Motif ID: VAX1_GSX2

Z-value: 0.289

Transcription factors associated with VAX1_GSX2:

Gene SymbolEntrez IDGene Name
GSX2 ENSG00000180613.6 GSX2
VAX1 ENSG00000148704.8 VAX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GSX2hg19_v2_chr4_+_54966198_549663400.125.8e-01Click!


Activity profile for motif VAX1_GSX2.

activity profile for motif VAX1_GSX2


Sorted Z-values histogram for motif VAX1_GSX2

Sorted Z-values for motif VAX1_GSX2



Network of associatons between targets according to the STRING database.



First level regulatory network of VAX1_GSX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_152386732 0.462 ENST00000271835.3
 CRNN
cornulin
chr4_-_69111401 0.336 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr13_+_32313658 0.316 ENST00000380314.1
ENST00000298386.2
 RXFP2

relaxin/insulin-like family peptide receptor 2

chr7_+_100770328 0.293 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr2_-_40680578 0.291 ENST00000455476.1
 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_152974218 0.279 ENST00000331860.3
ENST00000443178.1
ENST00000295367.4
 SPRR3


small proline-rich protein 3


chr13_-_36050819 0.257 ENST00000379919.4
 MAB21L1
mab-21-like 1 (C. elegans)
chr3_+_186353756 0.252 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
 FETUB


fetuin B


chr4_+_144354644 0.233 ENST00000512843.1
 GAB1
GRB2-associated binding protein 1
chr1_+_62439037 0.220 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr1_-_185597619 0.185 ENST00000608417.1
ENST00000436955.1
 GS1-204I12.1

GS1-204I12.1

chr12_+_15699286 0.184 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr3_-_164796269 0.180 ENST00000264382.3
 SI
sucrase-isomaltase (alpha-glucosidase)
chr7_-_88425025 0.179 ENST00000297203.2
 C7orf62
chromosome 7 open reading frame 62
chr11_+_65554493 0.175 ENST00000335987.3
 OVOL1
ovo-like zinc finger 1
chr4_-_169239921 0.173 ENST00000514995.1
ENST00000393743.3
 DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr4_-_109541539 0.148 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
 RPL34-AS1


RPL34 antisense RNA 1 (head to head)


chr7_-_121944491 0.141 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1


FEZ family zinc finger 1


chr9_+_125133315 0.139 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr1_+_192778161 0.129 ENST00000235382.5
 RGS2
regulator of G-protein signaling 2, 24kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.2 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.2 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:1904956 neural crest cell fate commitment(GO:0014034) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.1 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.0 GO:0055087 Ski complex(GO:0055087)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate