Motif ID: TBX1
Z-value: 1.256
Transcription factors associated with TBX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TBX1 | ENSG00000184058.8 | TBX1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX1 | hg19_v2_chr22_+_19744226_19744226 | 0.25 | 2.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 481 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 4.1 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 3.5 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 3.3 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.8 | 3.2 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.5 | 3.2 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 3.0 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.1 | 2.4 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.3 | 2.1 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.1 | 2.1 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 2.1 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 2.1 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.2 | 2.0 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.0 | 2.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 2.0 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.1 | 1.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 1.9 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.0 | 1.9 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 0.4 | 1.8 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.0 | 1.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 155 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 4.1 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 4.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 4.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.5 | 3.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.3 | 3.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.3 | 2.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 2.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.9 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 1.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.4 | 1.8 | GO:0032449 | CBM complex(GO:0032449) |
| 0.0 | 1.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.8 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 1.8 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 1.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.2 | 1.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 1.4 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 1.4 | GO:0072686 | mitotic spindle(GO:0072686) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 303 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 4.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 4.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.6 | 3.4 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.3 | 3.1 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.0 | 3.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 2.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 2.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 2.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 2.0 | GO:0008186 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.3 | 1.9 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.1 | 1.9 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 1.8 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 1.8 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 1.7 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 1.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.5 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.3 | 1.4 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.2 | 1.4 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 1.4 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 47 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 4.7 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.3 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 2.0 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 1.8 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 1.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.4 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.3 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.1 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.9 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.9 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.9 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.9 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.9 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 93 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 5.1 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 4.9 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 4.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 2.7 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 2.6 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 2.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.3 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.0 | REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.1 | 2.0 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.9 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.8 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.1 | 1.5 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 1.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.4 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.2 | REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.0 | 1.2 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.2 | REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
