Motif ID: TFAP4_MSC
Z-value: 0.712


Transcription factors associated with TFAP4_MSC:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
MSC | ENSG00000178860.8 | MSC |
TFAP4 | ENSG00000090447.7 | TFAP4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
MSC | hg19_v2_chr8_-_72756667_72756736 | -0.37 | 7.9e-02 | Click! |
TFAP4 | hg19_v2_chr16_-_4323015_4323076 | 0.05 | 8.0e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 142 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 3.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.4 | 3.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
0.0 | 3.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 3.3 | GO:0001578 | microtubule bundle formation(GO:0001578) |
0.3 | 2.9 | GO:0015889 | cobalamin transport(GO:0015889) |
0.0 | 2.5 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
0.2 | 2.1 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
0.1 | 2.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.7 | 2.0 | GO:0035283 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
0.5 | 2.0 | GO:0018032 | protein amidation(GO:0018032) |
0.1 | 1.9 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
0.0 | 1.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.1 | 1.8 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.2 | 1.7 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.0 | 1.7 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
0.2 | 1.3 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
0.1 | 1.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.4 | 1.2 | GO:0021524 | visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913) |
0.0 | 1.2 | GO:0010107 | potassium ion import(GO:0010107) |
0.4 | 1.1 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 61 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 4.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.0 | 3.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.3 | 2.9 | GO:0097427 | microtubule bundle(GO:0097427) |
0.0 | 2.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 1.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.2 | 1.7 | GO:0044294 | dendritic growth cone(GO:0044294) |
0.1 | 1.7 | GO:0097433 | dense body(GO:0097433) |
0.0 | 1.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 1.3 | GO:0036126 | sperm flagellum(GO:0036126) |
0.4 | 1.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
0.0 | 1.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.1 | 1.0 | GO:1990635 | proximal dendrite(GO:1990635) |
0.0 | 1.0 | GO:0000145 | exocyst(GO:0000145) |
0.0 | 1.0 | GO:0034704 | calcium channel complex(GO:0034704) |
0.1 | 0.9 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 0.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
0.1 | 0.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.0 | 0.6 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 0.6 | GO:0043235 | receptor complex(GO:0043235) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 86 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 4.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.9 | 3.7 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
0.3 | 3.0 | GO:0031419 | cobalamin binding(GO:0031419) |
0.1 | 2.1 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.1 | 2.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.5 | 2.0 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
0.0 | 1.8 | GO:0070888 | E-box binding(GO:0070888) |
0.1 | 1.7 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.1 | 1.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.0 | 1.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.1 | 1.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.0 | 1.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
0.1 | 1.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.0 | 1.3 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.2 | 1.2 | GO:0050682 | AF-2 domain binding(GO:0050682) |
0.0 | 1.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.2 | 1.1 | GO:0016403 | dimethylargininase activity(GO:0016403) |
0.0 | 1.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.1 | 1.0 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
Gene overrepresentation in C2:CP category:
Showing 1 to 11 of 11 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.5 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
0.0 | 1.2 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
0.0 | 1.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 0.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.0 | 0.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.8 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 0.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
0.0 | 0.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
0.0 | 0.2 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 0.2 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 17 of 17 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.9 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 1.4 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.1 | 1.2 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 1.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 1.1 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.1 | 0.9 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
0.0 | 0.9 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.0 | 0.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
0.0 | 0.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.0 | 0.7 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
0.0 | 0.7 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.5 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.0 | 0.3 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.0 | 0.3 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 0.2 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 0.2 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |