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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zfp282

Z-value: 1.52

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Transcription factors associated with Zfp282

Gene Symbol Gene ID Gene Info
ENSMUSG00000025821.9 zinc finger protein 282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp282mm10_v2_chr6_+_47877204_478772040.782.6e-08Click!

Activity profile of Zfp282 motif

Sorted Z-values of Zfp282 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp282

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0070488 neutrophil aggregation(GO:0070488)
3.3 9.9 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
2.6 7.8 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
1.3 10.3 GO:0015671 oxygen transport(GO:0015671)
1.3 3.8 GO:0070948 positive regulation of eosinophil degranulation(GO:0043311) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) positive regulation of renin secretion into blood stream(GO:1900135) positive regulation of eosinophil activation(GO:1902568)
1.0 4.0 GO:1902896 terminal web assembly(GO:1902896)
0.9 8.8 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.9 3.5 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.7 2.1 GO:0072194 intermediate mesoderm development(GO:0048389) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098) kidney smooth muscle tissue development(GO:0072194)
0.4 1.4 GO:0035552 tRNA wobble cytosine modification(GO:0002101) oxidative single-stranded DNA demethylation(GO:0035552)
0.3 2.1 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.3 2.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 3.0 GO:0036376 sodium ion export from cell(GO:0036376)
0.3 5.4 GO:0060263 regulation of respiratory burst(GO:0060263)
0.3 1.8 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 2.4 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 10.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.0 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 1.2 GO:0086043 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.9 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.1 1.4 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 0.4 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 2.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 2.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.7 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.4 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 1.1 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 2.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 11.7 GO:0048588 developmental cell growth(GO:0048588)
0.0 0.6 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.3 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 1.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 1.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 1.8 GO:0043200 response to amino acid(GO:0043200)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.1 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 9.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
2.2 8.8 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
1.3 10.3 GO:0005833 hemoglobin complex(GO:0005833)
0.7 10.9 GO:0042581 specific granule(GO:0042581)
0.5 5.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 1.3 GO:0000811 GINS complex(GO:0000811)
0.4 2.0 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.3 3.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 1.8 GO:0098536 deuterosome(GO:0098536)
0.2 1.7 GO:1990357 terminal web(GO:1990357)
0.2 3.8 GO:0031143 pseudopodium(GO:0031143)
0.2 1.3 GO:0042382 paraspeckles(GO:0042382)
0.2 2.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.3 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 1.8 GO:0032433 filopodium tip(GO:0032433)
0.1 11.4 GO:0072562 blood microparticle(GO:0072562)
0.1 11.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 7.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.2 GO:0014704 intercalated disc(GO:0014704)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.5 11.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.9 3.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.9 7.8 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.7 5.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.6 5.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 1.4 GO:0043734 DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.3 3.0 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 2.1 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 9.9 GO:0030507 spectrin binding(GO:0030507)
0.1 0.3 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 1.3 GO:1990405 protein antigen binding(GO:1990405)
0.1 0.6 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 1.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 10.2 GO:0005496 steroid binding(GO:0005496)
0.0 2.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 1.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 2.7 GO:0019843 rRNA binding(GO:0019843)
0.0 12.6 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 3.3 GO:0005125 cytokine activity(GO:0005125)
0.0 1.3 GO:0003725 double-stranded RNA binding(GO:0003725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 11.7 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.2 11.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 2.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.8 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 5.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.1 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 2.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 2.0 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.8 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 3.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 4.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 3.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism