Motif ID: ZFHX3

Z-value: 0.377


Transcription factors associated with ZFHX3:

Gene SymbolEntrez IDGene Name
ZFHX3 ENSG00000140836.10 ZFHX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274,
hg19_v2_chr16_-_73093597_73093597		0.213.3e-01Click!


Activity profile for motif ZFHX3.

activity profile for motif ZFHX3


Sorted Z-values histogram for motif ZFHX3

Sorted Z-values for motif ZFHX3



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFHX3

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_7921090 0.925 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_-_247921982 0.752 ENST00000408896.2
 OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr1_-_197036364 0.652 ENST00000367412.1
 F13B
coagulation factor XIII, B polypeptide
chr2_-_68052694 0.612 ENST00000457448.1
 AC010987.6
AC010987.6
chr12_-_131200810 0.591 ENST00000536002.1
ENST00000544034.1
 RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr5_-_35195338 0.534 ENST00000509839.1
 PRLR
prolactin receptor
chr20_-_21494654 0.529 ENST00000377142.4
 NKX2-2
NK2 homeobox 2
chr11_-_125366089 0.380 ENST00000366139.3
ENST00000278919.3
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr22_+_31488433 0.305 ENST00000455608.1
 SMTN
smoothelin
chr14_+_39703112 0.274 ENST00000555143.1
ENST00000280082.3
 MIA2

melanoma inhibitory activity 2

chr6_+_25754927 0.271 ENST00000377905.4
ENST00000439485.2
 SLC17A4

solute carrier family 17, member 4

chr15_+_76352178 0.264 ENST00000388942.3
 C15orf27
chromosome 15 open reading frame 27
chr17_+_41052808 0.261 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
 G6PC


glucose-6-phosphatase, catalytic subunit


chr12_-_7818474 0.221 ENST00000229304.4
 APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr6_-_32374900 0.220 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
 BTNL2







butyrophilin-like 2 (MHC class II associated)







chr11_+_8040739 0.198 ENST00000534099.1
 TUB
tubby bipartite transcription factor
chr4_-_155511887 0.170 ENST00000302053.3
ENST00000403106.3
 FGA

fibrinogen alpha chain

chr12_-_11184006 0.156 ENST00000390675.2
 TAS2R31
taste receptor, type 2, member 31
chr8_-_87242589 0.149 ENST00000419776.2
ENST00000297524.3
 SLC7A13

solute carrier family 7 (anionic amino acid transporter), member 13

chr3_+_69915385 0.144 ENST00000314589.5
 MITF
microphthalmia-associated transcription factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.5 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.4 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.2 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.2 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0032831 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.0 0.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) negative regulation by host of symbiont molecular function(GO:0052405)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular_function category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 0.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.5 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells