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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc13_Hoxd13

Z-value: 0.61

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Transcription factors associated with Hoxc13_Hoxd13

Gene Symbol Gene ID Gene Info
ENSMUSG00000001655.6 homeobox C13
ENSMUSG00000001819.4 homeobox D13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc13mm10_v2_chr15_+_102921103_102921132-0.251.5e-01Click!
Hoxd13mm10_v2_chr2_+_74668207_74668310-0.212.3e-01Click!

Activity profile of Hoxc13_Hoxd13 motif

Sorted Z-values of Hoxc13_Hoxd13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.4 1.1 GO:2001293 fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293)
0.3 0.9 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.2 1.5 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.2 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.7 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.5 GO:1990743 protein sialylation(GO:1990743)
0.1 0.3 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.1 0.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.3 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.2 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.0 1.0 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.9 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.2 GO:0021539 subthalamus development(GO:0021539)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.3 GO:0045945 urea cycle(GO:0000050) positive regulation of transcription from RNA polymerase III promoter(GO:0045945) cellular response to lithium ion(GO:0071285)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.2 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.4 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.1 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 0.7 GO:0006953 acute-phase response(GO:0006953)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0042567 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.2 0.7 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0005786 signal recognition particle receptor complex(GO:0005785) signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 2.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.3 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 0.9 GO:0070287 ferritin receptor activity(GO:0070287)
0.2 0.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 1.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.8 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.1 2.6 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.4 GO:0005047 signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312)
0.0 0.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.1 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID IGF1 PATHWAY IGF1 pathway
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID EPO PATHWAY EPO signaling pathway
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo