Motif ID: UGUGCUU

Z-value: 0.706


Mature miRNA associated with seed UGUGCUU:

NamemiRBase Accession
hsa-miR-218-5p MIMAT0000275



Activity profile for motif UGUGCUU.

activity profile for motif UGUGCUU


Sorted Z-values histogram for motif UGUGCUU

Sorted Z-values for motif UGUGCUU



Network of associatons between targets according to the STRING database.



First level regulatory network of UGUGCUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_132272504 3.029 ENST00000367976.3
 CTGF
connective tissue growth factor
chr5_-_100238956 2.824 ENST00000231461.5
 ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr3_+_238273 2.405 ENST00000256509.2
 CHL1
cell adhesion molecule L1-like
chr21_-_35831880 2.310 ENST00000399289.3
ENST00000432085.1
 KCNE1

potassium voltage-gated channel, Isk-related family, member 1

chr6_-_24911195 2.263 ENST00000259698.4
 FAM65B
family with sequence similarity 65, member B
chr17_+_55333876 1.885 ENST00000284073.2
 MSI2
musashi RNA-binding protein 2
chr9_-_3525968 1.811 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
 RFX3


regulatory factor X, 3 (influences HLA class II expression)


chr5_+_76506706 1.659 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
 PDE8B




phosphodiesterase 8B




chr17_+_14204389 1.623 ENST00000360954.2
 HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr3_+_113666748 1.528 ENST00000330212.3
ENST00000498275.1
 ZDHHC23

zinc finger, DHHC-type containing 23

chr22_-_39548627 1.507 ENST00000216133.5
 CBX7
chromobox homolog 7
chr3_+_3841108 1.442 ENST00000319331.3
 LRRN1
leucine rich repeat neuronal 1
chr7_+_106685079 1.386 ENST00000265717.4
 PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr19_+_32896697 1.363 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr2_+_39893043 1.263 ENST00000281961.2
 TMEM178A
transmembrane protein 178A
chr15_-_49255632 1.239 ENST00000332408.4
 SHC4
SHC (Src homology 2 domain containing) family, member 4
chr16_-_19896220 1.232 ENST00000562469.1
ENST00000300571.2
 GPRC5B

G protein-coupled receptor, family C, group 5, member B

chr3_-_66551351 1.231 ENST00000273261.3
 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr1_+_210406121 1.181 ENST00000367012.3
 SERTAD4
SERTA domain containing 4
chr19_-_14316980 1.151 ENST00000361434.3
ENST00000340736.6
 LPHN1

latrophilin 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0 3.0 GO:0034059 response to anoxia(GO:0034059)
0.2 2.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 2.6 GO:0035640 exploration behavior(GO:0035640)
0.1 2.4 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 2.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.6 1.8 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 1.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.5 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.3 1.4 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.4 GO:0097338 response to clozapine(GO:0097338)
0.2 1.4 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.2 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.2 1.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.1 GO:0006685 sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 1.1 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.3 1.0 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.3 0.9 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 2.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.1 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.7 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.7 GO:0097546 ciliary base(GO:0097546)
0.0 0.7 GO:0001772 immunological synapse(GO:0001772)
0.1 0.6 GO:0070695 FHF complex(GO:0070695)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.5 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.0 GO:0001968 fibronectin binding(GO:0001968)
0.4 2.8 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 2.3 GO:0031433 telethonin binding(GO:0031433)
0.1 2.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.9 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 1.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.2 1.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.3 0.8 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.1 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.1 REACTOME_SPHINGOLIPID_METABOLISM Genes involved in Sphingolipid metabolism
0.0 1.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 0.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.9 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.2 0.4 REACTOME_SHC_RELATED_EVENTS Genes involved in SHC-related events