Motif ID: YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.225

Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ:

Gene SymbolEntrez IDGene Name
CEBPZ ENSG00000115816.9 CEBPZ
FOS ENSG00000170345.5 FOS
NFYA ENSG00000001167.10 NFYA
NFYB ENSG00000120837.3 NFYB
NFYC ENSG00000066136.15 NFYC
YBX1 ENSG00000065978.13 YBX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOShg19_v2_chr14_+_75745477_757456800.656.6e-04Click!
NFYAhg19_v2_chr6_+_41040678_410407220.511.0e-02Click!
YBX1hg19_v2_chr1_+_43148059_431481110.321.3e-01Click!
NFYChg19_v2_chr1_+_41157671_41157695-0.232.8e-01Click!
NFYBhg19_v2_chr12_-_104531945_1045319960.203.5e-01Click!
CEBPZhg19_v2_chr2_-_37458749_37458856-0.145.0e-01Click!


Activity profile for motif YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ.

activity profile for motif YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ


Sorted Z-values histogram for motif YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Sorted Z-values for motif YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ



Network of associatons between targets according to the STRING database.



First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_54863739 21.747 ENST00000541304.1
 CDKN3
cyclin-dependent kinase inhibitor 3
chr14_+_54863667 20.763 ENST00000335183.6
 CDKN3
cyclin-dependent kinase inhibitor 3
chr14_+_54863682 20.548 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
 CDKN3



cyclin-dependent kinase inhibitor 3



chr17_-_38574169 17.859 ENST00000423485.1
 TOP2A
topoisomerase (DNA) II alpha 170kDa
chr1_+_206138457 15.305 ENST00000367128.3
ENST00000431655.2
 FAM72A

family with sequence similarity 72, member A

chr8_+_25316489 13.953 ENST00000330560.3
 CDCA2
cell division cycle associated 2
chr17_-_8113886 13.131 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
 AURKB





aurora kinase B





chr5_+_162887556 13.109 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
 HMMR


hyaluronan-mediated motility receptor (RHAMM)


chr17_+_6347729 12.492 ENST00000572447.1
 FAM64A
family with sequence similarity 64, member A
chr17_+_6347761 12.387 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A




family with sequence similarity 64, member A




chr20_-_54967187 11.854 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA













aurora kinase A













chr2_-_111435610 11.799 ENST00000447014.1
ENST00000420328.1
ENST00000535254.1
ENST00000409311.1
ENST00000302759.6
 BUB1




BUB1 mitotic checkpoint serine/threonine kinase




chr1_+_120839005 11.683 ENST00000369390.3
ENST00000452190.1
 FAM72B

family with sequence similarity 72, member B

chr16_+_2479390 11.438 ENST00000397066.4
 CCNF
cyclin F
chr1_-_143913143 11.425 ENST00000400889.1
 FAM72D
family with sequence similarity 72, member D
chr6_+_80714318 11.070 ENST00000369798.2
 TTK
TTK protein kinase
chr5_+_137514834 10.762 ENST00000508792.1
ENST00000504621.1
 KIF20A

kinesin family member 20A

chr5_+_137514687 10.762 ENST00000394894.3
 KIF20A
kinesin family member 20A
chr3_+_172468505 10.748 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
 ECT2




epithelial cell transforming sequence 2 oncogene




chr2_+_27008865 10.681 ENST00000335756.4
ENST00000233505.8
 CENPA

centromere protein A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 690 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 112.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.3 45.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
3.7 33.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 32.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.6 30.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.7 26.9 GO:0051310 metaphase plate congression(GO:0051310)
1.2 26.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.6 23.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
4.2 21.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.4 20.8 GO:0007077 mitotic nuclear envelope disassembly(GO:0007077)
0.3 20.0 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
3.9 19.5 GO:0016321 female meiosis chromosome segregation(GO:0016321)
6.3 19.0 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.8 18.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
6.1 18.3 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.8 18.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.8 17.9 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.5 17.9 GO:0006270 DNA replication initiation(GO:0006270)
2.7 16.2 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
5.3 15.8 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 57.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.7 50.7 GO:0005871 kinesin complex(GO:0005871)
5.5 44.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 40.3 GO:0005739 mitochondrion(GO:0005739)
0.4 35.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 35.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
6.9 34.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
5.7 28.6 GO:0097149 centralspindlin complex(GO:0097149)
1.0 25.0 GO:0010369 chromocenter(GO:0010369)
0.2 25.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 22.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.2 21.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.4 19.1 GO:0005876 spindle microtubule(GO:0005876)
6.2 18.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.1 18.0 GO:0042555 MCM complex(GO:0042555)
6.0 17.9 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
5.7 17.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 16.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 15.2 GO:0000922 spindle pole(GO:0000922)
3.0 14.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 442 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 58.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 47.1 GO:0017048 Rho GTPase binding(GO:0017048)
5.9 41.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.5 40.2 GO:0003777 microtubule motor activity(GO:0003777)
0.8 40.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
4.2 37.6 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 37.0 GO:0008017 microtubule binding(GO:0008017)
1.9 32.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 22.9 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.5 19.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 19.1 GO:0003678 DNA helicase activity(GO:0003678)
0.2 19.1 GO:0003684 damaged DNA binding(GO:0003684)
1.0 18.8 GO:0035173 histone kinase activity(GO:0035173)
6.0 17.9 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
2.2 17.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 16.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
3.0 14.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 13.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
2.7 13.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.4 13.3 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 151.3 PID_PLK1_PATHWAY PLK1 signaling events
1.5 100.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.7 35.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.7 34.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 26.9 PID_E2F_PATHWAY E2F transcription factor network
0.4 22.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 20.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 15.5 PID_CDC42_PATHWAY CDC42 signaling events
0.2 11.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 9.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.4 9.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 7.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 7.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.3 6.9 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 6.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 6.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 5.4 PID_BARD1_PATHWAY BARD1 signaling events
0.4 4.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 115.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
2.5 81.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
2.9 77.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.5 55.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.2 46.7 REACTOME_KINESINS Genes involved in Kinesins
2.3 41.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 26.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.2 25.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.5 23.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.7 18.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 17.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 14.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.4 13.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.7 13.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.6 13.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.5 12.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.3 10.7 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.3 10.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.5 10.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 9.1 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis