avrg: GSE58827: Dynamics of the Mouse Liver


Results for Evx2

Z-value: 0.50

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Transcription factors associated with Evx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000001815.9 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_172555932 1.82 ENSMUST00000061835.3
V-set and immunoglobulin domain containing 8
chr1_+_91801453 0.98 ENSMUST00000007949.3
twist basic helix-loop-helix transcription factor 2
chr3_-_15575065 0.84 ENSMUST00000091319.4
signal-regulatory protein beta 1B
chr6_-_69400097 0.84 ENSMUST00000177795.1
immunoglobulin kappa variable 4-62
chr16_-_38800193 0.81 ENSMUST00000057767.4
uroplakin 1B
chr6_+_116650674 0.79 ENSMUST00000067354.5
RIKEN cDNA 8430408G22 gene
chr2_-_168767029 0.76 ENSMUST00000075044.3
sal-like 4 (Drosophila)
chr6_-_69284319 0.75 ENSMUST00000103349.1
immunoglobulin kappa variable 4-69
chr2_-_168767136 0.74 ENSMUST00000029061.5
sal-like 4 (Drosophila)
chr2_+_154548888 0.71 ENSMUST00000045116.4
RIKEN cDNA 1700003F12 gene
chr7_-_48843663 0.55 ENSMUST00000167786.2
cysteine and glycine-rich protein 3
chr17_-_47834682 0.44 ENSMUST00000066368.6
MyoD family inhibitor
chr6_-_124779686 0.44 ENSMUST00000147669.1
leucine rich repeat containing 23
chr14_-_59365410 0.37 ENSMUST00000161031.1
PHD finger protein 11D
chr19_+_5088534 0.36 ENSMUST00000025811.4
Yip1 interacting factor homolog A (S. cerevisiae)
chr1_+_36761847 0.35 ENSMUST00000027291.4
zeta-chain (TCR) associated protein kinase
chr2_+_164613519 0.35 ENSMUST00000094346.2
WAP four-disulfide core domain 6B
chr14_-_59365465 0.35 ENSMUST00000095157.4
PHD finger protein 11D
chr10_-_80701811 0.31 ENSMUST00000003438.9
MOB kinase activator 3A
chr11_+_116843278 0.31 ENSMUST00000106370.3
methyltransferase like 23
chr4_+_109978004 0.28 ENSMUST00000061187.3
doublesex and mab-3 related transcription factor like family A2
chr9_-_107679592 0.28 ENSMUST00000010205.7
guanine nucleotide binding protein, alpha transducing 1
chrX_-_60893430 0.26 ENSMUST00000135107.2
SRY-box containing gene 3
chr4_-_132345715 0.25 ENSMUST00000084250.4
regulator of chromosome condensation 1
chr1_-_184999549 0.24 ENSMUST00000027929.4
MAP/microtubule affinity-regulating kinase 1
chr19_-_5560570 0.24 ENSMUST00000025861.1
OVO homolog-like 1 (Drosophila)
chr10_-_128525859 0.24 ENSMUST00000026427.6
extended synaptotagmin-like protein 1
chr11_-_113709520 0.23 ENSMUST00000173655.1
cleavage and polyadenylation specific factor 4-like
chr4_-_132345686 0.23 ENSMUST00000030726.6
regulator of chromosome condensation 1
chr2_-_155074447 0.23 ENSMUST00000137242.1
S-adenosylhomocysteine hydrolase
chr8_+_92855319 0.22 ENSMUST00000046290.1
lysophosphatidylcholine acyltransferase 2
chr17_-_36032682 0.21 ENSMUST00000102678.4
histocompatibility 2, T region locus 23
chr15_+_34453285 0.21 ENSMUST00000060894.7
cDNA sequence BC030476
chr7_-_126800354 0.21 ENSMUST00000106348.1
aldolase A, fructose-bisphosphate
chr18_+_77332394 0.20 ENSMUST00000148341.1
lipoxygenase homology domains 1
chr3_-_151835967 0.20 ENSMUST00000106126.1
prostaglandin F receptor
chr18_-_24603791 0.19 ENSMUST00000070726.3
solute carrier family 39 (metal ion transporter), member 6
chr6_+_122626410 0.19 ENSMUST00000049644.2
developmental pluripotency-associated 3
chr4_+_100478806 0.17 ENSMUST00000133493.2
ubiquitin-conjugating enzyme E2U (putative)
chr3_-_130709419 0.17 ENSMUST00000043937.7
oligosaccharyltransferase complex subunit
chrX_+_58030622 0.17 ENSMUST00000088627.4
zinc finger protein of the cerebellum 3
chr19_-_55241236 0.16 ENSMUST00000069183.6
guanylate cyclase 2g
chr18_-_24603464 0.16 ENSMUST00000154205.1
solute carrier family 39 (metal ion transporter), member 6
chr19_+_41933464 0.16 ENSMUST00000026154.7
zinc finger, DHHC domain containing 16
chr11_+_35121126 0.15 ENSMUST00000069837.3
slit homolog 3 (Drosophila)
chr11_-_113710017 0.15 ENSMUST00000018871.1
cleavage and polyadenylation specific factor 4-like
chr10_+_80264942 0.15 ENSMUST00000105362.1
DAZ associated protein 1
chr18_+_24603952 0.15 ENSMUST00000025120.6
elongator acetyltransferase complex subunit 2
chr16_-_42340595 0.15 ENSMUST00000102817.4
growth associated protein 43
chr2_+_91256813 0.15 ENSMUST00000144394.1
protein kinase C and casein kinase substrate in neurons 3
chrX_-_20950597 0.15 ENSMUST00000009550.7
ELK1, member of ETS oncogene family
chr2_+_91257323 0.14 ENSMUST00000111349.2
protein kinase C and casein kinase substrate in neurons 3
chr3_-_15426427 0.14 ENSMUST00000099201.3
signal-regulatory protein beta 1A
chr13_+_51645232 0.13 ENSMUST00000075853.5
CDC28 protein kinase regulatory subunit 2
chr2_-_150255591 0.13 ENSMUST00000063463.5
predicted gene 21994
chrX_+_58030999 0.13 ENSMUST00000088631.4
zinc finger protein of the cerebellum 3
chr11_-_120378692 0.13 ENSMUST00000026448.9
RIKEN cDNA 2310003H01 gene
chr17_-_49564262 0.12 ENSMUST00000057610.6
dishevelled associated activator of morphogenesis 2
chr12_-_98577940 0.12 ENSMUST00000110113.1
potassium channel, subfamily K, member 10
chr15_-_58034289 0.12 ENSMUST00000100655.3
RIKEN cDNA 9130401M01 gene
chr9_-_66514567 0.12 ENSMUST00000056890.8
F-box and leucine-rich repeat protein 22
chr10_+_39612934 0.11 ENSMUST00000019987.6
TRAF3 interacting protein 2
chr12_+_52699297 0.11 ENSMUST00000095737.3
A kinase (PRKA) anchor protein 6
chrM_+_10167 0.11 ENSMUST00000082414.1
mitochondrially encoded NADH dehydrogenase 4
chr4_+_140701466 0.11 ENSMUST00000038893.5
regulator of chromosome condensation 2
chr10_-_8886033 0.10 ENSMUST00000015449.5
SAM and SH3 domain containing 1
chr15_-_9529868 0.10 ENSMUST00000003981.4
interleukin 7 receptor
chr17_-_36462329 0.09 ENSMUST00000169950.1
histocompatibility 2, M region locus 10.4
chrM_+_7759 0.09 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr5_-_106926245 0.08 ENSMUST00000117588.1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr2_-_132247747 0.08 ENSMUST00000110163.1
transmembrane protein 230
chr4_-_129227883 0.08 ENSMUST00000106051.1
expressed sequence C77080
chr7_-_143460989 0.07 ENSMUST00000167912.1
cyclin-dependent kinase inhibitor 1C (P57)
chr16_-_45724600 0.07 ENSMUST00000096057.4
transgelin 3
chr9_-_120068263 0.07 ENSMUST00000064165.3
chemokine (C-X3-C) receptor 1
chr7_+_6222278 0.06 ENSMUST00000072662.5
zinc finger and SCAN domain containing 5B
chr6_+_72097561 0.06 ENSMUST00000069994.4
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr1_-_134955908 0.05 ENSMUST00000045665.6
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr12_+_109545390 0.02 ENSMUST00000146701.1
maternally expressed 3
chr17_+_36837123 0.02 ENSMUST00000179968.1
tripartite motif-containing 26
chr11_+_116657106 0.02 ENSMUST00000116318.2
predicted gene 11744
chr8_+_14888022 0.02 ENSMUST00000123990.1
ceroid-lipofuscinosis, neuronal 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903919 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
0.1 1.0 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 0.2 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 1.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.3 GO:0043366 beta selection(GO:0043366)
0.1 0.3 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.1 0.2 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.1 0.2 GO:2000566 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.2 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:1901536 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0 0.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.7 GO:0000792 heterochromatin(GO:0000792)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels