Motif ID: VDR
Z-value: 0.794
Transcription factors associated with VDR:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| VDR | ENSG00000111424.6 | VDR |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VDR | hg19_v2_chr12_-_48298785_48298828 | 0.54 | 6.1e-03 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 108 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.5 | 2.8 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.4 | 2.5 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 2.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 2.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.8 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.6 | 1.7 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.3 | 1.7 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.0 | 1.7 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.4 | 1.5 | GO:0042361 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.0 | 1.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.4 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.3 | 1.3 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.4 | 1.2 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.1 | 1.2 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.1 | 1.2 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 1.2 | GO:0043651 | alpha-linolenic acid metabolic process(GO:0036109) linoleic acid metabolic process(GO:0043651) |
| 0.0 | 1.2 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.1 | 1.1 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.0 | 1.1 | GO:2000178 | negative regulation of neural precursor cell proliferation(GO:2000178) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.3 | 2.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 2.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 2.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 2.0 | GO:0043034 | costamere(GO:0043034) |
| 0.4 | 1.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.2 | 1.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.1 | 1.4 | GO:0043203 | axon hillock(GO:0043203) |
| 0.3 | 1.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 1.0 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
| 0.1 | 0.8 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.7 | GO:0097546 | ciliary base(GO:0097546) |
| 0.1 | 0.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.6 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.5 | GO:0001652 | granular component(GO:0001652) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 82 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.9 | 2.8 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 2.7 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 2.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 1.7 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.3 | 1.6 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 1.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 1.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 1.3 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.1 | 1.3 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.2 | 1.2 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.2 | 1.2 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
| 0.0 | 1.2 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.1 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.2 | 1.0 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.1 | 1.0 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.2 | 0.9 | GO:0070404 | NADH binding(GO:0070404) |
Gene overrepresentation in C2:CP category:
Showing 1 to 14 of 14 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 1.7 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.1 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.7 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 0.7 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.3 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.1 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 32 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 2.0 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 1.7 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.6 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
| 0.0 | 1.5 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 1.2 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 1.1 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.1 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.0 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.0 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.8 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.8 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.7 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.6 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
