Motif ID: THRB

Z-value: 0.303


Transcription factors associated with THRB:

Gene SymbolEntrez IDGene Name
THRB ENSG00000151090.13 THRB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24207039_242070860.262.2e-01Click!


Activity profile for motif THRB.

activity profile for motif THRB


Sorted Z-values histogram for motif THRB

Sorted Z-values for motif THRB



Network of associatons between targets according to the STRING database.



First level regulatory network of THRB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_101084446 0.685 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
 CERS3


ceramide synthase 3


chr11_+_5617976 0.632 ENST00000445329.1
 TRIM6
tripartite motif containing 6
chr11_+_5617858 0.611 ENST00000380097.3
 TRIM6
tripartite motif containing 6
chr13_-_24007815 0.536 ENST00000382298.3
 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr15_-_101084547 0.533 ENST00000394113.1
 CERS3
ceramide synthase 3
chr1_-_113498943 0.522 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr1_-_113498616 0.511 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
 SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr17_-_73840415 0.362 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
 UNC13D


unc-13 homolog D (C. elegans)


chr10_+_62538089 0.327 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1


cyclin-dependent kinase 1


chr10_+_62538248 0.291 ENST00000448257.2
 CDK1
cyclin-dependent kinase 1
chr15_-_101084881 0.289 ENST00000284382.4
 CERS3
ceramide synthase 3
chr3_+_50606901 0.269 ENST00000455834.1
 HEMK1
HemK methyltransferase family member 1
chr8_-_124037890 0.268 ENST00000519018.1
ENST00000523036.1
 DERL1

derlin 1

chr3_+_50606577 0.245 ENST00000434410.1
ENST00000232854.4
 HEMK1

HemK methyltransferase family member 1

chr15_-_35838348 0.241 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
 DPH6


diphthamine biosynthesis 6


chr6_-_99842041 0.235 ENST00000254759.3
ENST00000369242.1
 COQ3

coenzyme Q3 methyltransferase

chr2_-_9563469 0.186 ENST00000484735.1
ENST00000456913.2
 ITGB1BP1

integrin beta 1 binding protein 1

chr18_-_47807829 0.167 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
 MBD1




methyl-CpG binding domain protein 1




chr11_-_64014379 0.132 ENST00000309318.3
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr22_+_19938419 0.132 ENST00000412786.1
 COMT
catechol-O-methyltransferase
chr18_-_47808120 0.119 ENST00000587605.1
ENST00000591416.1
ENST00000382948.5
ENST00000269471.5
ENST00000269468.5
ENST00000347968.3
ENST00000436910.1
ENST00000349085.2
 MBD1







methyl-CpG binding domain protein 1







chr17_+_7533439 0.114 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
 SHBG







sex hormone-binding globulin







chr18_-_47808050 0.109 ENST00000590208.1
 MBD1
methyl-CpG binding domain protein 1
chr19_-_52643157 0.100 ENST00000597013.1
ENST00000600228.1
ENST00000596290.1
 ZNF616


zinc finger protein 616


chr2_-_74692473 0.093 ENST00000535045.1
ENST00000409065.1
ENST00000414701.1
ENST00000448666.1
ENST00000233616.4
ENST00000452063.2
 MOGS





mannosyl-oligosaccharide glucosidase





chr20_+_388679 0.092 ENST00000356286.5
ENST00000475269.1
 RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr17_-_73840774 0.090 ENST00000207549.4
 UNC13D
unc-13 homolog D (C. elegans)
chr11_+_5617952 0.085 ENST00000354852.5
 TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr1_-_154164534 0.085 ENST00000271850.7
ENST00000368530.2
 TPM3

tropomyosin 3

chr11_+_73498898 0.075 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48





mitochondrial ribosomal protein L48





chr21_-_37914898 0.064 ENST00000399136.1
 CLDN14
claudin 14
chr11_+_57310114 0.060 ENST00000527972.1
ENST00000399154.2
 SMTNL1

smoothelin-like 1

chr6_+_151042224 0.058 ENST00000358517.2
 PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr19_+_55085248 0.051 ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
 LILRB1


LILRA2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2


chr2_-_9563319 0.047 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
 ITGB1BP1


integrin beta 1 binding protein 1


chr11_+_46366918 0.044 ENST00000528615.1
ENST00000395574.3
 DGKZ

diacylglycerol kinase, zeta

chr14_+_75761099 0.041 ENST00000561000.1
ENST00000558575.1
 RP11-293M10.5

RP11-293M10.5

chr7_-_100253993 0.041 ENST00000461605.1
ENST00000160382.5
 ACTL6B

actin-like 6B

chr8_+_22102626 0.035 ENST00000519237.1
ENST00000397802.4
 POLR3D

polymerase (RNA) III (DNA directed) polypeptide D, 44kDa

chr12_-_21810765 0.032 ENST00000450584.1
ENST00000350669.1
 LDHB

lactate dehydrogenase B

chr12_-_21810726 0.025 ENST00000396076.1
 LDHB
lactate dehydrogenase B
chr8_+_22102611 0.024 ENST00000306433.4
 POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr8_+_28174649 0.016 ENST00000301908.3
 PNOC
prepronociceptin
chr15_+_35838396 0.016 ENST00000501169.2
 DPH6-AS1
DPH6 antisense RNA 1 (head to head)
chr9_-_139268068 0.014 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
 CARD9


caspase recruitment domain family, member 9


chr20_+_388791 0.013 ENST00000441733.1
ENST00000353660.3
 RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr5_+_131746575 0.005 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
 C5orf56


chromosome 5 open reading frame 56


chr20_+_3024266 0.002 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
 GNRH2


gonadotropin-releasing hormone 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 1.2 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.6 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.5 GO:0043320 natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0050668 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.5 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 1.5 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0002290 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.3 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 1.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.4 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.0 1.2 GO:1990782 protein tyrosine kinase binding(GO:1990782)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis