avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Hnf4a
|
ENSMUSG00000017950.10 | hepatic nuclear factor 4, alpha |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hnf4a | mm10_v2_chr2_+_163547148_163547188 | 0.53 | 8.8e-04 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
19.3 | 77.4 | GO:0071718 | sodium-independent icosanoid transport(GO:0071718) |
18.6 | 55.9 | GO:0042450 | arginine biosynthetic process via ornithine(GO:0042450) |
13.5 | 40.4 | GO:0061402 | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
12.4 | 49.6 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
11.9 | 391.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
10.7 | 42.7 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
10.0 | 40.2 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
9.7 | 135.1 | GO:0015747 | urate transport(GO:0015747) |
9.6 | 57.8 | GO:0008355 | olfactory learning(GO:0008355) |
9.6 | 248.7 | GO:0035634 | response to stilbenoid(GO:0035634) |
7.8 | 23.3 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853) |
7.8 | 7.8 | GO:1903383 | neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) |
7.3 | 21.9 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
6.3 | 18.8 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) thymidine metabolic process(GO:0046104) |
5.1 | 30.8 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
4.9 | 14.7 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
4.7 | 23.7 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
4.6 | 13.8 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
4.6 | 18.4 | GO:0006742 | NADP catabolic process(GO:0006742) |
4.5 | 22.6 | GO:0009115 | xanthine catabolic process(GO:0009115) |
4.4 | 13.2 | GO:2001293 | fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293) |
4.2 | 155.1 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
3.9 | 23.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
3.7 | 11.1 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
3.7 | 11.1 | GO:0006553 | lysine metabolic process(GO:0006553) |
3.6 | 14.2 | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641) |
3.5 | 14.0 | GO:0009441 | glycolate metabolic process(GO:0009441) |
3.4 | 16.8 | GO:0015886 | heme transport(GO:0015886) |
3.3 | 16.5 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
3.1 | 49.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
2.9 | 17.4 | GO:0045964 | positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964) |
2.8 | 8.5 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
2.8 | 8.5 | GO:0035962 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
2.6 | 7.7 | GO:0006714 | sesquiterpenoid metabolic process(GO:0006714) |
2.4 | 4.7 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) |
2.3 | 37.4 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
2.3 | 11.4 | GO:0009446 | spermidine biosynthetic process(GO:0008295) putrescine biosynthetic process(GO:0009446) |
2.2 | 8.9 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
2.2 | 6.5 | GO:0010899 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
2.1 | 8.6 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
1.9 | 7.8 | GO:0046618 | drug export(GO:0046618) |
1.9 | 11.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
1.8 | 17.9 | GO:0051596 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
1.8 | 5.4 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
1.7 | 6.9 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
1.6 | 19.8 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
1.6 | 11.2 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
1.5 | 23.3 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
1.4 | 50.1 | GO:0050892 | intestinal absorption(GO:0050892) |
1.4 | 8.3 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
1.3 | 5.3 | GO:0003360 | brainstem development(GO:0003360) |
1.3 | 3.9 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
1.3 | 7.7 | GO:1903275 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) |
1.3 | 8.9 | GO:0001757 | somite specification(GO:0001757) |
1.3 | 6.3 | GO:1902221 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
1.2 | 8.6 | GO:0015862 | uridine transport(GO:0015862) |
1.2 | 4.9 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) fatty-acyl-CoA catabolic process(GO:0036115) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
1.1 | 6.9 | GO:0006642 | triglyceride mobilization(GO:0006642) |
1.1 | 17.1 | GO:0019321 | pentose metabolic process(GO:0019321) |
1.1 | 7.5 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
1.1 | 5.3 | GO:0015746 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
1.0 | 10.2 | GO:0006901 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
1.0 | 3.0 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
1.0 | 4.0 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
1.0 | 8.6 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
0.9 | 13.2 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
0.8 | 6.5 | GO:0009249 | protein lipoylation(GO:0009249) |
0.8 | 3.2 | GO:0036367 | adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367) |
0.8 | 4.7 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.8 | 3.1 | GO:0061235 | regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146) |
0.8 | 8.6 | GO:0097421 | liver regeneration(GO:0097421) |
0.8 | 5.4 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
0.8 | 10.5 | GO:0002934 | desmosome organization(GO:0002934) |
0.7 | 6.4 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
0.7 | 3.5 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
0.6 | 1.9 | GO:0003285 | septum secundum development(GO:0003285) cardiac muscle tissue regeneration(GO:0061026) negative regulation of connective tissue replacement(GO:1905204) |
0.6 | 5.6 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
0.6 | 7.3 | GO:0006824 | cobalt ion transport(GO:0006824) |
0.6 | 6.0 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
0.6 | 24.0 | GO:0051642 | centrosome localization(GO:0051642) |
0.5 | 2.7 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
0.5 | 21.9 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.5 | 17.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
0.5 | 25.3 | GO:0006956 | complement activation(GO:0006956) |
0.5 | 1.4 | GO:0060061 | Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954) |
0.5 | 5.6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
0.4 | 3.1 | GO:0007296 | vitellogenesis(GO:0007296) |
0.4 | 4.0 | GO:0030035 | microspike assembly(GO:0030035) |
0.4 | 14.6 | GO:0015893 | drug transport(GO:0015893) |
0.4 | 5.0 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
0.4 | 3.7 | GO:0043691 | reverse cholesterol transport(GO:0043691) |
0.4 | 1.2 | GO:0019405 | alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
0.4 | 7.1 | GO:0046697 | decidualization(GO:0046697) |
0.4 | 9.3 | GO:0034389 | lipid particle organization(GO:0034389) |
0.4 | 1.1 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
0.4 | 5.7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
0.3 | 4.7 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
0.3 | 5.1 | GO:0030497 | fatty acid elongation(GO:0030497) |
0.3 | 2.0 | GO:0015808 | L-alanine transport(GO:0015808) |
0.3 | 3.1 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668) |
0.3 | 2.3 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.3 | 41.3 | GO:0009636 | response to toxic substance(GO:0009636) |
0.3 | 35.3 | GO:0009166 | nucleotide catabolic process(GO:0009166) |
0.3 | 3.4 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
0.2 | 1.2 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
0.2 | 10.6 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
0.2 | 1.4 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.2 | 0.9 | GO:0061386 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
0.2 | 9.4 | GO:0006953 | acute-phase response(GO:0006953) |
0.2 | 2.2 | GO:0043649 | dicarboxylic acid catabolic process(GO:0043649) |
0.2 | 11.8 | GO:0050919 | negative chemotaxis(GO:0050919) |
0.2 | 7.7 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
0.2 | 0.8 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
0.2 | 38.1 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
0.2 | 18.3 | GO:0046889 | positive regulation of lipid biosynthetic process(GO:0046889) |
0.2 | 4.7 | GO:0002360 | T cell lineage commitment(GO:0002360) |
0.2 | 4.8 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
0.2 | 1.7 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
0.2 | 12.8 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
0.2 | 6.1 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.2 | 3.7 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.2 | 8.2 | GO:0007566 | embryo implantation(GO:0007566) |
0.1 | 3.1 | GO:0006491 | N-glycan processing(GO:0006491) |
0.1 | 1.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.1 | 2.6 | GO:0051205 | protein insertion into membrane(GO:0051205) |
0.1 | 1.5 | GO:0070914 | UV-damage excision repair(GO:0070914) |
0.1 | 1.7 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
0.1 | 8.7 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
0.1 | 0.5 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
0.1 | 9.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
0.1 | 3.0 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
0.1 | 20.8 | GO:0031668 | cellular response to extracellular stimulus(GO:0031668) |
0.1 | 1.8 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
0.1 | 24.6 | GO:0016042 | lipid catabolic process(GO:0016042) |
0.1 | 3.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.1 | 1.7 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
0.1 | 2.2 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
0.1 | 14.1 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
0.1 | 3.4 | GO:0007588 | excretion(GO:0007588) |
0.1 | 2.6 | GO:0035329 | hippo signaling(GO:0035329) |
0.1 | 6.2 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
0.1 | 0.5 | GO:0015879 | carnitine transport(GO:0015879) |
0.1 | 2.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
0.0 | 0.4 | GO:0015074 | DNA integration(GO:0015074) |
0.0 | 1.7 | GO:0051881 | regulation of mitochondrial membrane potential(GO:0051881) |
0.0 | 0.6 | GO:0008272 | sulfate transport(GO:0008272) |
0.0 | 7.5 | GO:0043523 | regulation of neuron apoptotic process(GO:0043523) |
0.0 | 0.9 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
0.0 | 4.5 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
0.0 | 4.3 | GO:0000209 | protein polyubiquitination(GO:0000209) |
0.0 | 3.0 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
0.0 | 3.2 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
0.0 | 2.4 | GO:0034976 | response to endoplasmic reticulum stress(GO:0034976) |
0.0 | 6.4 | GO:0032259 | methylation(GO:0032259) |
0.0 | 1.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.4 | 35.3 | GO:0045098 | type III intermediate filament(GO:0045098) |
3.9 | 43.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
3.3 | 50.1 | GO:0045179 | apical cortex(GO:0045179) |
2.8 | 31.1 | GO:0042627 | chylomicron(GO:0042627) |
1.8 | 19.8 | GO:0005579 | membrane attack complex(GO:0005579) |
1.5 | 6.1 | GO:0005610 | laminin-5 complex(GO:0005610) |
1.4 | 8.6 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
1.4 | 123.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
1.3 | 5.3 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
1.3 | 37.6 | GO:0044216 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
1.2 | 11.1 | GO:0097427 | microtubule bundle(GO:0097427) |
1.1 | 8.9 | GO:1990357 | terminal web(GO:1990357) |
0.9 | 5.6 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.9 | 24.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.9 | 13.2 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
0.9 | 8.6 | GO:0045298 | tubulin complex(GO:0045298) |
0.8 | 7.8 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.7 | 13.8 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.6 | 4.5 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
0.6 | 5.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
0.6 | 7.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.6 | 54.1 | GO:0005811 | lipid particle(GO:0005811) |
0.5 | 8.8 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.5 | 70.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
0.3 | 61.1 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.3 | 47.5 | GO:0072562 | blood microparticle(GO:0072562) |
0.3 | 7.1 | GO:0031528 | microvillus membrane(GO:0031528) |
0.3 | 32.2 | GO:0005814 | centriole(GO:0005814) |
0.3 | 465.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
0.2 | 25.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
0.2 | 4.8 | GO:0030057 | desmosome(GO:0030057) |
0.2 | 3.7 | GO:0045120 | pronucleus(GO:0045120) |
0.2 | 8.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.2 | 7.7 | GO:0034707 | chloride channel complex(GO:0034707) |
0.1 | 8.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.1 | 1.5 | GO:0036038 | MKS complex(GO:0036038) |
0.1 | 199.6 | GO:0005739 | mitochondrion(GO:0005739) |
0.1 | 1.5 | GO:0031011 | Ino80 complex(GO:0031011) |
0.1 | 3.4 | GO:0016592 | mediator complex(GO:0016592) |
0.1 | 8.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.1 | 2.1 | GO:0001533 | cornified envelope(GO:0001533) |
0.1 | 2.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.1 | 2.7 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.1 | 4.0 | GO:0030175 | filopodium(GO:0030175) |
0.1 | 3.2 | GO:0001772 | immunological synapse(GO:0001772) |
0.1 | 15.0 | GO:0014069 | postsynaptic density(GO:0014069) |
0.1 | 8.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.0 | 1.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 2.8 | GO:0072686 | mitotic spindle(GO:0072686) |
0.0 | 14.2 | GO:0005813 | centrosome(GO:0005813) |
0.0 | 37.9 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
0.0 | 2.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.0 | 3.0 | GO:0001650 | fibrillar center(GO:0001650) |
0.0 | 0.2 | GO:0070938 | contractile ring(GO:0070938) |
0.0 | 2.3 | GO:0012506 | vesicle membrane(GO:0012506) |
0.0 | 8.8 | GO:0005768 | endosome(GO:0005768) |
0.0 | 2.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.0 | 4.9 | GO:0044297 | cell body(GO:0044297) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
39.4 | 118.3 | GO:0005186 | pheromone activity(GO:0005186) |
32.2 | 193.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
30.0 | 119.9 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
20.3 | 81.4 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
14.0 | 55.9 | GO:0016743 | carboxyl- or carbamoyltransferase activity(GO:0016743) |
12.8 | 51.2 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
12.4 | 49.6 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
10.3 | 72.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
10.3 | 30.8 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
9.0 | 135.1 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
7.8 | 23.3 | GO:0050479 | glyceryl-ether monooxygenase activity(GO:0050479) |
7.1 | 35.3 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
6.4 | 19.1 | GO:0019150 | D-ribulokinase activity(GO:0019150) |
5.7 | 40.2 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
5.6 | 162.0 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
5.4 | 21.7 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
4.9 | 14.7 | GO:0008480 | sarcosine dehydrogenase activity(GO:0008480) |
4.9 | 117.1 | GO:0070330 | aromatase activity(GO:0070330) |
4.5 | 22.6 | GO:0004854 | xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726) |
4.2 | 16.8 | GO:0015232 | heme transporter activity(GO:0015232) |
4.2 | 33.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
3.9 | 23.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
3.9 | 23.3 | GO:0008453 | alanine-glyoxylate transaminase activity(GO:0008453) |
3.8 | 22.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
3.5 | 132.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
3.3 | 78.6 | GO:0005550 | pheromone binding(GO:0005550) |
3.1 | 31.4 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
2.8 | 11.1 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
2.7 | 18.8 | GO:0002054 | nucleobase binding(GO:0002054) |
2.6 | 13.2 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
2.5 | 10.1 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562) |
2.2 | 6.5 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
2.0 | 14.0 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
2.0 | 17.9 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
1.9 | 18.9 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
1.8 | 5.4 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
1.8 | 7.1 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
1.7 | 40.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
1.6 | 6.5 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
1.6 | 11.1 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
1.6 | 7.8 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
1.4 | 19.8 | GO:0019841 | retinol binding(GO:0019841) |
1.3 | 5.4 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573) |
1.2 | 8.6 | GO:0099609 | microtubule lateral binding(GO:0099609) |
1.2 | 10.8 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
1.1 | 6.9 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
1.1 | 18.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
1.1 | 5.3 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
1.1 | 5.3 | GO:0015137 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
1.1 | 3.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
1.0 | 11.4 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
1.0 | 7.8 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.9 | 24.6 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
0.9 | 6.9 | GO:0035473 | lipase binding(GO:0035473) |
0.8 | 13.2 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
0.7 | 14.3 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
0.7 | 12.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.7 | 2.0 | GO:0005302 | L-tyrosine transmembrane transporter activity(GO:0005302) |
0.7 | 8.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.6 | 2.6 | GO:0031849 | olfactory receptor binding(GO:0031849) |
0.6 | 16.5 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.6 | 14.6 | GO:0015238 | drug transmembrane transporter activity(GO:0015238) |
0.5 | 11.2 | GO:0008483 | transaminase activity(GO:0008483) |
0.5 | 19.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
0.5 | 3.2 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.4 | 5.0 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.4 | 4.0 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.4 | 77.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.4 | 5.6 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
0.4 | 32.3 | GO:0038024 | cargo receptor activity(GO:0038024) |
0.4 | 4.9 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
0.3 | 4.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.3 | 13.8 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
0.3 | 5.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
0.3 | 10.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.3 | 10.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.3 | 0.8 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
0.2 | 2.7 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
0.2 | 53.7 | GO:0008168 | methyltransferase activity(GO:0008168) |
0.2 | 1.9 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
0.2 | 0.9 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
0.2 | 3.6 | GO:0038191 | neuropilin binding(GO:0038191) |
0.2 | 27.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.2 | 8.9 | GO:0003785 | actin monomer binding(GO:0003785) |
0.2 | 23.7 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
0.2 | 17.3 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
0.2 | 1.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.2 | 7.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.2 | 2.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
0.1 | 8.9 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
0.1 | 3.0 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
0.1 | 5.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
0.1 | 3.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.1 | 1.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
0.1 | 1.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
0.1 | 0.5 | GO:0005124 | scavenger receptor binding(GO:0005124) |
0.1 | 3.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.1 | 2.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.1 | 1.2 | GO:0042288 | MHC class I protein binding(GO:0042288) |
0.1 | 4.3 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.1 | 1.4 | GO:0048018 | receptor agonist activity(GO:0048018) |
0.1 | 8.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.1 | 6.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.1 | 1.7 | GO:0005123 | death receptor binding(GO:0005123) |
0.1 | 3.7 | GO:0001221 | transcription cofactor binding(GO:0001221) |
0.1 | 9.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 1.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 1.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
0.1 | 1.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
0.1 | 2.3 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.0 | 2.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 1.7 | GO:0043531 | ADP binding(GO:0043531) |
0.0 | 0.2 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
0.0 | 1.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 0.6 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 2.2 | GO:0042805 | actinin binding(GO:0042805) |
0.0 | 0.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 4.7 | GO:0008083 | growth factor activity(GO:0008083) |
0.0 | 9.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 7.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
0.0 | 3.4 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
0.0 | 2.8 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.0 | 1.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 29.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.9 | 62.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.6 | 21.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
0.5 | 6.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.5 | 8.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
0.5 | 8.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.4 | 5.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.3 | 9.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
0.3 | 5.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
0.2 | 25.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
0.2 | 10.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.2 | 3.9 | PID ARF 3PATHWAY | Arf1 pathway |
0.1 | 4.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
0.1 | 3.1 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
0.1 | 9.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
0.1 | 4.7 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
0.1 | 4.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
0.1 | 4.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
0.1 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
0.1 | 1.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
0.0 | 1.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.0 | 1.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
0.0 | 1.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
0.0 | 0.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
0.0 | 0.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.9 | 23.7 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
7.1 | 99.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
7.0 | 77.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
6.0 | 48.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
4.6 | 77.4 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
4.0 | 40.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
3.2 | 22.6 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
2.9 | 41.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
2.8 | 35.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
2.0 | 51.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
1.4 | 15.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
1.3 | 23.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
1.0 | 19.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
1.0 | 10.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
0.8 | 13.8 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.7 | 11.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
0.6 | 29.1 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
0.5 | 48.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.5 | 13.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.4 | 11.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.4 | 5.0 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
0.4 | 80.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
0.4 | 9.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
0.3 | 6.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
0.3 | 8.9 | REACTOME KINESINS | Genes involved in Kinesins |
0.3 | 10.4 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
0.3 | 3.9 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
0.3 | 6.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
0.3 | 8.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.3 | 4.7 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
0.3 | 4.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
0.3 | 4.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
0.3 | 3.1 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.2 | 2.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
0.2 | 3.1 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
0.2 | 3.2 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
0.2 | 3.1 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
0.2 | 3.0 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.2 | 3.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.2 | 6.2 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.1 | 2.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
0.1 | 1.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.1 | 14.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
0.1 | 10.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
0.1 | 2.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
0.1 | 10.1 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
0.1 | 6.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
0.0 | 3.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
0.0 | 2.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.0 | 1.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
0.0 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 1.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 1.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |