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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rxrb

Z-value: 0.62

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Transcription factors associated with Rxrb

Gene Symbol Gene ID Gene Info
ENSMUSG00000039656.10 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rxrbmm10_v2_chr17_+_34031787_34031821-0.564.3e-04Click!

Activity profile of Rxrb motif

Sorted Z-values of Rxrb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rxrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.4 1.1 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.4 1.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.3 1.4 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.3 1.3 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.3 2.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 0.8 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.3 2.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 0.6 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.2 0.5 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.2 0.7 GO:0014916 regulation of lung blood pressure(GO:0014916)
0.2 0.9 GO:0015886 heme transport(GO:0015886)
0.1 0.7 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.8 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.8 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.1 1.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.3 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
0.1 0.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.3 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.4 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 0.8 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.3 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 2.0 GO:0015813 L-glutamate transport(GO:0015813)
0.1 0.3 GO:0097494 regulation of vesicle size(GO:0097494)
0.1 0.2 GO:0060854 patterning of lymph vessels(GO:0060854)
0.1 0.7 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.1 1.3 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.4 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 0.3 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.4 GO:0021539 subthalamus development(GO:0021539)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 2.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.2 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 0.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.3 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.3 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.4 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.1 GO:0009624 response to nematode(GO:0009624)
0.0 0.7 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.4 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.7 GO:0030903 notochord development(GO:0030903)
0.0 0.3 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.8 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.1 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0035902 response to immobilization stress(GO:0035902)
0.0 1.0 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0072144 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0 0.2 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0044316 cone cell pedicle(GO:0044316)
0.2 0.7 GO:0036019 endolysosome(GO:0036019)
0.2 1.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.3 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.0 2.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 1.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.2 GO:0097440 apical dendrite(GO:0097440)
0.0 1.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 3.3 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 2.4 GO:0001851 complement component C3b binding(GO:0001851)
0.3 2.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 0.8 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.3 0.8 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.2 0.9 GO:0015232 heme transporter activity(GO:0015232)
0.2 1.3 GO:0097016 L27 domain binding(GO:0097016)
0.2 2.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.8 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.2 1.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 1.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.6 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.7 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.2 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.8 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.3 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 1.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.4 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 1.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.4 GO:0030552 cAMP binding(GO:0030552)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.8 REACTOME OPSINS Genes involved in Opsins
0.1 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 3.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.4 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)