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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Mecom

Z-value: 0.99

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Transcription factors associated with Mecom

Gene Symbol Gene ID Gene Info
ENSMUSG00000027684.10 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mecommm10_v2_chr3_-_30509462_30509514-0.363.1e-02Click!

Activity profile of Mecom motif

Sorted Z-values of Mecom motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.5 2.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.4 1.3 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.4 0.8 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.4 10.7 GO:0035634 response to stilbenoid(GO:0035634)
0.3 0.8 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.2 0.6 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.5 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.6 GO:0060613 fat pad development(GO:0060613)
0.1 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.8 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.1 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 1.2 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.0 GO:0019050 suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526) response to cycloheximide(GO:0046898)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 0.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 1.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.7 GO:0005550 pheromone binding(GO:0005550)
0.2 6.2 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.2 1.3 GO:0033265 choline binding(GO:0033265)
0.2 0.9 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 2.0 GO:0043295 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.7 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.0 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events