Motif ID: STAT6

Z-value: 0.740


Transcription factors associated with STAT6:

Gene SymbolEntrez IDGene Name
STAT6 ENSG00000166888.6 STAT6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT6hg19_v2_chr12_-_57505121_575052160.262.2e-01Click!


Activity profile for motif STAT6.

activity profile for motif STAT6


Sorted Z-values histogram for motif STAT6

Sorted Z-values for motif STAT6



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_205391178 6.731 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chrX_+_135251783 2.323 ENST00000394153.2
 FHL1
four and a half LIM domains 1
chrX_+_135252050 2.096 ENST00000449474.1
ENST00000345434.3
 FHL1

four and a half LIM domains 1

chrX_+_135251835 2.080 ENST00000456445.1
 FHL1
four and a half LIM domains 1
chr2_+_113885138 1.944 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr10_+_102106829 1.798 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr11_-_128457446 1.519 ENST00000392668.4
 ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr2_-_31440377 1.432 ENST00000444918.2
ENST00000403897.3
 CAPN14

calpain 14

chr4_+_54966198 1.206 ENST00000326902.2
ENST00000503800.1
 GSX2

GS homeobox 2

chr9_+_36572851 1.161 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
 MELK







maternal embryonic leucine zipper kinase







chr1_-_160616804 1.158 ENST00000538290.1
 SLAMF1
signaling lymphocytic activation molecule family member 1
chr17_-_17740325 1.141 ENST00000338854.5
 SREBF1
sterol regulatory element binding transcription factor 1
chr8_+_49984894 1.122 ENST00000522267.1
ENST00000399653.4
ENST00000303202.8
 C8orf22


chromosome 8 open reading frame 22


chr22_+_44464923 1.113 ENST00000404989.1
 PARVB
parvin, beta
chrX_-_106960285 1.029 ENST00000503515.1
ENST00000372397.2
 TSC22D3

TSC22 domain family, member 3

chr14_+_55034599 0.980 ENST00000392067.3
ENST00000357634.3
 SAMD4A

sterile alpha motif domain containing 4A

chr2_-_190044480 0.980 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr11_+_65082289 0.968 ENST00000279249.2
 CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr12_+_9144626 0.948 ENST00000543895.1
 KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr11_+_76745385 0.921 ENST00000533140.1
ENST00000354301.5
ENST00000528622.1
 B3GNT6


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 2.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 1.9 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.9 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.6 1.8 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2 1.5 GO:0030578 PML body organization(GO:0030578)
0.4 1.2 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.3 1.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 1.2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 1.1 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 1.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 1.1 GO:0006833 water transport(GO:0006833)
0.3 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.0 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.0 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 0.9 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.9 GO:0006968 cellular defense response(GO:0006968)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0005925 focal adhesion(GO:0005925)
0.0 2.1 GO:0031430 M band(GO:0031430)
0.0 1.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.9 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.6 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.6 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.1 GO:0097679 other organism cytoplasm(GO:0097679)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.1 GO:0044325 ion channel binding(GO:0044325)
0.2 2.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 1.9 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.4 1.9 GO:0032810 sterol response element binding(GO:0032810)
0.4 1.8 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 1.7 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.1 GO:0015250 water channel activity(GO:0015250)
0.2 1.0 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.0 GO:0043426 MRF binding(GO:0043426)
0.0 1.0 GO:0030552 cAMP binding(GO:0030552)
0.0 1.0 GO:0030371 translation repressor activity(GO:0030371)
0.3 0.9 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.2 0.9 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.1 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.1 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.9 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 1.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.0 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 0.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME_OPSINS Genes involved in Opsins
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.4 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis