avrg: GSE58827: Dynamics of the Mouse Liver


Results for Cbfb

Z-value: 0.73

Motif logo

Transcription factors associated with Cbfb

Gene Symbol Gene ID Gene Info
ENSMUSG00000031885.7 core binding factor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Cbfb motif

Sorted Z-values of Cbfb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_40515362 3.16 ENSMUST00000027237.5
interleukin 18 receptor accessory protein
chr11_-_17008647 2.59 ENSMUST00000102881.3
chr2_+_164948219 2.55 ENSMUST00000017881.2
matrix metallopeptidase 9
chr2_+_172393900 2.13 ENSMUST00000109136.2
Cas scaffolding protein family member 4
chr16_-_92826004 1.98 ENSMUST00000023673.7
runt related transcription factor 1
chr2_-_58160495 1.73 ENSMUST00000028175.6
cytohesin 1 interacting protein
chr11_-_83649349 1.42 ENSMUST00000001008.5
chemokine (C-C motif) ligand 3
chr15_-_66801577 1.42 ENSMUST00000168589.1
src-like adaptor
chr7_-_67803489 1.40 ENSMUST00000181235.1
RIKEN cDNA 4833412C05 gene
chr5_-_147400352 1.15 ENSMUST00000049324.8
FMS-like tyrosine kinase 3
chr19_-_50678642 1.15 ENSMUST00000072685.6
VPS10 domain receptor protein SORCS 1
chr17_+_12119274 1.15 ENSMUST00000024594.2
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr6_-_136781718 1.12 ENSMUST00000078095.6
guanylate cyclase 2c
chr15_-_9529868 0.87 ENSMUST00000003981.4
interleukin 7 receptor
chr11_+_20631956 0.79 ENSMUST00000109586.2
SERTA domain containing 2
chr10_+_118441044 0.74 ENSMUST00000068592.3
interferon gamma
chr1_+_63176818 0.74 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr16_-_58718724 0.70 ENSMUST00000089318.3
G protein-coupled receptor 15
chr19_-_50678485 0.62 ENSMUST00000111756.3
VPS10 domain receptor protein SORCS 1
chr2_+_153938218 0.61 ENSMUST00000109757.1
BPI fold containing family B, member 4
chr7_-_115824699 0.61 ENSMUST00000169129.1
SRY-box containing gene 6
chr2_+_172393794 0.46 ENSMUST00000099061.2
Cas scaffolding protein family member 4
chr3_-_146651304 0.45 ENSMUST00000149825.1
RIKEN cDNA 4930503B20 gene
chr6_-_99726392 0.39 ENSMUST00000032152.8
prokineticin 2
chr4_-_117891994 0.37 ENSMUST00000030265.3
DPH2 homolog (S. cerevisiae)
chr15_-_101370125 0.35 ENSMUST00000077196.4
keratin 80
chr5_+_24364804 0.32 ENSMUST00000030834.4
nitric oxide synthase 3, endothelial cell
chr11_-_74724670 0.28 ENSMUST00000021091.8
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr19_+_12798574 0.26 ENSMUST00000025601.6
chr6_+_129408854 0.23 ENSMUST00000058352.8
C-type lectin domain family 9, member a
chr9_-_66126559 0.22 ENSMUST00000137542.1
sorting nexin 1
chr4_+_10874498 0.21 ENSMUST00000080517.7
RIKEN cDNA 2610301B20 gene
chr14_-_101729690 0.19 ENSMUST00000066461.3
predicted gene 9922
chr12_+_95692212 0.17 ENSMUST00000057324.3
fibronectin leucine rich transmembrane protein 2
chr4_+_83417715 0.15 ENSMUST00000030206.3
small nuclear RNA activating complex, polypeptide 3
chr4_+_108847827 0.15 ENSMUST00000102738.2
KTI12 homolog, chromatin associated (S. cerevisiae)
chr15_+_62039216 0.14 ENSMUST00000183297.1
plasmacytoma variant translocation 1
chr2_+_35132194 0.13 ENSMUST00000113034.1
centrosomal protein 110
chr14_+_64950037 0.12 ENSMUST00000043914.5
integrator complex subunit 9
chr8_+_27260327 0.08 ENSMUST00000033880.5
eukaryotic translation initiation factor 4E binding protein 1
chr1_-_16656843 0.04 ENSMUST00000115352.3
transcription elongation factor B (SIII), polypeptide 1
chr4_-_6990774 0.03 ENSMUST00000039987.3
thymocyte selection-associated high mobility group box
chr7_-_46795661 0.01 ENSMUST00000123725.1
Hermansky-Pudlak syndrome 5 homolog (human)

Network of associatons between targets according to the STRING database.

First level regulatory network of Cbfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.7 2.0 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.5 2.6 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560)
0.3 1.2 GO:0002572 pro-T cell differentiation(GO:0002572)
0.2 0.7 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.1 1.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.3 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 1.1 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:0009301 snRNA transcription(GO:0009301)
0.0 1.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.0 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.3 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.1 2.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.1 1.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.4 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 2.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation