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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxc2

Z-value: 1.15

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Transcription factors associated with Foxc2

Gene Symbol Gene ID Gene Info
ENSMUSG00000046714.6 forkhead box C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.086.5e-01Click!

Activity profile of Foxc2 motif

Sorted Z-values of Foxc2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.0 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.8 5.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.7 2.9 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.6 5.1 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 1.8 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.4 1.8 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.4 2.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 1.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 0.7 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.2 1.9 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 0.8 GO:1990401 embryonic lung development(GO:1990401)
0.2 0.7 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 0.5 GO:0009826 unidimensional cell growth(GO:0009826)
0.2 0.7 GO:1903028 regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028)
0.2 0.6 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.3 GO:0060613 fat pad development(GO:0060613)
0.1 0.4 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 0.7 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.5 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.4 GO:0015886 heme transport(GO:0015886)
0.1 0.8 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 1.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.6 GO:0031179 peptide modification(GO:0031179)
0.1 1.1 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.8 GO:0072310 glomerular basement membrane development(GO:0032836) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.6 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.1 0.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.2 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0 0.6 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.3 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 5.1 GO:0009166 nucleotide catabolic process(GO:0009166)
0.0 0.4 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.4 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 3.3 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 0.1 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.0 0.8 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0033572 transferrin transport(GO:0033572)
0.0 25.5 GO:0006508 proteolysis(GO:0006508)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.8 GO:0045098 type III intermediate filament(GO:0045098)
0.4 1.4 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.1 0.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 0.8 GO:0032437 cuticular plate(GO:0032437)
0.1 1.0 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 2.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 71.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.6 GO:0005903 brush border(GO:0005903)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 16.2 GO:0004556 alpha-amylase activity(GO:0004556)
1.0 4.8 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.0 2.9 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.9 30.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 8.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 0.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 0.7 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 1.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.6 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.8 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.1 0.7 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.4 GO:1990405 protein antigen binding(GO:1990405)
0.1 2.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.4 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 11.4 GO:0005179 hormone activity(GO:0005179)
0.1 0.2 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 5.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.3 GO:0008238 exopeptidase activity(GO:0008238)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0043531 ADP binding(GO:0043531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 4.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.9 PID IGF1 PATHWAY IGF1 pathway
0.0 1.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 4.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 2.9 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 2.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 5.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 5.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex