Motif ID: ZNF143

Z-value: 1.321


Transcription factors associated with ZNF143:

Gene SymbolEntrez IDGene Name
ZNF143 ENSG00000166478.5 ZNF143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF143hg19_v2_chr11_+_9482551_94826040.511.2e-02Click!


Activity profile for motif ZNF143.

activity profile for motif ZNF143


Sorted Z-values histogram for motif ZNF143

Sorted Z-values for motif ZNF143



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_76210267 5.662 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5



baculoviral IAP repeat containing 5



chr19_-_48673552 5.574 ENST00000536218.1
ENST00000596549.1
LIG1

ligase I, DNA, ATP-dependent

chr19_-_48673580 5.554 ENST00000427526.2
LIG1
ligase I, DNA, ATP-dependent
chr17_+_76210367 3.381 ENST00000592734.1
ENST00000587746.1
BIRC5

baculoviral IAP repeat containing 5

chr12_+_53895052 2.633 ENST00000552857.1
TARBP2
TAR (HIV-1) RNA binding protein 2
chr12_+_53895364 2.138 ENST00000552817.1
ENST00000394357.2
TARBP2

TAR (HIV-1) RNA binding protein 2

chr1_-_54303949 2.134 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr2_-_169746878 2.023 ENST00000282074.2
SPC25
SPC25, NDC80 kinetochore complex component
chr15_+_40453204 1.938 ENST00000287598.6
ENST00000412359.3
BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr14_+_97263641 1.937 ENST00000216639.3
VRK1
vaccinia related kinase 1
chr1_-_54304212 1.896 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr2_+_25015968 1.827 ENST00000380834.2
ENST00000473706.1
CENPO

centromere protein O

chr1_-_54303934 1.807 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr19_-_2456922 1.691 ENST00000582871.1
ENST00000325327.3
LMNB2

lamin B2

chr16_+_23690138 1.582 ENST00000300093.4
PLK1
polo-like kinase 1
chr19_+_50180317 1.478 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr1_+_19578033 1.409 ENST00000330263.4
MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr7_+_94285637 1.381 ENST00000482108.1
ENST00000488574.1
PEG10

paternally expressed 10

chr11_-_58345569 1.317 ENST00000528954.1
ENST00000528489.1
LPXN

leupaxin

chr7_-_134001663 1.316 ENST00000378509.4
SLC35B4
solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 11.1 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.5 10.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.9 5.8 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.9 5.6 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 4.0 GO:0007062 sister chromatid cohesion(GO:0007062)
0.3 2.6 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 2.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 2.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.7 2.2 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.4 2.2 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.2 2.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.5 1.9 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.3 1.9 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.1 1.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.7 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.5 1.6 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.3 1.6 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.2 1.6 GO:0036481 intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481)
0.1 1.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.4 1.5 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 10.0 GO:0032133 chromosome passenger complex(GO:0032133)
1.9 5.8 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.4 5.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 4.1 GO:0005871 kinesin complex(GO:0005871)
0.2 2.7 GO:0034709 methylosome(GO:0034709)
0.1 2.6 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 2.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.2 2.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.6 2.2 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.3 2.0 GO:0031262 Ndc80 complex(GO:0031262)
0.2 2.0 GO:0000796 condensin complex(GO:0000796)
0.0 2.0 GO:0005643 nuclear pore(GO:0005643)
0.2 1.9 GO:0005638 lamin filament(GO:0005638)
0.0 1.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.4 1.7 GO:1990423 RZZ complex(GO:1990423)
0.2 1.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 1.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 1.5 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.1 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.2 11.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 6.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.5 5.3 GO:0070883 pre-miRNA binding(GO:0070883)
0.5 3.6 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 3.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 2.5 GO:0002039 p53 binding(GO:0002039)
0.3 2.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 2.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.4 GO:0003684 damaged DNA binding(GO:0003684)
0.5 1.9 GO:0031493 nucleosomal histone binding(GO:0031493)
0.5 1.6 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.4 1.3 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.3 1.3 GO:0003896 DNA primase activity(GO:0003896)
0.1 1.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.1 1.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 4.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.4 PID_MYC_PATHWAY C-MYC pathway
0.0 2.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.8 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 13.2 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.2 5.8 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.2 4.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.1 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition
0.1 2.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.3 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 1.8 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 1.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.1 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME_APOPTOTIC_EXECUTION_PHASE Genes involved in Apoptotic execution phase
0.1 1.0 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX Genes involved in Formation of the HIV-1 Early Elongation Complex
0.0 0.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.9 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.8 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.8 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.7 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle