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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Isl1

Z-value: 0.43

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Transcription factors associated with Isl1

Gene Symbol Gene ID Gene Info
ENSMUSG00000042258.7 ISL1 transcription factor, LIM/homeodomain

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_1163096990.086.4e-01Click!

Activity profile of Isl1 motif

Sorted Z-values of Isl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Isl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070429 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.1 0.4 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.9 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 0.3 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.5 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.3 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 0.2 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.0 0.2 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.2 GO:0015793 glycerol transport(GO:0015793) renal water absorption(GO:0070295)
0.0 0.5 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.3 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.3 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.0 0.1 GO:0070315 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0 0.1 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.0 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.0 0.8 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.1 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.0 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0097513 myosin II filament(GO:0097513)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.1 0.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.4 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.2 GO:0019002 GMP binding(GO:0019002)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.2 GO:0019808 polyamine binding(GO:0019808)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade