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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zic4

Z-value: 0.53

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Transcription factors associated with Zic4

Gene Symbol Gene ID Gene Info
ENSMUSG00000036972.8 zinc finger protein of the cerebellum 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91378636_91378646-0.029.2e-01Click!

Activity profile of Zic4 motif

Sorted Z-values of Zic4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zic4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0051410 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.4 1.1 GO:0097274 urea homeostasis(GO:0097274)
0.3 0.9 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.3 1.8 GO:0015862 uridine transport(GO:0015862)
0.2 0.9 GO:0014916 regulation of lung blood pressure(GO:0014916)
0.2 0.7 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.2 0.6 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.2 1.1 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.2 0.5 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 1.3 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.7 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.6 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.4 GO:0002266 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268) interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.6 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 0.5 GO:0061428 positive regulation of oocyte development(GO:0060282) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.4 GO:0097490 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.1 0.7 GO:0060454 positive regulation of gastric acid secretion(GO:0060454)
0.1 0.4 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.1 0.5 GO:0035106 operant conditioning(GO:0035106)
0.1 0.3 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.1 0.3 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 0.2 GO:0009957 epidermal cell fate specification(GO:0009957)
0.1 0.5 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.3 GO:1903588 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 1.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.2 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.1 1.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.5 GO:0060214 endocardium formation(GO:0060214)
0.1 1.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 0.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.3 GO:0072719 cellular response to cisplatin(GO:0072719)
0.1 0.2 GO:0060854 patterning of lymph vessels(GO:0060854)
0.1 0.2 GO:0030026 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 1.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.2 GO:2001025 positive regulation of response to drug(GO:2001025)
0.0 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.3 GO:0070317 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.8 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.3 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.3 GO:0061042 vascular wound healing(GO:0061042)
0.0 1.6 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.7 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 0.2 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.1 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.5 GO:0060384 innervation(GO:0060384)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.2 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.0 0.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0 0.0 GO:0019230 proprioception(GO:0019230)
0.0 0.2 GO:0015874 norepinephrine transport(GO:0015874)
0.0 0.0 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.2 GO:0008272 sulfate transport(GO:0008272)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.4 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0034587 piRNA metabolic process(GO:0034587)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005608 laminin-3 complex(GO:0005608)
0.1 0.4 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.5 GO:0033010 paranodal junction(GO:0033010)
0.1 0.7 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 1.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:0071547 piP-body(GO:0071547)
0.0 0.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.3 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.4 1.2 GO:0051765 inositol tetrakisphosphate kinase activity(GO:0051765)
0.2 0.7 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.2 0.6 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.2 0.5 GO:0030977 taurine binding(GO:0030977)
0.2 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.9 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 3.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.5 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.1 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.7 GO:0002054 nucleobase binding(GO:0002054) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 1.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.1 1.0 GO:0043495 protein anchor(GO:0043495)
0.1 0.2 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.1 0.2 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.2 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.2 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.7 GO:0010314 DNA binding, bending(GO:0008301) phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.4 GO:0045499 neuropilin binding(GO:0038191) chemorepellent activity(GO:0045499)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 2.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.7 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation