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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zkscan1

Z-value: 1.18

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Transcription factors associated with Zkscan1

Gene Symbol Gene ID Gene Info
ENSMUSG00000029729.6 zinc finger with KRAB and SCAN domains 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zkscan1mm10_v2_chr5_+_138085083_138085147-0.183.0e-01Click!

Activity profile of Zkscan1 motif

Sorted Z-values of Zkscan1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.9 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.4 1.1 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
0.3 0.9 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 2.3 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.3 2.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.3 1.0 GO:0090235 regulation of metaphase plate congression(GO:0090235)
0.2 0.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 0.7 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.2 2.8 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2 0.6 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.2 1.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 1.2 GO:0060023 soft palate development(GO:0060023)
0.2 1.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 2.9 GO:0070307 lens fiber cell development(GO:0070307)
0.2 1.3 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 2.4 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.1 0.4 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 1.0 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.7 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 2.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 4.8 GO:0035411 catenin import into nucleus(GO:0035411)
0.1 1.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 1.0 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.1 1.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.2 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.0 2.3 GO:0051693 actin filament capping(GO:0051693)
0.0 0.3 GO:0015840 urea transport(GO:0015840)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.2 GO:1905146 lysosomal protein catabolic process(GO:1905146)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 2.1 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.4 GO:0042711 maternal behavior(GO:0042711)
0.0 0.2 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.6 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 0.0 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.5 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.9 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.5 GO:0032418 lysosome localization(GO:0032418)
0.0 0.8 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.2 0.7 GO:1990696 USH2 complex(GO:1990696)
0.2 0.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 1.3 GO:0000796 condensin complex(GO:0000796)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 2.1 GO:0031045 dense core granule(GO:0031045)
0.1 1.1 GO:0001739 sex chromatin(GO:0001739)
0.1 0.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 1.3 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 8.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 3.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 2.3 GO:0005884 actin filament(GO:0005884)
0.0 1.3 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.5 4.1 GO:0034711 inhibin binding(GO:0034711)
0.2 1.1 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 2.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.5 GO:0050436 microfibril binding(GO:0050436)
0.1 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 3.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.2 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 1.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 3.4 GO:0019955 cytokine binding(GO:0019955)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 7.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.9 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 2.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 3.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 2.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.1 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 3.0 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.2 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase