avrg: GSE58827: Dynamics of the Mouse Liver


Results for Bcl6b

Z-value: 0.60

Motif logo

Transcription factors associated with Bcl6b

Gene Symbol Gene ID Gene Info
ENSMUSG00000000317.5 B cell CLL/lymphoma 6, member B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Bcl6b motif

Sorted Z-values of Bcl6b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_95417352 1.80 ENSMUST00000181781.1
RIKEN cDNA 5730420D15 gene
chr2_+_173153048 1.63 ENSMUST00000029017.5
phosphoenolpyruvate carboxykinase 1, cytosolic
chr10_+_63024315 1.62 ENSMUST00000124784.1
phenazine biosynthesis-like protein domain containing 2
chr10_+_128971191 1.60 ENSMUST00000181142.1
RIKEN cDNA 9030616G12 gene
chr10_-_95417099 1.58 ENSMUST00000135822.1
suppressor of cytokine signaling 2
chr10_-_95416850 1.46 ENSMUST00000020215.9
suppressor of cytokine signaling 2
chr16_-_21787796 1.19 ENSMUST00000023559.5
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
chr10_-_86705485 1.08 ENSMUST00000020238.7
heat shock protein 90, beta (Grp94), member 1
chr13_-_19307551 1.01 ENSMUST00000103561.1
T-cell receptor gamma, constant 2
chr13_+_19342154 0.95 ENSMUST00000103566.3
T cell receptor gamma, constant 4
chr9_+_55326913 0.92 ENSMUST00000085754.3
expressed sequence AI118078
chr14_+_33941021 0.87 ENSMUST00000100720.1
growth differentiation factor 2
chr7_+_119900099 0.84 ENSMUST00000106516.1
LYR motif containing 1
chr8_-_124569696 0.79 ENSMUST00000063278.6
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_124916863 0.75 ENSMUST00000069553.2
RIKEN cDNA A230083G16 gene
chr12_-_98577940 0.74 ENSMUST00000110113.1
potassium channel, subfamily K, member 10
chr11_+_120530688 0.73 ENSMUST00000026119.7
glucagon receptor
chr18_-_32139570 0.71 ENSMUST00000171765.1
protein C
chr5_-_150665315 0.66 ENSMUST00000141857.1
NEDD4 binding protein 2-like 2
chr1_+_191717834 0.62 ENSMUST00000110855.1
lysophosphatidylglycerol acyltransferase 1
chr9_-_109568262 0.60 ENSMUST00000056745.6
F-box and WD-40 domain protein 15
chr6_+_139621888 0.60 ENSMUST00000032353.8
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr5_+_102481546 0.59 ENSMUST00000112854.1
Rho GTPase activating protein 24
chr2_-_180824596 0.58 ENSMUST00000148700.1
predicted gene 14340
chr9_-_43239816 0.58 ENSMUST00000034512.5
OAF homolog (Drosophila)
chr6_+_34598500 0.55 ENSMUST00000079391.3
caldesmon 1
chr6_+_34598530 0.54 ENSMUST00000115027.1
caldesmon 1
chr18_-_3281036 0.50 ENSMUST00000049942.6
cAMP responsive element modulator
chr15_+_25752860 0.50 ENSMUST00000022882.5
myosin X
chr15_-_97020322 0.50 ENSMUST00000166223.1
solute carrier family 38, member 4
chr16_-_35871544 0.50 ENSMUST00000042665.8
poly (ADP-ribose) polymerase family, member 14
chr5_-_150665560 0.48 ENSMUST00000118316.1
NEDD4 binding protein 2-like 2
chr12_-_40134175 0.48 ENSMUST00000078481.7
chr18_+_33794915 0.46 ENSMUST00000179138.1
RIKEN cDNA 2410004N09 gene
chr5_+_102724971 0.46 ENSMUST00000112853.1
Rho GTPase activating protein 24
chr4_+_155562348 0.45 ENSMUST00000030939.7
NAD kinase
chr15_-_54919961 0.44 ENSMUST00000167541.2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr7_+_100009914 0.43 ENSMUST00000107084.1
chordin-like 2
chr15_-_54920115 0.43 ENSMUST00000171545.1
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr5_+_87808082 0.42 ENSMUST00000072539.5
casein alpha s2-like B
chr18_-_37644185 0.41 ENSMUST00000066272.4
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_+_102481374 0.41 ENSMUST00000094559.2
Rho GTPase activating protein 24
chr3_-_96240317 0.41 ENSMUST00000078756.5
histone cluster 2, H2aa2
chr18_+_33794882 0.39 ENSMUST00000146010.2
RIKEN cDNA 2410004N09 gene
chr19_-_5797410 0.39 ENSMUST00000173314.1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr8_-_3748941 0.37 ENSMUST00000012847.1
CD209a antigen
chr16_-_34262945 0.36 ENSMUST00000114953.1
kalirin, RhoGEF kinase
chr2_-_65567505 0.36 ENSMUST00000100069.2
sodium channel, voltage-gated, type III, alpha
chr14_-_55713482 0.35 ENSMUST00000168729.1
transglutaminase 1, K polypeptide
chr16_-_34263179 0.35 ENSMUST00000114949.1
kalirin, RhoGEF kinase
chr6_+_106769120 0.34 ENSMUST00000113247.1
tRNA nucleotidyl transferase, CCA-adding, 1
chr5_+_130079370 0.34 ENSMUST00000040721.8
protein-tyrosine sulfotransferase 1
chr1_+_193301953 0.34 ENSMUST00000016315.9
laminin, beta 3
chr7_+_43579577 0.34 ENSMUST00000058104.7
zinc finger protein 719
chr1_+_21240581 0.34 ENSMUST00000027067.8
glutathione S-transferase, alpha 3
chr16_-_34262830 0.34 ENSMUST00000114947.1
kalirin, RhoGEF kinase
chr2_+_131133497 0.32 ENSMUST00000110225.1
predicted gene 11037
chr1_+_21240597 0.32 ENSMUST00000121676.1
glutathione S-transferase, alpha 3
chr8_+_27042555 0.32 ENSMUST00000033875.8
proline synthetase co-transcribed
chr11_+_70764209 0.29 ENSMUST00000060444.5
zinc finger protein 3
chrX_+_151344171 0.28 ENSMUST00000073364.5
family with sequence similarity 120, member C
chr1_-_173942445 0.27 ENSMUST00000042228.8
interferon activated gene 203
myeloid nuclear differentiation antigen like
chr10_+_57794335 0.26 ENSMUST00000151623.1
sphingomyelin phosphodiesterase, acid-like 3A
chr9_+_13765970 0.25 ENSMUST00000152532.1
myotubularin related protein 2
chr11_+_93098404 0.25 ENSMUST00000107859.1
carbonic anhydrase 10
chr10_+_69213084 0.25 ENSMUST00000163497.1
Rho-related BTB domain containing 1
chr10_+_81633694 0.25 ENSMUST00000140345.1
ankyrin repeat domain 24
chr1_+_82316452 0.24 ENSMUST00000027322.7
rhomboid domain containing 1
chr3_+_84925476 0.23 ENSMUST00000107675.1
F-box and WD-40 domain protein 7
chr5_-_35525567 0.23 ENSMUST00000132959.1
carboxypeptidase Z
chr14_-_41185188 0.22 ENSMUST00000077136.3
surfactant associated protein D
chr14_-_56262233 0.21 ENSMUST00000015581.4
granzyme B
chr11_-_121081129 0.21 ENSMUST00000106120.2
secreted and transmembrane 1A
chr3_+_10366903 0.21 ENSMUST00000029049.5
charged multivesicular body protein 4C
chr11_-_121081158 0.21 ENSMUST00000026162.5
secreted and transmembrane 1A
chr2_+_18698998 0.20 ENSMUST00000095132.3
cDNA sequence BC061194
chr12_+_104115970 0.20 ENSMUST00000021496.7
serine (or cysteine) peptidase inhibitor, clade A, member 3A
chr6_+_48986861 0.20 ENSMUST00000037696.4
seminal vesicle secretory protein 1
chr11_+_119913802 0.19 ENSMUST00000026434.6
charged multivesicular body protein 6
chr8_+_25601591 0.19 ENSMUST00000155861.1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr4_+_15881255 0.18 ENSMUST00000029876.1
calbindin 1
chr9_+_40269430 0.17 ENSMUST00000171835.2
sodium channel, voltage-gated, type III, beta
chr8_+_13907748 0.17 ENSMUST00000043520.3
F-box protein 25
chr11_-_80142123 0.17 ENSMUST00000131601.1
transcription elongation factor, mitochondrial
chr6_+_29361410 0.15 ENSMUST00000156163.1
chr8_+_95534078 0.15 ENSMUST00000041569.3
coiled-coil domain containing 113
chr9_-_95815389 0.14 ENSMUST00000119760.1
plastin 1 (I-isoform)
chr2_-_77946375 0.14 ENSMUST00000065889.3
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr11_-_80142164 0.13 ENSMUST00000050207.9
transcription elongation factor, mitochondrial
chr2_+_18699052 0.13 ENSMUST00000173763.1
cDNA sequence BC061194
chr2_-_77946331 0.12 ENSMUST00000111821.2
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr18_+_42275353 0.12 ENSMUST00000046972.7
RNA binding motif protein 27
chr3_+_55242526 0.12 ENSMUST00000054237.7
doublecortin-like kinase 1
chr4_+_3574872 0.12 ENSMUST00000052712.5
trimethylguanosine synthase homolog (S. cerevisiae)
chr11_+_95712673 0.11 ENSMUST00000107717.1
zinc finger protein 652
chr7_+_48789003 0.11 ENSMUST00000118927.1
zinc finger, DHHC domain containing 13
chr2_+_175283298 0.10 ENSMUST00000098998.3
predicted gene 14440
chr18_+_37320374 0.09 ENSMUST00000078271.2
protocadherin beta 5
chr9_-_109162021 0.08 ENSMUST00000120329.1
F-box and WD-40 domain protein 21
chr8_-_5105232 0.07 ENSMUST00000023835.1
solute carrier family 10, member 2
chrX_+_48623737 0.07 ENSMUST00000114936.1
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr11_-_19018714 0.07 ENSMUST00000177417.1
Meis homeobox 1
chr11_+_58432559 0.06 ENSMUST00000108825.1
predicted gene 12253
chr1_+_88306731 0.05 ENSMUST00000040210.7
transient receptor potential cation channel, subfamily M, member 8
chr13_+_50698329 0.05 ENSMUST00000099518.2
predicted gene 8765
chr17_-_73399289 0.05 ENSMUST00000095208.3
calpain 13
chr11_+_58171648 0.04 ENSMUST00000020820.1
mitochondrial ribosomal protein L22
chr16_+_49057399 0.03 ENSMUST00000168680.1
myosin, heavy chain 15
chr5_-_123721007 0.02 ENSMUST00000031376.7
zinc finger, CCHC domain containing 8
chr11_+_51085087 0.01 ENSMUST00000101255.1
RIKEN cDNA 9230009I02 gene
chr14_-_20452217 0.00 ENSMUST00000144797.1
tetratricopeptide repeat domain 18
chr10_-_78412949 0.00 ENSMUST00000062678.9
ribosomal RNA processing 1 homolog (S. cerevisiae)
chr5_-_116392766 0.00 ENSMUST00000153818.1
RIKEN cDNA 4930562A09 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Bcl6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.3 0.7 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377)
0.3 1.1 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.3 0.8 GO:1902022 regulation of renal output by angiotensin(GO:0002019) regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) response to muscle activity involved in regulation of muscle adaptation(GO:0014873) L-lysine transport(GO:1902022)
0.2 1.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.7 GO:0033762 response to glucagon(GO:0033762)
0.1 3.0 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 1.0 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.3 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.7 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.3 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.3 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.1 GO:0071318 cellular response to ATP(GO:0071318)
0.1 0.2 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.4 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 0.3 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.6 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.2 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.0 0.6 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.4 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 0.2 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 1.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.1 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 0.1 GO:0050955 thermoception(GO:0050955)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0030478 actin cap(GO:0030478)
0.1 0.3 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.4 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 0.7 GO:0004967 glucagon receptor activity(GO:0004967)
0.2 1.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 0.7 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 1.1 GO:0046790 virion binding(GO:0046790)
0.1 0.4 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 0.3 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.1 0.3 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 1.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.0 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.5 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.9 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 0.7 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 2.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane