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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Egr4

Z-value: 0.50

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Transcription factors associated with Egr4

Gene Symbol Gene ID Gene Info
Egr4
ENSMUSG00000071341.3 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr4mm10_v2_chr6_-_85513586_85513591-0.261.3e-01Click!

Activity profile of Egr4 motif

Sorted Z-values of Egr4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_49470555 0.77 ENSMUST00000042444.6
Arhgap36
Rho GTPase activating protein 36
chrX_+_49470450 0.76 ENSMUST00000114904.3
Arhgap36
Rho GTPase activating protein 36
chr11_-_53470479 0.51 ENSMUST00000057722.2
Gm9837
predicted gene 9837
chr4_-_43046196 0.45 ENSMUST00000036462.5
Fam214b
family with sequence similarity 214, member B
chr8_-_92356103 0.40 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr6_+_127149389 0.36 ENSMUST00000180811.1
9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr12_+_76370266 0.35 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr7_+_27653906 0.34 ENSMUST00000008088.7
Ttc9b
tetratricopeptide repeat domain 9B
chr8_-_92355764 0.34 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr14_-_79481268 0.32 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr2_+_105127200 0.32 ENSMUST00000139585.1
Wt1
Wilms tumor 1 homolog
chr5_+_137288273 0.32 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache
acetylcholinesterase
chr16_+_44173271 0.28 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608
predicted gene 608
chrX_-_143393893 0.27 ENSMUST00000166406.2
Chrdl1
chordin-like 1
chr14_+_79481164 0.27 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr15_-_36608959 0.26 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr2_-_9883993 0.26 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr10_-_116473418 0.24 ENSMUST00000087965.4
ENSMUST00000164271.1
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chrX_+_36195968 0.23 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chr16_-_36071515 0.21 ENSMUST00000004057.7
Fam162a
family with sequence similarity 162, member A
chr3_-_89089955 0.20 ENSMUST00000166687.1
Rusc1
RUN and SH3 domain containing 1
chr11_-_102407455 0.20 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39
solute carrier family 25, member 39
chr1_+_135132693 0.20 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chrX_+_36195950 0.20 ENSMUST00000115257.1
Zcchc12
zinc finger, CCHC domain containing 12
chr16_+_44173239 0.19 ENSMUST00000119746.1
Gm608
predicted gene 608
chr19_-_50678642 0.19 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1
VPS10 domain receptor protein SORCS 1
chr1_-_97661668 0.19 ENSMUST00000153115.1
ENSMUST00000142234.1
D1Ertd622e
DNA segment, Chr 1, ERATO Doi 622, expressed
chrX_+_36195904 0.19 ENSMUST00000115258.2
Zcchc12
zinc finger, CCHC domain containing 12
chr17_+_24470393 0.18 ENSMUST00000053024.6
Pgp
phosphoglycolate phosphatase
chr5_-_149051604 0.18 ENSMUST00000093196.4
Hmgb1
high mobility group box 1
chr15_+_102966794 0.17 ENSMUST00000001699.7
Hoxc10
homeobox C10
chr4_+_99656299 0.17 ENSMUST00000087285.3
Foxd3
forkhead box D3
chrX_+_36195938 0.17 ENSMUST00000048067.3
Zcchc12
zinc finger, CCHC domain containing 12
chr8_+_109868586 0.17 ENSMUST00000179721.1
ENSMUST00000034175.4
Phlpp2
PH domain and leucine rich repeat protein phosphatase 2
chr6_-_28261907 0.17 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800
zinc finger protein 800
chr11_-_102407899 0.16 ENSMUST00000124755.1
Slc25a39
solute carrier family 25, member 39
chr11_-_102407315 0.16 ENSMUST00000149777.1
ENSMUST00000154001.1
Slc25a39
solute carrier family 25, member 39
chr1_+_153425162 0.15 ENSMUST00000042373.5
Shcbp1l
Shc SH2-domain binding protein 1-like
chr6_-_85961631 0.15 ENSMUST00000032071.9
Dusp11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr14_+_56668242 0.14 ENSMUST00000116468.1
Mphosph8
M-phase phosphoprotein 8
chr16_+_8830093 0.14 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr6_-_3968357 0.14 ENSMUST00000031674.8
Tfpi2
tissue factor pathway inhibitor 2
chr7_-_4778141 0.14 ENSMUST00000094892.5
Il11
interleukin 11
chr19_-_50678485 0.13 ENSMUST00000111756.3
Sorcs1
VPS10 domain receptor protein SORCS 1
chr9_+_21032038 0.13 ENSMUST00000019616.4
Icam5
intercellular adhesion molecule 5, telencephalin
chr2_+_180589245 0.13 ENSMUST00000029087.3
Ogfr
opioid growth factor receptor
chr3_+_144570687 0.13 ENSMUST00000106211.1
Sep15
selenoprotein
chr1_-_36939521 0.13 ENSMUST00000027290.5
Tmem131
transmembrane protein 131
chr12_+_49382791 0.13 ENSMUST00000179669.1
Foxg1
forkhead box G1
chr17_-_31658729 0.13 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
chr16_+_36071624 0.12 ENSMUST00000164916.1
ENSMUST00000163352.1
Ccdc58
coiled-coil domain containing 58
chr17_+_26138661 0.12 ENSMUST00000074370.3
ENSMUST00000118904.2
ENSMUST00000163421.1
Axin1
axin 1
chr16_-_4213404 0.12 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr2_+_91922178 0.12 ENSMUST00000170432.1
Chrm4
cholinergic receptor, muscarinic 4
chr13_-_111490028 0.12 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr17_+_69383024 0.11 ENSMUST00000112674.1
Zbtb14
zinc finger and BTB domain containing 14
chr14_+_75845093 0.11 ENSMUST00000110894.2
Tpt1
tumor protein, translationally-controlled 1
chr13_+_55445301 0.11 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6
G protein-coupled receptor kinase 6
chr2_-_121355284 0.11 ENSMUST00000134796.1
ENSMUST00000110628.1
ENSMUST00000110627.1
ENSMUST00000110625.1
Ppip5k1
diphosphoinositol pentakisphosphate kinase 1
chr9_+_40269430 0.10 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chrX_+_7842056 0.09 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
Otud5
OTU domain containing 5
chr4_+_86748526 0.09 ENSMUST00000082026.7
ENSMUST00000045512.8
Dennd4c
DENN/MADD domain containing 4C
chr16_+_93832121 0.09 ENSMUST00000044068.6
Morc3
microrchidia 3
chr13_-_111490111 0.08 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr12_+_49383007 0.08 ENSMUST00000021333.3
Foxg1
forkhead box G1
chr2_-_48949206 0.08 ENSMUST00000090976.3
ENSMUST00000149679.1
ENSMUST00000028098.4
Orc4
origin recognition complex, subunit 4
chr2_+_164785823 0.08 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
Snx21
sorting nexin family member 21
chr4_+_127169131 0.08 ENSMUST00000046659.7
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr2_+_164785994 0.07 ENSMUST00000152471.1
Snx21
sorting nexin family member 21
chr11_-_86757483 0.07 ENSMUST00000060766.9
ENSMUST00000103186.4
Cltc
clathrin, heavy polypeptide (Hc)
chr9_+_65908967 0.07 ENSMUST00000034949.3
ENSMUST00000154589.1
Csnk1g1
casein kinase 1, gamma 1
chr9_-_44440868 0.06 ENSMUST00000098837.1
Foxr1
forkhead box R1
chr5_-_145084030 0.06 ENSMUST00000151196.1
Kpna7
karyopherin alpha 7 (importin alpha 8)
chr6_+_85451488 0.06 ENSMUST00000032078.6
Cct7
chaperonin containing Tcp1, subunit 7 (eta)
chr15_-_38078842 0.06 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr5_-_96161742 0.06 ENSMUST00000129646.1
ENSMUST00000113005.2
ENSMUST00000154500.1
ENSMUST00000141383.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr9_+_114688782 0.05 ENSMUST00000047404.6
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr8_+_69088646 0.05 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr10_+_93160824 0.04 ENSMUST00000069965.7
Cdk17
cyclin-dependent kinase 17
chr15_+_58141397 0.04 ENSMUST00000067563.7
Wdyhv1
WDYHV motif containing 1
chr1_-_177258182 0.04 ENSMUST00000111159.1
Akt3
thymoma viral proto-oncogene 3
chr4_+_99955715 0.04 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr19_-_8786245 0.04 ENSMUST00000177216.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr19_-_8786272 0.04 ENSMUST00000176610.1
ENSMUST00000177056.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr6_-_85451248 0.03 ENSMUST00000113770.1
ENSMUST00000032080.2
Pradc1
protease-associated domain containing 1
chr17_-_26841565 0.03 ENSMUST00000015723.4
Nkx2-5
NK2 homeobox 5
chr9_-_95511897 0.03 ENSMUST00000079659.5
ENSMUST00000078374.6
U2surp
U2 snRNP-associated SURP domain containing
chr4_+_128883549 0.03 ENSMUST00000035667.8
Trim62
tripartite motif-containing 62
chr18_+_86394952 0.03 ENSMUST00000058829.2
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr11_-_86993682 0.02 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr14_+_84443553 0.02 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr12_+_17690793 0.02 ENSMUST00000071858.3
Hpcal1
hippocalcin-like 1
chr2_+_92184106 0.02 ENSMUST00000111294.1
ENSMUST00000111293.2
ENSMUST00000162146.1
ENSMUST00000111292.1
ENSMUST00000162497.1
Phf21a
PHD finger protein 21A
chr19_+_38264761 0.02 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr19_-_8786408 0.02 ENSMUST00000176496.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr10_-_81350305 0.02 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr2_+_48949495 0.02 ENSMUST00000112745.1
Mbd5
methyl-CpG binding domain protein 5
chr10_-_81350389 0.02 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b
high mobility group 20B
chr16_+_64851991 0.01 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr10_-_81350191 0.01 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr19_-_21652714 0.01 ENSMUST00000177577.1
1110059E24Rik
RIKEN cDNA 1110059E24 gene
chr9_+_108306205 0.01 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr5_+_145084100 0.01 ENSMUST00000124379.1
Arpc1a
actin related protein 2/3 complex, subunit 1A
chr2_-_66634952 0.01 ENSMUST00000100064.2
ENSMUST00000100063.2
Scn9a
sodium channel, voltage-gated, type IX, alpha
chr1_+_167001457 0.01 ENSMUST00000126198.1
Fam78b
family with sequence similarity 78, member B
chr9_+_65630552 0.01 ENSMUST00000055844.8
Rbpms2
RNA binding protein with multiple splicing 2
chr9_+_108347827 0.01 ENSMUST00000035237.6
Usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr6_+_4747306 0.01 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
Peg10
paternally expressed 10
chr9_+_118926453 0.01 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr11_-_96777492 0.00 ENSMUST00000127375.1
ENSMUST00000021246.2
ENSMUST00000107661.3
Snx11
sorting nexin 11
chr7_-_63938862 0.00 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr17_+_34647128 0.00 ENSMUST00000015605.8
ENSMUST00000182587.1
Atf6b
activating transcription factor 6 beta
chr1_-_52500679 0.00 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr13_-_55513427 0.00 ENSMUST00000069929.6
ENSMUST00000069968.6
ENSMUST00000131306.1
ENSMUST00000046246.6
Pdlim7
PDZ and LIM domain 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:2000327 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 0.3 GO:2001076 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.1 0.3 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.2 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 0.3 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 0.2 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.1 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.2 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.0 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.1 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.0 0.1 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.0 0.1 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.0 GO:0003285 septum secundum development(GO:0003285) atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.1 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004104 cholinesterase activity(GO:0004104)
0.1 0.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC