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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Neurod2_Bhlha15_Bhlhe22_Olig1

Z-value: 0.97

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Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1

Gene Symbol Gene ID Gene Info
ENSMUSG00000038255.6 neurogenic differentiation 2
ENSMUSG00000052271.7 basic helix-loop-helix family, member a15
ENSMUSG00000025128.6 basic helix-loop-helix family, member e22
ENSMUSG00000046160.5 oligodendrocyte transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Olig1mm10_v2_chr16_+_91269759_912697780.382.4e-02Click!
Bhlhe22mm10_v2_chr3_+_18054258_18054325-0.353.6e-02Click!
Bhlha15mm10_v2_chr5_+_144190284_144190334-0.231.8e-01Click!
Neurod2mm10_v2_chr11_-_98329641_98329654-0.038.8e-01Click!

Activity profile of Neurod2_Bhlha15_Bhlhe22_Olig1 motif

Sorted Z-values of Neurod2_Bhlha15_Bhlhe22_Olig1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Neurod2_Bhlha15_Bhlhe22_Olig1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.8 3.3 GO:0042851 L-alanine metabolic process(GO:0042851)
0.8 4.7 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.3 0.9 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.3 2.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 0.6 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 3.0 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.2 0.8 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.2 0.5 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 0.7 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.2 1.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.9 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.5 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.3 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.1 0.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.5 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 3.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.4 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 1.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.9 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.1 0.4 GO:0034214 protein hexamerization(GO:0034214)
0.1 0.4 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 0.3 GO:0019364 pyridine nucleotide catabolic process(GO:0019364)
0.1 1.1 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.7 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 0.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.6 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.0 0.3 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.2 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.5 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0006449 regulation of translational termination(GO:0006449)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.3 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.1 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.3 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 2.8 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
0.0 0.2 GO:0045345 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0 0.1 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.1 GO:0031990 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.2 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.3 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.6 GO:0000045 autophagosome assembly(GO:0000045)
0.0 0.2 GO:0007320 insemination(GO:0007320)
0.0 0.3 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.1 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.4 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.0 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
0.0 0.4 GO:0044062 regulation of excretion(GO:0044062)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.7 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.2 3.0 GO:0031143 pseudopodium(GO:0031143)
0.1 0.7 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 0.5 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.4 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.6 GO:0000800 lateral element(GO:0000800)
0.0 2.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.7 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.3 0.8 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.1 4.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 3.3 GO:0008483 transaminase activity(GO:0008483)
0.1 0.5 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.4 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.1 0.3 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 2.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 1.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.7 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 1.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.4 GO:0015368 calcium:cation antiporter activity(GO:0015368)
0.0 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 1.4 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 2.9 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 PID IGF1 PATHWAY IGF1 pathway
0.0 2.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.0 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.9 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2