Project
avrg: GSE58827: Dynamics of the Mouse Liver
Navigation
Downloads
Results for Nr2e3
Z-value: 1.35
Motif logo
Transcription factors associated with Nr2e3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr2e3 | mm10_v2_chr9_-_59950068_59950122 | 0.49 | 2.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_90695706 Show fit | 9.16 |
ENSMUST00000069960.5
ENSMUST00000117167.1 |
S100 calcium binding protein A9 (calgranulin B) |
|
| chr6_+_142298419 Show fit | 6.33 |
ENSMUST00000041993.2
|
islet amyloid polypeptide |
|
| chr11_-_55185029 Show fit | 6.04 |
ENSMUST00000039305.5
|
solute carrier family 36 (proton/amino acid symporter), member 2 |
|
| chr10_-_75940633 Show fit | 5.86 |
ENSMUST00000059658.4
|
predicted gene 867 |
|
| chr19_+_38132767 Show fit | 5.49 |
ENSMUST00000025956.5
ENSMUST00000112329.1 |
phosphodiesterase 6C, cGMP specific, cone, alpha prime |
|
| chr3_-_137981523 Show fit | 4.12 |
ENSMUST00000136613.1
ENSMUST00000029806.6 |
dual adaptor for phosphotyrosine and 3-phosphoinositides 1 |
|
| chr7_+_100494044 Show fit | 3.62 |
ENSMUST00000153287.1
|
uncoupling protein 2 (mitochondrial, proton carrier) |
|
| chr1_-_66935333 Show fit | 3.58 |
ENSMUST00000120415.1
ENSMUST00000119429.1 |
myosin, light polypeptide 1 |
|
| chr10_-_45470201 Show fit | 3.56 |
ENSMUST00000079390.6
|
lin-28 homolog B (C. elegans) |
|
| chr11_+_104608000 Show fit | 3.43 |
ENSMUST00000021028.4
|
integrin beta 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr2e3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.4 | 7.0 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.9 | 6.4 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.8 | 6.3 | GO:0097647 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 1.5 | 6.0 | GO:0035524 | proline transmembrane transport(GO:0035524) glycine import(GO:0036233) |
| 0.5 | 5.5 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 4.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.1 | 4.5 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.4 | 3.6 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 1.2 | 3.5 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 7.9 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 7.8 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 0.0 | 6.3 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 4.7 | GO:0016459 | myosin complex(GO:0016459) |
| 1.2 | 3.5 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 1.1 | 3.4 | GO:0034679 | integrin alpha9-beta1 complex(GO:0034679) |
| 0.1 | 2.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 2.6 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.2 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786) |
| 1.2 | 7.0 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.3 | 6.9 | GO:0030553 | cGMP binding(GO:0030553) |
| 2.1 | 6.4 | GO:0033680 | ATP-dependent DNA/RNA helicase activity(GO:0033680) |
| 0.1 | 6.3 | GO:0005179 | hormone activity(GO:0005179) |
| 2.0 | 6.0 | GO:0005302 | L-tyrosine transmembrane transporter activity(GO:0005302) |
| 0.3 | 5.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.3 | 4.9 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 4.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 4.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 7.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 7.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 5.5 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.1 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 3.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 3.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 6.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 5.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 5.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 5.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 3.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 3.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 2.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 2.7 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.2 | 2.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |