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150) |
0.3 | 1.0 | GO:0060300 | regulation of cytokine activity(GO:0060300) |
0.3 | 2.5 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.2 | 1.7 | GO:1904378 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.2 | 2.3 | GO:0098953 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
0.2 | 0.8 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
0.2 | 29.9 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
0.2 | 0.4 | GO:2000449 | regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449) |
0.2 | 1.4 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.2 | 0.5 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
0.2 | 0.6 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
0.1 | 5.0 | GO:0002021 | response to dietary excess(GO:0002021) |
0.1 | 0.7 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
0.1 | 1.7 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
0.1 | 1.1 | GO:0008228 | opsonization(GO:0008228) |
0.1 | 0.4 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.1 | 1.0 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
0.1 | 1.4 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
0.1 | 1.0 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
0.1 | 2.7 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.1 | 0.5 | GO:0034627 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
0.1 | 0.7 | GO:0070447 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) |
0.1 | 0.3 | GO:0010578 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
0.1 | 1.8 | GO:0070986 | left/right axis specification(GO:0070986) |
0.1 | 1.4 | GO:0048664 | neuron fate determination(GO:0048664) |
0.1 | 0.6 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
0.1 | 1.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.1 | 1.1 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
0.1 | 0.6 | GO:2000344 | positive regulation of acrosome reaction(GO:2000344) |
0.1 | 1.0 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
0.1 | 0.5 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.1 | 0.2 | GO:0007208 | phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
0.1 | 0.6 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.1 | 0.4 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 0.2 | GO:0019255 | UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255) |
0.0 | 0.2 | GO:0097283 | keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) |
0.0 | 0.6 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
0.0 | 1.9 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
0.0 | 6.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
0.0 | 0.8 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
0.0 | 0.2 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
0.0 | 0.2 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560) |
0.0 | 0.8 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
0.0 | 0.4 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
0.0 | 0.1 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of reciprocal meiotic recombination(GO:0010845) |
0.0 | 0.7 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
0.0 | 0.2 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.0 | 0.8 | GO:0008053 | mitochondrial fusion(GO:0008053) |
0.0 | 0.1 | GO:0002767 | immune response-inhibiting cell surface receptor signaling pathway(GO:0002767) |
0.0 | 0.3 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
0.0 | 0.3 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) negative regulation of fibroblast apoptotic process(GO:2000270) |
0.0 | 0.5 | GO:0015858 | nucleoside transport(GO:0015858) |
0.0 | 1.0 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
0.0 | 0.6 | GO:0090382 | phagosome maturation(GO:0090382) |
0.0 | 0.9 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 0.9 | GO:0002053 | positive regulation of mesenchymal cell proliferation(GO:0002053) |
0.0 | 19.7 | GO:0055114 | oxidation-reduction process(GO:0055114) |
0.0 | 0.3 | GO:0015695 | drug transmembrane transport(GO:0006855) organic cation transport(GO:0015695) |
0.0 | 0.1 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
0.0 | 0.6 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
0.0 | 0.4 | GO:0009409 | response to cold(GO:0009409) |
0.0 | 0.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 36.6 | GO:0042589 | zymogen granule membrane(GO:0042589) |
1.9 | 28.7 | GO:0042588 | zymogen granule(GO:0042588) |
0.6 | 2.3 | GO:0099522 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
0.3 | 1.4 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.2 | 1.7 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.2 | 2.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.2 | 0.6 | GO:0097447 | dendritic tree(GO:0097447) |
0.1 | 0.9 | GO:0005927 | muscle tendon junction(GO:0005927) |
0.1 | 1.0 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
0.1 | 0.7 | GO:0008091 | spectrin(GO:0008091) |
0.1 | 0.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.1 | 1.8 | GO:0035253 | ciliary rootlet(GO:0035253) |
0.1 | 2.1 | GO:0031528 | microvillus membrane(GO:0031528) |
0.1 | 12.2 | GO:0072562 | blood microparticle(GO:0072562) |
0.1 | 2.5 | GO:0031430 | M band(GO:0031430) |
0.0 | 78.2 | GO:0005615 | extracellular space(GO:0005615) |
0.0 | 0.4 | GO:0097342 | ripoptosome(GO:0097342) |
0.0 | 0.8 | GO:0005861 | troponin complex(GO:0005861) |
0.0 | 1.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 0.5 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.0 | 17.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
0.0 | 0.8 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.0 | 3.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 0.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.7 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
0.0 | 1.8 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 1.0 | GO:0000791 | euchromatin(GO:0000791) |
0.0 | 2.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 1.0 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 44.0 | GO:0070062 | extracellular exosome(GO:0070062) |
0.0 | 0.3 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.0 | 0.6 | GO:0031526 | brush border membrane(GO:0031526) |
0.0 | 0.1 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
10.7 | 75.1 | GO:0004556 | alpha-amylase activity(GO:0004556) |
2.9 | 22.9 | GO:0050649 | testosterone 6-beta-hydroxylase activity(GO:0050649) |
2.4 | 36.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
1.3 | 8.0 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
0.7 | 3.6 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
0.5 | 2.1 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.5 | 1.4 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
0.3 | 55.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.3 | 1.8 | GO:0099609 | microtubule lateral binding(GO:0099609) |
0.2 | 0.6 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
0.2 | 2.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.2 | 0.8 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
0.2 | 28.7 | GO:0008083 | growth factor activity(GO:0008083) |
0.2 | 1.0 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
0.2 | 0.5 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
0.1 | 1.2 | GO:0019957 | C-C chemokine binding(GO:0019957) |
0.1 | 0.9 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.1 | 0.5 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
0.1 | 0.7 | GO:0072510 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
0.1 | 1.7 | GO:0015643 | toxic substance binding(GO:0015643) |
0.1 | 1.0 | GO:0036122 | BMP binding(GO:0036122) |
0.1 | 0.4 | GO:0031699 | beta-3 adrenergic receptor binding(GO:0031699) |
0.1 | 0.4 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
0.1 | 2.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.1 | 1.0 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.1 | 4.8 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 1.4 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
0.1 | 0.6 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.1 | 3.0 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 1.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.8 | GO:0051400 | BH domain binding(GO:0051400) |
0.0 | 0.2 | GO:0004875 | complement receptor activity(GO:0004875) |
0.0 | 1.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.0 | 0.6 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.0 | 0.3 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) |
0.0 | 0.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.0 | 0.9 | GO:0042169 | SH2 domain binding(GO:0042169) |
0.0 | 0.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.0 | 0.5 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
0.0 | 0.2 | GO:0051378 | serotonin binding(GO:0051378) |
0.0 | 0.4 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.0 | 0.2 | GO:0032557 | pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569) |
0.0 | 0.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 12.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
0.2 | 3.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
0.1 | 34.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 2.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.0 | 1.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.2 | PID S1P S1P3 PATHWAY | S1P3 pathway |
0.0 | 0.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
0.0 | 0.8 | PID ENDOTHELIN PATHWAY | Endothelins |
0.0 | 2.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 35.2 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
0.3 | 12.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.1 | 2.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
0.1 | 2.7 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 2.3 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 1.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.1 | 3.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.1 | 0.8 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
0.0 | 0.4 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
0.0 | 0.3 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.0 | 1.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
0.0 | 0.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.0 | 1.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.0 | 1.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.0 | 0.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 0.8 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
0.0 | 0.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.0 | 0.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
0.0 | 0.3 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
0.0 | 0.4 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
0.0 | 0.2 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
0.0 | 0.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
0.0 | 0.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
0.0 | 0.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |