Motif ID: TGIF1

Z-value: 0.712


Transcription factors associated with TGIF1:

Gene SymbolEntrez IDGene Name
TGIF1 ENSG00000177426.16 TGIF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TGIF1hg19_v2_chr18_+_3448455_34484970.252.4e-01Click!


Activity profile for motif TGIF1.

activity profile for motif TGIF1


Sorted Z-values histogram for motif TGIF1

Sorted Z-values for motif TGIF1



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_32407619 3.076 ENST00000395388.2
ENST00000374982.5
 HLA-DRA

major histocompatibility complex, class II, DR alpha

chr4_-_149365827 2.082 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr11_+_6411670 1.471 ENST00000530395.1
ENST00000527275.1
 SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr12_-_25348007 1.416 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr11_+_6411636 1.411 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
 SMPD1


sphingomyelin phosphodiesterase 1, acid lysosomal


chr16_+_2880369 1.309 ENST00000572863.1
 ZG16B
zymogen granule protein 16B
chr16_+_2880157 1.279 ENST00000382280.3
 ZG16B
zymogen granule protein 16B
chr1_+_111888890 1.258 ENST00000369738.4
 PIFO
primary cilia formation
chr1_+_111889212 1.228 ENST00000369737.4
 PIFO
primary cilia formation
chr16_+_2880296 1.226 ENST00000571723.1
 ZG16B
zymogen granule protein 16B
chr17_+_68165657 1.224 ENST00000243457.3
 KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr16_+_2880254 1.198 ENST00000570670.1
 ZG16B
zymogen granule protein 16B
chr2_+_71163051 1.137 ENST00000412314.1
 ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr2_+_71162995 1.114 ENST00000234396.4
 ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr1_+_228870824 1.056 ENST00000366691.3
 RHOU
ras homolog family member U
chr22_-_36013368 1.051 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
 MB



myoglobin



chr11_+_27076764 1.021 ENST00000525090.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr2_-_172750733 1.020 ENST00000392592.4
ENST00000422440.2
 SLC25A12

solute carrier family 25 (aspartate/glutamate carrier), member 12

chr1_-_146697185 0.986 ENST00000533174.1
ENST00000254090.4
 FMO5

flavin containing monooxygenase 5

chr20_+_18794370 0.926 ENST00000377428.2
 SCP2D1
SCP2 sterol-binding domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0001895 retina homeostasis(GO:0001895)
0.8 3.1 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.4 2.9 GO:0023021 termination of signal transduction(GO:0023021)
0.0 2.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 2.3 GO:0090383 phagosome acidification(GO:0090383)
0.0 1.8 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 1.6 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.4 1.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.4 1.2 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.2 1.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 1.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.3 1.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 0.8 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.8 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.8 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 0.7 GO:0045925 positive regulation of female receptivity(GO:0045925)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0036064 ciliary basal body(GO:0036064)
0.1 3.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.7 GO:0042599 lamellar body(GO:0042599)
0.2 2.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.8 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.7 GO:0032982 myosin filament(GO:0032982)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 0.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.3 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.1 0.2 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0030246 carbohydrate binding(GO:0030246)
0.2 3.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 2.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 2.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.2 1.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 1.7 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.1 1.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.3 1.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 1.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 0.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.7 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID_MYC_PATHWAY C-MYC pathway
0.0 0.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 2.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.5 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism