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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-1

Z-value: 1.15

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Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
ENSMUSG00000001496.9 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.241.6e-01Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.9 6.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.8 4.7 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.6 1.7 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.5 1.4 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.4 1.5 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.4 1.8 GO:0097167 circadian regulation of translation(GO:0097167)
0.3 3.5 GO:0015705 iodide transport(GO:0015705)
0.3 1.7 GO:1903059 regulation of protein lipidation(GO:1903059)
0.3 1.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.3 3.4 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.3 1.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.6 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 0.7 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.2 2.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.2 2.4 GO:0035898 parathyroid hormone secretion(GO:0035898) calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 1.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 0.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.2 0.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 0.7 GO:1904306 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.2 1.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 1.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.3 GO:0019046 release from viral latency(GO:0019046)
0.1 1.4 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 7.8 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.1 0.9 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 0.9 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 1.0 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.1 0.2 GO:0072034 renal vesicle induction(GO:0072034)
0.1 1.4 GO:0031280 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.7 GO:0035878 nail development(GO:0035878)
0.1 1.4 GO:0051573 lateral ventricle development(GO:0021670) negative regulation of histone H3-K9 methylation(GO:0051573)
0.1 0.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 3.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 1.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.9 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.8 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.3 GO:0071397 cellular response to cholesterol(GO:0071397)
0.0 2.3 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 1.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.7 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 1.5 GO:0045471 response to ethanol(GO:0045471)
0.0 2.6 GO:0007586 digestion(GO:0007586)
0.0 0.1 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 1.3 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.3 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.0 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 2.1 GO:0000910 cytokinesis(GO:0000910)
0.0 0.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.4 5.0 GO:0097208 alveolar lamellar body(GO:0097208)
0.4 1.6 GO:0014802 terminal cisterna(GO:0014802)
0.3 1.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 2.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 1.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.5 GO:0042629 mast cell granule(GO:0042629)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.2 GO:0032039 integrator complex(GO:0032039)
0.1 0.7 GO:0000801 central element(GO:0000801)
0.1 0.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 1.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 5.3 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 22.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.4 GO:0004977 melanocortin receptor activity(GO:0004977)
1.1 13.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.5 1.6 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.5 1.5 GO:0019959 interleukin-8 binding(GO:0019959)
0.5 6.9 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.4 2.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.2 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 2.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 5.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 2.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 3.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 2.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 4.6 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 3.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.1 PID AURORA A PATHWAY Aurora A signaling
0.1 1.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 6.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.5 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.4 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.1 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 6.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 11.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 4.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME TRANSLATION Genes involved in Translation