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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rhox4e_Rhox6_Vax2

Z-value: 1.24

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Transcription factors associated with Rhox4e_Rhox6_Vax2

Gene Symbol Gene ID Gene Info
ENSMUSG00000071770.4 reproductive homeobox 4E
ENSMUSG00000006200.3 reproductive homeobox 6
ENSMUSG00000034777.1 ventral anterior homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rhox4emm10_v2_chrX_+_37557412_37557412-0.563.7e-04Click!
Vax2mm10_v2_chr6_+_83711232_83711288-0.492.2e-03Click!

Activity profile of Rhox4e_Rhox6_Vax2 motif

Sorted Z-values of Rhox4e_Rhox6_Vax2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.6 2.6 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.6 1.8 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.5 1.4 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.5 5.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.4 1.6 GO:0032379 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.4 3.1 GO:0019532 oxalate transport(GO:0019532)
0.4 1.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.4 5.1 GO:0015747 urate transport(GO:0015747)
0.3 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 1.4 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.3 1.9 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.3 0.9 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.3 1.2 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.3 1.4 GO:0006048 glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.2 0.7 GO:0060364 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 3.2 GO:0030497 fatty acid elongation(GO:0030497)
0.2 0.9 GO:0006742 NADP catabolic process(GO:0006742)
0.2 11.8 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 0.7 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.2 0.7 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.2 1.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.4 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 0.4 GO:0072244 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.8 GO:0033762 response to glucagon(GO:0033762)
0.1 0.8 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.8 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 2.3 GO:0051923 sulfation(GO:0051923)
0.1 1.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 1.1 GO:0050955 thermoception(GO:0050955)
0.1 0.7 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 1.2 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 1.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 3.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 2.5 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.6 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 0.5 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.1 2.8 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.5 GO:0018158 protein oxidation(GO:0018158)
0.1 0.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.2 GO:0006566 threonine metabolic process(GO:0006566)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 1.6 GO:0021854 hypothalamus development(GO:0021854)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 3.8 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 1.0 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.3 GO:0009946 proximal/distal axis specification(GO:0009946)
0.0 0.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 1.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 3.5 GO:0007566 embryo implantation(GO:0007566)
0.0 2.9 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 2.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.0 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 1.0 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.4 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.5 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 0.4 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.3 GO:0072221 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 2.1 GO:0016574 histone ubiquitination(GO:0016574)
0.0 1.1 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.5 GO:0002544 chronic inflammatory response(GO:0002544)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.4 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.0 0.7 GO:0044062 regulation of excretion(GO:0044062)
0.0 0.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.4 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.3 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.7 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 1.0 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.3 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.5 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 4.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.1 GO:0002606 dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 0.0 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0033503 HULC complex(GO:0033503)
0.3 1.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.2 5.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 1.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 2.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.6 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 0.7 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.8 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.5 GO:0097413 Lewy body(GO:0097413)
0.1 3.3 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 3.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.0 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 9.0 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 4.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.6 2.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.5 1.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.5 1.4 GO:0070540 stearic acid binding(GO:0070540)
0.5 2.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.5 3.6 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.4 1.6 GO:0033814 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.4 9.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.4 1.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 3.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 3.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.9 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.7 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.1 0.6 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 0.8 GO:0034056 estrogen response element binding(GO:0034056)
0.1 3.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 6.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 3.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 3.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 2.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.2 GO:0004793 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.2 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.1 2.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.4 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.0 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 2.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.1 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.3 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 1.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.2 GO:0051378 serotonin binding(GO:0051378)
0.0 5.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.4 GO:0048029 monosaccharide binding(GO:0048029)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 14.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID IGF1 PATHWAY IGF1 pathway
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 ST ADRENERGIC Adrenergic Pathway
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 3.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 0.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 0.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 0.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 2.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo