ISMARA results: Elf1_Elf2_Etv2

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Elf1_Elf2_Etv2_Elf4

Z-value: 2.34

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Transcription factors associated with Elf1_Elf2_Etv2_Elf4

Gene Symbol	Gene ID	Gene Info
Elf1 Ensembl NCBI MGI UniProt	ENSMUSG00000036461.9	E74-like factor 1
Elf2 Ensembl NCBI MGI UniProt	ENSMUSG00000037174.12	E74-like factor 2
Etv2 Ensembl NCBI MGI UniProt	ENSMUSG00000006311.8	ets variant 2
Elf4 Ensembl NCBI MGI UniProt	ENSMUSG00000031103.6	E74-like factor 4 (ets domain transcription factor)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Elf4	mm10_v2_chrX_-_48454152_48454193	0.49	2.4e-03	Click!
Elf2	mm10_v2_chr3_-_51340555_51340584	0.29	8.3e-02	Click!
Elf1	mm10_v2_chr14_+_79515618_79515694	0.12	4.9e-01	Click!
Etv2	mm10_v2_chr7_-_30635852_30635852	0.12	5.0e-01	Click!

Activity profile of Elf1_Elf2_Etv2_Elf4 motif

Sorted Z-values of Elf1_Elf2_Etv2_Elf4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_118620763 Show fit	19.44	ENSMUST00000071972.4	Wdr65 Ensembl NCBI MGI UniProt Show fit	WD repeat domain 65
chr11_+_87793722 Show fit	12.29	ENSMUST00000143021.2	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr2_-_26021532 Show fit	12.26	ENSMUST00000136750.1	Ubac1 Ensembl NCBI MGI UniProt Show fit	ubiquitin associated domain containing 1
chr8_+_72761868 Show fit	11.77	ENSMUST00000058099.8	F2rl3 Ensembl NCBI MGI UniProt Show fit	coagulation factor II (thrombin) receptor-like 3
chr16_-_18811972 Show fit	11.40	ENSMUST00000000028.7 ENSMUST00000115585.1	Cdc45 Ensembl NCBI MGI UniProt Show fit	cell division cycle 45
chr11_+_87793470 Show fit	11.35	ENSMUST00000020779.4	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr2_-_26021679 Show fit	10.89	ENSMUST00000036509.7	Ubac1 Ensembl NCBI MGI UniProt Show fit	ubiquitin associated domain containing 1
chr7_-_24760311 Show fit	10.34	ENSMUST00000063956.5	Cd177 Ensembl NCBI MGI UniProt Show fit	CD177 antigen
chr10_+_79879614 Show fit	10.06	ENSMUST00000006679.8	Prtn3 Ensembl NCBI MGI UniProt Show fit	proteinase 3
chr8_-_85380964 Show fit	9.98	ENSMUST00000122452.1	Mylk3 Ensembl NCBI MGI UniProt Show fit	myosin light chain kinase 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf1_Elf2_Etv2_Elf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	44.8	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.6	40.0	GO:0002181	cytoplasmic translation(GO:0002181)
1.5	33.9	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.2	30.3	GO:0000375	RNA splicing, via transesterification reactions(GO:0000375)
8.8	26.4	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
0.7	26.4	GO:0051310	metaphase plate congression(GO:0051310)
0.6	24.5	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.5	20.3	GO:0006406	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.7	19.2	GO:0034724	DNA replication-independent nucleosome organization(GO:0034724)
4.6	18.4	GO:0006014	D-ribose metabolic process(GO:0006014)

Showing 1 to 10 of 956 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	82.1	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
1.1	56.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	42.2	GO:0005813	centrosome(GO:0005813)
1.7	34.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.5	30.6	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3	30.5	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.5	28.9	GO:0005871	kinesin complex(GO:0005871)
0.2	27.7	GO:0017053	transcriptional repressor complex(GO:0017053)
1.7	27.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
2.0	24.3	GO:0005687	U4 snRNP(GO:0005687)

Showing 1 to 10 of 350 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	74.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	52.9	GO:0003723	RNA binding(GO:0003723)
0.6	31.0	GO:0019843	rRNA binding(GO:0019843)
0.4	30.7	GO:0003777	microtubule motor activity(GO:0003777)
2.8	27.8	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
1.7	23.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	22.1	GO:0030695	GTPase regulator activity(GO:0030695)
0.2	21.2	GO:0042393	histone binding(GO:0042393)
0.1	21.0	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3	20.0	GO:0004601	peroxidase activity(GO:0004601)

Showing 1 to 10 of 548 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	42.1	PID ATR PATHWAY	ATR signaling pathway
1.0	41.1	PID AURORA A PATHWAY	Aurora A signaling
0.9	37.2	PID AURORA B PATHWAY	Aurora B signaling
0.6	28.3	PID IL23 PATHWAY	IL23-mediated signaling events
1.3	25.9	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	21.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.5	21.1	PID PLK1 PATHWAY	PLK1 signaling events
0.5	18.3	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.2	16.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	16.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 106 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	76.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.2	63.6	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6	59.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
2.2	34.5	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.7	32.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.2	31.9	REACTOME KINESINS	Genes involved in Kinesins
0.1	28.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6	25.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.5	25.3	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
1.1	22.8	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes

Showing 1 to 10 of 182 entries

Results for Elf1_Elf2_Etv2_Elf4

Z-value: 2.34

Motif logo

Transcription factors associated with Elf1_Elf2_Etv2_Elf4

Activity-expression correlation:

Activity profile of Elf1_Elf2_Etv2_Elf4 motif

Sorted Z-values of Elf1_Elf2_Etv2_Elf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf1_Elf2_Etv2_Elf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: