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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for En2

Z-value: 1.45

Motif logo

Transcription factors associated with En2

Gene Symbol Gene ID Gene Info
ENSMUSG00000039095.7 engrailed 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.289.4e-02Click!

Activity profile of En2 motif

Sorted Z-values of En2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of En2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
1.0 2.9 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.8 6.4 GO:0046874 quinolinate metabolic process(GO:0046874)
0.7 2.0 GO:0061290 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 1.1 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.5 1.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 5.3 GO:0005513 detection of calcium ion(GO:0005513)
0.5 1.9 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.4 3.1 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.4 1.3 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.4 1.3 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.4 1.6 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.4 1.6 GO:0050975 sensory perception of touch(GO:0050975)
0.4 1.6 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.3 1.0 GO:0050973 detection of mechanical stimulus involved in equilibrioception(GO:0050973)
0.3 3.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.3 2.5 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.3 4.1 GO:0015747 urate transport(GO:0015747)
0.3 1.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.3 1.8 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.2 1.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.2 0.9 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 1.4 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 4.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 1.7 GO:0019695 choline metabolic process(GO:0019695)
0.2 0.6 GO:0052564 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.2 1.8 GO:0006551 leucine metabolic process(GO:0006551)
0.2 1.3 GO:0019532 oxalate transport(GO:0019532)
0.2 1.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 0.5 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.4 GO:0060066 oviduct development(GO:0060066)
0.1 1.9 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 1.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 2.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.6 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 1.3 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.1 2.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.7 GO:0060178 regulation of exocyst localization(GO:0060178)
0.1 0.3 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.1 1.6 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.4 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 2.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 4.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 2.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.3 GO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220)
0.1 1.8 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.3 GO:1903538 meiotic sister chromatid cohesion, centromeric(GO:0051754) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.1 0.7 GO:0006449 regulation of translational termination(GO:0006449)
0.1 1.4 GO:0010225 response to UV-C(GO:0010225)
0.1 1.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.0 GO:0030497 fatty acid elongation(GO:0030497)
0.1 3.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.5 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.1 0.4 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.1 0.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 1.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 1.2 GO:0016556 mRNA modification(GO:0016556)
0.0 0.6 GO:0014029 neural crest formation(GO:0014029)
0.0 0.4 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.3 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.0 1.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 1.0 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 1.1 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.7 GO:0032570 response to progesterone(GO:0032570)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 2.6 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.0 0.1 GO:1903632 positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.0 1.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 2.6 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.7 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 1.3 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 1.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.2 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.8 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.7 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.7 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.6 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.3 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 1.3 GO:0006821 chloride transport(GO:0006821)
0.0 0.8 GO:0015807 L-amino acid transport(GO:0015807)
0.0 0.3 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.3 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.7 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 3.4 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.3 1.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 8.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 1.6 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.2 4.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.1 GO:1990357 terminal web(GO:1990357)
0.1 0.9 GO:0070695 FHF complex(GO:0070695)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.4 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 9.1 GO:0070469 respiratory chain(GO:0070469)
0.1 1.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.1 2.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.4 GO:0016600 flotillin complex(GO:0016600)
0.0 2.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 4.0 GO:0072562 blood microparticle(GO:0072562)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0071437 invadopodium(GO:0071437)
0.0 3.4 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.1 GO:0032420 stereocilium(GO:0032420)
0.0 1.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.4 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)
0.0 7.8 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.0 GO:0035841 growing cell tip(GO:0035838) new growing cell tip(GO:0035841)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.7 2.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.5 7.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 2.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 1.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 1.7 GO:0004104 cholinesterase activity(GO:0004104)
0.4 8.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.4 1.9 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.3 8.1 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 4.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 1.8 GO:0034056 estrogen response element binding(GO:0034056)
0.2 1.3 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 1.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 3.0 GO:0019825 oxygen binding(GO:0019825)
0.1 2.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.0 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.7 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.5 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 1.0 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 1.0 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 1.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 1.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.1 3.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.3 GO:0003681 bent DNA binding(GO:0003681)
0.1 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 3.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 3.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.3 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 2.9 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.8 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 2.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 2.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 2.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.0 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.1 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.3 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 2.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.9 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.6 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.4 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 3.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 2.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.4 6.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 5.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 1.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 1.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 4.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription