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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pou2f1

Z-value: 1.46

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Transcription factors associated with Pou2f1

Gene Symbol Gene ID Gene Info
ENSMUSG00000026565.12 POU domain, class 2, transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou2f1mm10_v2_chr1_-_165934900_1659350360.728.0e-07Click!

Activity profile of Pou2f1 motif

Sorted Z-values of Pou2f1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou2f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.0 4.0 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.9 2.8 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.8 2.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.8 3.8 GO:2000471 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.7 3.7 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.7 2.2 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.7 2.0 GO:0007521 muscle cell fate determination(GO:0007521)
0.7 5.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.6 2.6 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.6 1.9 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.6 1.8 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.6 2.9 GO:0009115 xanthine catabolic process(GO:0009115) xanthine metabolic process(GO:0046110)
0.5 2.6 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 1.4 GO:0030210 heparin biosynthetic process(GO:0030210)
0.5 2.3 GO:0035617 stress granule disassembly(GO:0035617)
0.4 2.1 GO:0042938 dipeptide transport(GO:0042938)
0.4 2.8 GO:0002326 B cell lineage commitment(GO:0002326)
0.4 1.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.3 2.7 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 13.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 4.8 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.3 1.3 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.3 2.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.3 2.9 GO:0070314 G1 to G0 transition(GO:0070314)
0.3 1.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 1.5 GO:0018343 protein farnesylation(GO:0018343)
0.3 1.7 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.3 1.1 GO:0046898 response to cycloheximide(GO:0046898)
0.3 1.6 GO:0072675 osteoclast fusion(GO:0072675)
0.3 1.0 GO:0043056 forward locomotion(GO:0043056)
0.2 6.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 2.5 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 1.6 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.2 1.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 0.7 GO:0090260 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.2 2.5 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.2 0.6 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.2 0.6 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.2 0.4 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 0.9 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.2 3.5 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.2 3.0 GO:0006000 fructose metabolic process(GO:0006000)
0.2 7.2 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 1.0 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.2 0.5 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.1 0.6 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.1 1.5 GO:0050862 adult feeding behavior(GO:0008343) positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 2.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.7 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.1 0.9 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.3 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 1.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 0.3 GO:2000584 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 9.4 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.8 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 8.6 GO:0006334 nucleosome assembly(GO:0006334)
0.1 6.4 GO:0030317 sperm motility(GO:0030317)
0.1 0.9 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 1.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.2 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.1 2.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.3 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 0.5 GO:0070561 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.1 10.6 GO:0007051 spindle organization(GO:0007051)
0.1 0.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.6 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 0.2 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.1 7.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 1.3 GO:0002385 mucosal immune response(GO:0002385)
0.0 1.8 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.6 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 6.0 GO:0007586 digestion(GO:0007586)
0.0 0.3 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0 0.8 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.9 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 1.0 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.7 GO:0010447 response to acidic pH(GO:0010447)
0.0 2.0 GO:0035690 cellular response to drug(GO:0035690)
0.0 1.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 1.3 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.6 GO:0031424 keratinization(GO:0031424)
0.0 2.5 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 1.5 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 1.6 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.4 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 1.1 GO:0048477 oogenesis(GO:0048477)
0.0 0.4 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.8 GO:0009988 cell-cell recognition(GO:0009988)
0.0 0.9 GO:0008542 visual learning(GO:0008542)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.4 GO:0060512 prostate gland morphogenesis(GO:0060512)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.0 7.2 GO:0008091 spectrin(GO:0008091)
0.7 13.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.5 1.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.5 2.5 GO:0097149 centralspindlin complex(GO:0097149)
0.5 2.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 2.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.3 1.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 1.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.3 9.5 GO:0001533 cornified envelope(GO:0001533)
0.2 14.4 GO:0000786 nucleosome(GO:0000786)
0.2 2.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.4 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.1 1.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 6.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 2.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.4 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.7 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 2.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 10.2 GO:0000922 spindle pole(GO:0000922)
0.1 0.8 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 5.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 1.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 3.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 0.8 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 1.0 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.5 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 3.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 11.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.0 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.6 GO:0014704 intercalated disc(GO:0014704)
0.0 1.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 5.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 2.0 GO:0030017 sarcomere(GO:0030017)
0.0 0.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.7 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
0.9 1.9 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.9 2.6 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.8 4.8 GO:0031493 nucleosomal histone binding(GO:0031493)
0.7 3.7 GO:0043532 angiostatin binding(GO:0043532)
0.7 2.1 GO:0042936 dipeptide transporter activity(GO:0042936)
0.6 2.9 GO:0004854 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.6 4.0 GO:0032027 myosin light chain binding(GO:0032027)
0.5 13.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.5 1.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.5 1.9 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.4 2.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.4 5.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.4 6.5 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 2.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 2.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 2.7 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 1.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2 1.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.6 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 8.2 GO:0030506 ankyrin binding(GO:0030506)
0.2 24.2 GO:0004540 ribonuclease activity(GO:0004540)
0.2 1.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.4 GO:0004064 arylesterase activity(GO:0004064)
0.2 2.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 4.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.8 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 2.0 GO:0003680 AT DNA binding(GO:0003680) miRNA binding(GO:0035198)
0.1 0.4 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 1.0 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.1 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 2.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667) prostaglandin-E synthase activity(GO:0050220)
0.1 0.9 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 6.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.9 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.3 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 1.3 GO:0016208 AMP binding(GO:0016208)
0.1 2.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 1.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.6 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 1.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 1.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.3 GO:0005549 odorant binding(GO:0005549)
0.0 6.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 2.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 5.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.9 PID AURORA B PATHWAY Aurora B signaling
0.1 4.0 PID S1P S1P3 PATHWAY S1P3 pathway
0.1 1.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 3.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 3.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.4 PID IL3 PATHWAY IL3-mediated signaling events
0.1 2.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 4.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 6.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID ATM PATHWAY ATM pathway
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.7 PID E2F PATHWAY E2F transcription factor network
0.0 1.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.3 3.8 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 7.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 1.8 REACTOME DEFENSINS Genes involved in Defensins
0.2 7.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 5.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 4.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 10.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 5.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 0.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 8.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.7 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.6 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription