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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for AAGUGCU

Z-value: 0.75

Motif logo

miRNA associated with seed AAGUGCU

NamemiRBASE accession
MIMAT0000368
MIMAT0000372
MIMAT0000373
MIMAT0000380
MIMAT0003374
MIMAT0003377

Activity profile of AAGUGCU motif

Sorted Z-values of AAGUGCU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGUGCU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.4 1.2 GO:0048627 myoblast development(GO:0048627)
0.4 1.5 GO:0048294 regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.4 1.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.3 1.0 GO:0036446 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.3 2.3 GO:0030242 pexophagy(GO:0030242)
0.3 0.9 GO:0016598 protein arginylation(GO:0016598)
0.3 0.9 GO:0015881 creatine transport(GO:0015881)
0.2 1.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.2 0.7 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.2 0.8 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.2 0.6 GO:0038189 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.2 0.6 GO:0070375 ERK5 cascade(GO:0070375)
0.2 0.6 GO:0019858 cytosine metabolic process(GO:0019858)
0.2 0.9 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 1.0 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 0.7 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.2 1.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 0.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.9 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.7 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 1.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 0.9 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.4 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.1 3.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.5 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.3 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157)
0.1 0.3 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.7 GO:0038161 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.4 GO:0050975 sensory perception of touch(GO:0050975)
0.1 1.1 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.1 0.7 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.5 GO:1903179 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.1 0.3 GO:0048320 axial mesoderm formation(GO:0048320)
0.1 1.0 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 1.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 0.3 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 0.5 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.3 GO:0070933 histone H4 deacetylation(GO:0070933) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.2 GO:1990859 cellular response to endothelin(GO:1990859)
0.1 0.4 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 0.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 0.3 GO:1903999 negative regulation of eating behavior(GO:1903999)
0.1 0.2 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.1 0.3 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.7 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.4 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.1 1.0 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.1 0.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 0.2 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.2 GO:0030070 insulin processing(GO:0030070)
0.1 0.2 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.1 0.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.1 0.2 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 0.2 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 0.2 GO:0071873 response to norepinephrine(GO:0071873)
0.1 0.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831) nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 1.9 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.4 GO:0030035 microspike assembly(GO:0030035)
0.0 0.5 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.6 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.3 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.1 GO:1901382 transforming growth factor beta receptor complex assembly(GO:0007181) chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.5 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.1 GO:0039521 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.0 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.2 GO:2001280 JUN phosphorylation(GO:0007258) positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:2001270 regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 1.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.5 GO:1904948 midbrain dopaminergic neuron differentiation(GO:1904948)
0.0 1.5 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.5 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.1 GO:0090156 negative regulation of sphingolipid biosynthetic process(GO:0090155) cellular sphingolipid homeostasis(GO:0090156)
0.0 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.7 GO:0060009 Sertoli cell development(GO:0060009)
0.0 1.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.4 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.3 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.2 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.6 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.4 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.0 0.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.2 GO:0043970 histone H3-K9 acetylation(GO:0043970)
0.0 0.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.5 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.1 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0 1.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0001842 neural fold formation(GO:0001842)
0.0 0.1 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0044806 primary miRNA processing(GO:0031053) G-quadruplex DNA unwinding(GO:0044806)
0.0 0.0 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.6 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0005608 laminin-3 complex(GO:0005608)
0.2 1.1 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 0.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.1 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.4 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 1.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 0.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.4 GO:0097413 Lewy body(GO:0097413)
0.1 1.2 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0090537 CERF complex(GO:0090537)
0.0 0.2 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.3 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.4 GO:0005657 replication fork(GO:0005657)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.0 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.1 GO:0005776 autophagosome(GO:0005776)
0.0 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 2.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0071144 activin responsive factor complex(GO:0032444) SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.5 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 2.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.9 GO:0000502 proteasome complex(GO:0000502)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.4 1.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.3 0.9 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.3 1.0 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.2 0.7 GO:0034188 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 0.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 1.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.1 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.1 1.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.3 GO:0031208 POZ domain binding(GO:0031208)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.4 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.8 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.3 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 1.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.1 GO:0043236 laminin binding(GO:0043236)
0.1 0.5 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0038052 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.2 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 0.5 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.9 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0 1.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.9 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.0 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.6 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.0 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 0.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.1 PID FOXO PATHWAY FoxO family signaling
0.0 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.7 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.9 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 1.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling