Motif ID: SREBF2

Z-value: 0.671


Transcription factors associated with SREBF2:

Gene SymbolEntrez IDGene Name
SREBF2 ENSG00000198911.7 SREBF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.664.9e-04Click!


Activity profile for motif SREBF2.

activity profile for motif SREBF2


Sorted Z-values histogram for motif SREBF2

Sorted Z-values for motif SREBF2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF2

PNG image of the network

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Top targets:


Showing 1 to 20 of 72 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_151561085 3.638 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_55505184 2.500 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr4_+_75230853 2.420 ENST00000244869.2
EREG
epiregulin
chr8_+_26435359 2.257 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr19_+_11200038 1.823 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR





low density lipoprotein receptor





chr6_-_53213587 1.761 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5


ELOVL fatty acid elongase 5


chr20_+_33464238 1.612 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr20_+_33464407 1.440 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr9_+_126131131 1.349 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr18_-_21166841 1.295 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr2_-_26205340 1.261 ENST00000264712.3
KIF3C
kinesin family member 3C
chr10_-_74856608 1.151 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chr5_-_43313574 1.093 ENST00000325110.6
ENST00000433297.2
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr10_-_3827417 1.070 ENST00000497571.1
ENST00000542957.1
KLF6

Kruppel-like factor 6

chr3_-_98620500 1.038 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr17_-_40075197 0.994 ENST00000590770.1
ENST00000590151.1
ACLY

ATP citrate lyase

chr17_-_40075219 0.964 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY



ATP citrate lyase



chr19_-_11308190 0.919 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2




KN motif and ankyrin repeat domains 2




chr17_-_39274606 0.869 ENST00000391413.2
KRTAP4-11
keratin associated protein 4-11
chr1_-_42384343 0.853 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.8 3.1 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.8 2.5 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.8 2.4 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.3 2.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 2.3 GO:0046618 drug export(GO:0046618)
0.1 2.0 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 1.9 GO:0030516 regulation of axon extension(GO:0030516)
0.5 1.8 GO:1905167 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 1.3 GO:0014028 notochord formation(GO:0014028)
0.2 1.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 1.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.3 0.9 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.7 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.7 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 0.5 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.3 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.8 2.4 GO:0097447 dendritic tree(GO:0097447)
0.0 2.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.3 1.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.9 GO:0097542 ciliary tip(GO:0097542)
0.1 0.7 GO:0000796 condensin complex(GO:0000796)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.6 3.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.5 3.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.8 2.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.3 2.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.8 2.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.4 2.3 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.4 1.8 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 1.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 1.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.3 GO:0003777 microtubule motor activity(GO:0003777)
0.2 1.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.7 GO:0043426 MRF binding(GO:0043426)
0.0 0.6 GO:0042608 T cell receptor binding(GO:0042608)
0.2 0.5 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.1 0.4 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 3.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation