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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zbtb12

Z-value: 1.23

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Transcription factors associated with Zbtb12

Gene Symbol Gene ID Gene Info
ENSMUSG00000049823.8 zinc finger and BTB domain containing 12

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.702.5e-06Click!

Activity profile of Zbtb12 motif

Sorted Z-values of Zbtb12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0070347 brown fat cell proliferation(GO:0070342) regulation of brown fat cell proliferation(GO:0070347)
1.6 4.7 GO:1903918 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
1.5 4.5 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
1.0 3.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.7 2.1 GO:0046439 cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.5 2.1 GO:2001027 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.4 1.3 GO:0046166 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 0.9 GO:0061193 taste bud development(GO:0061193)
0.2 0.5 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608)
0.2 1.1 GO:0018094 protein polyglycylation(GO:0018094)
0.2 1.5 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.2 0.5 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.5 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 0.6 GO:1902303 negative regulation of potassium ion export(GO:1902303)
0.2 1.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 1.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.7 GO:0034196 blood coagulation, intrinsic pathway(GO:0007597) acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.3 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.2 GO:0015755 fructose transport(GO:0015755)
0.1 1.6 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.2 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 0.6 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.8 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.8 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.0 0.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 1.0 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 2.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.4 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0 1.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.5 GO:0001832 blastocyst growth(GO:0001832)
0.0 0.3 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.4 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.2 GO:0042101 T cell receptor complex(GO:0042101)
0.2 2.1 GO:0001520 outer dense fiber(GO:0001520)
0.2 0.5 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.1 1.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.8 GO:0061617 MICOS complex(GO:0061617)
0.1 0.4 GO:1990745 EARP complex(GO:1990745)
0.0 0.9 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 3.3 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.8 4.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.7 14.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.5 2.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.4 1.1 GO:0070736 protein-glycine ligase activity, initiating(GO:0070736)
0.3 0.9 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.2 1.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 2.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.2 GO:2001069 glycogen binding(GO:2001069)
0.1 0.3 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0034056 estrogen response element binding(GO:0034056)
0.0 1.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 1.5 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.9 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport