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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxa9_Hoxb9

Z-value: 1.01

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Transcription factors associated with Hoxa9_Hoxb9

Gene Symbol Gene ID Gene Info
ENSMUSG00000038227.9 homeobox A9
ENSMUSG00000020875.8 homeobox B9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb9mm10_v2_chr11_+_96271453_962715230.134.5e-01Click!
Hoxa9mm10_v2_chr6_-_52226165_52226196-0.067.2e-01Click!

Activity profile of Hoxa9_Hoxb9 motif

Sorted Z-values of Hoxa9_Hoxb9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa9_Hoxb9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0018879 biphenyl metabolic process(GO:0018879)
0.2 0.7 GO:0010534 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.2 4.1 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.2 0.6 GO:2000229 pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229)
0.2 0.8 GO:0006069 ethanol oxidation(GO:0006069)
0.2 0.5 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) thymidine metabolic process(GO:0046104)
0.2 0.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.4 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 0.5 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1 0.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.3 GO:0014916 regulation of lung blood pressure(GO:0014916)
0.1 0.2 GO:1903660 transforming growth factor beta activation(GO:0036363) regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.3 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.1 0.6 GO:0071231 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 1.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.2 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.1 0.8 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.4 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.4 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.3 GO:0018992 germ-line sex determination(GO:0018992)
0.0 0.2 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.5 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:2000503 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) diapedesis(GO:0050904) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.8 GO:0032098 regulation of appetite(GO:0032098)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.7 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 0.6 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 2.6 GO:0009166 nucleotide catabolic process(GO:0009166)
0.0 0.1 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.0 0.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.3 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.4 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0045098 type III intermediate filament(GO:0045098)
0.1 1.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.9 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 3.3 GO:0030057 desmosome(GO:0030057)
0.1 0.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.2 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0097447 dendritic tree(GO:0097447)
0.0 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.5 2.6 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.3 0.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.2 0.7 GO:0070540 stearic acid binding(GO:0070540)
0.1 0.4 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.1 1.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.5 GO:0002054 nucleobase binding(GO:0002054)
0.1 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.6 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.6 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.2 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.2 GO:0002135 CTP binding(GO:0002135)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.8 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0008061 chitin binding(GO:0008061)
0.0 0.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0052723 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0019840 isoprenoid binding(GO:0019840)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 4.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis