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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Nfia
Z-value: 2.60
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Transcription factors associated with Nfia
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfia | mm10_v2_chr4_+_97777780_97777834 | 0.53 | 9.5e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_97417730 Show fit | 16.40 |
ENSMUST00000043077.7
|
thyroid hormone responsive |
|
| chr8_-_93131271 Show fit | 14.30 |
ENSMUST00000034189.8
|
carboxylesterase 1C |
|
| chr4_-_62054112 Show fit | 11.87 |
ENSMUST00000074018.3
|
major urinary protein 20 |
|
| chr7_+_140763739 Show fit | 11.58 |
ENSMUST00000026552.7
|
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
| chr1_+_167618246 Show fit | 10.28 |
ENSMUST00000111380.1
|
retinoid X receptor gamma |
|
| chr3_-_81975742 Show fit | 10.03 |
ENSMUST00000029645.8
|
tryptophan 2,3-dioxygenase |
|
| chr4_-_61674094 Show fit | 9.91 |
ENSMUST00000098040.3
|
major urinary protein 18 |
|
| chr4_-_60421933 Show fit | 9.29 |
ENSMUST00000107506.2
ENSMUST00000122381.1 ENSMUST00000118759.1 ENSMUST00000122177.1 |
major urinary protein 9 |
|
| chr4_-_60582152 Show fit | 9.27 |
ENSMUST00000098047.2
|
major urinary protein 10 |
|
| chr7_-_48848023 Show fit | 9.03 |
ENSMUST00000032658.6
|
cysteine and glycine-rich protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfia
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 24.6 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 4.1 | 16.6 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 2.5 | 14.7 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 0.4 | 14.3 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.4 | 14.0 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.3 | 13.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.9 | 13.0 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 1.1 | 12.1 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 4.0 | 11.9 | GO:1902617 | response to fluoride(GO:1902617) |
| 2.0 | 11.9 | GO:0008355 | olfactory learning(GO:0008355) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 58.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 36.3 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 31.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.3 | 20.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.2 | 14.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 14.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 12.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.0 | 11.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 3.1 | 9.2 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 1.3 | 9.0 | GO:0097441 | basilar dendrite(GO:0097441) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.1 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.8 | 23.7 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 4.4 | 22.1 | GO:0008142 | oxysterol binding(GO:0008142) |
| 2.1 | 21.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.9 | 19.7 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.5 | 17.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 4.1 | 16.6 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 2.1 | 12.4 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 4.0 | 11.9 | GO:0004063 | aryldialkylphosphatase activity(GO:0004063) |
| 4.0 | 11.9 | GO:0005186 | pheromone activity(GO:0005186) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 32.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 13.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 10.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 9.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 9.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 7.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 7.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 6.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 5.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 5.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.6 | 28.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 5.7 | 17.1 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.8 | 15.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.4 | 15.5 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.4 | 15.2 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.7 | 12.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.9 | 12.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 11.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 9.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |