ISMARA results: Sp1

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sp1

Z-value: 3.51

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Transcription factors associated with Sp1

Gene Symbol	Gene ID	Gene Info
Sp1 Ensembl NCBI MGI UniProt	ENSMUSG00000001280.6	trans-acting transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sp1	mm10_v2_chr15_+_102406143_102406380	-0.65	2.0e-05	Click!

Activity profile of Sp1 motif

Sorted Z-values of Sp1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_105269837 Show fit	19.89	ENSMUST00000172525.1 ENSMUST00000174837.1 ENSMUST00000173859.1	Hsf4 Ensembl NCBI MGI UniProt Show fit	heat shock transcription factor 4
chr8_+_105269788 Show fit	19.52	ENSMUST00000036127.2 ENSMUST00000163734.2	Hsf4 Ensembl NCBI MGI UniProt Show fit	heat shock transcription factor 4
chr1_+_74332596 Show fit	19.24	ENSMUST00000087225.5	Pnkd Ensembl NCBI MGI UniProt Show fit	paroxysmal nonkinesiogenic dyskinesia
chr10_-_88503952 Show fit	17.12	ENSMUST00000020253.8	Chpt1 Ensembl NCBI MGI UniProt Show fit	choline phosphotransferase 1
chr2_+_58567360 Show fit	16.68	ENSMUST00000071543.5	Upp2 Ensembl NCBI MGI UniProt Show fit	uridine phosphorylase 2
chr19_+_46131888 Show fit	16.30	ENSMUST00000043739.3	Elovl3 Ensembl NCBI MGI UniProt Show fit	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr18_-_38211957 Show fit	15.77	ENSMUST00000159405.1 ENSMUST00000160721.1	Pcdh1 Ensembl NCBI MGI UniProt Show fit	protocadherin 1
chr12_+_108334341 Show fit	15.36	ENSMUST00000021684.4	Cyp46a1 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 46, subfamily a, polypeptide 1
chr12_-_84450944 Show fit	15.14	ENSMUST00000085192.5	Aldh6a1 Ensembl NCBI MGI UniProt Show fit	aldehyde dehydrogenase family 6, subfamily A1
chr11_-_120660565 Show fit	15.12	ENSMUST00000106177.1	Notum Ensembl NCBI MGI UniProt Show fit	notum pectinacetylesterase homolog (Drosophila)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	45.6	GO:0033169	histone H3-K9 demethylation(GO:0033169)
7.4	44.2	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
2.1	40.3	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
1.1	37.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
1.7	36.4	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.8	34.7	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5	30.5	GO:0009062	fatty acid catabolic process(GO:0009062)
1.1	28.8	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6	28.3	GO:0019835	cytolysis(GO:0019835)
2.8	28.0	GO:0051596	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Showing 1 to 10 of 1,161 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	216.2	GO:0005739	mitochondrion(GO:0005739)
0.9	170.5	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.2	124.6	GO:0005768	endosome(GO:0005768)
0.4	86.4	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.6	81.8	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.2	69.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.3	61.0	GO:0000139	Golgi membrane(GO:0000139)
0.1	43.6	GO:0005783	endoplasmic reticulum(GO:0005783)
0.7	41.8	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3	37.4	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 352 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.0	45.2	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.8	39.3	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.1	36.9	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.8	32.8	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
6.0	29.9	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.6	28.9	GO:0016790	thiolester hydrolase activity(GO:0016790)
0.5	28.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
5.5	27.4	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.5	27.4	GO:0015485	cholesterol binding(GO:0015485)
0.5	27.4	GO:0008395	steroid hydroxylase activity(GO:0008395)

Showing 1 to 10 of 719 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	71.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.9	49.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.9	47.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.7	36.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.5	32.1	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.7	31.2	PID BMP PATHWAY	BMP receptor signaling
0.9	28.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.6	28.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.7	27.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
1.0	24.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	94.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.5	86.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
2.6	56.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
2.1	55.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
2.0	53.9	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
1.4	48.5	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
1.5	46.5	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
1.6	45.0	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
2.0	44.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
1.2	41.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 177 entries

Results for Sp1

Z-value: 3.51

Motif logo

Transcription factors associated with Sp1

Activity-expression correlation:

Activity profile of Sp1 motif

Sorted Z-values of Sp1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: