avrg: GSE58827: Dynamics of the Mouse Liver


Results for GUAGUGU

Z-value: 0.60

Motif logo

miRNA associated with seed GUAGUGU

NamemiRBASE accession

Activity profile of GUAGUGU motif

Sorted Z-values of GUAGUGU motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_110018301 1.46 ENSMUST00000084731.3
importin 7
chr2_+_23068168 1.37 ENSMUST00000028121.7
acyl-Coenzyme A binding domain containing 5
chr5_+_73491026 1.31 ENSMUST00000063882.5
DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
chr18_+_34220978 1.23 ENSMUST00000079362.5
adenomatosis polyposis coli
chr2_-_12301914 1.11 ENSMUST00000028106.4
integrin alpha 8
chr5_-_106696819 1.08 ENSMUST00000127434.1
zinc finger protein 644
chr10_-_12861735 1.05 ENSMUST00000076817.4
chr11_-_23497867 1.03 ENSMUST00000128559.1
AHA1, activator of heat shock protein ATPase 2
chr18_-_39490649 1.00 ENSMUST00000115567.1
nuclear receptor subfamily 3, group C, member 1
chr2_+_6322621 0.97 ENSMUST00000114937.1
USP6 N-terminal like
chr1_+_151755339 0.97 ENSMUST00000059498.5
ER degradation enhancer, mannosidase alpha-like 3
chr5_-_76304474 0.92 ENSMUST00000075159.1
circadian locomotor output cycles kaput
chr10_+_7681197 0.92 ENSMUST00000165952.1
large tumor suppressor
chr4_+_47353222 0.90 ENSMUST00000007757.8
transforming growth factor, beta receptor I
chr12_+_32953874 0.89 ENSMUST00000076698.5
synaptophysin-like protein
chr15_-_3995708 0.86 ENSMUST00000046633.8
expressed sequence AW549877
chr3_+_65528404 0.83 ENSMUST00000047906.3
TCDD-inducible poly(ADP-ribose) polymerase
chr9_-_101251810 0.77 ENSMUST00000075941.5
protein phosphatase 2, regulatory subunit B'', alpha
chrX_-_56598069 0.71 ENSMUST00000059899.2
membrane magnesium transporter 1
chr5_+_43233463 0.71 ENSMUST00000169035.1
cytoplasmic polyadenylation element binding protein 2
chr18_-_6241486 0.70 ENSMUST00000025083.7
kinesin family member 5B
chr12_-_51691883 0.69 ENSMUST00000013130.8
striatin, calmodulin binding protein 3
chr1_+_55131231 0.69 ENSMUST00000162364.1
MOB family member 4, phocein
chr10_-_7956223 0.68 ENSMUST00000146444.1
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr2_+_83724397 0.67 ENSMUST00000028499.4
integrin alpha V
chr10_-_68278713 0.66 ENSMUST00000020106.7
AT rich interactive domain 5B (MRF1-like)
chr3_-_10440054 0.65 ENSMUST00000099223.4
sorting nexin 16
chr12_-_51829525 0.64 ENSMUST00000179265.1
HECT domain containing 1
chr11_+_23256001 0.63 ENSMUST00000020538.6
exportin 1, CRM1 homolog (yeast)
chr17_+_53566971 0.63 ENSMUST00000000724.8
K(lysine) acetyltransferase 2B
chr13_-_3611064 0.62 ENSMUST00000096069.3
cDNA sequence BC016423
chr1_-_151428440 0.60 ENSMUST00000064771.5
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr12_+_111574491 0.59 ENSMUST00000084953.5
MAP/microtubule affinity-regulating kinase 3
chr14_-_72709986 0.59 ENSMUST00000089017.5
fibronectin type III domain containing 3A
chr7_-_141434532 0.59 ENSMUST00000133021.1
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr1_-_161876656 0.58 ENSMUST00000048377.5
SUN domain containing ossification factor
chr13_+_113794505 0.55 ENSMUST00000091201.6
ADP-ribosylation factor-like 15
chr18_+_42275353 0.55 ENSMUST00000046972.7
RNA binding motif protein 27
chr5_-_62766153 0.54 ENSMUST00000076623.4
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_66173051 0.53 ENSMUST00000113726.1
RNA binding motif protein 47
chr9_-_123851855 0.53 ENSMUST00000184082.1
FYVE and coiled-coil domain containing 1
chr15_+_12117813 0.53 ENSMUST00000122941.1
zinc finger RNA binding protein
chr6_-_24664960 0.52 ENSMUST00000041737.7
Wiskott-Aldrich syndrome-like (human)
chr14_-_25769033 0.51 ENSMUST00000069180.7
zinc finger, CCHC domain containing 24
chr1_+_139422196 0.51 ENSMUST00000039867.7
zinc finger and BTB domain containing 41 homolog
chr15_-_97055942 0.51 ENSMUST00000023101.3
solute carrier family 38, member 4
chr1_+_180726019 0.50 ENSMUST00000027780.4
acyl-Coenzyme A binding domain containing 3
chr8_-_34965631 0.50 ENSMUST00000033929.4
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr7_-_118243564 0.50 ENSMUST00000179047.1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr2_-_103303179 0.49 ENSMUST00000090475.3
ets homologous factor
chr5_+_64970069 0.48 ENSMUST00000031080.8
family with sequence similarity 114, member A1
chr19_-_12796108 0.48 ENSMUST00000038627.8
zinc finger protein 91
chr14_+_18271122 0.46 ENSMUST00000132374.1
NFKB inhibitor interacting Ras-like protein 1
chr16_+_87698904 0.46 ENSMUST00000026703.5
BTB and CNC homology 1
chr3_+_9250602 0.45 ENSMUST00000155203.1
zinc finger and BTB domain containing 10
chr16_-_64786321 0.44 ENSMUST00000052588.4
zinc finger protein 654
chr9_-_43105718 0.44 ENSMUST00000165665.1
Rho guanine nucleotide exchange factor (GEF) 12
chr15_-_94589870 0.43 ENSMUST00000023087.6
twinfilin, actin-binding protein, homolog 1 (Drosophila)
chr5_+_138085083 0.43 ENSMUST00000019660.4
zinc finger with KRAB and SCAN domains 1
chr9_-_90114812 0.42 ENSMUST00000085248.5
mortality factor 4 like 1
chr7_+_113207465 0.41 ENSMUST00000047321.7
aryl hydrocarbon receptor nuclear translocator-like
chr16_+_10488175 0.41 ENSMUST00000023147.6
class II transactivator
chr17_-_66519666 0.41 ENSMUST00000167962.1
RAB12, member RAS oncogene family
chr17_+_83350925 0.40 ENSMUST00000096766.4
echinoderm microtubule associated protein like 4
chr2_+_14074091 0.40 ENSMUST00000102960.4
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr16_-_56717446 0.38 ENSMUST00000065515.7
Trk-fused gene
chr2_+_52857844 0.38 ENSMUST00000090952.4
formin-like 2
chrX_-_13846508 0.38 ENSMUST00000115436.2
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr8_-_122974793 0.38 ENSMUST00000098334.5
ankyrin repeat domain 11
chr10_+_20312461 0.37 ENSMUST00000092678.3
BCL2-associated transcription factor 1
chr14_+_14012491 0.35 ENSMUST00000022257.2
ataxin 7
chrX_-_108834303 0.35 ENSMUST00000101283.3
bromodomain and WD repeat domain containing 3
chr12_+_16894894 0.35 ENSMUST00000020904.6
Rho-associated coiled-coil containing protein kinase 2
chr4_+_102254993 0.34 ENSMUST00000106908.2
phosphodiesterase 4B, cAMP specific
chr11_+_75679259 0.31 ENSMUST00000017920.7
v-crk sarcoma virus CT10 oncogene homolog (avian)
chr3_-_122619663 0.31 ENSMUST00000162409.1
formin binding protein 1-like
chr11_+_52232009 0.30 ENSMUST00000037324.5
S-phase kinase-associated protein 1A
chr5_+_108461222 0.30 ENSMUST00000046975.5
polycomb group ring finger 3
chr2_-_73892530 0.29 ENSMUST00000136958.1
activating transcription factor 2
chr18_+_5591860 0.29 ENSMUST00000025081.5
zinc finger E-box binding homeobox 1
chr18_+_66458587 0.28 ENSMUST00000025399.7
phorbol-12-myristate-13-acetate-induced protein 1
chrX_+_18162575 0.28 ENSMUST00000044484.6
lysine (K)-specific demethylase 6A
chr4_+_8535604 0.28 ENSMUST00000060232.7
RAB2A, member RAS oncogene family
chr2_+_155381808 0.28 ENSMUST00000043237.7
transformation related protein 53 inducible nuclear protein 2
chr16_-_32247152 0.28 ENSMUST00000042732.5
F-box protein 45
chr8_-_121652895 0.28 ENSMUST00000046386.4
zinc finger, CCHC domain containing 14
chr11_+_80428598 0.27 ENSMUST00000173938.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr2_-_39065438 0.27 ENSMUST00000112850.2
golgi autoantigen, golgin subfamily a, 1
chr7_-_66689589 0.27 ENSMUST00000124899.1
ankyrin repeat and SOCS box-containing 7
chr10_+_70097102 0.26 ENSMUST00000147545.1
coiled-coil domain containing 6
chr15_+_6708372 0.25 ENSMUST00000061656.6
RPTOR independent companion of MTOR, complex 2
chr11_+_90249469 0.24 ENSMUST00000004050.6
monocyte to macrophage differentiation-associated
chr10_+_69533761 0.24 ENSMUST00000182884.1
ankyrin 3, epithelial
chr1_-_186705980 0.23 ENSMUST00000045288.8
transforming growth factor, beta 2
chr3_-_116007399 0.23 ENSMUST00000067485.3
solute carrier family 30 (zinc transporter), member 7
chr7_-_16614937 0.23 ENSMUST00000171937.1
glucocorticoid receptor DNA binding factor 1
chr3_-_144720315 0.22 ENSMUST00000163279.1
SH3-domain GRB2-like B1 (endophilin)
chr2_+_113327711 0.22 ENSMUST00000099576.2
formin 1
chr2_+_48814109 0.21 ENSMUST00000063886.3
activin receptor IIA
chrX_+_6047453 0.20 ENSMUST00000103007.3
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr3_-_41082992 0.19 ENSMUST00000058578.7
progesterone receptor membrane component 2
chr11_-_31671863 0.19 ENSMUST00000058060.7
biorientation of chromosomes in cell division 1
chr5_-_24842579 0.19 ENSMUST00000030787.8
Ras homolog enriched in brain
chr2_+_117121374 0.18 ENSMUST00000028829.6
sprouty protein with EVH-1 domain 1, related sequence
chr2_+_113441064 0.18 ENSMUST00000081349.6
formin 1
chr1_-_46854046 0.17 ENSMUST00000027131.4
solute carrier family 39 (zinc transporter), member 10
chr9_-_51008936 0.17 ENSMUST00000176824.1
salt inducible kinase 2
chr4_+_116720920 0.17 ENSMUST00000045542.6
testis-specific kinase 2
chr11_-_6475992 0.16 ENSMUST00000179343.1
purine rich element binding protein B
chr6_-_92214897 0.15 ENSMUST00000014694.8
zinc finger, FYVE domain containing 20
chr4_+_131921771 0.15 ENSMUST00000094666.3
transmembrane protein 200B
chr3_+_145292472 0.14 ENSMUST00000029848.4
collagen, type XXIV, alpha 1
chr18_-_88894322 0.14 ENSMUST00000070116.5
suppressor of cytokine signaling 6
chr15_-_77842133 0.14 ENSMUST00000016771.6
myosin, heavy polypeptide 9, non-muscle
chr18_-_77713978 0.13 ENSMUST00000074653.4
RIKEN cDNA 8030462N17 gene
chr13_+_112464070 0.13 ENSMUST00000183663.1
interleukin 6 signal transducer
chr2_-_130840091 0.13 ENSMUST00000044766.8
RIKEN cDNA 4930402H24 gene
chr14_-_21052420 0.13 ENSMUST00000154460.1
adaptor-related protein complex 3, mu 1 subunit
chr2_-_35200923 0.13 ENSMUST00000028238.8
RAB14, member RAS oncogene family
chr5_+_143403819 0.13 ENSMUST00000110731.2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr5_-_149053038 0.12 ENSMUST00000085546.6
high mobility group box 1
chr8_+_27023793 0.12 ENSMUST00000033873.7
ER lipid raft associated 2
chr2_-_166996098 0.12 ENSMUST00000049412.5
staufen (RNA binding protein) homolog 1 (Drosophila)
chr8_+_25602236 0.12 ENSMUST00000146919.1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr5_-_36796722 0.11 ENSMUST00000068795.3
Morf4 family associated protein 1
chr13_+_37826225 0.11 ENSMUST00000128570.1
ras responsive element binding protein 1
chr15_+_34837381 0.11 ENSMUST00000072868.3
K+ voltage-gated channel, subfamily S, 2
chr5_-_122502192 0.10 ENSMUST00000179939.1
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chrX_-_48208566 0.09 ENSMUST00000037960.4
zinc finger, DHHC domain containing 9
chr7_+_90130227 0.09 ENSMUST00000049537.7
phosphatidylinositol binding clathrin assembly protein
chr15_-_103158002 0.08 ENSMUST00000064067.8
single-strand selective monofunctional uracil DNA glycosylase
chr6_-_52208694 0.08 ENSMUST00000062829.7
homeobox A6
chrX_-_74023908 0.07 ENSMUST00000033769.8
interleukin-1 receptor-associated kinase 1
chr12_-_54862783 0.07 ENSMUST00000078124.7
cofilin 2, muscle
chr12_-_119238794 0.07 ENSMUST00000026360.8
integrin beta 8
chr1_+_131910458 0.06 ENSMUST00000062264.6
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr6_+_71543797 0.06 ENSMUST00000059462.5
charged multivesicular body protein 3
chr12_-_91590009 0.06 ENSMUST00000021345.6
general transcription factor II A, 1
chr6_-_39725448 0.05 ENSMUST00000002487.8
Braf transforming gene
chr2_-_52742169 0.05 ENSMUST00000102759.1
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chrX_-_144688180 0.05 ENSMUST00000040184.3
transient receptor potential cation channel, subfamily C, member 5
chr10_+_21994666 0.04 ENSMUST00000020145.5
serum/glucocorticoid regulated kinase 1
chrX_-_136743675 0.03 ENSMUST00000166478.1
mortality factor 4 like 2
chr16_+_42907563 0.03 ENSMUST00000151244.1
zinc finger and BTB domain containing 20
chr12_-_102878406 0.03 ENSMUST00000045652.6
BTB (POZ) domain containing 7
chr12_+_4769278 0.03 ENSMUST00000020967.4
profilin family, member 4
chr10_+_67537861 0.03 ENSMUST00000048289.7
early growth response 2
chr7_-_144553657 0.02 ENSMUST00000168134.3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr6_-_39377681 0.02 ENSMUST00000090243.4
solute carrier family 37 (glycerol-3-phosphate transporter), member 3
chr12_+_118846329 0.01 ENSMUST00000063918.2
trans-acting transcription factor 8
chr3_+_136670076 0.00 ENSMUST00000070198.7
protein phosphatase 3, catalytic subunit, alpha isoform

Network of associatons between targets according to the STRING database.

First level regulatory network of GUAGUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0007525 somatic muscle development(GO:0007525)
0.3 1.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.3 0.9 GO:1905223 epicardium morphogenesis(GO:1905223)
0.3 1.1 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.2 1.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 0.9 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.2 0.7 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.2 1.2 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.2 1.4 GO:0030242 pexophagy(GO:0030242)
0.2 1.0 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.2 1.3 GO:0051775 response to redox state(GO:0051775) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.2 1.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.2 0.5 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.6 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.3 GO:1990859 cellular response to endothelin(GO:1990859)
0.1 0.5 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.7 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.1 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.2 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.3 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.7 GO:0006824 cobalt ion transport(GO:0006824)
0.1 0.3 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.5 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.2 GO:0046881 positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.1 0.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.7 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 0.4 GO:0045345 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:1903551 regulation of extracellular exosome assembly(GO:1903551)
0.0 0.5 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:1903919 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
0.0 0.1 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.0 0.1 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.0 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.1 GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470)
0.0 0.2 GO:1901907 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.8 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.2 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.6 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.6 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.1 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.0 0.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.3 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 0.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.0 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.1 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0045176 apical protein localization(GO:0045176)
0.0 0.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.4 GO:0008333 endosome to lysosome transport(GO:0008333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0034685 integrin alphav-beta5 complex(GO:0034684) integrin alphav-beta6 complex(GO:0034685)
0.2 1.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 0.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.7 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.5 GO:0030478 actin cap(GO:0030478)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.0 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.7 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.3 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.8 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.7 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.4 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.9 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.7 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 1.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.7 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.1 1.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.0 GO:0017166 vinculin binding(GO:0017166)
0.1 1.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0004923 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0000401 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 1.0 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.1 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL