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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pgr_Nr3c1

Z-value: 1.40

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Transcription factors associated with Pgr_Nr3c1

Gene Symbol Gene ID Gene Info
ENSMUSG00000031870.10 progesterone receptor
ENSMUSG00000024431.8 nuclear receptor subfamily 3, group C, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pgrmm10_v2_chr9_+_8900459_8900489-0.474.1e-03Click!
Nr3c1mm10_v2_chr18_-_39489880_39489915-0.241.5e-01Click!

Activity profile of Pgr_Nr3c1 motif

Sorted Z-values of Pgr_Nr3c1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pgr_Nr3c1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.9 GO:0034760 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.9 3.7 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.8 2.4 GO:0006507 GPI anchor release(GO:0006507)
0.6 1.7 GO:2000041 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.5 5.4 GO:0006569 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)
0.4 1.3 GO:0072034 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
0.3 3.5 GO:0005513 detection of calcium ion(GO:0005513)
0.3 3.3 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.3 1.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.3 1.1 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.3 13.1 GO:0050891 multicellular organismal water homeostasis(GO:0050891)
0.3 0.8 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.3 1.5 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 1.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.2 0.4 GO:0003169 coronary vein morphogenesis(GO:0003169)
0.2 2.1 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.2 1.2 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.2 1.4 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.2 1.2 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.2 1.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 0.5 GO:0010446 response to alkaline pH(GO:0010446)
0.2 1.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 1.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.1 0.9 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:0051466 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.5 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.6 GO:0000429 carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) carbon catabolite activation of transcription(GO:0045991)
0.1 0.3 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1 0.4 GO:0035483 gastric emptying(GO:0035483)
0.1 0.2 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.2 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 3.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.6 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.3 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 1.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.5 GO:0034453 microtubule anchoring(GO:0034453)
0.1 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:0072053 renal inner medulla development(GO:0072053)
0.1 1.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 1.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.8 GO:0042407 cristae formation(GO:0042407)
0.0 0.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 2.0 GO:0051642 centrosome localization(GO:0051642)
0.0 0.3 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 2.5 GO:0006956 complement activation(GO:0006956)
0.0 0.6 GO:0010155 regulation of proton transport(GO:0010155)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 1.0 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.0 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 1.9 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 0.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.4 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.1 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.9 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.0 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.4 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.6 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.0 GO:0002946 tRNA C5-cytosine methylation(GO:0002946)
0.0 0.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 4.5 GO:0015833 peptide transport(GO:0015833)
0.0 1.8 GO:0006865 amino acid transport(GO:0006865)
0.0 0.2 GO:0003094 glomerular filtration(GO:0003094)
0.0 2.6 GO:0015711 organic anion transport(GO:0015711)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.0 GO:0034706 sodium channel complex(GO:0034706)
0.2 2.9 GO:0031045 dense core granule(GO:0031045)
0.1 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 3.3 GO:0005922 connexon complex(GO:0005922)
0.1 0.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.2 GO:0070578 RISC-loading complex(GO:0070578)
0.1 0.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 3.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.8 GO:0061617 MICOS complex(GO:0061617)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.8 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.3 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 2.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0045298 tubulin complex(GO:0045298)
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0031105 septin complex(GO:0031105)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.5 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.6 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.7 2.9 GO:0030348 syntaxin-3 binding(GO:0030348)
0.4 1.8 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.3 1.5 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.3 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.3 2.4 GO:0004630 phospholipase D activity(GO:0004630)
0.2 3.3 GO:0005243 gap junction channel activity(GO:0005243)
0.2 0.6 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.2 1.2 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 1.5 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.4 GO:0032564 dATP binding(GO:0032564)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 1.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.9 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.4 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 13.9 GO:0005179 hormone activity(GO:0005179)
0.1 1.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 0.8 GO:0005113 patched binding(GO:0005113)
0.1 1.9 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.6 GO:0033142 progesterone receptor binding(GO:0033142)
0.1 1.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.8 GO:0030169 signaling pattern recognition receptor activity(GO:0008329) low-density lipoprotein particle binding(GO:0030169) pattern recognition receptor activity(GO:0038187)
0.1 1.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 5.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.4 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 1.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 7.7 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 1.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.5 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0015250 water channel activity(GO:0015250)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.8 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.4 PID P73PATHWAY p73 transcription factor network
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 5.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 2.9 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 2.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 2.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling