Motif ID: SRY

Z-value: 0.657


Transcription factors associated with SRY:

Gene SymbolEntrez IDGene Name
SRY ENSG00000184895.6 SRY

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRYhg19_v2_chrY_-_2655644_2655740-0.125.8e-01Click!


Activity profile for motif SRY.

activity profile for motif SRY


Sorted Z-values histogram for motif SRY

Sorted Z-values for motif SRY



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_39564993 2.458 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr6_-_32557610 2.206 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr4_+_165675197 1.874 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr20_-_3762087 1.772 ENST00000379756.3
 SPEF1
sperm flagellar 1
chr17_+_17876127 1.518 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
 LRRC48









leucine rich repeat containing 48









chr6_+_163148973 1.484 ENST00000366888.2
 PACRG
PARK2 co-regulated
chr4_+_165675269 1.341 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr14_-_92413727 1.339 ENST00000267620.10
 FBLN5
fibulin 5
chr1_+_61547405 1.268 ENST00000371189.4
 NFIA
nuclear factor I/A
chr19_+_13134772 1.093 ENST00000587760.1
ENST00000585575.1
 NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr1_-_217311090 0.970 ENST00000493603.1
ENST00000366940.2
 ESRRG

estrogen-related receptor gamma

chr14_-_92413353 0.869 ENST00000556154.1
 FBLN5
fibulin 5
chr20_-_21494654 0.868 ENST00000377142.4
 NKX2-2
NK2 homeobox 2
chr14_-_89883412 0.858 ENST00000557258.1
 FOXN3
forkhead box N3
chr14_-_92414055 0.850 ENST00000342058.4
 FBLN5
fibulin 5
chr1_-_40367668 0.815 ENST00000397332.2
ENST00000429311.1
 MYCL

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog

chr14_-_23288930 0.809 ENST00000554517.1
ENST00000285850.7
ENST00000397529.2
ENST00000555702.1
 SLC7A7



solute carrier family 7 (amino acid transporter light chain, y+L system), member 7



chr5_-_111091948 0.807 ENST00000447165.2
 NREP
neuronal regeneration related protein
chr4_-_105416039 0.787 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr2_-_157198860 0.776 ENST00000409572.1
 NR4A2
nuclear receptor subfamily 4, group A, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 2.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.4 2.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.2 1.9 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.4 1.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.3 GO:0072189 ureter development(GO:0072189)
0.0 1.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.0 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 1.0 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 1.0 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.3 0.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.3 0.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.8 GO:1990822 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.1 0.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.8 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.7 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:0071953 elastic fiber(GO:0071953)
0.0 2.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 2.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.8 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.1 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.5 2.3 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.2 2.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.2 1.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 1.0 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 0.7 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 2.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 2.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME_OPSINS Genes involved in Opsins