avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Hnf1a
|
ENSMUSG00000029556.6 | HNF1 homeobox A |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hnf1a | mm10_v2_chr5_-_114971056_114971079 | 0.47 | 3.5e-03 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.5 | 10.6 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
2.8 | 17.0 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
2.6 | 15.6 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
2.5 | 7.6 | GO:0010534 | regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569) |
2.3 | 13.9 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
2.2 | 6.7 | GO:0051659 | maintenance of mitochondrion location(GO:0051659) |
2.0 | 5.9 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
1.9 | 7.8 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
1.7 | 6.9 | GO:0015851 | nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855) |
1.6 | 23.6 | GO:0052695 | cellular glucuronidation(GO:0052695) |
1.5 | 6.2 | GO:0009436 | glyoxylate catabolic process(GO:0009436) |
1.4 | 10.1 | GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) |
1.4 | 7.1 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
1.4 | 6.9 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) |
1.2 | 3.6 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
1.1 | 4.5 | GO:0009750 | response to fructose(GO:0009750) |
1.1 | 5.6 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
1.1 | 4.4 | GO:0009441 | glycolate metabolic process(GO:0009441) |
1.1 | 3.2 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
0.9 | 4.3 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.8 | 37.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.7 | 2.1 | GO:0033686 | positive regulation of luteinizing hormone secretion(GO:0033686) |
0.7 | 2.1 | GO:0033189 | response to vitamin A(GO:0033189) |
0.6 | 11.4 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
0.5 | 6.0 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
0.5 | 13.7 | GO:0017144 | drug metabolic process(GO:0017144) |
0.5 | 2.0 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
0.5 | 2.0 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
0.5 | 2.9 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.5 | 7.9 | GO:0051608 | histamine transport(GO:0051608) |
0.4 | 10.5 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.4 | 3.9 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
0.3 | 2.4 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.3 | 1.0 | GO:0034443 | negative regulation of lipoprotein oxidation(GO:0034443) |
0.3 | 9.5 | GO:0008211 | glucocorticoid metabolic process(GO:0008211) |
0.3 | 2.8 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.3 | 1.8 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
0.3 | 1.0 | GO:0035565 | regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146) |
0.2 | 5.5 | GO:0071501 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
0.2 | 3.4 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
0.2 | 1.9 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
0.2 | 9.4 | GO:0051180 | vitamin transport(GO:0051180) |
0.1 | 3.9 | GO:0014823 | response to activity(GO:0014823) |
0.1 | 1.3 | GO:0015705 | iodide transport(GO:0015705) |
0.1 | 2.2 | GO:0010225 | response to UV-C(GO:0010225) |
0.1 | 13.2 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
0.1 | 4.9 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.1 | 4.6 | GO:0010824 | regulation of centrosome duplication(GO:0010824) |
0.1 | 2.1 | GO:0055090 | acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328) |
0.1 | 0.2 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
0.1 | 0.2 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
0.1 | 15.4 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
0.1 | 0.4 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
0.0 | 0.2 | GO:0042488 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) regulation of enamel mineralization(GO:0070173) |
0.0 | 4.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 4.4 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
0.0 | 5.7 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
0.0 | 4.4 | GO:0001578 | microtubule bundle formation(GO:0001578) |
0.0 | 2.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
0.0 | 0.8 | GO:0010996 | response to auditory stimulus(GO:0010996) |
0.0 | 3.5 | GO:0098656 | anion transmembrane transport(GO:0098656) |
0.0 | 1.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 2.2 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) |
0.0 | 3.6 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 2.8 | GO:0070507 | regulation of microtubule cytoskeleton organization(GO:0070507) |
0.0 | 0.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 17.0 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567) |
1.8 | 7.1 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
1.0 | 1.0 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
0.8 | 10.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.7 | 5.9 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.6 | 5.6 | GO:0005579 | membrane attack complex(GO:0005579) |
0.3 | 3.4 | GO:0031983 | vesicle lumen(GO:0031983) |
0.3 | 2.9 | GO:0005915 | zonula adherens(GO:0005915) |
0.3 | 40.4 | GO:0072562 | blood microparticle(GO:0072562) |
0.3 | 6.0 | GO:0005922 | connexon complex(GO:0005922) |
0.2 | 27.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
0.1 | 1.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.1 | 2.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.1 | 1.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.1 | 20.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.1 | 0.4 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
0.0 | 4.6 | GO:0072686 | mitotic spindle(GO:0072686) |
0.0 | 10.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
0.0 | 4.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 3.9 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 6.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 3.6 | GO:0030133 | transport vesicle(GO:0030133) |
0.0 | 2.8 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 2.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.0 | 1.3 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 4.4 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 9.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.0 | 24.7 | GO:0005794 | Golgi apparatus(GO:0005794) |
0.0 | 5.7 | GO:0005667 | transcription factor complex(GO:0005667) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.6 | 13.9 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
4.2 | 12.7 | GO:0008431 | vitamin E binding(GO:0008431) |
3.8 | 11.4 | GO:1902271 | D3 vitamins binding(GO:1902271) |
3.1 | 15.6 | GO:0004925 | prolactin receptor activity(GO:0004925) |
2.6 | 7.9 | GO:0005333 | norepinephrine transmembrane transporter activity(GO:0005333) |
2.5 | 7.6 | GO:0070540 | stearic acid binding(GO:0070540) |
2.5 | 10.1 | GO:0004058 | aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468) |
1.5 | 6.2 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
1.4 | 6.9 | GO:0005350 | purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254) |
1.3 | 7.8 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
1.1 | 42.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
1.1 | 4.4 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
0.7 | 5.9 | GO:0015198 | oligopeptide transporter activity(GO:0015198) |
0.6 | 3.6 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
0.6 | 4.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
0.5 | 7.1 | GO:1990405 | protein antigen binding(GO:1990405) |
0.5 | 5.9 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.5 | 3.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.4 | 17.0 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539) |
0.4 | 6.7 | GO:0015643 | toxic substance binding(GO:0015643) |
0.4 | 13.7 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
0.4 | 3.6 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
0.4 | 6.0 | GO:0005243 | gap junction channel activity(GO:0005243) |
0.4 | 49.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.4 | 6.0 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.3 | 3.9 | GO:0005347 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
0.2 | 5.7 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
0.2 | 4.4 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.2 | 1.3 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
0.1 | 7.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.1 | 3.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.1 | 2.0 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 2.9 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.1 | 0.4 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
0.1 | 2.2 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.1 | 0.2 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
0.1 | 13.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.1 | 2.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 5.6 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
0.1 | 7.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.1 | 3.6 | GO:0005549 | odorant binding(GO:0005549) |
0.0 | 2.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.0 | 0.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.0 | 2.8 | GO:0005518 | collagen binding(GO:0005518) |
0.0 | 2.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
0.0 | 1.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 4.0 | GO:0015293 | symporter activity(GO:0015293) |
0.0 | 4.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 4.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 1.0 | GO:0016209 | antioxidant activity(GO:0016209) |
0.0 | 2.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 7.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
0.4 | 22.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.2 | 13.9 | PID FOXO PATHWAY | FoxO family signaling |
0.2 | 9.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.2 | 15.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
0.2 | 7.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 22.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 3.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
0.1 | 3.6 | PID FGF PATHWAY | FGF signaling pathway |
0.1 | 7.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.1 | 4.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
0.0 | 1.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
0.0 | 2.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 3.5 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.6 | 13.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
1.2 | 16.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
0.8 | 15.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
0.7 | 6.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
0.6 | 9.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
0.6 | 7.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
0.6 | 7.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
0.6 | 6.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.5 | 10.1 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
0.5 | 3.7 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.4 | 5.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.4 | 18.4 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
0.3 | 11.4 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
0.3 | 6.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
0.3 | 5.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.2 | 7.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
0.2 | 6.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
0.2 | 3.6 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
0.1 | 1.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.1 | 6.9 | REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
0.1 | 1.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
0.1 | 2.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.1 | 2.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 4.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 4.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
0.0 | 3.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |