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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Stat1

Z-value: 1.00

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Transcription factors associated with Stat1

Gene Symbol Gene ID Gene Info
ENSMUSG00000026104.8 signal transducer and activator of transcription 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Stat1mm10_v2_chr1_+_52119438_521194990.401.6e-02Click!

Activity profile of Stat1 motif

Sorted Z-values of Stat1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.5 1.6 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.4 1.3 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.4 0.4 GO:1903059 regulation of protein lipidation(GO:1903059)
0.3 1.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 1.7 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.3 1.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 0.9 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.3 0.9 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 1.7 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 0.9 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.2 0.6 GO:1902022 regulation of renal output by angiotensin(GO:0002019) regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) response to muscle activity involved in regulation of muscle adaptation(GO:0014873) L-lysine transport(GO:1902022)
0.2 1.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.2 0.5 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
0.2 0.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 0.8 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.9 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.1 0.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.5 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.1 0.4 GO:0002436 immune complex clearance by monocytes and macrophages(GO:0002436) monocyte homeostasis(GO:0035702) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265)
0.1 1.1 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.4 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.1 0.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 1.1 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.1 0.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.5 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.2 GO:0034760 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.1 2.1 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 3.0 GO:0009409 response to cold(GO:0009409)
0.1 0.2 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 1.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.2 GO:0060416 response to growth hormone(GO:0060416)
0.1 0.9 GO:0031000 response to caffeine(GO:0031000)
0.1 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.6 GO:0002551 mast cell chemotaxis(GO:0002551) mast cell migration(GO:0097531)
0.0 0.4 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.6 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.0 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 1.3 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.1 GO:0043096 germinal center B cell differentiation(GO:0002314) adenosine catabolic process(GO:0006154) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) purine deoxyribonucleoside metabolic process(GO:0046122) negative regulation of mucus secretion(GO:0070256)
0.0 0.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.4 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.8 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 1.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.3 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.6 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.5 GO:0030220 platelet formation(GO:0030220)
0.0 0.6 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0 0.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.3 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043) regulation of somitogenesis(GO:0014807)
0.0 0.9 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 0.3 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.4 GO:0070266 necroptotic process(GO:0070266)
0.0 0.1 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.0 0.2 GO:2000194 regulation of female gonad development(GO:2000194)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0033193 Lsd1/2 complex(GO:0033193)
0.4 1.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 1.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.0 GO:0060187 cell pole(GO:0060187)
0.2 1.1 GO:0001740 Barr body(GO:0001740)
0.1 0.4 GO:0044299 C-fiber(GO:0044299)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.1 0.7 GO:0042825 TAP complex(GO:0042825)
0.1 0.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.4 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.7 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 1.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.2 GO:0097165 nuclear stress granule(GO:0097165)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 2.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 1.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 3.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 1.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.3 0.9 GO:0004461 lactose synthase activity(GO:0004461)
0.2 0.9 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 0.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 1.8 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 0.7 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 0.8 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 0.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.2 1.3 GO:0045545 syndecan binding(GO:0045545)
0.2 1.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.7 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.7 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 0.3 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.9 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.4 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0000401 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 4.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 2.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0043621 protein self-association(GO:0043621)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 0.9 REACTOME DEFENSINS Genes involved in Defensins
0.1 0.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 0.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway