Motif ID: STAT4

Z-value: 0.660


Transcription factors associated with STAT4:

Gene SymbolEntrez IDGene Name
STAT4 ENSG00000138378.13 STAT4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT4hg19_v2_chr2_-_192016316_192016325-0.546.6e-03Click!


Activity profile for motif STAT4.

activity profile for motif STAT4


Sorted Z-values histogram for motif STAT4

Sorted Z-values for motif STAT4



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_32407619 3.095 ENST00000395388.2
ENST00000374982.5
 HLA-DRA

major histocompatibility complex, class II, DR alpha

chr1_-_161337662 3.019 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr14_-_21270561 2.245 ENST00000412779.2
 RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr1_-_109655377 2.075 ENST00000369948.3
 C1orf194
chromosome 1 open reading frame 194
chr1_-_109655355 2.073 ENST00000369945.3
 C1orf194
chromosome 1 open reading frame 194
chr6_+_32821924 1.442 ENST00000374859.2
ENST00000453265.2
 PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr5_+_140227048 1.337 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr5_-_121413974 1.290 ENST00000231004.4
 LOX
lysyl oxidase
chr16_+_19467772 1.277 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
 TMC5


transmembrane channel-like 5


chr5_+_140261703 1.268 ENST00000409494.1
ENST00000289272.2
 PCDHA13

protocadherin alpha 13

chr3_-_148939835 1.250 ENST00000264613.6
 CP
ceruloplasmin (ferroxidase)
chr16_+_58283814 1.037 ENST00000443128.2
ENST00000219299.4
 CCDC113

coiled-coil domain containing 113

chr5_-_16509101 0.942 ENST00000399793.2
 FAM134B
family with sequence similarity 134, member B
chr12_+_113587558 0.898 ENST00000335621.6
 CCDC42B
coiled-coil domain containing 42B
chr19_+_35168567 0.806 ENST00000457781.2
ENST00000505163.1
ENST00000505242.1
ENST00000423823.2
ENST00000507959.1
ENST00000446502.2
 ZNF302





zinc finger protein 302





chr5_-_111092873 0.769 ENST00000509025.1
ENST00000515855.1
 NREP

neuronal regeneration related protein

chr7_+_117120017 0.741 ENST00000003084.6
ENST00000454343.1
 CFTR

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

chr19_+_35225060 0.733 ENST00000599244.1
ENST00000392232.3
 ZNF181

zinc finger protein 181

chr6_-_110011704 0.725 ENST00000448084.2
 AK9
adenylate kinase 9
chr3_-_114866084 0.712 ENST00000357258.3
 ZBTB20
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.1 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 1.7 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 1.6 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5 1.4 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.1 1.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 1.2 GO:0006825 copper ion transport(GO:0006825)
0.3 0.9 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.6 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.2 0.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.5 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.4 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.3 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 0.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 1.0 GO:0034451 centriolar satellite(GO:0034451)
0.2 0.9 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.0 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.0 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 2.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 1.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.4 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.3 1.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 0.9 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.2 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.1 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG