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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Smad3

Z-value: 0.98

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Transcription factors associated with Smad3

Gene Symbol Gene ID Gene Info
ENSMUSG00000032402.6 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.251.4e-01Click!

Activity profile of Smad3 motif

Sorted Z-values of Smad3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.6 12.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.5 1.8 GO:0046898 response to cycloheximide(GO:0046898)
0.2 1.0 GO:0010040 response to iron(II) ion(GO:0010040)
0.1 1.0 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.4 GO:0046101 germinal center B cell differentiation(GO:0002314) adenosine catabolic process(GO:0006154) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) purine deoxyribonucleoside metabolic process(GO:0046122)
0.1 2.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.4 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.1 0.5 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.1 0.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 1.3 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.3 GO:0060618 nipple development(GO:0060618)
0.1 0.8 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.1 9.1 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.3 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 0.2 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 0.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.5 GO:0051025 negative regulation of immunoglobulin secretion(GO:0051025)
0.0 0.4 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 0.2 GO:0018197 peptidyl-aspartic acid modification(GO:0018197)
0.0 4.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.7 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.6 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.7 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.2 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.4 GO:0046325 negative regulation of glucose import(GO:0046325)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0046691 intracellular canaliculus(GO:0046691)
0.3 11.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 9.0 GO:0000786 nucleosome(GO:0000786)
0.2 1.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.2 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 1.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0001520 outer dense fiber(GO:0001520)
0.0 4.9 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.3 0.8 GO:0005009 insulin-activated receptor activity(GO:0005009) pheromone activity(GO:0005186)
0.2 1.8 GO:0051434 BH3 domain binding(GO:0051434)
0.2 1.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.3 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 0.4 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.1 1.0 GO:0015250 water channel activity(GO:0015250)
0.1 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 12.1 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 1.3 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 17.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.3 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)