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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxm1

Z-value: 0.77

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Transcription factors associated with Foxm1

Gene Symbol Gene ID Gene Info
ENSMUSG00000001517.8 forkhead box M1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxm1mm10_v2_chr6_+_128362919_128363058-0.192.7e-01Click!

Activity profile of Foxm1 motif

Sorted Z-values of Foxm1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxm1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.2 0.7 GO:0030573 bile acid catabolic process(GO:0030573)
0.2 4.0 GO:0019374 galactolipid metabolic process(GO:0019374)
0.1 1.7 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.4 GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.1 0.4 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 1.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.3 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 0.3 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.1 0.3 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1 0.2 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.1 0.3 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.0 1.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 1.1 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.0 0.3 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.8 GO:0097435 fibril organization(GO:0097435)
0.0 0.2 GO:0060022 hard palate development(GO:0060022)
0.0 1.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0090235 regulation of metaphase plate congression(GO:0090235)
0.0 0.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.6 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.3 GO:0043586 tongue development(GO:0043586)
0.0 0.2 GO:0015747 urate transport(GO:0015747)
0.0 0.3 GO:0090662 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.0 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.1 1.6 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.8 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 0.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 0.7 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.2 0.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 1.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.4 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.3 GO:0015254 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.1 1.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 1.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0036004 GAF domain binding(GO:0036004)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.3 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.2 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.0 0.4 GO:0005123 death receptor binding(GO:0005123)
0.0 2.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.2 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 3.7 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.1 2.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 2.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression