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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Rora

Z-value: 0.64

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Transcription factors associated with Rora

Gene Symbol Gene ID Gene Info
ENSMUSG00000032238.11 RAR-related orphan receptor alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Roramm10_v2_chr9_+_68653761_686537860.105.6e-01Click!

Activity profile of Rora motif

Sorted Z-values of Rora motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rora

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.5 1.4 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.4 1.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.3 1.0 GO:2000417 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of integrin activation(GO:0033624) negative regulation of interleukin-1 alpha secretion(GO:0050712) regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773) positive regulation of ovarian follicle development(GO:2000386) regulation of antral ovarian follicle growth(GO:2000387) positive regulation of antral ovarian follicle growth(GO:2000388) negative regulation of eosinophil migration(GO:2000417)
0.3 2.0 GO:0007144 female meiosis I(GO:0007144)
0.2 1.4 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.2 1.4 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 0.8 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.2 0.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 1.0 GO:0045585 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 0.6 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.6 GO:0036376 sodium ion export from cell(GO:0036376)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 1.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.9 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.3 GO:2000642 intralumenal vesicle formation(GO:0070676) negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 1.1 GO:0030432 peristalsis(GO:0030432)
0.1 0.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 1.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.4 GO:0048014 negative regulation of cytokine secretion involved in immune response(GO:0002740) Tie signaling pathway(GO:0048014)
0.1 0.2 GO:1903969 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 0.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 0.3 GO:0007113 endomitotic cell cycle(GO:0007113)
0.1 0.2 GO:0071846 actin filament debranching(GO:0071846)
0.1 0.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.3 GO:0021888 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
0.1 0.4 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616)
0.0 0.2 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0045872 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.5 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.6 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.4 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.3 GO:0043313 regulation of neutrophil degranulation(GO:0043313) regulation of neutrophil activation(GO:1902563)
0.0 0.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0051683 establishment of Golgi localization(GO:0051683)
0.0 0.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.1 GO:0015960 basophil activation involved in immune response(GO:0002276) diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.6 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0046103 inosine biosynthetic process(GO:0046103)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0003137 Notch signaling pathway involved in heart induction(GO:0003137) regulation of Notch signaling pathway involved in heart induction(GO:0035480) positive regulation of Notch signaling pathway involved in heart induction(GO:0035481) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 0.4 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.4 GO:0032693 positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of interleukin-10 production(GO:0032693)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:0031077 post-embryonic camera-type eye development(GO:0031077)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 1.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 1.2 GO:0005927 muscle tendon junction(GO:0005927)
0.2 0.9 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.7 GO:0071439 clathrin complex(GO:0071439)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.5 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.2 GO:0072534 perineuronal net(GO:0072534)
0.1 0.6 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.3 GO:0071546 pi-body(GO:0071546)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0097413 Lewy body(GO:0097413)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.4 GO:0005657 replication fork(GO:0005657)
0.0 0.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 1.8 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.2 1.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 0.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 1.0 GO:0002135 CTP binding(GO:0002135)
0.1 1.0 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.8 GO:0042731 PH domain binding(GO:0042731)
0.1 1.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.3 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 1.8 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 1.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.1 0.7 GO:0034711 inhibin binding(GO:0034711)
0.1 0.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding(GO:1990269)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.4 GO:0045294 dystroglycan binding(GO:0002162) alpha-catenin binding(GO:0045294)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.4 GO:0043621 protein self-association(GO:0043621)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0016918 retinal binding(GO:0016918)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0046625 sphingolipid binding(GO:0046625)
0.0 2.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID E2F PATHWAY E2F transcription factor network
0.0 0.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.9 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.0 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 0.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 0.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 2.4 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling