Motif ID: ZNF423

Z-value: 0.959


Transcription factors associated with ZNF423:

Gene SymbolEntrez IDGene Name
ZNF423 ENSG00000102935.7 ZNF423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49698136_496982090.414.6e-02Click!


Activity profile for motif ZNF423.

activity profile for motif ZNF423


Sorted Z-values histogram for motif ZNF423

Sorted Z-values for motif ZNF423



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_22022800 3.292 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr5_+_150400124 3.235 ENST00000388825.4
ENST00000521650.1
ENST00000517973.1
GPX3


glutathione peroxidase 3 (plasma)


chr6_+_151186554 2.507 ENST00000367321.3
ENST00000367307.4
MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

chr19_-_11689752 2.363 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
ACP5



acid phosphatase 5, tartrate resistant



chr1_-_204121013 2.289 ENST00000367201.3
ETNK2
ethanolamine kinase 2
chr10_-_121296045 2.285 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr1_-_204121102 2.277 ENST00000367202.4
ETNK2
ethanolamine kinase 2
chr1_-_204121298 2.231 ENST00000367199.2
ETNK2
ethanolamine kinase 2
chr11_-_61062762 2.201 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr8_+_22022223 2.161 ENST00000306385.5
BMP1
bone morphogenetic protein 1
chr17_+_6347729 1.864 ENST00000572447.1
FAM64A
family with sequence similarity 64, member A
chr5_+_135385202 1.848 ENST00000514554.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr17_+_6347761 1.840 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
FAM64A




family with sequence similarity 64, member A




chr8_+_22022653 1.839 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1


bone morphogenetic protein 1


chr16_+_71392616 1.831 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2


calbindin 2


chr12_-_125348329 1.800 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
SCARB1




scavenger receptor class B, member 1




chr9_-_131486367 1.748 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12




zinc finger, DHHC-type containing 12




chrX_-_51239425 1.667 ENST00000375992.3
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr22_-_37823468 1.660 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr12_-_125348448 1.617 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr10_+_17271266 1.486 ENST00000224237.5
VIM
vimentin
chr11_+_60691924 1.455 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
TMEM132A


transmembrane protein 132A


chr17_+_7341586 1.286 ENST00000575235.1
FGF11
fibroblast growth factor 11
chrX_-_107019181 1.279 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3



TSC22 domain family, member 3



chr1_-_155177677 1.264 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3


thrombospondin 3


chr15_+_41523417 1.259 ENST00000560397.1
CHP1
calcineurin-like EF-hand protein 1
chr3_-_48594248 1.248 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
PFKFB4





6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4





chrX_+_49028265 1.179 ENST00000376322.3
ENST00000376327.5
PLP2

proteolipid protein 2 (colonic epithelium-enriched)

chr11_-_61658853 1.178 ENST00000525588.1
ENST00000540820.1
FADS3

fatty acid desaturase 3

chr7_-_23053719 1.176 ENST00000432176.2
ENST00000440481.1
FAM126A

family with sequence similarity 126, member A

chr6_+_151187074 1.175 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr10_+_135340859 1.154 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1


cytochrome P450, family 2, subfamily E, polypeptide 1


chr7_-_23053693 1.135 ENST00000409763.1
ENST00000409923.1
FAM126A

family with sequence similarity 126, member A

chr19_-_10679644 1.129 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr11_-_61659006 1.118 ENST00000278829.2
FADS3
fatty acid desaturase 3
chr20_-_62475273 1.080 ENST00000596861.1
AL158091.1
Protein LOC100509861
chrX_-_107018969 1.071 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr10_-_76859247 1.058 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
DUSP13


dual specificity phosphatase 13


chr9_+_112542572 1.019 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr8_+_22423219 1.010 ENST00000523965.1
ENST00000521554.1
SORBS3

sorbin and SH3 domain containing 3

chr19_-_15311713 0.897 ENST00000601011.1
ENST00000263388.2
NOTCH3

notch 3

chr16_+_27325202 0.863 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R






interleukin 4 receptor






chr9_+_116638562 0.809 ENST00000374126.5
ENST00000288466.7
ZNF618

zinc finger protein 618

chr17_+_36584662 0.792 ENST00000431231.2
ENST00000437668.3
ARHGAP23

Rho GTPase activating protein 23

chr8_+_22422749 0.778 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr10_+_124913793 0.763 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3


BUB3 mitotic checkpoint protein


chr1_+_155278625 0.762 ENST00000368356.4
ENST00000356657.6
FDPS

farnesyl diphosphate synthase

chr19_+_45971246 0.739 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB





FBJ murine osteosarcoma viral oncogene homolog B





chr2_+_62932779 0.738 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EHBP1


EH domain binding protein 1


chr19_+_45582453 0.692 ENST00000587566.1
ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
MARK4
GEMIN7



MAP/microtubule affinity-regulating kinase 4
gem (nuclear organelle) associated protein 7



chr3_-_195808980 0.689 ENST00000360110.4
TFRC
transferrin receptor
chr4_+_4388805 0.686 ENST00000504171.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr11_+_61595752 0.677 ENST00000521849.1
FADS2
fatty acid desaturase 2
chr3_-_195808952 0.673 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC



transferrin receptor



chr12_-_54779511 0.657 ENST00000551109.1
ENST00000546970.1
ZNF385A

zinc finger protein 385A

chr11_-_47207950 0.657 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
PACSIN3




protein kinase C and casein kinase substrate in neurons 3




chr13_+_21277482 0.653 ENST00000304920.3
IL17D
interleukin 17D
chr6_+_33589161 0.614 ENST00000605930.1
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr8_+_30241934 0.611 ENST00000538486.1
RBPMS
RNA binding protein with multiple splicing
chr3_+_6902794 0.596 ENST00000357716.4
ENST00000486284.1
ENST00000389336.4
ENST00000403881.1
ENST00000402647.2
GRM7




glutamate receptor, metabotropic 7




chr13_+_96743093 0.573 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr9_-_35619539 0.560 ENST00000396757.1
CD72
CD72 molecule
chr6_+_142468361 0.553 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr11_-_67120974 0.517 ENST00000539074.1
ENST00000312419.3
POLD4

polymerase (DNA-directed), delta 4, accessory subunit

chr4_-_20985632 0.515 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr17_-_48227877 0.514 ENST00000316878.6
PPP1R9B
protein phosphatase 1, regulatory subunit 9B
chr4_+_4388245 0.510 ENST00000433139.2
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr6_-_35480640 0.508 ENST00000428978.1
ENST00000322263.4
TULP1

tubby like protein 1

chr9_+_112542591 0.498 ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
ENST00000483909.1
ENST00000314527.4
PALM2-AKAP2

AKAP2

PALM2

PALM2-AKAP2 readthrough

A kinase (PRKA) anchor protein 2

paralemmin 2

chrX_+_106163626 0.471 ENST00000336803.1
CLDN2
claudin 2
chr11_-_64013663 0.465 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr6_-_35480705 0.435 ENST00000229771.6
TULP1
tubby like protein 1
chr4_+_4387983 0.431 ENST00000397958.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr1_+_55271736 0.431 ENST00000358193.3
ENST00000371273.3
C1orf177

chromosome 1 open reading frame 177

chr1_-_102462565 0.431 ENST00000370103.4
OLFM3
olfactomedin 3
chr5_-_172756506 0.426 ENST00000265087.4
STC2
stanniocalcin 2
chr15_+_41523335 0.421 ENST00000334660.5
CHP1
calcineurin-like EF-hand protein 1
chr8_+_22423168 0.407 ENST00000518912.1
ENST00000428103.1
SORBS3

sorbin and SH3 domain containing 3

chr6_+_42896865 0.388 ENST00000372836.4
ENST00000394142.3
CNPY3

canopy FGF signaling regulator 3

chr12_-_50101003 0.378 ENST00000550488.1
FMNL3
formin-like 3
chr22_+_35653445 0.354 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4



HMG box domain containing 4



chr3_+_180630444 0.350 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
FXR1



fragile X mental retardation, autosomal homolog 1



chr12_-_118810688 0.336 ENST00000542532.1
ENST00000392533.3
TAOK3

TAO kinase 3

chr7_-_5570229 0.336 ENST00000331789.5
ACTB
actin, beta
chr10_+_124914285 0.335 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr12_-_4554780 0.331 ENST00000228837.2
FGF6
fibroblast growth factor 6
chr16_+_3014269 0.325 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
KREMEN2


kringle containing transmembrane protein 2


chr18_-_60985914 0.323 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chr8_+_30241995 0.314 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RBPMS



RNA binding protein with multiple splicing



chr7_-_100253993 0.313 ENST00000461605.1
ENST00000160382.5
ACTL6B

actin-like 6B

chr19_+_20011775 0.305 ENST00000592160.1
ENST00000343769.5
ENST00000592245.1
ZNF93

AC007204.2
zinc finger protein 93

AC007204.2
chr6_-_91296602 0.291 ENST00000369325.3
ENST00000369327.3
MAP3K7

mitogen-activated protein kinase kinase kinase 7

chrX_+_136648297 0.282 ENST00000287538.5
ZIC3
Zic family member 3
chr9_+_135037334 0.280 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
NTNG2



netrin G2



chr13_-_46626847 0.278 ENST00000242848.4
ENST00000282007.3
ZC3H13

zinc finger CCCH-type containing 13

chr8_-_42234745 0.274 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr16_+_3014217 0.273 ENST00000572045.1
KREMEN2
kringle containing transmembrane protein 2
chr6_-_91296737 0.269 ENST00000369332.3
ENST00000369329.3
MAP3K7

mitogen-activated protein kinase kinase kinase 7

chr11_-_62783276 0.260 ENST00000535878.1
ENST00000545207.1
SLC22A8

solute carrier family 22 (organic anion transporter), member 8

chr4_+_128982490 0.253 ENST00000394288.3
ENST00000432347.2
ENST00000264584.5
ENST00000441387.1
ENST00000427266.1
ENST00000354456.3
LARP1B





La ribonucleoprotein domain family, member 1B





chr3_+_9958758 0.248 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
IL17RC






interleukin 17 receptor C






chr1_+_10459111 0.239 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD



phosphogluconate dehydrogenase



chr4_+_128982430 0.231 ENST00000512292.1
ENST00000508819.1
LARP1B

La ribonucleoprotein domain family, member 1B

chr19_-_57183114 0.228 ENST00000537055.2
ENST00000601659.1
ZNF835

zinc finger protein 835

chr2_+_12246664 0.223 ENST00000449986.1
AC096559.1
AC096559.1
chr15_-_75660919 0.219 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
MAN2C1






mannosidase, alpha, class 2C, member 1






chr2_+_171785824 0.213 ENST00000452526.2
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr4_-_120548779 0.208 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chr10_+_124913930 0.208 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr8_-_133493200 0.199 ENST00000388996.4
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr7_-_44265492 0.187 ENST00000425809.1
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr7_+_150748288 0.185 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr22_-_38484922 0.178 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr7_-_27219849 0.172 ENST00000396344.4
HOXA10
homeobox A10
chr11_-_62783303 0.171 ENST00000336232.2
ENST00000430500.2
SLC22A8

solute carrier family 22 (organic anion transporter), member 8

chr4_+_152330390 0.169 ENST00000503146.1
ENST00000435205.1
FAM160A1

family with sequence similarity 160, member A1

chr5_+_78407602 0.165 ENST00000274353.5
ENST00000524080.1
BHMT

betaine--homocysteine S-methyltransferase

chrX_+_30265256 0.152 ENST00000397548.2
MAGEB1
melanoma antigen family B, 1
chr1_+_26644441 0.149 ENST00000374213.2
CD52
CD52 molecule
chr11_-_64510409 0.147 ENST00000394429.1
ENST00000394428.1
RASGRP2

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

chr3_+_9958870 0.146 ENST00000413608.1
IL17RC
interleukin 17 receptor C
chr2_+_171785012 0.139 ENST00000234160.4
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr7_+_20370746 0.136 ENST00000222573.4
ITGB8
integrin, beta 8
chr4_-_78740511 0.132 ENST00000504123.1
ENST00000264903.4
ENST00000515441.1
CNOT6L


CCR4-NOT transcription complex, subunit 6-like


chr2_+_135011731 0.129 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr1_+_53527854 0.127 ENST00000371500.3
ENST00000395871.2
ENST00000312553.5
PODN


podocan


chr15_-_66649010 0.111 ENST00000367709.4
ENST00000261881.4
TIPIN

TIMELESS interacting protein

chr20_+_23016057 0.108 ENST00000255008.3
SSTR4
somatostatin receptor 4
chr6_+_30130969 0.104 ENST00000376694.4
TRIM15
tripartite motif containing 15
chr17_+_28705921 0.103 ENST00000225719.4
CPD
carboxypeptidase D
chr9_-_16870704 0.097 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2



basonuclin 2



chr14_-_77608121 0.097 ENST00000319374.4
ZDHHC22
zinc finger, DHHC-type containing 22
chr3_+_196439275 0.088 ENST00000296333.5
PIGX
phosphatidylinositol glycan anchor biosynthesis, class X
chr10_-_75255724 0.079 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
PPP3CB




protein phosphatase 3, catalytic subunit, beta isozyme




chr6_+_168841817 0.061 ENST00000356284.2
ENST00000354536.5
SMOC2

SPARC related modular calcium binding 2

chr5_-_176057365 0.057 ENST00000310112.3
SNCB
synuclein, beta
chr3_+_32726774 0.049 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr16_-_11681023 0.046 ENST00000570904.1
ENST00000574701.1
LITAF

lipopolysaccharide-induced TNF factor

chr5_+_68788594 0.041 ENST00000396442.2
ENST00000380766.2
OCLN

occludin

chr11_+_92702886 0.039 ENST00000257068.2
ENST00000528076.1
MTNR1B

melatonin receptor 1B

chr14_-_93582214 0.034 ENST00000556603.2
ENST00000354313.3
ITPK1

inositol-tetrakisphosphate 1-kinase

chr19_-_36391434 0.018 ENST00000396901.1
ENST00000585925.1
NFKBID

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

chr12_+_7037461 0.014 ENST00000396684.2
ATN1
atrophin 1
chr3_+_196439170 0.011 ENST00000392391.3
ENST00000314118.4
PIGX

phosphatidylinositol glycan anchor biosynthesis, class X

chr14_-_93582148 0.010 ENST00000267615.6
ENST00000553452.1
ITPK1

inositol-tetrakisphosphate 1-kinase

chr1_-_48462566 0.005 ENST00000606738.2
TRABD2B
TraB domain containing 2B
chr5_-_176057518 0.004 ENST00000393693.2
SNCB
synuclein, beta
chr7_-_100491854 0.004 ENST00000426415.1
ENST00000430554.1
ENST00000412389.1
ACHE


acetylcholinesterase (Yt blood group)


chr1_-_33366931 0.003 ENST00000373463.3
ENST00000329151.5
TMEM54

transmembrane protein 54


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.9 3.7 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.5 3.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 2.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 7.6 GO:0001502 cartilage condensation(GO:0001502)
0.3 1.7 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 2.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 6.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.7 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.2 1.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.2 GO:0010193 response to ozone(GO:0010193)
0.2 0.9 GO:1990834 negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834)
0.2 0.5 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.2 0.8 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 1.6 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.1 0.7 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 1.5 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 0.6 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.1 0.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.1 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.9 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 2.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.9 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.6 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 1.3 GO:0060346 bone trabecula formation(GO:0060346)
0.1 0.3 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.2 GO:0019521 pentose-phosphate shunt, oxidative branch(GO:0009051) aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.1 1.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.9 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 3.0 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.2 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.6 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.4 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 1.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 2.2 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.7 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.6 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.2 1.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.6 GO:0098845 postsynaptic endosome(GO:0098845)
0.1 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 1.8 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.9 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 3.2 GO:0043679 axon terminus(GO:0043679)
0.0 8.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 1.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.9 3.7 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.7 6.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.5 1.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.3 3.2 GO:0008430 selenium binding(GO:0008430)
0.3 0.9 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.3 1.7 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.3 2.4 GO:0043426 MRF binding(GO:0043426)
0.2 1.5 GO:1990254 keratin filament binding(GO:1990254)
0.2 1.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 0.6 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 2.4 GO:0008199 ferric iron binding(GO:0008199)
0.2 1.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 0.6 GO:0005220 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 0.8 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.7 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 0.9 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.6 GO:0070905 serine binding(GO:0070905)
0.1 2.2 GO:0017166 vinculin binding(GO:0017166)
0.1 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 1.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.2 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 1.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 7.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 2.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.2 GO:0019956 chemokine binding(GO:0019956)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.0 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 2.0 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 1.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 6.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID_P73PATHWAY p73 transcription factor network
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 6.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 0.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 0.6 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.6 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 2.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 2.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.8 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.3 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes