avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Irf3
|
ENSMUSG00000003184.8 | interferon regulatory factor 3 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Irf3 | mm10_v2_chr7_+_44997648_44997700 | 0.42 | 1.1e-02 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 2.3 | GO:0002477 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
1.0 | 4.0 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
0.9 | 4.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
0.9 | 2.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
0.8 | 2.4 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
0.8 | 1.5 | GO:0002589 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) |
0.6 | 33.0 | GO:0035456 | response to interferon-beta(GO:0035456) |
0.6 | 2.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
0.5 | 1.6 | GO:0039530 | MDA-5 signaling pathway(GO:0039530) |
0.5 | 4.6 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
0.3 | 1.4 | GO:0035697 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) CD8-positive, alpha-beta T cell extravasation(GO:0035697) positive regulation of natural killer cell chemotaxis(GO:2000503) |
0.3 | 2.3 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
0.2 | 2.0 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
0.2 | 1.3 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
0.2 | 0.9 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
0.2 | 1.7 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
0.1 | 2.4 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
0.1 | 1.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
0.1 | 0.7 | GO:0010990 | regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) |
0.1 | 0.4 | GO:1901146 | regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146) |
0.1 | 1.9 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.1 | 1.3 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
0.1 | 0.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
0.1 | 0.1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
0.1 | 0.3 | GO:0035546 | interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) |
0.0 | 0.5 | GO:0045625 | regulation of T-helper 1 cell differentiation(GO:0045625) |
0.0 | 1.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.0 | 1.1 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
0.0 | 0.4 | GO:0042228 | interleukin-8 biosynthetic process(GO:0042228) |
0.0 | 0.3 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
0.0 | 0.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.0 | 0.2 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
0.0 | 0.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 16.7 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
0.6 | 4.7 | GO:0042825 | TAP complex(GO:0042825) |
0.3 | 1.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
0.3 | 2.0 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
0.3 | 3.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
0.3 | 3.9 | GO:0044754 | autolysosome(GO:0044754) |
0.2 | 0.7 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
0.2 | 1.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
0.1 | 0.5 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.1 | 0.5 | GO:1990462 | omegasome(GO:1990462) |
0.0 | 0.3 | GO:0071547 | piP-body(GO:0071547) |
0.0 | 0.1 | GO:0097232 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
0.0 | 2.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 10.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
0.0 | 3.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.7 | GO:0031901 | early endosome membrane(GO:0031901) |
0.0 | 1.2 | GO:0005643 | nuclear pore(GO:0005643) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 4.6 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
1.3 | 14.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
0.9 | 4.7 | GO:0046980 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
0.5 | 1.9 | GO:0031849 | olfactory receptor binding(GO:0031849) |
0.5 | 1.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
0.4 | 4.0 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.3 | 1.3 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.3 | 3.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.2 | 2.0 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
0.2 | 4.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.1 | 1.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.1 | 1.1 | GO:0039706 | co-receptor binding(GO:0039706) |
0.1 | 0.9 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
0.1 | 1.7 | GO:0070628 | proteasome binding(GO:0070628) |
0.1 | 0.3 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
0.1 | 1.1 | GO:0031386 | protein tag(GO:0031386) |
0.1 | 23.4 | GO:0003924 | GTPase activity(GO:0003924) |
0.1 | 1.1 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
0.1 | 0.7 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.1 | 0.3 | GO:0034584 | piRNA binding(GO:0034584) |
0.0 | 0.5 | GO:0003993 | acid phosphatase activity(GO:0003993) |
0.0 | 1.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 0.5 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.0 | 0.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 1.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 1.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 10.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.1 | 1.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
0.0 | 1.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 1.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 2.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
0.0 | 2.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
0.0 | 4.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
0.0 | 0.7 | PID ARF 3PATHWAY | Arf1 pathway |
0.0 | 2.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.0 | 0.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.3 | 5.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.2 | 4.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
0.2 | 4.6 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
0.1 | 1.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
0.1 | 3.6 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
0.1 | 2.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
0.1 | 1.3 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 2.6 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
0.0 | 0.7 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
0.0 | 1.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.7 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 1.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
0.0 | 1.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |