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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr1h2

Z-value: 1.37

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Transcription factors associated with Nr1h2

Gene Symbol Gene ID Gene Info
ENSMUSG00000060601.6 nuclear receptor subfamily 1, group H, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_44553955-0.473.9e-03Click!

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0 2.9 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.9 3.8 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.7 2.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.5 2.7 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.4 17.2 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.4 3.4 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.4 3.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.4 2.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 3.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte maturation(GO:1900194)
0.3 2.8 GO:0007144 female meiosis I(GO:0007144)
0.3 1.0 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.3 1.7 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of arachidonic acid secretion(GO:0090238) positive regulation of ceramide biosynthetic process(GO:2000304)
0.3 0.9 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.3 1.0 GO:2000338 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.3 0.8 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.3 2.0 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 0.7 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.2 0.7 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) endothelial cell-cell adhesion(GO:0071603)
0.2 1.4 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.2 4.0 GO:0042448 progesterone metabolic process(GO:0042448)
0.2 3.6 GO:0046415 urate metabolic process(GO:0046415)
0.2 5.2 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.2 0.7 GO:1903943 skeletal muscle atrophy(GO:0014732) negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 0.5 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.2 0.7 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 0.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 9.0 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.1 1.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 1.1 GO:0006013 mannose metabolic process(GO:0006013)
0.1 1.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 1.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.1 0.7 GO:0048318 protein O-linked glycosylation via serine(GO:0018242) axial mesoderm development(GO:0048318)
0.1 0.5 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 2.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.6 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.1 0.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 3.8 GO:0050891 multicellular organismal water homeostasis(GO:0050891)
0.1 1.1 GO:0002934 desmosome organization(GO:0002934)
0.1 3.4 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.5 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 2.2 GO:1901739 regulation of myoblast fusion(GO:1901739) positive regulation of myoblast fusion(GO:1901741)
0.1 1.5 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.1 1.8 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.5 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 0.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 1.2 GO:0007141 male meiosis I(GO:0007141)
0.1 0.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.6 GO:0070673 response to interleukin-18(GO:0070673)
0.1 1.6 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 5.2 GO:0000045 autophagosome assembly(GO:0000045)
0.1 0.9 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.8 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 1.0 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 3.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 1.5 GO:0019236 response to pheromone(GO:0019236)
0.0 0.4 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 2.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.8 GO:0097435 fibril organization(GO:0097435)
0.0 0.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.6 GO:0030575 nuclear body organization(GO:0030575)
0.0 1.6 GO:0042439 ethanolamine-containing compound metabolic process(GO:0042439)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.3 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.0 1.0 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0006265 DNA topological change(GO:0006265)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0097447 dendritic tree(GO:0097447)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.2 3.8 GO:0034706 sodium channel complex(GO:0034706)
0.1 1.2 GO:0045098 type III intermediate filament(GO:0045098)
0.1 3.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.8 GO:0005827 polar microtubule(GO:0005827)
0.1 1.6 GO:0044754 autolysosome(GO:0044754)
0.1 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.8 GO:0042627 chylomicron(GO:0042627)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.1 4.8 GO:0005776 autophagosome(GO:0005776)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.8 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 10.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.6 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.8 3.8 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.7 3.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.7 3.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.6 2.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.5 2.5 GO:0032810 sterol response element binding(GO:0032810)
0.5 3.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.3 1.0 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.3 2.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 3.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.3 1.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704) IkappaB kinase activity(GO:0008384)
0.2 4.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 1.8 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 0.7 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.2 1.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 5.7 GO:0070330 aromatase activity(GO:0070330)
0.2 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 1.7 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 3.1 GO:0019825 oxygen binding(GO:0019825)
0.2 1.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.5 GO:0019809 spermidine binding(GO:0019809)
0.1 0.8 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 4.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.7 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 1.0 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.1 0.6 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 0.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.2 GO:0019215 intermediate filament binding(GO:0019215)
0.1 3.2 GO:0005109 frizzled binding(GO:0005109)
0.1 0.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 1.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 1.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 4.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.8 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 1.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 13.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 3.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 3.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.7 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 8.5 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 3.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 7.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.3 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.1 3.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 2.5 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis