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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hlf

Z-value: 0.94

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Transcription factors associated with Hlf

Gene Symbol Gene ID Gene Info
ENSMUSG00000003949.10 hepatic leukemia factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_903909260.511.3e-03Click!

Activity profile of Hlf motif

Sorted Z-values of Hlf motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hlf

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.4 1.2 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.4 1.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.3 3.0 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.3 1.3 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.3 1.6 GO:0097167 circadian regulation of translation(GO:0097167)
0.3 0.9 GO:0071288 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) cellular response to mercury ion(GO:0071288)
0.3 0.9 GO:0046710 GDP metabolic process(GO:0046710)
0.3 1.4 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.3 2.2 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.2 1.0 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.2 1.4 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 0.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 0.5 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 1.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 0.5 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.2 0.9 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.1 0.4 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 0.4 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 4.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.5 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.1 0.5 GO:0034760 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.1 0.4 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 0.3 GO:0071727 response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 1.1 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 0.4 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.1 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.1 0.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.3 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.3 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.1 0.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 2.8 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 0.4 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 1.1 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.4 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.1 0.3 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 0.2 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) regulation of glutamine transport(GO:2000485)
0.1 0.6 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 0.2 GO:0016259 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.1 0.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.6 GO:0044539 long-chain fatty acid import(GO:0044539)
0.1 0.5 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
0.1 2.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.4 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.1 1.7 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.3 GO:0072672 neutrophil extravasation(GO:0072672)
0.1 0.3 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.2 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.8 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 2.0 GO:0035036 sperm-egg recognition(GO:0035036)
0.0 1.8 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.2 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:1903722 regulation of centriole elongation(GO:1903722)
0.0 0.2 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 1.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 1.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.0 1.0 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.0 1.4 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0097501 stress response to metal ion(GO:0097501)
0.0 0.1 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.2 GO:0009651 response to salt stress(GO:0009651)
0.0 0.3 GO:0015747 urate transport(GO:0015747)
0.0 0.3 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 1.8 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.1 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.0 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.1 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.0 1.6 GO:0031638 zymogen activation(GO:0031638)
0.0 0.1 GO:1902477 defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.0 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.0 1.7 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0010845 regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.2 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 0.2 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 1.0 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 1.1 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 2.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 2.1 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.0 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0032010 phagolysosome(GO:0032010)
0.4 1.8 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.2 1.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 0.8 GO:0042583 chromaffin granule(GO:0042583)
0.1 2.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.4 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 1.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 1.1 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 3.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.7 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 20.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.4 1.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 2.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.3 0.9 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.3 1.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 2.0 GO:0001851 complement component C3b binding(GO:0001851)
0.3 0.8 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
0.2 1.9 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.2 1.0 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.2 1.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.2 3.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.5 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.2 0.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 0.5 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 0.9 GO:0045340 mercury ion binding(GO:0045340)
0.1 0.6 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.4 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.4 GO:0070401 NADP+ binding(GO:0070401) lithocholic acid binding(GO:1902121)
0.1 0.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.7 GO:0016019 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.1 1.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.9 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 4.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.4 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 0.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.6 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.4 GO:0019809 spermidine binding(GO:0019809)
0.1 0.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 1.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 2.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.3 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.1 1.0 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 0.2 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 5.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.4 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.2 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 2.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.2 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 2.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.8 GO:0043531 ADP binding(GO:0043531)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0030547 receptor inhibitor activity(GO:0030547)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 6.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 6.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 2.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 1.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.9 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.5 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 3.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.9 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell