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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Smad2

Z-value: 0.31

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
ENSMUSG00000024563.9 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241892_76242046-0.144.1e-01Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.0 0.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0038189 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0021853 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.8 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.4 GO:0014823 response to activity(GO:0014823)
0.0 0.4 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.4 GO:0019433 triglyceride catabolic process(GO:0019433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:1990239 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
0.0 0.1 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 0.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors