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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rbpj

Z-value: 0.53

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Transcription factors associated with Rbpj

Gene Symbol Gene ID Gene Info
ENSMUSG00000039191.6 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rbpjmm10_v2_chr5_+_53590215_53590351-0.028.9e-01Click!

Activity profile of Rbpj motif

Sorted Z-values of Rbpj motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rbpj

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.3 1.2 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.2 0.7 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.7 GO:0046271 phenylpropanoid catabolic process(GO:0046271) olefin metabolic process(GO:1900673)
0.1 0.4 GO:1904017 response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1 0.3 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.1 0.5 GO:0003322 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.1 0.7 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0033577 protein glycosylation in endoplasmic reticulum(GO:0033577)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.3 GO:0003134 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) embryonic heart tube anterior/posterior pattern specification(GO:0035054) corticotropin hormone secreting cell differentiation(GO:0060128)
0.1 0.2 GO:2000485 activation of protein kinase C activity(GO:1990051) regulation of glutamine transport(GO:2000485)
0.1 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.2 GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.1 0.2 GO:0036343 psychomotor behavior(GO:0036343)
0.1 0.4 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.2 GO:0046832 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.3 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 1.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.3 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.1 GO:1990859 cellular response to endothelin(GO:1990859)
0.0 0.2 GO:0002265 astrocyte activation involved in immune response(GO:0002265)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.0 0.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 1.2 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.1 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.7 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0048597 post-embryonic eye morphogenesis(GO:0048050) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.1 GO:0046294 ethanol oxidation(GO:0006069) formaldehyde catabolic process(GO:0046294)
0.0 0.1 GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.0 0.1 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.1 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.2 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.1 GO:0021995 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.3 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.1 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1990923 PET complex(GO:1990923)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.1 1.0 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.2 GO:0017133 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 3.8 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.7 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.3 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 3.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.5 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.4 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.4 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.1 0.4 GO:0033142 progesterone receptor binding(GO:0033142)
0.1 1.8 GO:0005550 pheromone binding(GO:0005550)
0.1 0.3 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.1 0.3 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 1.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 1.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.9 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.3 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.7 GO:0008408 3'-5' exonuclease activity(GO:0008408)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.4 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis