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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pou6f2_Pou4f2

Z-value: 1.13

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Transcription factors associated with Pou6f2_Pou4f2

Gene Symbol Gene ID Gene Info
ENSMUSG00000009734.11 POU domain, class 6, transcription factor 2
ENSMUSG00000031688.3 POU domain, class 4, transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou4f2mm10_v2_chr8_-_78436640_78436649-0.271.1e-01Click!
Pou6f2mm10_v2_chr13_-_18382041_18382041-0.163.4e-01Click!

Activity profile of Pou6f2_Pou4f2 motif

Sorted Z-values of Pou6f2_Pou4f2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.6 1.8 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.2 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.2 0.6 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 1.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 0.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.1 0.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.1 1.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.3 GO:2000293 negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 0.2 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.1 0.8 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.2 GO:0099548 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 1.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:1900239 regulation of phenotypic switching(GO:1900239) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.2 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.5 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.5 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0060197 cloacal septation(GO:0060197)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:1903774 mitotic cytokinesis checkpoint(GO:0044878) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.2 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 0.5 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0060618 nipple development(GO:0060618)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.0 0.1 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.2 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.5 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.0 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
0.0 1.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 1.9 GO:0000502 proteasome complex(GO:0000502)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.6 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.9 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 5.4 GO:0008009 chemokine activity(GO:0008009)
0.1 1.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0030620 U2 snRNA binding(GO:0030620)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides