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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr2c1

Z-value: 1.09

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Transcription factors associated with Nr2c1

Gene Symbol Gene ID Gene Info
ENSMUSG00000005897.8 nuclear receptor subfamily 2, group C, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2c1mm10_v2_chr10_+_94147982_941480230.038.8e-01Click!

Activity profile of Nr2c1 motif

Sorted Z-values of Nr2c1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2c1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0010710 regulation of collagen catabolic process(GO:0010710) negative regulation of extracellular matrix disassembly(GO:0010716)
0.6 6.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.5 1.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.4 1.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 1.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.4 3.4 GO:0032264 IMP salvage(GO:0032264)
0.3 1.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.6 GO:0015793 glycerol transport(GO:0015793) renal water absorption(GO:0070295)
0.3 1.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 1.1 GO:0060578 subthalamic nucleus development(GO:0021763) superior vena cava morphogenesis(GO:0060578)
0.2 2.1 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.2 4.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.2 1.3 GO:1904923 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.2 3.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 0.5 GO:0009173 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.2 0.8 GO:0060313 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 0.5 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.7 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 0.7 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 2.1 GO:0032060 bleb assembly(GO:0032060)
0.1 0.9 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.5 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 0.4 GO:0061295 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.1 1.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.8 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.8 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.7 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 0.5 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.8 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.5 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0 1.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.9 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.6 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.3 GO:0015879 carnitine transport(GO:0015879)
0.0 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 2.2 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.1 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 1.2 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.4 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.0 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.5 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.1 GO:1900364 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0042583 chromaffin granule(GO:0042583)
0.2 1.8 GO:0071438 invadopodium membrane(GO:0071438)
0.2 0.8 GO:0036396 MIS complex(GO:0036396)
0.2 0.8 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.1 5.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 1.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.1 GO:0071565 nBAF complex(GO:0071565)
0.0 4.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 1.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 4.7 GO:0005903 brush border(GO:0005903)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 3.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 5.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.8 4.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.4 1.5 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.4 3.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 1.8 GO:1990254 keratin filament binding(GO:1990254)
0.3 1.6 GO:0015254 glycerol channel activity(GO:0015254)
0.3 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.9 GO:0051373 FATZ binding(GO:0051373)
0.2 1.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.5 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 1.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.9 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.3 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.3 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 1.2 GO:0071949 FAD binding(GO:0071949)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 3.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.5 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 2.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.7 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 3.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 4.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 0.8 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing