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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Irf4

Z-value: 0.31

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Transcription factors associated with Irf4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021356.3 interferon regulatory factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf4mm10_v2_chr13_+_30749226_307492470.077.0e-01Click!

Activity profile of Irf4 motif

Sorted Z-values of Irf4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.1 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.2 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.0 0.2 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.4 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0034769 basement membrane disassembly(GO:0034769)
0.0 0.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.1 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0 0.1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)
0.0 0.0 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.0 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.0 0.1 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 0.1 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.1 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 0.1 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.1 GO:0002135 CTP binding(GO:0002135)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.0 0.2 GO:0042608 T cell receptor binding(GO:0042608)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion