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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gsc2_Dmbx1

Z-value: 1.06

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Transcription factors associated with Gsc2_Dmbx1

Gene Symbol Gene ID Gene Info
ENSMUSG00000022738.6 goosecoid homebox 2
ENSMUSG00000028707.9 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_115939928-0.344.4e-02Click!
Gsc2mm10_v2_chr16_-_17915059_17915059-0.202.5e-01Click!

Activity profile of Gsc2_Dmbx1 motif

Sorted Z-values of Gsc2_Dmbx1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0 3.0 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.9 4.4 GO:0001692 histamine metabolic process(GO:0001692)
0.4 1.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.4 1.5 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.4 1.1 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982)
0.3 1.3 GO:0090472 dibasic protein processing(GO:0090472)
0.3 3.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 1.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 0.7 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.9 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 0.8 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.6 GO:0002188 translation reinitiation(GO:0002188)
0.1 3.7 GO:0007602 phototransduction(GO:0007602)
0.1 1.0 GO:0098909 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 1.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.4 GO:0045872 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.1 1.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.3 GO:0046710 purine deoxyribonucleotide biosynthetic process(GO:0009153) GDP metabolic process(GO:0046710)
0.1 0.5 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.5 GO:0044838 cell quiescence(GO:0044838)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.1 GO:0071655 macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.1 0.5 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.6 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 0.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0 0.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 2.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.8 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.4 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.5 GO:0019236 response to pheromone(GO:0019236)
0.0 1.1 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 3.1 GO:0007623 circadian rhythm(GO:0007623)
0.0 0.4 GO:0007274 synaptic transmission, cholinergic(GO:0007271) neuromuscular synaptic transmission(GO:0007274)
0.0 3.7 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 7.8 GO:0030673 axolemma(GO:0030673)
0.1 3.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 7.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 5.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 2.7 GO:0014704 intercalated disc(GO:0014704)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 3.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.4 1.2 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.3 1.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.3 1.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 2.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 1.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 0.9 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 0.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 1.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 2.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.5 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 1.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.5 GO:0031014 troponin T binding(GO:0031014)
0.1 0.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.7 GO:0005550 pheromone binding(GO:0005550)
0.1 1.1 GO:0030553 cGMP binding(GO:0030553)
0.1 1.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.9 GO:0043855 cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 4.4 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 1.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.4 GO:0042166 acetylcholine binding(GO:0042166)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.6 GO:0005549 odorant binding(GO:0005549)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.7 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.4 3.4 REACTOME OPSINS Genes involved in Opsins
0.1 7.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME G1 PHASE Genes involved in G1 Phase