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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Egr4

Z-value: 0.50

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Transcription factors associated with Egr4

Gene Symbol Gene ID Gene Info
ENSMUSG00000071341.3 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr4mm10_v2_chr6_-_85513586_85513591-0.261.3e-01Click!

Activity profile of Egr4 motif

Sorted Z-values of Egr4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:2000327 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 0.3 GO:2001076 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.1 0.3 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.2 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 0.3 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 0.2 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.1 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.2 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.0 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.1 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.0 0.1 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.0 0.1 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.0 GO:0003285 septum secundum development(GO:0003285) atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.1 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004104 cholinesterase activity(GO:0004104)
0.1 0.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC