Motif ID: WRNIP1

Z-value: 1.892


Transcription factors associated with WRNIP1:

Gene SymbolEntrez IDGene Name
WRNIP1 ENSG00000124535.11 WRNIP1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
WRNIP1hg19_v2_chr6_+_2765595_2765797-0.125.7e-01Click!


Activity profile for motif WRNIP1.

activity profile for motif WRNIP1


Sorted Z-values histogram for motif WRNIP1

Sorted Z-values for motif WRNIP1



Network of associatons between targets according to the STRING database.



First level regulatory network of WRNIP1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471381 17.211 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr19_-_51504852 16.665 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
KLK8



kallikrein-related peptidase 8



chr19_-_51471362 14.441 ENST00000376853.4
ENST00000424910.2
KLK6

kallikrein-related peptidase 6

chr7_+_157318477 13.635 ENST00000444154.1
AC006372.1
AC006372.1
chr19_-_51472031 12.493 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr19_-_51466681 10.753 ENST00000456750.2
KLK6
kallikrein-related peptidase 6
chr19_+_35645817 10.282 ENST00000423817.3
FXYD5
FXYD domain containing ion transport regulator 5
chr19_+_35645618 10.250 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD5






FXYD domain containing ion transport regulator 5






chr19_-_51456344 9.837 ENST00000336334.3
ENST00000593428.1
KLK5

kallikrein-related peptidase 5

chr19_-_51504411 9.580 ENST00000593490.1
KLK8
kallikrein-related peptidase 8
chr19_-_51487282 9.258 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
KLK7


kallikrein-related peptidase 7


chr19_-_51487071 8.213 ENST00000391807.1
ENST00000593904.1
KLK7

kallikrein-related peptidase 7

chr1_-_205391178 7.727 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1



LEM domain containing 1



chr19_-_51456321 7.488 ENST00000391809.2
KLK5
kallikrein-related peptidase 5
chr19_-_51472823 7.371 ENST00000310157.2
KLK6
kallikrein-related peptidase 6
chr8_-_23261589 7.133 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2



lysyl oxidase-like 2



chr19_-_51845378 6.849 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_-_51472222 6.842 ENST00000376851.3
KLK6
kallikrein-related peptidase 6
chr8_-_7274385 6.746 ENST00000318157.2
DEFB4B
defensin, beta 4B
chr1_-_28503693 6.733 ENST00000373857.3
PTAFR
platelet-activating factor receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,646 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 71.2 GO:0016540 protein autoprocessing(GO:0016540)
0.4 40.2 GO:0070268 cornification(GO:0070268)
6.6 39.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
3.2 25.6 GO:0031642 negative regulation of myelination(GO:0031642)
0.9 21.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
6.5 19.5 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.6 17.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 16.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.8 14.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 13.7 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.3 13.1 GO:1901998 toxin transport(GO:1901998)
0.2 13.0 GO:0030574 collagen catabolic process(GO:0030574)
1.4 12.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.7 11.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.7 11.5 GO:0014883 transition between fast and slow fiber(GO:0014883)
2.8 11.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.6 11.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
2.1 10.7 GO:0061143 alveolar primary septum development(GO:0061143)
0.7 10.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
3.3 10.0 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 518 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 139.4 GO:0005615 extracellular space(GO:0005615)
0.1 67.7 GO:0030055 cell-substrate junction(GO:0030055)
5.9 41.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.4 27.7 GO:0001533 cornified envelope(GO:0001533)
0.2 20.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 20.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 19.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.8 18.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 18.7 GO:0005882 intermediate filament(GO:0005882)
0.1 17.0 GO:0016324 apical plasma membrane(GO:0016324)
0.2 16.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 15.1 GO:0005901 caveola(GO:0005901)
0.8 14.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 14.1 GO:0001726 ruffle(GO:0001726)
0.7 13.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 13.2 GO:0030673 axolemma(GO:0030673)
0.5 12.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 11.7 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 11.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.9 11.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 876 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 176.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 31.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 25.9 GO:0051015 actin filament binding(GO:0051015)
0.0 21.2 GO:0005198 structural molecule activity(GO:0005198)
0.6 19.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 18.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 18.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.1 16.1 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 15.1 GO:0045296 cadherin binding(GO:0045296)
0.1 14.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.8 13.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 12.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.9 12.4 GO:0031014 troponin T binding(GO:0031014)
1.4 12.3 GO:0043426 MRF binding(GO:0043426)
0.2 11.9 GO:0003785 actin monomer binding(GO:0003785)
0.3 11.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 11.2 GO:0043236 laminin binding(GO:0043236)
0.2 11.1 GO:0050699 WW domain binding(GO:0050699)
0.1 11.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 10.9 GO:0030506 ankyrin binding(GO:0030506)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 81.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.2 67.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 39.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 38.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 35.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 25.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 24.3 NABA_COLLAGENS Genes encoding collagen proteins
0.4 19.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.6 19.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 13.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 12.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 11.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.5 11.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 11.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.8 11.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 11.0 PID_PLK1_PATHWAY PLK1 signaling events
0.4 10.6 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4 10.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.3 10.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.3 10.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 30.9 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.4 30.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.4 27.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 20.3 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.3 19.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 19.8 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2 19.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 18.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 18.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 16.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4 15.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.4 15.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.6 13.9 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.4 13.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.4 12.4 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.6 12.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.6 12.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 11.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 11.6 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.4 11.0 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism