Motif ID: TFAP4_MSC
Z-value: 0.712
Transcription factors associated with TFAP4_MSC:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
MSC | ENSG00000178860.8 | MSC |
TFAP4 | ENSG00000090447.7 | TFAP4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
MSC | hg19_v2_chr8_-_72756667_72756736 | -0.37 | 7.9e-02 | Click! |
TFAP4 | hg19_v2_chr16_-_4323015_4323076 | 0.05 | 8.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0035283 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
0.5 | 2.0 | GO:0018032 | protein amidation(GO:0018032) |
0.4 | 1.2 | GO:0021524 | visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913) |
0.4 | 3.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
0.4 | 1.1 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
0.3 | 2.9 | GO:0015889 | cobalamin transport(GO:0015889) |
0.3 | 3.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.3 | 0.8 | GO:0006788 | heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806) negative regulation of mast cell cytokine production(GO:0032764) |
0.2 | 1.7 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.2 | 0.8 | GO:2001293 | fatty-acyl-CoA catabolic process(GO:0036115) malonyl-CoA metabolic process(GO:2001293) |
0.2 | 1.3 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
0.2 | 2.1 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
0.2 | 1.1 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
0.2 | 0.5 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
0.2 | 0.8 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
0.1 | 0.5 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
0.1 | 0.5 | GO:0002086 | diaphragm contraction(GO:0002086) |
0.1 | 0.4 | GO:1904760 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) |
0.1 | 0.4 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
0.1 | 2.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.1 | 0.3 | GO:0018894 | dibenzo-p-dioxin metabolic process(GO:0018894) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
0.1 | 0.5 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
0.1 | 0.7 | GO:0023021 | termination of signal transduction(GO:0023021) |
0.1 | 1.1 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
0.1 | 0.5 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
0.1 | 1.1 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
0.1 | 0.3 | GO:0090156 | cellular sphingolipid homeostasis(GO:0090156) |
0.1 | 1.9 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
0.1 | 0.3 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) |
0.1 | 0.3 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
0.1 | 1.1 | GO:0006527 | arginine catabolic process(GO:0006527) |
0.1 | 0.6 | GO:0051604 | protein maturation(GO:0051604) |
0.1 | 0.6 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
0.1 | 1.8 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.1 | 0.2 | GO:0032765 | positive regulation of mast cell cytokine production(GO:0032765) |
0.1 | 0.3 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.1 | 0.3 | GO:0006740 | NADPH regeneration(GO:0006740) |
0.1 | 1.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.1 | 0.3 | GO:0035936 | testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
0.1 | 0.4 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
0.1 | 0.2 | GO:1902908 | regulation of melanosome transport(GO:1902908) |
0.1 | 0.1 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
0.1 | 0.2 | GO:0051685 | maintenance of ER location(GO:0051685) |
0.0 | 0.2 | GO:0007468 | regulation of rhodopsin gene expression(GO:0007468) |
0.0 | 0.3 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
0.0 | 0.4 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.0 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.0 | 0.1 | GO:0035494 | SNARE complex disassembly(GO:0035494) |
0.0 | 0.2 | GO:0060168 | positive regulation of adenosine receptor signaling pathway(GO:0060168) |
0.0 | 0.5 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
0.0 | 0.2 | GO:0006051 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
0.0 | 2.5 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
0.0 | 0.4 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.0 | 0.7 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
0.0 | 0.8 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
0.0 | 0.2 | GO:0060437 | lung growth(GO:0060437) |
0.0 | 0.1 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.0 | 0.2 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
0.0 | 0.5 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.0 | 0.3 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
0.0 | 0.9 | GO:0002467 | germinal center formation(GO:0002467) |
0.0 | 0.3 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.0 | 0.5 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
0.0 | 0.3 | GO:0032869 | response to insulin(GO:0032868) cellular response to insulin stimulus(GO:0032869) |
0.0 | 3.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 0.1 | GO:0070253 | somatostatin secretion(GO:0070253) |
0.0 | 0.1 | GO:0021650 | vestibulocochlear nerve formation(GO:0021650) |
0.0 | 0.1 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
0.0 | 0.1 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
0.0 | 3.3 | GO:0001578 | microtubule bundle formation(GO:0001578) |
0.0 | 0.1 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
0.0 | 0.2 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
0.0 | 0.1 | GO:0007525 | somatic muscle development(GO:0007525) |
0.0 | 1.0 | GO:0061157 | mRNA destabilization(GO:0061157) |
0.0 | 0.4 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
0.0 | 0.3 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
0.0 | 0.5 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
0.0 | 0.2 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
0.0 | 0.2 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
0.0 | 0.2 | GO:0001554 | luteolysis(GO:0001554) |
0.0 | 0.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
0.0 | 1.2 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.4 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.0 | 0.1 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
0.0 | 0.6 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
0.0 | 0.8 | GO:0010842 | retina layer formation(GO:0010842) |
0.0 | 0.4 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
0.0 | 0.6 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
0.0 | 0.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.0 | 0.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.0 | 0.3 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
0.0 | 0.1 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
0.0 | 0.1 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
0.0 | 0.2 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 1.7 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
0.0 | 1.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 0.4 | GO:0060539 | diaphragm development(GO:0060539) |
0.0 | 0.2 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
0.0 | 0.3 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
0.0 | 0.1 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
0.0 | 0.1 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
0.0 | 0.3 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.0 | 0.1 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
0.0 | 0.1 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
0.0 | 0.1 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
0.0 | 0.1 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
0.0 | 0.5 | GO:0034389 | lipid particle organization(GO:0034389) |
0.0 | 0.3 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
0.0 | 0.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
0.0 | 0.3 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
0.0 | 0.1 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
0.0 | 1.1 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
0.0 | 0.1 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
0.0 | 0.0 | GO:2000974 | negative regulation of pro-B cell differentiation(GO:2000974) |
0.0 | 0.0 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
0.0 | 0.5 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
0.0 | 0.1 | GO:0019827 | stem cell population maintenance(GO:0019827) maintenance of cell number(GO:0098727) |
0.0 | 0.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
0.0 | 0.0 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
0.0 | 0.9 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.1 | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
0.0 | 0.2 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
0.0 | 0.1 | GO:0031642 | negative regulation of myelination(GO:0031642) |
0.0 | 0.1 | GO:0042246 | tissue regeneration(GO:0042246) |
0.0 | 0.3 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
0.0 | 0.1 | GO:0002933 | lipid hydroxylation(GO:0002933) |
0.0 | 0.2 | GO:0006086 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) |
0.0 | 0.2 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
0.0 | 0.1 | GO:1904970 | brush border assembly(GO:1904970) |
0.0 | 0.0 | GO:0010816 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.0 | 0.3 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
0.0 | 0.1 | GO:0044597 | polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
0.0 | 0.0 | GO:0038183 | bile acid signaling pathway(GO:0038183) |
0.0 | 0.3 | GO:0071218 | cellular response to misfolded protein(GO:0071218) |
0.0 | 0.1 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) |
0.0 | 0.0 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
0.0 | 0.1 | GO:0090649 | response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
0.0 | 0.2 | GO:0043523 | regulation of neuron apoptotic process(GO:0043523) |
0.0 | 0.1 | GO:1903232 | melanosome assembly(GO:1903232) |
0.0 | 0.4 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
0.0 | 0.1 | GO:0033183 | negative regulation of histone ubiquitination(GO:0033183) histone H2A K63-linked ubiquitination(GO:0070535) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
0.3 | 2.9 | GO:0097427 | microtubule bundle(GO:0097427) |
0.2 | 1.7 | GO:0044294 | dendritic growth cone(GO:0044294) |
0.2 | 0.5 | GO:0072534 | perineuronal net(GO:0072534) |
0.1 | 1.0 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 1.7 | GO:0097433 | dense body(GO:0097433) |
0.1 | 0.5 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
0.1 | 0.2 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
0.1 | 4.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 0.3 | GO:0035339 | SPOTS complex(GO:0035339) |
0.1 | 0.9 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.1 | 0.5 | GO:0030870 | Mre11 complex(GO:0030870) |
0.1 | 0.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.0 | 0.3 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
0.0 | 0.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 1.0 | GO:0000145 | exocyst(GO:0000145) |
0.0 | 0.2 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
0.0 | 4.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.0 | 0.1 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
0.0 | 0.2 | GO:1990393 | 3M complex(GO:1990393) |
0.0 | 0.4 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.5 | GO:0097431 | mitotic spindle pole(GO:0097431) |
0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
0.0 | 0.3 | GO:0001673 | male germ cell nucleus(GO:0001673) |
0.0 | 0.2 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.0 | 0.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.0 | 0.5 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 0.3 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
0.0 | 0.1 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.0 | 0.3 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.0 | 0.1 | GO:0031085 | BLOC-3 complex(GO:0031085) |
0.0 | 0.1 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) junctional membrane complex(GO:0030314) |
0.0 | 0.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
0.0 | 0.6 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 0.3 | GO:0097225 | sperm midpiece(GO:0097225) |
0.0 | 0.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
0.0 | 0.1 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.6 | GO:0043235 | receptor complex(GO:0043235) |
0.0 | 1.3 | GO:0036126 | sperm flagellum(GO:0036126) |
0.0 | 3.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 2.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 0.1 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
0.0 | 0.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 0.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 0.4 | GO:0016580 | Sin3 complex(GO:0016580) |
0.0 | 1.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.3 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 0.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 0.2 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.0 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.1 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
0.0 | 1.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 1.0 | GO:0034704 | calcium channel complex(GO:0034704) |
0.0 | 1.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 0.1 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
0.0 | 0.2 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 0.1 | GO:0044455 | mitochondrial membrane part(GO:0044455) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 3.7 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
0.5 | 2.0 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
0.3 | 0.9 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
0.3 | 3.0 | GO:0031419 | cobalamin binding(GO:0031419) |
0.3 | 0.8 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
0.2 | 0.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.2 | 1.2 | GO:0050682 | AF-2 domain binding(GO:0050682) |
0.2 | 1.1 | GO:0016403 | dimethylargininase activity(GO:0016403) |
0.2 | 0.5 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
0.1 | 1.7 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.1 | 0.9 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
0.1 | 0.3 | GO:0008746 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
0.1 | 0.4 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
0.1 | 2.1 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.1 | 2.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.1 | 0.3 | GO:0090541 | MIT domain binding(GO:0090541) |
0.1 | 1.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 0.3 | GO:0034188 | apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.1 | 0.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.1 | 0.3 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.1 | 1.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.1 | 0.5 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.1 | 0.5 | GO:0031013 | troponin I binding(GO:0031013) |
0.1 | 0.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
0.1 | 0.2 | GO:0052642 | lysophosphatidic acid phosphatase activity(GO:0052642) |
0.1 | 0.7 | GO:0038132 | neuregulin binding(GO:0038132) |
0.1 | 1.0 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.1 | 0.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.1 | 1.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.1 | 0.2 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
0.1 | 0.7 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.0 | 0.3 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
0.0 | 1.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.0 | 0.3 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
0.0 | 1.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
0.0 | 0.1 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
0.0 | 0.2 | GO:0001588 | dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) |
0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
0.0 | 0.4 | GO:1901612 | cardiolipin binding(GO:1901612) |
0.0 | 0.2 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
0.0 | 0.1 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.0 | 0.2 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
0.0 | 0.2 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
0.0 | 1.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.2 | GO:0050815 | phosphoserine binding(GO:0050815) |
0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.0 | 0.1 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.0 | 0.3 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
0.0 | 1.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
0.0 | 1.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.4 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
0.0 | 0.1 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
0.0 | 0.1 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
0.0 | 1.8 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) mannosidase activity(GO:0015923) |
0.0 | 4.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.0 | 0.4 | GO:0015197 | peptide transporter activity(GO:0015197) |
0.0 | 1.0 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
0.0 | 0.1 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.1 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
0.0 | 1.3 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.1 | GO:0051425 | PTB domain binding(GO:0051425) |
0.0 | 0.6 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.0 | 0.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
0.0 | 0.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.1 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
0.0 | 0.1 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
0.0 | 0.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.1 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
0.0 | 0.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 0.4 | GO:0051393 | alpha-actinin binding(GO:0051393) |
0.0 | 0.5 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.1 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
0.0 | 0.4 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 0.1 | GO:0034046 | poly(G) binding(GO:0034046) |
0.0 | 0.0 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
0.0 | 0.0 | GO:0038181 | bile acid receptor activity(GO:0038181) |
0.0 | 0.1 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.0 | 0.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.0 | 0.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.5 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
0.0 | 0.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.0 | 1.2 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
0.0 | 1.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 0.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
0.0 | 0.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 0.8 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 0.2 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 0.2 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.9 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
0.1 | 1.9 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.1 | 1.2 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 0.9 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.0 | 1.4 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 1.1 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.0 | 0.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
0.0 | 0.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.0 | 0.5 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.0 | 0.2 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 0.3 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.0 | 0.2 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
0.0 | 1.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.3 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.0 | 0.7 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
0.0 | 0.7 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |