avrg: GSE58827: Dynamics of the Mouse Liver


Results for Atoh1_Bhlhe23

Z-value: 0.33

Motif logo

Transcription factors associated with Atoh1_Bhlhe23

Gene Symbol Gene ID Gene Info
ENSMUSG00000073043.4 atonal bHLH transcription factor 1
ENSMUSG00000045493.3 basic helix-loop-helix family, member e23

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of Atoh1_Bhlhe23 motif

Sorted Z-values of Atoh1_Bhlhe23 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_87861309 0.81 ENSMUST00000122100.1
insulin-like growth factor 1
chr6_-_87690819 0.67 ENSMUST00000162547.1
Riken cDNA 1810020O05 gene
chr7_+_30458280 0.63 ENSMUST00000126297.1
nephrosis 1, nephrin
chr3_+_3508024 0.40 ENSMUST00000108393.1
hepatocyte nuclear factor 4, gamma
chr16_+_43235856 0.39 ENSMUST00000146708.1
zinc finger and BTB domain containing 20
chr5_+_124194894 0.35 ENSMUST00000159053.1
predicted gene 16338
chr10_-_25200110 0.30 ENSMUST00000100012.2
A kinase (PRKA) anchor protein 7
chr17_+_36898110 0.29 ENSMUST00000078438.4
tripartite motif-containing 31
chr1_+_167618246 0.28 ENSMUST00000111380.1
retinoid X receptor gamma
chr9_+_66946057 0.27 ENSMUST00000040917.7
ribosomal protein S27-like
chr2_+_118772766 0.27 ENSMUST00000130293.1
proline/histidine/glycine-rich 1
chr3_-_84259812 0.25 ENSMUST00000107691.1
tripartite motif-containing 2
chrX_+_103321398 0.24 ENSMUST00000033689.2
caudal type homeobox 4
chr4_+_86053887 0.24 ENSMUST00000107178.2
ADAMTS-like 1
chr5_-_66618772 0.22 ENSMUST00000162994.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr18_+_34759551 0.21 ENSMUST00000097622.3
family with sequence similarity 53, member C
chr4_-_82850721 0.21 ENSMUST00000139401.1
zinc finger, DHHC domain containing 21
chr4_+_11579647 0.20 ENSMUST00000180239.1
fibrinogen silencer binding protein
chr11_-_69920581 0.20 ENSMUST00000108610.1
eukaryotic translation initiation factor 5A
chr11_-_53773187 0.19 ENSMUST00000170390.1
predicted gene, 17334
chr11_+_78503449 0.19 ENSMUST00000001130.6
SEBOX homeobox
chr11_+_117232254 0.19 ENSMUST00000106354.2
septin 9
chr9_+_24283433 0.18 ENSMUST00000154644.1
neuropeptide S receptor 1
chr17_+_82539258 0.18 ENSMUST00000097278.3
predicted pseudogene 6594
chr11_-_87404380 0.17 ENSMUST00000067692.6
RAD51 homolog C
chr19_-_37176055 0.17 ENSMUST00000142973.1
cytoplasmic polyadenylation element binding protein 3
chr2_-_79456750 0.16 ENSMUST00000041099.4
neurogenic differentiation 1
chrX_+_36328353 0.16 ENSMUST00000016383.3
LON peptidase N-terminal domain and ring finger 3
chr2_+_137663424 0.15 ENSMUST00000134833.1
predicted gene 14064
chr11_-_96747419 0.15 ENSMUST00000181758.1
RIKEN cDNA 2010300F17 gene
chr3_+_118430299 0.13 ENSMUST00000180774.1
predicted gene, 26871
chr14_+_28511344 0.13 ENSMUST00000112272.1
wingless-related MMTV integration site 5A
chr6_+_147032528 0.12 ENSMUST00000036194.4
RAB15 effector protein
chr9_-_99717259 0.12 ENSMUST00000112882.2
claudin 18
chr11_-_101417615 0.12 ENSMUST00000070395.8
alanyl-tRNA synthetase domain containing 1
chr7_+_17972124 0.12 ENSMUST00000094799.2
carcinoembryonic antigen-related cell adhesion molecule 11
chr7_+_18065929 0.12 ENSMUST00000032520.2
carcinoembryonic antigen-related cell adhesion molecule 12
chr2_-_52558539 0.11 ENSMUST00000102760.3
calcium channel, voltage-dependent, beta 4 subunit
chr15_-_81408261 0.11 ENSMUST00000057236.3
DnaJ (Hsp40) homolog, subfamily B, member 7
chr2_+_62046623 0.11 ENSMUST00000112480.2
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr2_+_62046580 0.11 ENSMUST00000054484.8
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr16_+_43510267 0.11 ENSMUST00000114695.2
zinc finger and BTB domain containing 20
chr7_-_90129339 0.11 ENSMUST00000181189.1
RIKEN cDNA 2310010J17 gene
chr13_+_108046411 0.10 ENSMUST00000095458.4
small integral membrane protein 15
chr8_+_94838321 0.10 ENSMUST00000034234.8
coenzyme Q9 homolog (yeast)
chr1_+_15287259 0.10 ENSMUST00000175681.1
potassium voltage gated channel, Shab-related subfamily, member 2
chr17_-_25792284 0.09 ENSMUST00000072735.7
family with sequence similarity 173, member A
chr8_+_25601591 0.09 ENSMUST00000155861.1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr2_+_127587214 0.09 ENSMUST00000028852.6
mitochondrial ribosomal protein S5
chr11_+_53433299 0.09 ENSMUST00000018382.6
growth differentiation factor 9
chr19_-_53589067 0.09 ENSMUST00000095978.3
nuclear transport factor 2, pseudogene 1
chr11_-_98329641 0.09 ENSMUST00000041685.6
neurogenic differentiation 2
chr8_+_25602236 0.09 ENSMUST00000146919.1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr2_-_105399286 0.09 ENSMUST00000006128.6
reticulocalbin 1
chr16_+_11008898 0.08 ENSMUST00000180624.1
predicted gene 4262
chr13_-_97747399 0.08 ENSMUST00000144993.1
RIKEN cDNA 5330416C01 gene
chr7_+_101394361 0.08 ENSMUST00000154239.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr9_+_26999668 0.08 ENSMUST00000039161.8
thymocyte nuclear protein 1
chr5_-_66618636 0.08 ENSMUST00000162382.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_+_108920342 0.08 ENSMUST00000052915.7
chr14_-_16249675 0.08 ENSMUST00000022311.4
3-oxoacyl-ACP synthase, mitochondrial
chr3_-_129804030 0.08 ENSMUST00000179187.1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr11_-_35980473 0.08 ENSMUST00000018993.6
WW, C2 and coiled-coil domain containing 1
chr4_-_25281801 0.07 ENSMUST00000102994.3
UFM1 specific ligase 1
chr12_+_86734381 0.07 ENSMUST00000095527.5
predicted gene 6772
chr2_+_62046462 0.07 ENSMUST00000102735.3
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr9_+_72985568 0.07 ENSMUST00000150826.2
cell cycle progression 1
chr17_-_47016956 0.07 ENSMUST00000165525.1
predicted gene 16494
chr6_-_128275577 0.07 ENSMUST00000130454.1
TEA domain family member 4
chr2_+_74727074 0.07 ENSMUST00000111980.2
homeobox D3
chr2_-_54085542 0.07 ENSMUST00000100089.2
reprimo, TP53 dependent G2 arrest mediator candidate
chr10_-_22149270 0.07 ENSMUST00000179054.1
RIKEN cDNA E030030I06 gene
chr7_-_141437829 0.06 ENSMUST00000019226.7
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr15_-_58364148 0.06 ENSMUST00000068515.7
annexin A13
chr11_-_94704499 0.06 ENSMUST00000069852.1
predicted gene 11541
chr9_+_78175898 0.06 ENSMUST00000180974.1
RIKEN cDNA C920006O11 gene
chr15_+_78913916 0.06 ENSMUST00000089378.4
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr1_+_177444653 0.06 ENSMUST00000094276.3
zinc finger and BTB domain containing 18
chr6_-_113501818 0.06 ENSMUST00000101059.1
proline-rich transmembrane protein 3
chr16_+_95258036 0.06 ENSMUST00000113859.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr7_-_141437587 0.06 ENSMUST00000172654.1
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr5_-_5479120 0.05 ENSMUST00000115447.1
RIKEN cDNA 1700015F17 gene
chr3_-_123236134 0.05 ENSMUST00000106427.1
synaptopodin 2
chr6_+_17743582 0.05 ENSMUST00000000674.6
suppression of tumorigenicity 7
chr1_+_177445660 0.05 ENSMUST00000077225.6
zinc finger and BTB domain containing 18
chr5_-_66618752 0.05 ENSMUST00000162366.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_+_60479915 0.05 ENSMUST00000126522.1
myosin XV
chr18_+_55057557 0.05 ENSMUST00000181765.1
predicted gene 4221
chr14_-_79223876 0.05 ENSMUST00000040802.4
zinc finger protein 957
chr1_+_6730051 0.05 ENSMUST00000043578.6
suppression of tumorigenicity 18
chr6_+_83034173 0.05 ENSMUST00000000707.2
lysyl oxidase-like 3
chr10_+_61175206 0.05 ENSMUST00000079235.5
thymus, brain and testes associated
chr9_-_26999491 0.05 ENSMUST00000060513.7
acyl-Coenzyme A dehydrogenase family, member 8
chr1_+_6730135 0.05 ENSMUST00000155921.1
suppression of tumorigenicity 18
chr1_-_178337774 0.04 ENSMUST00000037748.7
heterogeneous nuclear ribonucleoprotein U
chr7_-_133602110 0.04 ENSMUST00000033275.2
testis expressed 36
chr19_-_11856001 0.04 ENSMUST00000079875.3
olfactory receptor 1418
chr10_-_92164666 0.04 ENSMUST00000183123.1
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr5_+_113226909 0.04 ENSMUST00000086615.2
transmembrane protein 211
chr16_+_57353271 0.04 ENSMUST00000099667.2
filamin A interacting protein 1-like
chr10_+_53596936 0.04 ENSMUST00000020004.6
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr16_+_95258209 0.04 ENSMUST00000113858.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_+_100320596 0.04 ENSMUST00000152521.1
eukaryotic translation initiation factor 1
chrY_-_30840278 0.04 ENSMUST00000180175.1
predicted gene, 21529
chr10_+_80142295 0.03 ENSMUST00000003156.8
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr2_-_39065505 0.03 ENSMUST00000039165.8
golgi autoantigen, golgin subfamily a, 1
chr15_+_84669565 0.03 ENSMUST00000171460.1
proline rich 5 (renal)
chr5_-_28210168 0.03 ENSMUST00000117098.1
canopy 1 homolog (zebrafish)
chr1_-_183147461 0.03 ENSMUST00000171366.1
dispatched homolog 1 (Drosophila)
chr17_-_6449571 0.03 ENSMUST00000180035.1
transmembrane protein 181B, pseudogene
chrX_-_160735747 0.03 ENSMUST00000135856.1
protein phosphatase with EF hand calcium-binding domain 1
chr2_+_21367532 0.03 ENSMUST00000055946.7
G protein-coupled receptor 158
chr6_-_148831395 0.03 ENSMUST00000145960.1
importin 8
chr2_+_78051155 0.03 ENSMUST00000145972.1
RIKEN cDNA 4930440I19 gene
chr10_+_80142358 0.03 ENSMUST00000105366.1
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr19_-_37207293 0.03 ENSMUST00000132580.1
cytoplasmic polyadenylation element binding protein 3
chr3_+_125404072 0.03 ENSMUST00000173932.1
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr1_+_150392794 0.03 ENSMUST00000124973.2
translocated promoter region
chr9_+_35669624 0.03 ENSMUST00000118254.1
prostate and testis expressed 2
chr5_-_24447587 0.03 ENSMUST00000127194.1
transmembrane and ubiquitin-like domain containing 1
chr17_-_6827990 0.03 ENSMUST00000181895.1
predicted gene 2885
chr9_-_88719798 0.03 ENSMUST00000113110.3
predicted gene 2382
chr14_-_51071442 0.02 ENSMUST00000048478.5
olfactory receptor 750
chr5_-_74068361 0.02 ENSMUST00000119154.1
ubiquitin specific peptidase 46
chr4_+_127172866 0.02 ENSMUST00000106094.2
discs, large (Drosophila) homolog-associated protein 3
chr2_-_39065438 0.02 ENSMUST00000112850.2
golgi autoantigen, golgin subfamily a, 1
chr17_+_35552128 0.02 ENSMUST00000044804.7
chr16_+_16213318 0.02 ENSMUST00000162150.1
plakophilin 2
chr16_-_57292845 0.02 ENSMUST00000023434.8
transmembrane protein 30C
chr10_+_69706326 0.02 ENSMUST00000182992.1
ankyrin 3, epithelial
chrY_-_3410167 0.02 ENSMUST00000169382.2
predicted gene, 21704
chr11_+_67774608 0.02 ENSMUST00000181566.1
predicted gene 12302
chr2_-_156180135 0.02 ENSMUST00000126992.1
RNA binding motif protein 39
chr19_-_53371766 0.02 ENSMUST00000086887.1
predicted gene 10197
chr1_-_150392719 0.02 ENSMUST00000006167.6
cDNA sequence BC003331
chr17_+_86917348 0.02 ENSMUST00000042172.5
transmembrane protein 247
chr17_+_35126316 0.02 ENSMUST00000061859.6
DNA segment, Chr 17, human D6S53E
chr15_+_30172570 0.02 ENSMUST00000081728.5
catenin (cadherin associated protein), delta 2
chr4_+_55350043 0.02 ENSMUST00000030134.8
RAD23b homolog (S. cerevisiae)
chr6_-_3494587 0.01 ENSMUST00000049985.8
HEPACAM family member 2
chr17_-_86947867 0.01 ENSMUST00000065758.7
ATPase, H+ transporting, lysosomal V1 subunit E2
chr13_+_37345338 0.01 ENSMUST00000021860.5
lymphocyte antigen 86
chr2_+_164833841 0.01 ENSMUST00000152721.1
cathepsin A
chr4_-_141598206 0.01 ENSMUST00000131317.1
filamin binding LIM protein 1
chr1_-_111864869 0.01 ENSMUST00000035462.5
dermatan sulfate epimerase-like
chr11_+_49247462 0.01 ENSMUST00000109194.1
mannoside acetylglucosaminyltransferase 1
chr11_+_31872100 0.01 ENSMUST00000020543.6
cytoplasmic polyadenylation element binding protein 4
chr18_-_77186257 0.01 ENSMUST00000097520.2
predicted gene 7276
chr2_+_69670100 0.01 ENSMUST00000100050.3
kelch-like 41
chr5_+_3343893 0.00 ENSMUST00000165117.1
cyclin-dependent kinase 6
chr15_+_25622525 0.00 ENSMUST00000110457.1
myosin X
chr8_+_4243264 0.00 ENSMUST00000110996.1
mitogen-activated protein kinase kinase 7
chr2_-_80128834 0.00 ENSMUST00000102654.4
phosphodiesterase 1A, calmodulin-dependent

Network of associatons between targets according to the STRING database.

First level regulatory network of Atoh1_Bhlhe23

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.2 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:2000292 negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.0 0.2 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.0 0.1 GO:0061349 cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.1 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.1 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.0 0.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.6 GO:0044062 regulation of excretion(GO:0044062)
0.0 0.0 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.0 0.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.0 0.0 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0033572 transferrin transport(GO:0033572)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0097441 basilar dendrite(GO:0097441)
0.0 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.0 0.2 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.0 0.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0016208 AMP binding(GO:0016208)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.8 PID IGF1 PATHWAY IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells