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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox21

Z-value: 1.09

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Transcription factors associated with Sox21

Gene Symbol Gene ID Gene Info
ENSMUSG00000061517.7 SRY (sex determining region Y)-box 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.353.4e-02Click!

Activity profile of Sox21 motif

Sorted Z-values of Sox21 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:1990535 negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535)
0.7 2.1 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.6 4.6 GO:0051572 negative regulation of histone H3-K4 methylation(GO:0051572)
0.6 1.7 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.5 1.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.4 1.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 1.1 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.4 2.1 GO:0007412 axon target recognition(GO:0007412)
0.3 1.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.9 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.9 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.2 1.3 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 0.5 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 1.2 GO:0051013 microtubule severing(GO:0051013)
0.2 4.1 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.3 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347)
0.1 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 1.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.5 GO:0009816 defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.1 1.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 4.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 1.2 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.4 GO:0033373 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.1 0.5 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.6 GO:0006265 DNA topological change(GO:0006265)
0.1 0.3 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.1 0.6 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 15.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.6 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.1 0.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 0.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 1.4 GO:0019236 response to pheromone(GO:0019236)
0.0 1.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.5 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 3.1 GO:0051225 spindle assembly(GO:0051225)
0.0 0.9 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 1.4 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.4 GO:1905144 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.0 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 0.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.5 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.5 GO:0032437 cuticular plate(GO:0032437)
0.4 1.6 GO:0060187 cell pole(GO:0060187)
0.3 1.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 4.3 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 0.6 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 2.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 4.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0032797 SMN complex(GO:0032797)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.1 GO:0071547 piP-body(GO:0071547)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.3 2.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 0.6 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 1.3 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.8 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 4.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.9 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 1.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 15.4 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 1.1 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.3 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1 1.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0043236 fibronectin binding(GO:0001968) laminin binding(GO:0043236)
0.0 0.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0 1.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 3.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 4.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 7.4 GO:0003779 actin binding(GO:0003779)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.1 GO:0020037 heme binding(GO:0020037)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 12.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.7 PID AURORA A PATHWAY Aurora A signaling
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.8 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 4.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.4 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 1.3 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells