Motif ID: ZFX

Z-value: 1.170


Transcription factors associated with ZFX:

Gene SymbolEntrez IDGene Name
ZFX ENSG00000005889.11 ZFX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZFXhg19_v2_chrX_+_24167828_241679070.511.0e-02Click!


Activity profile for motif ZFX.

activity profile for motif ZFX


Sorted Z-values histogram for motif ZFX

Sorted Z-values for motif ZFX



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFX

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_66638685 1.510 ENST00000565003.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr19_+_2096868 1.443 ENST00000395296.1
ENST00000395301.3
IZUMO4

IZUMO family member 4

chr8_-_144651024 1.416 ENST00000524906.1
ENST00000532862.1
ENST00000534459.1
MROH6


maestro heat-like repeat family member 6


chr7_-_76256557 1.377 ENST00000275569.4
ENST00000310842.4
POMZP3

POM121 and ZP3 fusion

chr20_+_58179582 1.150 ENST00000371015.1
ENST00000395639.4
PHACTR3

phosphatase and actin regulator 3

chr8_-_143858590 1.096 ENST00000398906.1
ENST00000522929.1
LYNX1

Ly6/neurotoxin 1

chr8_-_143859197 1.092 ENST00000395192.2
LYNX1
Ly6/neurotoxin 1
chr3_-_52090461 1.048 ENST00000296483.6
ENST00000495880.1
DUSP7

dual specificity phosphatase 7

chr7_-_1199781 1.029 ENST00000397083.1
ENST00000401903.1
ENST00000316495.3
ZFAND2A


zinc finger, AN1-type domain 2A


chr2_+_64681103 1.013 ENST00000464281.1
LGALSL
lectin, galactoside-binding-like
chr9_+_35605274 0.958 ENST00000336395.5
TESK1
testis-specific kinase 1
chr10_+_99344104 0.929 ENST00000555577.1
ENST00000370649.3
PI4K2A
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein
chr16_+_66638616 0.918 ENST00000564060.1
ENST00000565922.1
CMTM3

CKLF-like MARVEL transmembrane domain containing 3

chr5_+_176560742 0.896 ENST00000439151.2
NSD1
nuclear receptor binding SET domain protein 1
chr7_-_4923259 0.885 ENST00000536091.1
RADIL
Ras association and DIL domains
chr7_-_4923315 0.879 ENST00000399583.3
RADIL
Ras association and DIL domains
chr15_+_44829334 0.870 ENST00000535391.1
EIF3J
eukaryotic translation initiation factor 3, subunit J
chr12_+_6493319 0.868 ENST00000536876.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr9_-_33167308 0.825 ENST00000535206.1
ENST00000379731.4
B4GALT1

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

chr11_+_66025167 0.825 ENST00000394067.2
ENST00000316924.5
ENST00000421552.1
ENST00000394078.1
KLC2



kinesin light chain 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 471 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 2.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.3 GO:0071318 cellular response to ATP(GO:0071318)
0.0 2.2 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.1 1.8 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 1.6 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 1.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.6 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 1.6 GO:0016126 sterol biosynthetic process(GO:0016126)
0.5 1.4 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.2 1.4 GO:0035803 egg coat formation(GO:0035803)
0.0 1.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.4 1.3 GO:1903519 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.2 1.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 1.3 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 1.2 GO:0016540 protein autoprocessing(GO:0016540)
0.0 1.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 1.2 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 1.1 GO:0002934 desmosome organization(GO:0002934)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.9 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.8 GO:0030056 hemidesmosome(GO:0030056)
0.3 1.7 GO:0005927 muscle tendon junction(GO:0005927)
0.0 1.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.5 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.5 1.4 GO:0016938 kinesin I complex(GO:0016938)
0.3 1.4 GO:0035838 growing cell tip(GO:0035838)
0.1 1.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.4 GO:0000502 proteasome complex(GO:0000502)
0.0 1.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.1 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.0 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 324 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0005178 integrin binding(GO:0005178)
0.0 4.0 GO:0005125 cytokine activity(GO:0005125)
0.0 3.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.5 GO:0051015 actin filament binding(GO:0051015)
0.1 2.3 GO:0000146 microfilament motor activity(GO:0000146)
0.2 2.2 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 2.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 1.9 GO:0051434 BH3 domain binding(GO:0051434)
0.0 1.7 GO:0019209 kinase activator activity(GO:0019209)
0.5 1.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 1.4 GO:0004461 lactose synthase activity(GO:0004461)
0.3 1.4 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 1.4 GO:0032190 acrosin binding(GO:0032190)
0.1 1.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 1.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 2.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 2.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.1 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 2.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 2.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.2 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 2.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.8 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.6 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.2 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription