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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Myb

Z-value: 3.16

Motif logo

Transcription factors associated with Myb

Gene Symbol Gene ID Gene Info
ENSMUSG00000019982.8 myeloblastosis oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mybmm10_v2_chr10_-_21160925_211609840.812.4e-09Click!

Activity profile of Myb motif

Sorted Z-values of Myb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Myb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.2 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
6.3 19.0 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
5.8 17.3 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079) neutrophil mediated killing of fungus(GO:0070947)
5.4 16.3 GO:0000821 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
4.5 31.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
3.7 11.0 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
3.6 10.8 GO:0098763 mitotic cell cycle phase(GO:0098763)
3.3 9.9 GO:0071846 actin filament debranching(GO:0071846)
2.4 7.2 GO:0002865 regulation of type IV hypersensitivity(GO:0001807) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884)
2.1 10.7 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
2.1 6.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
1.9 9.6 GO:0035617 stress granule disassembly(GO:0035617)
1.9 9.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.8 32.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.7 31.5 GO:0070986 left/right axis specification(GO:0070986)
1.5 6.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
1.5 6.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.3 7.9 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
1.2 21.0 GO:0030953 astral microtubule organization(GO:0030953)
1.2 3.7 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
1.2 4.9 GO:0032053 ciliary basal body organization(GO:0032053)
1.2 3.5 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
1.2 9.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.0 2.1 GO:0072717 cellular response to actinomycin D(GO:0072717)
1.0 1.0 GO:0061511 centriole elongation(GO:0061511)
1.0 4.0 GO:0046898 response to cycloheximide(GO:0046898)
0.9 1.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.9 7.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.9 2.7 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.9 23.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.9 3.5 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.9 4.3 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.8 2.5 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.8 1.6 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.8 2.3 GO:0002353 plasma kallikrein-kinin cascade(GO:0002353)
0.7 3.7 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.7 4.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.7 4.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.7 1.4 GO:0010710 regulation of collagen catabolic process(GO:0010710)
0.7 4.8 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.7 8.9 GO:0019985 translesion synthesis(GO:0019985)
0.7 2.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.6 1.9 GO:0014878 response to muscle activity involved in regulation of muscle adaptation(GO:0014873) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.6 12.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.6 8.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.6 1.8 GO:0007315 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.6 2.4 GO:1904008 response to monosodium glutamate(GO:1904008) cellular response to monosodium glutamate(GO:1904009)
0.6 5.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.6 16.8 GO:0007099 centriole replication(GO:0007099)
0.6 1.7 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.5 2.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.5 2.0 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.5 20.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.5 6.0 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.4 3.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 1.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.4 1.5 GO:0019659 fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.4 1.4 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.3 1.4 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.3 9.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 1.0 GO:0090172 microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
0.3 6.2 GO:0071539 protein localization to centrosome(GO:0071539)
0.3 10.4 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.3 5.8 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.3 1.4 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.3 1.4 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.3 5.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.3 8.0 GO:0034508 centromere complex assembly(GO:0034508)
0.3 1.0 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 4.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.2 1.0 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.2 1.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2 2.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.2 1.9 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.2 1.4 GO:0030242 pexophagy(GO:0030242)
0.2 1.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.2 3.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 8.3 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 1.0 GO:1901673 regulation of spindle assembly(GO:0090169) regulation of mitotic spindle assembly(GO:1901673)
0.2 2.0 GO:0014029 neural crest formation(GO:0014029)
0.2 7.9 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.2 1.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 0.6 GO:1900368 regulation of RNA interference(GO:1900368)
0.1 1.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.6 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 10.4 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.2 GO:0045759 negative regulation of action potential(GO:0045759)
0.1 3.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.9 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 5.2 GO:0048255 mRNA stabilization(GO:0048255)
0.1 6.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.5 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 14.4 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 1.7 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.2 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 1.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.6 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 1.6 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 1.9 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 0.7 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.1 4.7 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
0.1 0.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 1.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 3.6 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 1.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 1.8 GO:0030252 growth hormone secretion(GO:0030252)
0.1 1.2 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.1 2.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 2.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 1.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 0.5 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.8 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.1 0.9 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 1.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 1.2 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.1 5.5 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 3.0 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.1 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 4.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 0.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.0 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.1 2.2 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 6.4 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.1 0.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:0034351 negative regulation of glial cell apoptotic process(GO:0034351)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 1.7 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 1.5 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 1.3 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 22.5 GO:0051301 cell division(GO:0051301)
0.0 3.5 GO:0060563 neuroepithelial cell differentiation(GO:0060563)
0.0 0.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 6.6 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 1.8 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.8 GO:0042130 negative regulation of T cell proliferation(GO:0042130)
0.0 0.9 GO:0001541 ovarian follicle development(GO:0001541)
0.0 1.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.3 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 1.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.6 GO:0006970 response to osmotic stress(GO:0006970)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.1 GO:1990423 RZZ complex(GO:1990423)
3.1 6.3 GO:0042585 germinal vesicle(GO:0042585)
3.1 9.3 GO:0000799 nuclear condensin complex(GO:0000799)
2.8 11.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
2.3 23.2 GO:0008290 F-actin capping protein complex(GO:0008290)
2.0 6.0 GO:0005588 collagen type V trimer(GO:0005588)
2.0 7.9 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
1.4 23.2 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.3 7.9 GO:0098536 deuterosome(GO:0098536)
1.3 9.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.2 3.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
1.1 35.4 GO:0034451 centriolar satellite(GO:0034451)
0.9 19.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.9 5.5 GO:0071547 piP-body(GO:0071547)
0.8 5.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.8 29.5 GO:0035371 microtubule plus-end(GO:0035371)
0.7 14.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.6 3.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.6 3.5 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.6 4.1 GO:0001940 male pronucleus(GO:0001940)
0.6 1.7 GO:0035061 interchromatin granule(GO:0035061)
0.5 15.9 GO:0097228 sperm principal piece(GO:0097228)
0.5 50.3 GO:0036126 sperm flagellum(GO:0036126)
0.5 1.4 GO:1990047 spindle matrix(GO:1990047)
0.4 3.1 GO:0001740 Barr body(GO:0001740)
0.4 6.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.4 10.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.4 1.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.4 3.5 GO:0072687 meiotic spindle(GO:0072687)
0.4 4.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.4 4.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 3.9 GO:0000243 commitment complex(GO:0000243)
0.3 1.4 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.3 2.4 GO:0005638 lamin filament(GO:0005638)
0.3 19.5 GO:0005871 kinesin complex(GO:0005871)
0.3 1.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.3 3.1 GO:0016272 prefoldin complex(GO:0016272)
0.3 0.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 26.1 GO:0005814 centriole(GO:0005814)
0.3 2.0 GO:0097255 R2TP complex(GO:0097255)
0.3 3.4 GO:0036038 MKS complex(GO:0036038)
0.3 1.8 GO:0071546 pi-body(GO:0071546)
0.3 5.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 6.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 2.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 10.5 GO:0043034 costamere(GO:0043034)
0.2 1.4 GO:0005927 muscle tendon junction(GO:0005927)
0.2 1.4 GO:0071438 invadopodium membrane(GO:0071438)
0.2 13.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 2.3 GO:0000974 Prp19 complex(GO:0000974)
0.2 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 8.2 GO:0031672 A band(GO:0031672)
0.2 19.6 GO:0000776 kinetochore(GO:0000776)
0.2 1.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 9.5 GO:0005844 polysome(GO:0005844)
0.1 1.7 GO:0031011 Ino80 complex(GO:0031011)
0.1 4.8 GO:0030673 axolemma(GO:0030673)
0.1 1.4 GO:0045298 tubulin complex(GO:0045298)
0.1 8.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 15.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 13.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.9 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 4.3 GO:0097440 apical dendrite(GO:0097440)
0.1 1.0 GO:0097346 INO80-type complex(GO:0097346)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 8.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.9 GO:0044613 nuclear pore central transport channel(GO:0044613) Flemming body(GO:0090543)
0.1 1.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.8 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 0.9 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.1 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 12.0 GO:0005813 centrosome(GO:0005813)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 2.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.2 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.3 GO:0045178 basal part of cell(GO:0045178)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 23.3 GO:0005730 nucleolus(GO:0005730)
0.0 2.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.7 GO:0032993 protein-DNA complex(GO:0032993)
0.0 10.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 7.9 GO:0043235 receptor complex(GO:0043235)
0.0 5.1 GO:0005635 nuclear envelope(GO:0005635)
0.0 3.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 4.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0016235 aggresome(GO:0016235)
0.0 1.5 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
1.8 10.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.4 5.4 GO:0097100 supercoiled DNA binding(GO:0097100)
1.2 4.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
1.1 16.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.9 11.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.9 8.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.8 14.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.7 3.7 GO:0004849 uridine kinase activity(GO:0004849)
0.7 2.7 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.7 19.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5 6.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.5 1.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.5 14.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 19.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 1.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.5 3.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.4 8.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.4 3.9 GO:1990446 U1 snRNP binding(GO:1990446)
0.4 4.0 GO:0051434 BH3 domain binding(GO:0051434)
0.4 1.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.4 2.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 6.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 2.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.3 1.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 22.5 GO:0030507 spectrin binding(GO:0030507)
0.3 19.7 GO:0004601 peroxidase activity(GO:0004601)
0.3 3.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 1.6 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 3.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 0.9 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.3 1.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.3 10.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 19.5 GO:0003777 microtubule motor activity(GO:0003777)
0.3 1.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.3 2.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 4.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.3 1.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 1.0 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 2.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 1.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 8.3 GO:0008009 chemokine activity(GO:0008009)
0.2 5.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 0.8 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.2 8.2 GO:0003785 actin monomer binding(GO:0003785)
0.2 1.9 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 16.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 8.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 1.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 0.9 GO:0051425 PTB domain binding(GO:0051425)
0.2 2.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 2.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 3.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 4.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.6 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 4.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 12.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 9.9 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 6.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 10.0 GO:0004386 helicase activity(GO:0004386)
0.1 0.9 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 2.0 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 8.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 1.4 GO:0051371 vinculin binding(GO:0017166) muscle alpha-actinin binding(GO:0051371)
0.1 2.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 20.3 GO:0042393 histone binding(GO:0042393)
0.1 0.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.0 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 4.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 22.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 0.7 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 3.6 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 1.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.2 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 12.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 3.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 2.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 33.9 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 2.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.6 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 18.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 3.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 5.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0019767 IgE receptor activity(GO:0019767)
0.0 0.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.2 GO:0044325 ion channel binding(GO:0044325)
0.0 5.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.7 GO:0003774 motor activity(GO:0003774)
0.0 2.9 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 42.3 PID AURORA B PATHWAY Aurora B signaling
0.6 12.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.6 21.0 PID AURORA A PATHWAY Aurora A signaling
0.5 7.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 23.2 PID IL23 PATHWAY IL23-mediated signaling events
0.5 23.6 PID PLK1 PATHWAY PLK1 signaling events
0.4 17.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 4.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 10.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 6.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 4.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 12.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 3.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 8.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 4.3 PID ATM PATHWAY ATM pathway
0.1 6.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 2.0 PID MYC PATHWAY C-MYC pathway
0.1 2.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 2.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 7.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 12.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.1 PID EPO PATHWAY EPO signaling pathway
0.1 2.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 31.0 REACTOME KINESINS Genes involved in Kinesins
0.8 7.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.7 70.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 5.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.6 17.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.5 5.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 11.5 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.3 6.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 10.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 4.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 7.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 4.0 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 6.4 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 3.0 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 8.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.5 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 3.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 8.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 6.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 6.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 5.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 3.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 1.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 3.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.6 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 0.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 3.7 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 5.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 3.4 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 1.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 5.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 2.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 3.4 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation