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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr4a2

Z-value: 0.92

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Transcription factors associated with Nr4a2

Gene Symbol Gene ID Gene Info
ENSMUSG00000026826.7 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57113053_57113072-0.202.5e-01Click!

Activity profile of Nr4a2 motif

Sorted Z-values of Nr4a2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr4a2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 1.7 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.3 1.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 2.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 3.2 GO:0015747 urate transport(GO:0015747)
0.2 0.9 GO:0050787 detoxification of mercury ion(GO:0050787)
0.2 0.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 3.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.7 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 0.7 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.1 1.0 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.1 0.5 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.5 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 1.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.4 GO:0003104 positive regulation of glomerular filtration(GO:0003104)
0.1 0.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.3 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.7 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.7 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 1.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.2 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.7 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.1 0.4 GO:0070672 response to interleukin-15(GO:0070672)
0.1 0.6 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.2 GO:0002465 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment(GO:0002362) peripheral T cell tolerance induction(GO:0002458) peripheral tolerance induction(GO:0002465) negative regulation of histone deacetylation(GO:0031064) negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.1 0.3 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 2.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.7 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.6 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.3 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.2 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.7 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.0 0.8 GO:0007602 phototransduction(GO:0007602)
0.0 0.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.2 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 1.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.3 GO:0007625 grooming behavior(GO:0007625)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0 0.6 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.8 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0006308 DNA catabolic process(GO:0006308)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.8 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.9 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.7 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0045179 apical cortex(GO:0045179)
0.0 1.8 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 3.2 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 2.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 3.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 1.0 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 0.5 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.2 1.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.7 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.3 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.3 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.8 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 2.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1