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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Creb3

Z-value: 2.23

Motif logo

Transcription factors associated with Creb3

Gene Symbol Gene ID Gene Info
ENSMUSG00000028466.9 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_435629470.173.4e-01Click!

Activity profile of Creb3 motif

Sorted Z-values of Creb3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.8 GO:0036483 neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382)
1.5 6.0 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.4 6.8 GO:0009115 xanthine catabolic process(GO:0009115)
1.3 3.9 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
1.2 17.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.0 3.1 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
1.0 4.0 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.9 4.7 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.9 5.4 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.7 3.7 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.7 2.1 GO:1904057 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) regulation of cytokine activity(GO:0060300) negative regulation of sensory perception of pain(GO:1904057)
0.6 1.9 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.6 3.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.6 1.7 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.5 4.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.5 2.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.5 2.0 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.5 1.9 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5 6.3 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.5 4.7 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.5 1.4 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.5 1.4 GO:1903168 enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 3.7 GO:0090166 Golgi disassembly(GO:0090166)
0.4 1.6 GO:0006566 threonine metabolic process(GO:0006566)
0.4 2.0 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.4 0.8 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.4 5.2 GO:0014850 response to muscle activity(GO:0014850)
0.4 4.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 2.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 1.4 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.3 1.3 GO:0036343 psychomotor behavior(GO:0036343)
0.3 1.3 GO:0090298 negative regulation of mitochondrial DNA replication(GO:0090298)
0.3 1.0 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.3 2.0 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.3 1.0 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.3 1.9 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.3 1.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.3 1.0 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.3 2.6 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.3 1.8 GO:0018158 protein oxidation(GO:0018158)
0.2 0.7 GO:0070625 zymogen granule exocytosis(GO:0070625)
0.2 1.8 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 2.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.2 1.1 GO:0035063 nuclear speck organization(GO:0035063)
0.2 0.4 GO:0070375 ERK5 cascade(GO:0070375)
0.2 8.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 0.8 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 1.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 5.0 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.2 1.5 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.2 0.5 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 4.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 0.5 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.2 1.3 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 1.1 GO:1901072 N-acetylneuraminate catabolic process(GO:0019262) glucosamine-containing compound catabolic process(GO:1901072)
0.2 6.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.2 1.1 GO:1901552 sphingosine-1-phosphate signaling pathway(GO:0003376) positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.2 7.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 1.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.8 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 2.1 GO:0061525 hindgut development(GO:0061525)
0.1 2.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 1.4 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.8 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.5 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.1 1.6 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.5 GO:0006824 cobalt ion transport(GO:0006824)
0.1 1.4 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 2.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.6 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 2.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.3 GO:0007141 male meiosis I(GO:0007141)
0.1 4.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 1.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 4.1 GO:0050892 intestinal absorption(GO:0050892)
0.1 1.7 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 2.5 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 4.1 GO:0001706 endoderm formation(GO:0001706)
0.1 1.1 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.1 0.9 GO:0016093 polyprenol metabolic process(GO:0016093)
0.1 1.2 GO:0007220 Notch receptor processing(GO:0007220)
0.1 1.9 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.1 1.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.3 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 1.5 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.1 2.2 GO:0060009 Sertoli cell development(GO:0060009)
0.1 0.8 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.7 GO:0045794 negative regulation of cell volume(GO:0045794)
0.1 1.3 GO:0015874 norepinephrine transport(GO:0015874)
0.1 1.0 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.6 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 1.4 GO:0021794 thalamus development(GO:0021794)
0.1 0.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 1.6 GO:0043277 apoptotic cell clearance(GO:0043277)
0.1 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.7 GO:0034982 mitochondrial protein processing(GO:0034982)
0.1 1.0 GO:0036296 cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296)
0.1 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.9 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 1.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.4 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.1 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 1.4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 2.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 1.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.6 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.0 1.4 GO:0002369 T cell cytokine production(GO:0002369)
0.0 0.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 1.1 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.5 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.9 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.0 1.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.6 GO:0000045 autophagosome assembly(GO:0000045)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.5 GO:0060324 face development(GO:0060324)
0.0 2.5 GO:0048489 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.0 0.2 GO:0060770 epithelial cell proliferation involved in prostate gland development(GO:0060767) regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.0 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.8 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.3 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 1.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.7 GO:0017145 stem cell division(GO:0017145)
0.0 1.2 GO:0030203 glycosaminoglycan metabolic process(GO:0030203)
0.0 2.9 GO:0006914 autophagy(GO:0006914)
0.0 0.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 1.2 GO:0008203 cholesterol metabolic process(GO:0008203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.5 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.8 11.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.8 4.0 GO:0044316 cone cell pedicle(GO:0044316)
0.8 11.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.7 5.0 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.6 7.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 4.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.4 3.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 5.4 GO:0044754 autolysosome(GO:0044754)
0.4 2.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.3 5.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 2.5 GO:0097413 Lewy body(GO:0097413)
0.3 1.2 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.3 1.4 GO:0072487 MSL complex(GO:0072487)
0.3 4.1 GO:0045179 apical cortex(GO:0045179)
0.2 1.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.2 3.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 1.0 GO:0070876 SOSS complex(GO:0070876)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)
0.2 3.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 0.7 GO:0005745 m-AAA complex(GO:0005745)
0.2 0.9 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.2 1.8 GO:0016272 prefoldin complex(GO:0016272)
0.2 2.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 5.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 2.6 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 3.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 0.7 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 1.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.0 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.8 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.7 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.2 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 1.3 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.4 GO:0031011 Ino80 complex(GO:0031011)
0.1 1.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.7 GO:0031201 SNARE complex(GO:0031201)
0.1 0.6 GO:0033263 CORVET complex(GO:0033263)
0.1 1.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 3.5 GO:0005801 cis-Golgi network(GO:0005801)
0.1 14.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 3.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.6 GO:0005776 autophagosome(GO:0005776)
0.1 7.5 GO:0055037 recycling endosome(GO:0055037)
0.1 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.5 GO:0005795 Golgi stack(GO:0005795)
0.0 1.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 8.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 7.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.0 2.5 GO:0030018 Z disc(GO:0030018)
0.0 6.3 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.4 6.8 GO:0016623 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
1.3 3.9 GO:0072541 peroxynitrite reductase activity(GO:0072541)
1.2 4.8 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
1.1 3.2 GO:0042954 lipoprotein transporter activity(GO:0042954)
1.0 2.9 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.6 4.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.6 1.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.6 5.7 GO:0001594 trace-amine receptor activity(GO:0001594)
0.6 7.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 1.6 GO:0070905 serine binding(GO:0070905)
0.5 2.7 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.5 1.4 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.5 1.4 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.4 1.3 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.4 1.6 GO:0048408 epidermal growth factor binding(GO:0048408)
0.4 2.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 1.0 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.3 1.5 GO:0070568 guanylyltransferase activity(GO:0070568)
0.3 3.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.3 0.9 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.3 5.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 2.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.3 1.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 3.2 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.1 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.2 5.0 GO:0097602 cullin family protein binding(GO:0097602)
0.2 1.2 GO:0005047 signal recognition particle binding(GO:0005047)
0.2 4.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 1.4 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 9.1 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 0.8 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 1.6 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.3 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 2.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.7 GO:0015250 water channel activity(GO:0015250)
0.1 5.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 3.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 1.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 4.0 GO:0030552 cAMP binding(GO:0030552)
0.1 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 10.8 GO:0020037 heme binding(GO:0020037)
0.1 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 3.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 3.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.5 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.9 GO:0031386 protein tag(GO:0031386)
0.1 0.8 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 1.1 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 2.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.9 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 6.2 GO:0000149 SNARE binding(GO:0000149)
0.1 1.3 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 3.5 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 5.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.7 GO:0030332 cyclin binding(GO:0030332)
0.0 1.5 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 1.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 6.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 3.4 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.1 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.4 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 1.4 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.8 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.9 GO:0005506 iron ion binding(GO:0005506)
0.0 2.1 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 3.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0061135 endopeptidase regulator activity(GO:0061135)
0.0 0.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.2 PID ARF 3PATHWAY Arf1 pathway
0.1 6.0 PID IL1 PATHWAY IL1-mediated signaling events
0.1 4.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 0.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 5.5 PID LKB1 PATHWAY LKB1 signaling events
0.1 1.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 1.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID FOXO PATHWAY FoxO family signaling
0.0 1.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 9.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 5.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 3.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 6.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 3.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 11.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 1.8 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 1.7 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 4.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 4.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.3 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 2.1 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.9 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 1.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 2.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 9.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.1 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.8 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins