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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rorc_Nr1d1

Z-value: 0.36

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Transcription factors associated with Rorc_Nr1d1

Gene Symbol Gene ID Gene Info
ENSMUSG00000028150.8 RAR-related orphan receptor gamma
ENSMUSG00000020889.11 nuclear receptor subfamily 1, group D, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1d1mm10_v2_chr11_-_98775333_98775354-0.173.1e-01Click!
Rorcmm10_v2_chr3_+_94372794_94372872-0.163.6e-01Click!

Activity profile of Rorc_Nr1d1 motif

Sorted Z-values of Rorc_Nr1d1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rorc_Nr1d1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.1 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.2 GO:0071104 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 1.0 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.2 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of neutrophil migration(GO:1902623)
0.0 0.1 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of eosinophil activation(GO:1902567) negative regulation of activation of JAK2 kinase activity(GO:1902569) negative regulation of eosinophil migration(GO:2000417)
0.0 0.2 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 0.1 GO:0050973 detection of mechanical stimulus involved in equilibrioception(GO:0050973)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.2 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.2 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0 0.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.1 GO:0007113 endomitotic cell cycle(GO:0007113)
0.0 0.3 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.2 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 1.3 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding(GO:1990269)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.0 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0016503 pheromone receptor activity(GO:0016503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling