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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for E2f1
Z-value: 6.52
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Transcription factors associated with E2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f1 | mm10_v2_chr2_-_154569845_154569892 | 0.95 | 2.2e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 98.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 9.2 | 92.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 5.7 | 85.9 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 5.4 | 70.8 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 2.6 | 69.3 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 21.5 | 64.6 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 3.6 | 64.1 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 1.8 | 56.5 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 5.0 | 55.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.1 | 53.4 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 184.3 | GO:0005694 | chromosome(GO:0005694) |
| 2.1 | 144.5 | GO:0005657 | replication fork(GO:0005657) |
| 9.0 | 134.7 | GO:0042555 | MCM complex(GO:0042555) |
| 0.4 | 69.5 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 6.9 | 69.1 | GO:0000796 | condensin complex(GO:0000796) |
| 0.9 | 68.0 | GO:0005844 | polysome(GO:0005844) |
| 0.7 | 65.8 | GO:0005814 | centriole(GO:0005814) |
| 1.8 | 59.2 | GO:0051233 | spindle midzone(GO:0051233) |
| 11.3 | 56.7 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.4 | 55.3 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 107.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.5 | 94.1 | GO:0042393 | histone binding(GO:0042393) |
| 13.7 | 82.3 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 0.5 | 63.1 | GO:0004386 | helicase activity(GO:0004386) |
| 10.3 | 61.5 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 1.7 | 58.5 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 11.3 | 56.7 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.3 | 55.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 4.9 | 54.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 9.0 | 45.0 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 221.3 | PID ATR PATHWAY | ATR signaling pathway |
| 2.1 | 203.5 | PID E2F PATHWAY | E2F transcription factor network |
| 2.1 | 102.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 43.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 36.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.0 | 33.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 33.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 32.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.8 | 29.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 1.0 | 28.6 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 142.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 5.7 | 101.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.6 | 86.2 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 4.6 | 78.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 5.1 | 66.6 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.7 | 58.0 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 3.0 | 45.0 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 3.1 | 43.1 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.8 | 42.6 | REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | Genes involved in Cleavage of Growing Transcript in the Termination Region |
| 0.8 | 39.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |