Motif ID: WRNIP1
Z-value: 1.892

Transcription factors associated with WRNIP1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
WRNIP1 | ENSG00000124535.11 | WRNIP1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
WRNIP1 | hg19_v2_chr6_+_2765595_2765797 | -0.12 | 5.7e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,646 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.2 | 71.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
0.4 | 40.2 | GO:0070268 | cornification(GO:0070268) |
6.6 | 39.5 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
3.2 | 25.6 | GO:0031642 | negative regulation of myelination(GO:0031642) |
0.9 | 21.8 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
6.5 | 19.5 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
0.6 | 17.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 16.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.8 | 14.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.3 | 13.7 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
0.3 | 13.1 | GO:1901998 | toxin transport(GO:1901998) |
0.2 | 13.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
1.4 | 12.8 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.7 | 11.6 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
0.7 | 11.5 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
2.8 | 11.2 | GO:0046110 | xanthine metabolic process(GO:0046110) |
0.6 | 11.1 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
2.1 | 10.7 | GO:0061143 | alveolar primary septum development(GO:0061143) |
0.7 | 10.1 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
3.3 | 10.0 | GO:1904298 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 518 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 139.4 | GO:0005615 | extracellular space(GO:0005615) |
0.1 | 67.7 | GO:0030055 | cell-substrate junction(GO:0030055) |
5.9 | 41.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
0.4 | 27.7 | GO:0001533 | cornified envelope(GO:0001533) |
0.2 | 20.8 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.2 | 20.0 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
0.2 | 19.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
0.8 | 18.9 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.1 | 18.7 | GO:0005882 | intermediate filament(GO:0005882) |
0.1 | 17.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
0.2 | 16.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
0.1 | 15.1 | GO:0005901 | caveola(GO:0005901) |
0.8 | 14.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.1 | 14.1 | GO:0001726 | ruffle(GO:0001726) |
0.7 | 13.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.3 | 13.2 | GO:0030673 | axolemma(GO:0030673) |
0.5 | 12.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 11.7 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
0.0 | 11.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
0.9 | 11.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 876 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 176.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.1 | 31.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.1 | 25.9 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 21.2 | GO:0005198 | structural molecule activity(GO:0005198) |
0.6 | 19.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.2 | 18.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.2 | 18.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
1.1 | 16.1 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
0.1 | 15.1 | GO:0045296 | cadherin binding(GO:0045296) |
0.1 | 14.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.8 | 13.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.1 | 12.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.9 | 12.4 | GO:0031014 | troponin T binding(GO:0031014) |
1.4 | 12.3 | GO:0043426 | MRF binding(GO:0043426) |
0.2 | 11.9 | GO:0003785 | actin monomer binding(GO:0003785) |
0.3 | 11.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.3 | 11.2 | GO:0043236 | laminin binding(GO:0043236) |
0.2 | 11.1 | GO:0050699 | WW domain binding(GO:0050699) |
0.1 | 11.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
0.3 | 10.9 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 121 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 81.7 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.2 | 67.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 39.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.5 | 38.2 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.1 | 35.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.3 | 25.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.4 | 24.3 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.4 | 19.4 | PID_RAS_PATHWAY | Regulation of Ras family activation |
0.6 | 19.1 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.4 | 13.1 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.2 | 12.4 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.1 | 11.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.5 | 11.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.3 | 11.5 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.8 | 11.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.2 | 11.0 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.4 | 10.6 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.4 | 10.4 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.3 | 10.4 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.3 | 10.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 213 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 30.9 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
0.4 | 30.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.4 | 27.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.4 | 20.3 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
0.3 | 19.9 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.1 | 19.8 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
0.2 | 19.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.7 | 18.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.3 | 18.1 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.1 | 16.0 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
0.4 | 15.4 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.4 | 15.3 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
0.6 | 13.9 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.4 | 13.0 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
0.4 | 12.4 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
0.6 | 12.3 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.6 | 12.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.4 | 11.6 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.2 | 11.6 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
0.4 | 11.0 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |