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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Vdr

Z-value: 0.79

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Transcription factors associated with Vdr

Gene Symbol Gene ID Gene Info
ENSMUSG00000022479.9 vitamin D (1,25-dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Vdrmm10_v2_chr15_-_97908261_979083160.134.4e-01Click!

Activity profile of Vdr motif

Sorted Z-values of Vdr motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Vdr

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.2 0.6 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.1 0.4 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 2.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.3 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.3 GO:1904446 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161) positive regulation of establishment of Sertoli cell barrier(GO:1904446) negative regulation of type B pancreatic cell development(GO:2000077)
0.1 0.4 GO:0036233 glycine import(GO:0036233)
0.1 0.4 GO:0006014 D-ribose metabolic process(GO:0006014)
0.1 0.3 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.9 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 0.6 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.2 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.2 GO:0071314 cellular response to cocaine(GO:0071314)
0.1 0.4 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.5 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.6 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.1 0.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 0.3 GO:0009814 defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.1 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.2 GO:0000239 pachytene(GO:0000239)
0.1 0.2 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.1 0.9 GO:0033280 response to vitamin D(GO:0033280)
0.1 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.9 GO:0006670 sphingosine metabolic process(GO:0006670)
0.1 0.2 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.1 0.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.3 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.1 GO:0051466 paracrine signaling(GO:0038001) corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.4 GO:0060974 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.0 0.4 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.2 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0061511 centriole elongation(GO:0061511)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0015675 nickel cation transport(GO:0015675)
0.0 0.6 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.4 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.2 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.0 0.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.1 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.0 0.2 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.1 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.0 GO:1904348 negative regulation of gastro-intestinal system smooth muscle contraction(GO:1904305) negative regulation of small intestine smooth muscle contraction(GO:1904348)
0.0 0.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:1903026 ribosomal large subunit export from nucleus(GO:0000055) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:0060468 prevention of polyspermy(GO:0060468)
0.0 0.2 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.0 0.0 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.3 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.3 GO:0070633 transepithelial transport(GO:0070633)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.2 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.0 0.3 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 1.2 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.2 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 0.0 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.0 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 0.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.3 GO:0045070 positive regulation of viral genome replication(GO:0045070)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.1 0.3 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
0.1 0.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.3 GO:1990812 growth cone filopodium(GO:1990812)
0.1 0.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 2.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:1990923 PET complex(GO:1990923)
0.0 0.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:0070820 tertiary granule(GO:0070820)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0005767 secondary lysosome(GO:0005767)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.1 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0008147 structural constituent of bone(GO:0008147)
0.2 1.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 0.6 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.4 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 0.3 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 0.7 GO:0034711 inhibin binding(GO:0034711)
0.1 0.3 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 2.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.1 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.0 0.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.2 GO:0034584 piRNA binding(GO:0034584)
0.0 1.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.4 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.2 GO:0015099 nickel cation transmembrane transporter activity(GO:0015099)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.1 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.2 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID EPO PATHWAY EPO signaling pathway
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 1.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides