avrg: GSE58827: Dynamics of the Mouse Liver


Results for Glis3

Z-value: 0.88

Motif logo

Transcription factors associated with Glis3

Gene Symbol Gene ID Gene Info
ENSMUSG00000052942.7 GLIS family zinc finger 3
ENSMUSG00000091294.1 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Glis3 motif

Sorted Z-values of Glis3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_55561060 2.87 ENSMUST00000117701.1
DDB1 and CUL4 associated factor 11
chr14_+_55560904 2.66 ENSMUST00000072530.4
DDB1 and CUL4 associated factor 11
chr6_+_17463826 2.35 ENSMUST00000140070.1
met proto-oncogene
chr14_+_55560480 2.18 ENSMUST00000121622.1
DDB1 and CUL4 associated factor 11
chr4_+_144893077 2.16 ENSMUST00000154208.1
dehydrogenase/reductase (SDR family) member 3
chr19_+_4711153 2.10 ENSMUST00000008991.6
spectrin beta, non-erythrocytic 2
chr13_-_29984219 2.06 ENSMUST00000146092.1
E2F transcription factor 3
chr11_+_101468164 1.91 ENSMUST00000001347.6
Rho family GTPase 2
chr4_+_144893127 1.90 ENSMUST00000142808.1
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 1.86 ENSMUST00000105744.1
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463927 1.67 ENSMUST00000115442.1
met proto-oncogene
chr6_+_17463749 1.62 ENSMUST00000115443.1
met proto-oncogene
chr14_-_55560340 1.62 ENSMUST00000066106.3
RIKEN cDNA A730061H03 gene
chrX_-_136868537 1.59 ENSMUST00000058814.6
RAB9B, member RAS oncogene family
chr16_+_44173271 1.43 ENSMUST00000088356.4
predicted gene 608
chr13_+_119690462 1.34 ENSMUST00000179869.1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
chr2_+_32646586 1.30 ENSMUST00000009705.7
chr4_+_86053887 1.28 ENSMUST00000107178.2
ADAMTS-like 1
chr16_+_20733104 1.27 ENSMUST00000115423.1
chr6_-_28134545 1.25 ENSMUST00000115323.1
glutamate receptor, metabotropic 8
chr10_-_68278713 1.24 ENSMUST00000020106.7
AT rich interactive domain 5B (MRF1-like)
chr2_-_29253001 1.20 ENSMUST00000071201.4
netrin G2
chr13_+_38345716 1.05 ENSMUST00000171970.1
bone morphogenetic protein 6
chr4_+_118428078 1.03 ENSMUST00000006557.6
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr1_-_168431695 0.99 ENSMUST00000176790.1
pre B cell leukemia homeobox 1
chr15_-_39857459 0.93 ENSMUST00000022915.3
chr6_-_122820606 0.93 ENSMUST00000181317.1
predicted gene, 26826
chrX_+_71364901 0.90 ENSMUST00000132837.1
myotubularin related protein 1
chr1_-_168432270 0.89 ENSMUST00000072863.4
pre B cell leukemia homeobox 1
chr11_-_102296618 0.88 ENSMUST00000107132.2
ataxin 7-like 3
chr5_-_72974702 0.85 ENSMUST00000043711.8
predicted gene 10135
chr2_+_131234043 0.84 ENSMUST00000041362.5
mitochondrial antiviral signaling protein
chr5_-_91402905 0.82 ENSMUST00000121044.2
betacellulin, epidermal growth factor family member
chr9_+_31280525 0.81 ENSMUST00000117389.1
PR domain containing 10
chr3_+_66981352 0.81 ENSMUST00000162036.1
arginine/serine-rich coiled-coil 1
chr10_+_93641041 0.80 ENSMUST00000020204.4
netrin 4
chr15_+_102406143 0.79 ENSMUST00000170884.1
trans-acting transcription factor 1
chrX_+_71364745 0.79 ENSMUST00000114601.1
myotubularin related protein 1
chr4_-_41695935 0.77 ENSMUST00000145379.1
ciliary neurotrophic factor receptor
chrM_+_9452 0.76 ENSMUST00000082411.1
mitochondrially encoded NADH dehydrogenase 3
chr11_-_97187872 0.74 ENSMUST00000001479.4
karyopherin (importin) beta 1
chr11_+_98927785 0.70 ENSMUST00000107474.1
retinoic acid receptor, alpha
chr9_-_29412204 0.68 ENSMUST00000115237.1
chr5_+_104459450 0.64 ENSMUST00000086831.3
polycystic kidney disease 2
chr11_-_72489904 0.64 ENSMUST00000045303.3
spinster homolog 2
chr11_+_97663366 0.60 ENSMUST00000044730.5
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chrX_-_38564519 0.59 ENSMUST00000016681.8
cullin 4B
chr15_+_102921103 0.59 ENSMUST00000001700.6
homeobox C13
chr7_-_49636847 0.57 ENSMUST00000032717.6
developing brain homeobox 1
chr17_+_56326045 0.56 ENSMUST00000139679.1
lysine (K)-specific demethylase 4B
chr17_-_70851189 0.56 ENSMUST00000059775.8
TGFB-induced factor homeobox 1
chr1_-_64121389 0.55 ENSMUST00000055001.3
Kruppel-like factor 7 (ubiquitous)
chr13_+_119428583 0.55 ENSMUST00000109203.2
polyadenylate binding protein-interacting protein 1
chr9_-_48835932 0.53 ENSMUST00000093852.3
zinc finger and BTB domain containing 16
chr14_+_25607797 0.53 ENSMUST00000160229.1
zinc finger, MIZ-type containing 1
chr15_+_102407144 0.53 ENSMUST00000169619.1
trans-acting transcription factor 1
chr7_+_46796088 0.53 ENSMUST00000006774.4
general transcription factor II H, polypeptide 1
chr2_-_73892588 0.51 ENSMUST00000154456.1
activating transcription factor 2
chr6_-_83572429 0.51 ENSMUST00000068054.7
STAM binding protein
chr5_+_110135823 0.50 ENSMUST00000112519.2
checkpoint with forkhead and ring finger domains
chr3_+_52268337 0.50 ENSMUST00000053764.5
forkhead box O1
chr11_+_98795495 0.50 ENSMUST00000037915.2
male-specific lethal 1 homolog (Drosophila)
chr17_-_34031644 0.48 ENSMUST00000171872.1
solute carrier family 39 (zinc transporter), member 7
chr9_-_108305941 0.46 ENSMUST00000044725.7
T cell leukemia translocation altered gene
chr17_-_34031544 0.44 ENSMUST00000025186.8
solute carrier family 39 (zinc transporter), member 7
chr2_-_73892619 0.44 ENSMUST00000112007.1
activating transcription factor 2
chr6_+_108660616 0.43 ENSMUST00000032194.4
basic helix-loop-helix family, member e40
chr10_+_61175206 0.43 ENSMUST00000079235.5
thymus, brain and testes associated
chr13_+_37826018 0.42 ENSMUST00000110238.2
ras responsive element binding protein 1
chr1_-_93445642 0.41 ENSMUST00000042498.7
high density lipoprotein (HDL) binding protein
chr13_+_37825975 0.40 ENSMUST00000138043.1
ras responsive element binding protein 1
chr17_+_80944611 0.40 ENSMUST00000025092.4
transmembrane protein 178
chr17_-_34031684 0.39 ENSMUST00000169397.1
solute carrier family 39 (zinc transporter), member 7
chrX_-_101419788 0.39 ENSMUST00000117901.1
zinc finger, MYM-type 3
chr6_+_108660772 0.39 ENSMUST00000163617.1
basic helix-loop-helix family, member e40
chr16_+_20673264 0.35 ENSMUST00000154950.1
eukaryotic translation initiation factor 4, gamma 1
chr3_+_121426495 0.34 ENSMUST00000029773.8
calponin 3, acidic
chr1_-_168431502 0.34 ENSMUST00000064438.4
pre B cell leukemia homeobox 1
chr11_-_69801716 0.34 ENSMUST00000011285.4
fibroblast growth factor 11
chr16_+_20673517 0.33 ENSMUST00000115460.1
eukaryotic translation initiation factor 4, gamma 1
chr7_+_90442729 0.33 ENSMUST00000061767.4
CREB/ATF bZIP transcription factor
chr3_+_89245952 0.31 ENSMUST00000040888.5
keratinocyte associated protein 2
chr4_+_137993445 0.30 ENSMUST00000105831.2
eukaryotic translation initiation factor 4 gamma, 3
chr11_-_70237761 0.29 ENSMUST00000108576.3
RIKEN cDNA 0610010K14 gene
chr11_+_116030304 0.29 ENSMUST00000021116.5
unkempt homolog (Drosophila)
chrX_+_151522352 0.27 ENSMUST00000148622.1
PHD finger protein 8
chr11_-_85139939 0.26 ENSMUST00000108075.2
ubiquitin specific peptidase 32
chr17_+_86963279 0.26 ENSMUST00000139344.1
ras homolog gene family, member Q
chr2_-_73892530 0.26 ENSMUST00000136958.1
activating transcription factor 2
chr5_-_24527276 0.26 ENSMUST00000088311.4
gastrulation brain homeobox 1
chr7_+_125368861 0.24 ENSMUST00000166958.1
RIKEN cDNA 4930571K23 gene
chr3_-_94582716 0.23 ENSMUST00000029783.9
sorting nexin family member 27
chr3_-_142881942 0.23 ENSMUST00000043812.8
protein kinase N2
chr2_-_144331695 0.21 ENSMUST00000103171.3
ovo-like 2 (Drosophila)
chr17_+_37045963 0.21 ENSMUST00000025338.9
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_-_46795881 0.21 ENSMUST00000107653.1
Hermansky-Pudlak syndrome 5 homolog (human)
chrM_+_8600 0.20 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr10_+_127739516 0.20 ENSMUST00000054287.7
zinc finger and BTB domain containing 39
chr3_-_94582548 0.20 ENSMUST00000107283.1
sorting nexin family member 27
chr8_-_87472576 0.19 ENSMUST00000034076.8
cerebellin 1 precursor protein
chr3_+_89246397 0.19 ENSMUST00000168900.1
keratinocyte associated protein 2
chr13_+_119428888 0.18 ENSMUST00000026520.7
polyadenylate binding protein-interacting protein 1
chr4_-_120747248 0.18 ENSMUST00000030376.7
potassium voltage-gated channel, subfamily Q, member 4
chr9_+_107928440 0.16 ENSMUST00000085073.1
actin-like 11
chr11_-_70237852 0.15 ENSMUST00000108575.2
RIKEN cDNA 0610010K14 gene
chr11_-_70237886 0.15 ENSMUST00000108577.1
RIKEN cDNA 0610010K14 gene
chr13_-_40730416 0.15 ENSMUST00000021787.5
transcription factor AP-2, alpha
chr17_-_23745829 0.15 ENSMUST00000046525.8
kringle containing transmembrane protein 2
chr11_-_97744659 0.15 ENSMUST00000018691.8
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr9_+_108306205 0.14 ENSMUST00000007959.8
ras homolog gene family, member A
chr7_-_126200413 0.14 ENSMUST00000163959.1
exportin 6
chr4_+_129058133 0.13 ENSMUST00000030584.4
ring finger protein 19B
chrX_-_23365044 0.12 ENSMUST00000115313.1
kelch-like 13
chr10_+_63457505 0.12 ENSMUST00000105440.1
catenin (cadherin associated protein), alpha 3
chr11_+_69632927 0.12 ENSMUST00000018909.3
fragile X mental retardation, autosomal homolog 2
chr11_-_52000432 0.12 ENSMUST00000020657.6
ubiquitin-conjugating enzyme E2B
chrX_-_111697069 0.11 ENSMUST00000113422.2
highly divergent homeobox
chrX_+_105764262 0.10 ENSMUST00000033581.3
fibroblast growth factor 16
chr13_+_37826225 0.09 ENSMUST00000128570.1
ras responsive element binding protein 1
chr19_-_6987621 0.09 ENSMUST00000130048.1
vascular endothelial growth factor B
chrX_-_135009185 0.08 ENSMUST00000113185.2
zinc finger, matrin type 1
chr3_+_96601084 0.08 ENSMUST00000062058.3
chr8_+_70863127 0.07 ENSMUST00000050921.2
RIKEN cDNA A230052G05 gene
chr9_-_110117379 0.06 ENSMUST00000111991.2
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr17_-_65613521 0.06 ENSMUST00000024897.8
vesicle-associated membrane protein, associated protein A
chr11_-_70237638 0.04 ENSMUST00000100950.3
RIKEN cDNA 0610010K14 gene
chr2_-_119477613 0.04 ENSMUST00000110808.1
INO80 homolog (S. cerevisiae)
chr6_+_145934113 0.04 ENSMUST00000032383.7
chr8_-_88362154 0.04 ENSMUST00000034085.7
bromodomain containing 7
chr7_-_46795661 0.04 ENSMUST00000123725.1
Hermansky-Pudlak syndrome 5 homolog (human)
chr7_+_25268387 0.04 ENSMUST00000169392.1
capicua homolog (Drosophila)
chr19_+_46305682 0.03 ENSMUST00000111881.2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr12_+_102949450 0.03 ENSMUST00000179002.1
unc-79 homolog (C. elegans)
chr11_-_52000748 0.03 ENSMUST00000109086.1
ubiquitin-conjugating enzyme E2B
chr7_+_45017953 0.03 ENSMUST00000044111.7
Harvey rat sarcoma oncogene, subgroup R
chr2_-_144332146 0.03 ENSMUST00000037423.3
ovo-like 2 (Drosophila)
chr11_+_77216180 0.03 ENSMUST00000037912.5
slingshot homolog 2 (Drosophila)
chr11_+_96271453 0.03 ENSMUST00000000010.8
homeobox B9
chr12_+_69241832 0.02 ENSMUST00000063445.6
kelch domain containing 1
chr4_+_63215402 0.02 ENSMUST00000036300.6
collagen, type XXVII, alpha 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Glis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 1.3 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.4 6.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 0.9 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.3 0.8 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.3 1.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.2 1.2 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 0.7 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 0.6 GO:0003127 detection of nodal flow(GO:0003127) detection of endogenous stimulus(GO:0009726) cellular response to water stimulus(GO:0071462)
0.2 0.6 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.2 0.8 GO:0003360 brainstem development(GO:0003360)
0.2 1.3 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.2 0.7 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.2 1.0 GO:0032349 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.2 0.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.2 1.4 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 1.2 GO:0060613 fat pad development(GO:0060613)
0.1 0.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 1.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 1.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.1 GO:0070342 brown fat cell proliferation(GO:0070342) regulation of brown fat cell proliferation(GO:0070347)
0.1 0.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) eye pigmentation(GO:0048069)
0.1 0.3 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 1.0 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.5 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.5 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.1 GO:0043366 beta selection(GO:0043366)
0.1 0.5 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.1 0.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 1.9 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 0.6 GO:0043587 tongue morphogenesis(GO:0043587)
0.1 0.8 GO:0035810 positive regulation of urine volume(GO:0035810)
0.1 1.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 0.7 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 0.4 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.1 1.3 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.2 GO:0021622 oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.1 1.4 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.6 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.6 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0055093 response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455)
0.0 0.2 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.9 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.2 GO:0060214 endocardium formation(GO:0060214)
0.0 0.2 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.0 0.5 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.5 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 1.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.4 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.4 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.2 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0 0.8 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.0 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0008091 spectrin(GO:0008091)
0.2 8.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 0.8 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.6 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.5 GO:0072487 MSL complex(GO:0072487)
0.1 0.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 5.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.4 GO:0071203 WASH complex(GO:0071203)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.5 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.2 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0044194 cytolytic granule(GO:0044194)
0.0 1.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 3.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.0 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8 5.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 1.3 GO:0005534 galactose binding(GO:0005534)
0.2 1.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.2 0.6 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.2 0.6 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.2 1.3 GO:0045545 syndecan binding(GO:0045545)
0.1 0.9 GO:0016812 nucleobase binding(GO:0002054) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 0.8 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 1.0 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.0 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.7 GO:0008494 translation activator activity(GO:0008494)
0.1 0.8 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.7 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.8 GO:0047485 protein N-terminus binding(GO:0047485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 PID ARF6 PATHWAY Arf6 signaling events
0.1 7.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.3 PID BMP PATHWAY BMP receptor signaling
0.0 2.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.1 PID E2F PATHWAY E2F transcription factor network
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 5.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 0.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.9 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.1 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane