Motif ID: TFAP4_MSC

Z-value: 0.712

Transcription factors associated with TFAP4_MSC:

Gene SymbolEntrez IDGene Name
MSC ENSG00000178860.8 MSC
TFAP4 ENSG00000090447.7 TFAP4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MSChg19_v2_chr8_-_72756667_72756736-0.377.9e-02Click!
TFAP4hg19_v2_chr16_-_4323015_43230760.058.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4_MSC

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_24911195 4.509 ENST00000259698.4
FAM65B
family with sequence similarity 65, member B
chr16_-_21289627 3.732 ENST00000396023.2
ENST00000415987.2
CRYM

crystallin, mu

chr3_+_3841108 3.636 ENST00000319331.3
LRRN1
leucine rich repeat neuronal 1
chr16_-_67427389 2.910 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
TPPP3


tubulin polymerization-promoting protein family member 3


chr6_-_39197226 2.237 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr8_-_72274095 2.231 ENST00000303824.7
EYA1
eyes absent homolog 1 (Drosophila)
chr20_-_39317868 1.948 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr15_-_40401062 1.928 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF



Bcl2 modifying factor



chr2_+_85981008 1.842 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr11_+_45918092 1.729 ENST00000395629.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr8_-_110660999 1.712 ENST00000424158.2
ENST00000533895.1
ENST00000446070.2
ENST00000528331.1
ENST00000526302.1
ENST00000433638.1
ENST00000408908.2
ENST00000524720.1
SYBU







syntabulin (syntaxin-interacting)







chr6_+_17281573 1.557 ENST00000379052.5
RBM24
RNA binding motif protein 24
chr4_+_75858318 1.495 ENST00000307428.7
PARM1
prostate androgen-regulated mucin-like protein 1
chr22_-_36013368 1.349 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB



myoglobin



chr9_-_112970436 1.316 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr8_+_81398444 1.311 ENST00000455036.3
ENST00000426744.2
ZBTB10

zinc finger and BTB domain containing 10

chr12_+_49297899 1.257 ENST00000552942.1
ENST00000320516.4
CCDC65

coiled-coil domain containing 65

chr4_+_75858290 1.257 ENST00000513238.1
PARM1
prostate androgen-regulated mucin-like protein 1
chr8_-_72274467 1.199 ENST00000340726.3
EYA1
eyes absent homolog 1 (Drosophila)
chr1_-_216896780 1.186 ENST00000459955.1
ENST00000366937.1
ENST00000408911.3
ENST00000391890.3
ESRRG



estrogen-related receptor gamma




Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.4 3.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 3.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 3.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 2.9 GO:0015889 cobalamin transport(GO:0015889)
0.0 2.5 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.2 2.1 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 2.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.7 2.0 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.5 2.0 GO:0018032 protein amidation(GO:0018032)
0.1 1.9 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 1.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 1.8 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 1.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.2 1.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 1.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 1.2 GO:0021524 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.4 1.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 4.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 3.1 GO:0032993 protein-DNA complex(GO:0032993)
0.3 2.9 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.7 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.7 GO:0097433 dense body(GO:0097433)
0.0 1.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.3 GO:0036126 sperm flagellum(GO:0036126)
0.4 1.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 1.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.0 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.0 1.0 GO:0034704 calcium channel complex(GO:0034704)
0.1 0.9 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.8 GO:0000790 nuclear chromatin(GO:0000790)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.9 3.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 3.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.5 2.0 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.1 1.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.4 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 1.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 1.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 1.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 1.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.0 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.2 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 1.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 0.9 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction