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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Cebpa_Cebpg

Z-value: 1.78

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Transcription factors associated with Cebpa_Cebpg

Gene Symbol Gene ID Gene Info
ENSMUSG00000034957.9 CCAAT/enhancer binding protein (C/EBP), alpha
ENSMUSG00000056216.8 CCAAT/enhancer binding protein (C/EBP), gamma

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cebpamm10_v2_chr7_+_35119285_351193010.582.1e-04Click!
Cebpgmm10_v2_chr7_-_35056467_350565560.067.2e-01Click!

Activity profile of Cebpa_Cebpg motif

Sorted Z-values of Cebpa_Cebpg motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpa_Cebpg

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.4 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
1.8 10.6 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.3 1.3 GO:0071288 cellular response to mercury ion(GO:0071288)
0.8 3.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.7 0.7 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
0.6 1.8 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.5 2.0 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.5 15.8 GO:0046688 response to copper ion(GO:0046688)
0.4 0.8 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.4 5.1 GO:0015747 urate transport(GO:0015747)
0.4 1.8 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.3 15.5 GO:0006953 acute-phase response(GO:0006953)
0.3 1.1 GO:0046684 response to pyrethroid(GO:0046684)
0.3 1.9 GO:0051410 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.3 2.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.2 1.2 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 0.7 GO:0006507 GPI anchor release(GO:0006507) response to iron(II) ion(GO:0010040)
0.2 0.9 GO:0001887 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.2 1.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 0.8 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.2 0.9 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.2 0.9 GO:0006548 histidine catabolic process(GO:0006548)
0.2 4.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 5.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 1.4 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.2 0.6 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.2 0.3 GO:0045818 negative regulation of glycogen catabolic process(GO:0045818)
0.2 0.6 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.2 1.4 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.4 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 1.1 GO:0046449 creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1 6.7 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.8 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 1.1 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
0.1 0.5 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 3.5 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 0.7 GO:2000667 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.1 0.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 2.0 GO:0014823 response to activity(GO:0014823)
0.1 0.2 GO:1990868 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 0.4 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 2.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.5 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 1.4 GO:0033622 integrin activation(GO:0033622)
0.0 0.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.0 1.3 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:2001184 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 11.1 GO:0008202 steroid metabolic process(GO:0008202)
0.0 2.2 GO:0008542 visual learning(GO:0008542)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 1.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 2.0 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
0.0 0.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0030913 protein localization to paranode region of axon(GO:0002175) paranodal junction assembly(GO:0030913)
0.0 1.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.0 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.5 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.3 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.8 10.6 GO:0097418 neurofibrillary tangle(GO:0097418)
0.6 2.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 12.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 1.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.3 15.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.5 GO:0005577 fibrinogen complex(GO:0005577)
0.2 0.9 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.4 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 13.5 GO:0072562 blood microparticle(GO:0072562)
0.1 1.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.4 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.7 GO:0045179 apical cortex(GO:0045179)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.9 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.0 1.4 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 3.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 39.5 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
1.6 15.8 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.8 3.8 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.7 2.0 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.4 10.6 GO:0051787 misfolded protein binding(GO:0051787)
0.4 2.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 1.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.3 11.4 GO:0042056 chemoattractant activity(GO:0042056)
0.3 5.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 0.9 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.3 1.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 6.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 2.7 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 13.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.2 1.3 GO:0045340 mercury ion binding(GO:0045340)
0.2 1.3 GO:0005499 vitamin D binding(GO:0005499)
0.2 1.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 5.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.9 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.6 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.8 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.7 GO:0004630 phospholipase D activity(GO:0004630)
0.1 2.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.9 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 5.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 3.2 GO:0005507 copper ion binding(GO:0005507)
0.0 1.1 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.6 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 1.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 2.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.4 GO:0050815 phosphoserine binding(GO:0050815)
0.0 3.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.7 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 3.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 2.0 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.2 GO:0005262 calcium channel activity(GO:0005262)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 6.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 2.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 15.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 10.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 6.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.8 PID BMP PATHWAY BMP receptor signaling
0.1 1.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.7 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 2.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.4 15.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.4 6.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 2.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.3 2.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 1.8 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 3.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 12.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.2 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.2 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.7 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins