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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-4

Z-value: 0.85

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Transcription factors associated with Nkx2-4

Gene Symbol Gene ID Gene Info
ENSMUSG00000054160.2 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.316.4e-02Click!

Activity profile of Nkx2-4 motif

Sorted Z-values of Nkx2-4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0007341 penetration of zona pellucida(GO:0007341)
0.4 1.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.2 0.3 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.2 0.5 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.1 1.5 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 0.4 GO:0070340 detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 0.5 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.4 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.8 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.3 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 2.0 GO:0097320 membrane tubulation(GO:0097320)
0.1 0.3 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 1.9 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 0.3 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.4 GO:0015705 iodide transport(GO:0015705)
0.0 1.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.4 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.7 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 4.0 GO:0007586 digestion(GO:0007586)
0.0 0.5 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.1 GO:0002784 regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 1.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.8 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0018377 protein myristoylation(GO:0018377)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 1.9 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.0 0.2 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0033280 response to vitamin D(GO:0033280)
0.0 0.3 GO:0050832 defense response to fungus(GO:0050832)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 GO:0002102 podosome(GO:0002102)
0.1 1.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 4.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.7 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.3 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0044299 C-fiber(GO:0044299)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.5 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 0.3 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.9 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0005113 patched binding(GO:0005113)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID AURORA A PATHWAY Aurora A signaling
0.0 0.5 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events