avrg: GSE58827: Dynamics of the Mouse Liver
Gene Symbol | Gene ID | Gene Info |
---|---|---|
Smad4
|
ENSMUSG00000024515.7 | SMAD family member 4 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Smad4 | mm10_v2_chr18_-_73703739_73703806 | 0.03 | 8.8e-01 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 4.2 | GO:1900619 | acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619) |
0.8 | 4.0 | GO:0051140 | regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142) |
0.6 | 1.9 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.5 | 1.4 | GO:1905204 | negative regulation of connective tissue replacement(GO:1905204) positive regulation of dendritic cell differentiation(GO:2001200) |
0.5 | 1.4 | GO:0070315 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315) |
0.5 | 2.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.4 | 2.5 | GO:1904849 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
0.4 | 1.5 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.3 | 0.7 | GO:0051885 | positive regulation of anagen(GO:0051885) |
0.3 | 0.9 | GO:0045763 | regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763) |
0.3 | 0.8 | GO:2000321 | positive regulation of T-helper 17 cell differentiation(GO:2000321) |
0.2 | 0.7 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) |
0.2 | 2.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.2 | 4.3 | GO:0048368 | lateral mesoderm development(GO:0048368) |
0.2 | 1.5 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
0.2 | 0.5 | GO:0036363 | transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
0.2 | 1.2 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
0.2 | 0.7 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
0.2 | 1.7 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
0.1 | 1.7 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
0.1 | 0.7 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608) |
0.1 | 0.4 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
0.1 | 1.0 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
0.1 | 0.7 | GO:0070100 | negative regulation of chemokine-mediated signaling pathway(GO:0070100) |
0.1 | 0.4 | GO:0061193 | taste bud development(GO:0061193) |
0.1 | 0.4 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) |
0.1 | 1.0 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
0.1 | 0.9 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
0.1 | 1.7 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
0.1 | 1.7 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.1 | 1.2 | GO:0033572 | transferrin transport(GO:0033572) |
0.1 | 1.7 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
0.1 | 0.9 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
0.1 | 1.2 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) |
0.1 | 0.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
0.1 | 0.5 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
0.1 | 0.3 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.1 | 0.3 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
0.1 | 0.5 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
0.1 | 0.4 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
0.1 | 1.1 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.1 | 1.7 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
0.0 | 0.2 | GO:0036215 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306) |
0.0 | 0.3 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.0 | 0.6 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
0.0 | 1.1 | GO:0033622 | integrin activation(GO:0033622) |
0.0 | 1.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.0 | 0.1 | GO:0043686 | co-translational protein modification(GO:0043686) |
0.0 | 0.9 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
0.0 | 0.5 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) regulation of somatic stem cell population maintenance(GO:1904672) |
0.0 | 0.1 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
0.0 | 0.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 0.4 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.0 | 0.7 | GO:0001553 | luteinization(GO:0001553) |
0.0 | 0.1 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
0.0 | 0.4 | GO:0038092 | nodal signaling pathway(GO:0038092) |
0.0 | 0.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
0.0 | 0.6 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
0.0 | 1.0 | GO:0042246 | tissue regeneration(GO:0042246) |
0.0 | 0.4 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
0.0 | 0.0 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
0.0 | 0.1 | GO:0021773 | striatal medium spiny neuron differentiation(GO:0021773) |
0.0 | 0.3 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
0.0 | 0.8 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
0.0 | 1.6 | GO:0055092 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
0.0 | 0.3 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
0.0 | 0.5 | GO:0060065 | uterus development(GO:0060065) |
0.0 | 0.2 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804) |
0.0 | 1.1 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
0.0 | 0.1 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
0.0 | 0.1 | GO:0000733 | DNA strand renaturation(GO:0000733) |
0.0 | 0.3 | GO:0040023 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 4.3 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
0.6 | 1.7 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
0.5 | 1.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.4 | 1.5 | GO:0043293 | apoptosome(GO:0043293) |
0.3 | 4.6 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 4.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.2 | 0.5 | GO:0005610 | laminin-2 complex(GO:0005607) laminin-5 complex(GO:0005610) |
0.1 | 1.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.1 | 1.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
0.1 | 0.8 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
0.1 | 0.3 | GO:0044302 | dentate gyrus mossy fiber(GO:0044302) |
0.1 | 1.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.1 | 0.5 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
0.0 | 1.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 3.7 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.3 | GO:0070652 | HAUS complex(GO:0070652) |
0.0 | 0.6 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.0 | 0.2 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.6 | GO:0005686 | U2 snRNP(GO:0005686) |
0.0 | 1.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 0.9 | GO:0097228 | sperm principal piece(GO:0097228) |
0.0 | 1.7 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.5 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 2.6 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 2.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.5 | GO:0008305 | integrin complex(GO:0008305) |
0.0 | 0.0 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
0.0 | 0.1 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.0 | 1.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 1.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 4.2 | GO:0004104 | cholinesterase activity(GO:0004104) |
0.6 | 1.7 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
0.6 | 1.7 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
0.5 | 2.5 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
0.4 | 2.1 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
0.2 | 4.3 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.2 | 0.7 | GO:0050436 | microfibril binding(GO:0050436) |
0.1 | 0.7 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.1 | 0.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.1 | 1.5 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
0.1 | 1.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.1 | 0.3 | GO:0036004 | GAF domain binding(GO:0036004) |
0.1 | 1.8 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.1 | 0.7 | GO:0048495 | Roundabout binding(GO:0048495) |
0.1 | 0.9 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.1 | 1.4 | GO:0031432 | titin binding(GO:0031432) |
0.1 | 0.3 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
0.1 | 0.5 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.1 | 1.7 | GO:0030275 | LRR domain binding(GO:0030275) |
0.1 | 0.9 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
0.1 | 1.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
0.1 | 0.4 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
0.1 | 1.8 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.1 | 0.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.1 | 0.3 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
0.1 | 1.7 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.0 | 2.0 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.1 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
0.0 | 1.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.3 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.0 | 0.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.0 | 0.2 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.0 | 0.5 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.0 | 0.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.0 | 0.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.0 | 0.1 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
0.0 | 1.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.4 | GO:0070628 | proteasome binding(GO:0070628) |
0.0 | 0.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.0 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
0.0 | 0.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.0 | 0.1 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
0.0 | 1.1 | GO:0019955 | cytokine binding(GO:0019955) |
0.0 | 0.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 8.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
0.1 | 3.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
0.0 | 1.9 | PID AURORA B PATHWAY | Aurora B signaling |
0.0 | 3.0 | PID FGF PATHWAY | FGF signaling pathway |
0.0 | 0.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.0 | 1.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
0.0 | 1.4 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
0.0 | 0.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
0.0 | 0.7 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
0.0 | 0.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
0.0 | 1.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
0.0 | 0.9 | PID REELIN PATHWAY | Reelin signaling pathway |
0.0 | 0.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 1.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
0.0 | 0.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
0.0 | 3.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.8 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.0 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
0.1 | 1.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
0.1 | 2.3 | REACTOME KINESINS | Genes involved in Kinesins |
0.1 | 7.8 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
0.1 | 0.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
0.1 | 3.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
0.1 | 2.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.1 | 1.0 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
0.0 | 1.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.0 | 0.7 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
0.0 | 1.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
0.0 | 0.5 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
0.0 | 0.2 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
0.0 | 1.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
0.0 | 0.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
0.0 | 0.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.0 | 0.8 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
0.0 | 0.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 0.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
0.0 | 0.7 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
0.0 | 1.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.0 | 0.4 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.0 | 0.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
0.0 | 0.1 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |