Motif ID: TFAP2E

Z-value: 0.391


Transcription factors associated with TFAP2E:

Gene SymbolEntrez IDGene Name
TFAP2E ENSG00000116819.6 TFAP2E

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.396.3e-02Click!


Activity profile for motif TFAP2E.

activity profile for motif TFAP2E


Sorted Z-values histogram for motif TFAP2E

Sorted Z-values for motif TFAP2E



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2E

PNG image of the network

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Top targets:


Showing 1 to 20 of 128 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_65503801 0.732 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr2_+_38893208 0.647 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr19_+_45504688 0.635 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr19_-_35981358 0.522 ENST00000484218.2
ENST00000338897.3
KRTDAP

keratinocyte differentiation-associated protein

chr1_-_151778630 0.469 ENST00000368820.3
LINGO4
leucine rich repeat and Ig domain containing 4
chr11_-_82612727 0.349 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
PRCP


prolylcarboxypeptidase (angiotensinase C)


chr19_-_54676884 0.317 ENST00000376591.4
TMC4
transmembrane channel-like 4
chr19_-_54676846 0.294 ENST00000301187.4
TMC4
transmembrane channel-like 4
chr5_-_179499108 0.289 ENST00000521389.1
RNF130
ring finger protein 130
chr5_-_179499086 0.284 ENST00000261947.4
RNF130
ring finger protein 130
chr17_+_72428218 0.261 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_-_15942503 0.251 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr9_-_86432547 0.239 ENST00000376365.3
ENST00000376371.2
GKAP1

G kinase anchoring protein 1

chr2_-_45236540 0.227 ENST00000303077.6
SIX2
SIX homeobox 2
chr1_+_211433275 0.220 ENST00000367005.4
RCOR3
REST corepressor 3
chr12_-_15942309 0.217 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8


epidermal growth factor receptor pathway substrate 8


chr2_-_174828892 0.207 ENST00000418194.2
SP3
Sp3 transcription factor
chr1_-_32801825 0.199 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr3_+_49591881 0.192 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr14_-_25519095 0.192 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6



syntaxin binding protein 6 (amisyn)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.8 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.3 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.2 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.1 GO:0060775 cardiac right atrium morphogenesis(GO:0003213) negative regulation of melanin biosynthetic process(GO:0048022) positive regulation of anagen(GO:0051885) mediolateral intercalation(GO:0060031) cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) negative regulation of secondary metabolite biosynthetic process(GO:1900377) regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.0 GO:0072156 distal tubule morphogenesis(GO:0072156)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.0 GO:0032173 septin ring(GO:0005940) septin collar(GO:0032173)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 0.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.0 GO:0030626 U12 snRNA binding(GO:0030626)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway