Motif ID: SPIB

Z-value: 0.870


Transcription factors associated with SPIB:

Gene SymbolEntrez IDGene Name
SPIB ENSG00000269404.2 SPIB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_509222150.501.3e-02Click!


Activity profile for motif SPIB.

activity profile for motif SPIB


Sorted Z-values histogram for motif SPIB

Sorted Z-values for motif SPIB



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51471362 7.324 ENST00000376853.4
ENST00000424910.2
KLK6

kallikrein-related peptidase 6

chr19_-_51471381 7.251 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr1_+_120839412 3.520 ENST00000355228.4
FAM72B
family with sequence similarity 72, member B
chr1_+_206138884 3.222 ENST00000341209.5
ENST00000607379.1
FAM72A

family with sequence similarity 72, member A

chr2_+_113885138 2.637 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr19_+_48828788 2.572 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
EMP3


epithelial membrane protein 3


chr19_+_48828582 2.368 ENST00000270221.6
ENST00000596315.1
EMP3

epithelial membrane protein 3

chr12_+_15699286 2.176 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO



protein tyrosine phosphatase, receptor type, O



chr22_-_37640456 2.028 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr19_+_54371114 2.013 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
MYADM



myeloid-associated differentiation marker



chr10_-_121302195 1.969 ENST00000369103.2
RGS10
regulator of G-protein signaling 10
chr22_-_37640277 1.902 ENST00000401529.3
ENST00000249071.6
RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr2_+_233925064 1.889 ENST00000359570.5
ENST00000538935.1
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr5_-_39270725 1.812 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB


FYN binding protein


chr2_-_208031943 1.784 ENST00000421199.1
ENST00000457962.1
KLF7

Kruppel-like factor 7 (ubiquitous)

chr3_+_121774202 1.678 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86



CD86 molecule



chr3_+_121796697 1.670 ENST00000482356.1
ENST00000393627.2
CD86

CD86 molecule

chr1_-_43855444 1.652 ENST00000372455.4
MED8
mediator complex subunit 8
chr2_-_190044480 1.631 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr22_-_37915535 1.626 ENST00000403299.1
CARD10
caspase recruitment domain family, member 10
chr1_+_206138457 1.598 ENST00000367128.3
ENST00000431655.2
FAM72A

family with sequence similarity 72, member A

chr1_-_143913143 1.592 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr7_+_74188309 1.588 ENST00000289473.4
ENST00000433458.1
NCF1

neutrophil cytosolic factor 1

chr1_+_120839005 1.564 ENST00000369390.3
ENST00000452190.1
FAM72B

family with sequence similarity 72, member B

chr16_+_30194916 1.548 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
CORO1A


coronin, actin binding protein, 1A


chr19_-_15344243 1.524 ENST00000602233.1
EPHX3
epoxide hydrolase 3
chr1_+_15736359 1.456 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr17_-_5138099 1.369 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SCIMP



SLP adaptor and CSK interacting membrane protein



chr4_-_80994619 1.365 ENST00000404191.1
ANTXR2
anthrax toxin receptor 2
chr11_+_65408273 1.358 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr4_+_8201091 1.338 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr20_+_62492566 1.300 ENST00000369916.3
ABHD16B
abhydrolase domain containing 16B
chr4_-_103266626 1.281 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_-_43487780 1.277 ENST00000532038.1
ENST00000528677.1
ARHGAP27

Rho GTPase activating protein 27

chr6_+_31126291 1.244 ENST00000376257.3
ENST00000376255.4
TCF19

transcription factor 19

chrX_-_47489244 1.243 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP


complement factor properdin


chr11_-_64851496 1.173 ENST00000404147.3
ENST00000275517.3
CDCA5

cell division cycle associated 5

chr17_-_43487741 1.138 ENST00000455881.1
ARHGAP27
Rho GTPase activating protein 27
chrX_+_138612889 1.129 ENST00000218099.2
ENST00000394090.2
F9

coagulation factor IX

chr12_-_122240792 1.115 ENST00000541657.1
ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
RHOF
AC084018.1





ras homolog family member F (in filopodia)
AC084018.1





chr14_+_85996471 1.102 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_-_144385698 1.095 ENST00000444202.1
ENST00000437412.1
PLAGL1

pleiomorphic adenoma gene-like 1

chr15_-_34629922 1.088 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
SLC12A6



solute carrier family 12 (potassium/chloride transporter), member 6



chr5_+_159848854 1.063 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
PTTG1


pituitary tumor-transforming 1


chr9_-_95640218 1.040 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484


zinc finger protein 484


chr6_-_11382478 1.033 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9



neural precursor cell expressed, developmentally down-regulated 9



chr6_-_167571817 1.016 ENST00000366834.1
GPR31
G protein-coupled receptor 31
chr3_+_98482175 1.011 ENST00000485391.1
ENST00000492254.1
ST3GAL6

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

chr16_+_71392616 0.987 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2


calbindin 2


chr12_-_51785182 0.968 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
GALNT6



UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)



chr2_+_173940163 0.934 ENST00000539448.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr15_-_34630234 0.931 ENST00000558667.1
ENST00000561120.1
ENST00000559236.1
ENST00000397702.2
SLC12A6



solute carrier family 12 (potassium/chloride transporter), member 6



chr10_-_74856608 0.885 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chr18_-_31802056 0.861 ENST00000538587.1
NOL4
nucleolar protein 4
chr15_-_34628951 0.847 ENST00000397707.2
ENST00000560611.1
SLC12A6

solute carrier family 12 (potassium/chloride transporter), member 6

chr2_+_173940442 0.838 ENST00000409176.2
ENST00000338983.3
ENST00000431503.2
MLTK


Mitogen-activated protein kinase kinase kinase MLT


chr10_+_106028605 0.835 ENST00000450629.2
GSTO2
glutathione S-transferase omega 2
chr7_+_139529040 0.825 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr15_-_33360342 0.823 ENST00000558197.1
FMN1
formin 1
chr12_+_49717081 0.810 ENST00000547807.1
ENST00000551567.1
TROAP

trophinin associated protein

chr15_-_34610962 0.809 ENST00000290209.5
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr5_-_140013275 0.807 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14


CD14 molecule


chr3_-_151047327 0.797 ENST00000325602.5
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr16_+_28889801 0.785 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr19_-_40791211 0.785 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr17_+_65374075 0.783 ENST00000581322.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chrX_-_153637612 0.781 ENST00000369807.1
ENST00000369808.3
DNASE1L1

deoxyribonuclease I-like 1

chr10_+_106028923 0.781 ENST00000338595.2
GSTO2
glutathione S-transferase omega 2
chr22_+_37309662 0.772 ENST00000403662.3
ENST00000262825.5
CSF2RB

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

chr12_+_49717019 0.770 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP







trophinin associated protein







chr19_+_50919056 0.762 ENST00000599632.1
CTD-2545M3.6
CTD-2545M3.6
chr17_+_65373531 0.754 ENST00000580974.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr17_-_1395954 0.752 ENST00000359786.5
MYO1C
myosin IC
chr21_-_46340807 0.742 ENST00000397846.3
ENST00000524251.1
ENST00000522688.1
ITGB2


integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)


chr6_-_41254403 0.727 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1



triggering receptor expressed on myeloid cells 1



chr6_-_32145861 0.720 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr2_-_43019698 0.719 ENST00000431905.1
ENST00000294973.6
HAAO

3-hydroxyanthranilate 3,4-dioxygenase

chr16_+_28889703 0.716 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_+_139528952 0.700 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr13_+_31309645 0.694 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr3_-_179169330 0.694 ENST00000232564.3
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr6_+_130339710 0.684 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr17_-_39093672 0.684 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23


keratin 23 (histone deacetylase inducible)


chr5_+_96079240 0.672 ENST00000515663.1
CAST
calpastatin
chr20_-_46415341 0.671 ENST00000484875.1
ENST00000361612.4
SULF2

sulfatase 2

chr12_+_9102632 0.666 ENST00000539240.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr1_-_47069886 0.666 ENST00000371946.4
ENST00000371945.4
ENST00000428112.2
ENST00000529170.1
MKNK1



MAP kinase interacting serine/threonine kinase 1



chr10_-_92617671 0.662 ENST00000371721.3
HTR7
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
chrX_-_40594755 0.655 ENST00000324817.1
MED14
mediator complex subunit 14
chr1_-_47069955 0.652 ENST00000341183.5
ENST00000496619.1
MKNK1

MAP kinase interacting serine/threonine kinase 1

chr11_+_1860832 0.646 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr1_+_209941827 0.637 ENST00000367023.1
TRAF3IP3
TRAF3 interacting protein 3
chr11_+_1861399 0.634 ENST00000381905.3
TNNI2
troponin I type 2 (skeletal, fast)
chr14_+_67291158 0.633 ENST00000555456.1
GPHN
gephyrin
chr10_-_98031265 0.622 ENST00000224337.5
ENST00000371176.2
BLNK

B-cell linker

chr7_+_106505912 0.613 ENST00000359195.3
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr6_-_133079022 0.609 ENST00000525289.1
ENST00000326499.6
VNN2

vanin 2

chr7_+_106505696 0.609 ENST00000440650.2
ENST00000496166.1
ENST00000473541.1
PIK3CG


phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma


chr6_+_116782527 0.597 ENST00000368606.3
ENST00000368605.1
FAM26F

family with sequence similarity 26, member F

chr16_+_30960375 0.595 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
ORAI3


ORAI calcium release-activated calcium modulator 3


chr11_-_3859089 0.593 ENST00000396979.1
RHOG
ras homolog family member G
chr2_-_188419078 0.591 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI



tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)



chr20_-_46415297 0.590 ENST00000467815.1
ENST00000359930.4
SULF2

sulfatase 2

chr6_+_42952237 0.589 ENST00000485511.1
ENST00000394110.3
ENST00000472118.1
ENST00000461010.1
PPP2R5D



protein phosphatase 2, regulatory subunit B', delta



chr8_+_27632083 0.589 ENST00000519637.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr11_-_67120974 0.589 ENST00000539074.1
ENST00000312419.3
POLD4

polymerase (DNA-directed), delta 4, accessory subunit

chr9_+_112403088 0.579 ENST00000448454.2
PALM2
paralemmin 2
chr9_+_34653861 0.575 ENST00000556792.1
ENST00000318041.9
ENST00000378817.4
IL11RA


interleukin 11 receptor, alpha


chr11_+_60145997 0.569 ENST00000530614.1
ENST00000530027.1
ENST00000530234.2
ENST00000528215.1
ENST00000531787.1
MS4A7



MS4A14
membrane-spanning 4-domains, subfamily A, member 7



membrane-spanning 4-domains, subfamily A, member 14
chr4_+_177241094 0.568 ENST00000503362.1
SPCS3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr9_-_113800981 0.561 ENST00000538760.1
LPAR1
lysophosphatidic acid receptor 1
chr17_-_37009882 0.547 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23




ribosomal protein L23




chr13_-_25745857 0.545 ENST00000381853.3
AMER2
APC membrane recruitment protein 2
chr3_-_28390120 0.541 ENST00000334100.6
AZI2
5-azacytidine induced 2
chr1_-_231560790 0.538 ENST00000366641.3
EGLN1
egl-9 family hypoxia-inducible factor 1
chr7_-_129592471 0.536 ENST00000473814.2
ENST00000490974.1
UBE2H

ubiquitin-conjugating enzyme E2H

chr6_+_15246501 0.524 ENST00000341776.2
JARID2
jumonji, AT rich interactive domain 2
chrX_-_74376108 0.517 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ABCB7




ATP-binding cassette, sub-family B (MDR/TAP), member 7




chr1_-_160616804 0.516 ENST00000538290.1
SLAMF1
signaling lymphocytic activation molecule family member 1
chrX_+_28605516 0.511 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr1_+_22979474 0.511 ENST00000509305.1
C1QB
complement component 1, q subcomponent, B chain
chr3_-_116163830 0.509 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr6_+_69345166 0.509 ENST00000370598.1
BAI3
brain-specific angiogenesis inhibitor 3
chr12_+_120105558 0.494 ENST00000229328.5
ENST00000541640.1
PRKAB1

protein kinase, AMP-activated, beta 1 non-catalytic subunit

chr1_+_205473720 0.489 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
CDK18


cyclin-dependent kinase 18


chr7_-_121944491 0.489 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr1_-_159893507 0.487 ENST00000368096.1
TAGLN2
transgelin 2
chr9_+_112403059 0.481 ENST00000374531.2
PALM2
paralemmin 2
chr5_+_95997769 0.480 ENST00000338252.3
ENST00000508830.1
CAST

calpastatin

chr2_+_173940668 0.475 ENST00000375213.3
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr1_+_22979676 0.469 ENST00000432749.2
ENST00000314933.6
C1QB

complement component 1, q subcomponent, B chain

chr2_-_241737128 0.468 ENST00000404283.3
KIF1A
kinesin family member 1A
chr5_-_142783175 0.465 ENST00000231509.3
ENST00000394464.2
NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

chr1_+_161676739 0.464 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
FCRLA






Fc receptor-like A






chr10_-_98031310 0.458 ENST00000427367.2
ENST00000413476.2
BLNK

B-cell linker

chr6_+_26251835 0.453 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr1_+_46713357 0.452 ENST00000442598.1
RAD54L
RAD54-like (S. cerevisiae)
chr1_+_161632937 0.451 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
FCGR2B


Fc fragment of IgG, low affinity IIb, receptor (CD32)


chr19_+_16254488 0.446 ENST00000588246.1
ENST00000593031.1
HSH2D

hematopoietic SH2 domain containing

chr1_+_46713404 0.444 ENST00000371975.4
ENST00000469835.1
RAD54L

RAD54-like (S. cerevisiae)

chr1_+_161676983 0.438 ENST00000367957.2
FCRLA
Fc receptor-like A
chr11_-_64546202 0.437 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
SF1




splicing factor 1




chr3_-_28390298 0.435 ENST00000457172.1
AZI2
5-azacytidine induced 2
chr12_+_10124001 0.435 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
CLEC12A


C-type lectin domain family 12, member A


chr9_-_21995249 0.431 ENST00000494262.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr19_+_30863271 0.428 ENST00000355537.3
ZNF536
zinc finger protein 536
chr1_-_175161890 0.423 ENST00000545251.2
ENST00000423313.1
KIAA0040

KIAA0040

chr11_+_60145967 0.423 ENST00000534016.1
MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chrX_+_79591003 0.421 ENST00000538312.1
FAM46D
family with sequence similarity 46, member D
chr3_-_16555150 0.421 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr11_+_131240373 0.420 ENST00000374791.3
ENST00000436745.1
NTM

neurotrimin

chr3_-_28390415 0.419 ENST00000414162.1
ENST00000420543.2
AZI2

5-azacytidine induced 2

chr6_+_125304502 0.418 ENST00000519799.1
ENST00000368414.2
ENST00000359704.2
RNF217


ring finger protein 217


chr17_-_76356148 0.417 ENST00000587578.1
ENST00000330871.2
SOCS3

suppressor of cytokine signaling 3

chr1_+_39456895 0.415 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1


akirin 1


chr5_+_169064245 0.412 ENST00000256935.8
DOCK2
dedicator of cytokinesis 2
chr3_-_178984759 0.410 ENST00000349697.2
ENST00000497599.1
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr8_+_27632047 0.390 ENST00000397418.2
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr14_+_85996507 0.389 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr17_-_7835228 0.388 ENST00000303731.4
ENST00000571947.1
ENST00000540486.1
ENST00000572656.1
TRAPPC1



trafficking protein particle complex 1



chr1_+_40505891 0.382 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP1


CAP, adenylate cyclase-associated protein 1 (yeast)


chr1_-_20834586 0.381 ENST00000264198.3
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr1_+_15802594 0.381 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr18_-_31802282 0.380 ENST00000535475.1
NOL4
nucleolar protein 4
chr5_-_146833222 0.377 ENST00000534907.1
DPYSL3
dihydropyrimidinase-like 3
chr10_-_103578182 0.370 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr8_-_95449155 0.370 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr7_+_23145884 0.368 ENST00000409689.1
ENST00000410047.1
KLHL7

kelch-like family member 7

chr3_-_52273098 0.364 ENST00000597542.1
ENST00000499914.2
ENST00000305533.5
TLR9
TWF2

toll-like receptor 9
twinfilin actin-binding protein 2

chr11_-_58980342 0.362 ENST00000361050.3
MPEG1
macrophage expressed 1
chr2_-_188419200 0.362 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
TFPI



tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)



chr6_-_34524049 0.362 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr8_-_101962777 0.361 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr19_+_48867652 0.361 ENST00000344846.2
SYNGR4
synaptogyrin 4
chr11_-_116658758 0.360 ENST00000227322.3
ZNF259
zinc finger protein 259
chr14_-_45431091 0.360 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
KLHL28


kelch-like family member 28


chr6_-_47009996 0.360 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr6_-_34524093 0.357 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr2_-_71062938 0.355 ENST00000410009.3
CD207
CD207 molecule, langerin
chr10_+_11207438 0.354 ENST00000609692.1
ENST00000354897.3
CELF2

CUGBP, Elav-like family member 2

chr16_+_12059050 0.353 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_+_24072833 0.351 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr1_-_156675368 0.351 ENST00000368222.3
CRABP2
cellular retinoic acid binding protein 2
chr6_+_31553901 0.349 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1



leukocyte specific transcript 1



chr11_-_46722117 0.348 ENST00000311956.4
ARHGAP1
Rho GTPase activating protein 1
chr13_-_36050819 0.344 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr1_-_38325256 0.344 ENST00000373036.4
MTF1
metal-regulatory transcription factor 1
chr3_-_176914238 0.341 ENST00000430069.1
ENST00000428970.1
TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr16_-_19725899 0.338 ENST00000567367.1
KNOP1
lysine-rich nucleolar protein 1
chr10_+_72238517 0.338 ENST00000263563.6
PALD1
phosphatase domain containing, paladin 1
chrX_+_56259316 0.335 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr1_-_43833628 0.333 ENST00000413844.2
ENST00000372458.3
ELOVL1

ELOVL fatty acid elongase 1

chr6_+_142468383 0.332 ENST00000367621.1
ENST00000452973.2
VTA1

vesicle (multivesicular body) trafficking 1

chr1_-_157522180 0.330 ENST00000356953.4
ENST00000368188.2
ENST00000368190.3
ENST00000368189.3
FCRL5



Fc receptor-like 5



chr1_-_43638168 0.329 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr5_+_57787254 0.329 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT


GRB2-binding adaptor protein, transmembrane


chr20_-_33732952 0.328 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr7_-_36764142 0.325 ENST00000258749.5
ENST00000535891.1
AOAH

acyloxyacyl hydrolase (neutrophil)

chr9_-_21995300 0.321 ENST00000498628.2
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr11_-_116658695 0.320 ENST00000429220.1
ENST00000444935.1
ZNF259

zinc finger protein 259


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.7 3.7 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.7 2.2 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.7 14.6 GO:0016540 protein autoprocessing(GO:0016540)
0.6 1.9 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.5 1.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 2.0 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.5 1.5 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.4 1.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.4 3.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.3 1.6 GO:0044565 dendritic cell proliferation(GO:0044565)
0.3 1.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 0.9 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.3 2.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 1.4 GO:0042631 cellular response to water deprivation(GO:0042631)
0.3 2.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 1.5 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.2 1.5 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 5.5 GO:0032060 bleb assembly(GO:0032060)
0.2 0.6 GO:0072579 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.2 1.2 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.2 0.8 GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.2 0.8 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.2 0.7 GO:0042223 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401)
0.2 0.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 0.7 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.2 1.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.6 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 0.6 GO:0060322 head development(GO:0060322)
0.1 0.6 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.8 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1 0.8 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.4 GO:0002605 negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.1 0.7 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 1.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.5 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.3 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.7 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 1.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 0.4 GO:1901895 regulation of interleukin-18 production(GO:0032661) positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.1 2.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.3 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 1.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.4 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 1.2 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 0.2 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.7 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 0.9 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.2 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.3 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.1 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.4 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.8 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.3 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.1 0.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.1 0.7 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.8 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 1.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.3 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 0.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.6 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.3 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:0032672 interleukin-3 production(GO:0032632) regulation of interleukin-3 production(GO:0032672)
0.0 0.5 GO:0015886 heme transport(GO:0015886)
0.0 0.2 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.3 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.3 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 1.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0071673 positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.0 0.1 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.3 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.4 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.3 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.3 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.3 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 1.0 GO:0097503 sialylation(GO:0097503)
0.0 1.6 GO:1901998 toxin transport(GO:1901998)
0.0 0.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:2000812 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.0 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 0.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 1.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:0061198 fungiform papilla formation(GO:0061198)
0.0 1.1 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 0.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.7 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:0007398 ectoderm development(GO:0007398)
0.0 0.9 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.2 GO:0060022 hard palate development(GO:0060022)
0.0 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 1.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.1 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 0.0 GO:0032482 Rab protein signal transduction(GO:0032482) regulation of Rab protein signal transduction(GO:0032483)
0.0 0.5 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 0.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.5 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.4 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 1.4 GO:0007127 meiosis I(GO:0007127)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 1.8 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)
0.0 0.4 GO:0008038 neuron recognition(GO:0008038)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0005588 collagen type V trimer(GO:0005588)
0.3 1.6 GO:0032449 CBM complex(GO:0032449)
0.3 1.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.2 0.9 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 1.6 GO:0032010 phagolysosome(GO:0032010)
0.2 1.0 GO:0005602 complement component C1 complex(GO:0005602)
0.2 0.8 GO:0045160 myosin I complex(GO:0045160)
0.1 0.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.9 GO:0019815 B cell receptor complex(GO:0019815)
0.1 1.2 GO:0008278 cohesin complex(GO:0008278)
0.1 0.6 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 0.4 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 0.7 GO:0070847 core mediator complex(GO:0070847)
0.1 1.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.6 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 1.3 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 3.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.0 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 2.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.7 GO:0043197 dendritic spine(GO:0043197)
0.0 0.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.4 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.2 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 11.1 GO:0030141 secretory granule(GO:0030141)
0.0 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.5 1.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.3 3.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 1.9 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.3 1.6 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.3 1.0 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.2 0.7 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 0.6 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 1.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 0.8 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.2 0.5 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.2 1.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 1.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 1.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.5 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.3 GO:0031014 troponin T binding(GO:0031014)
0.1 1.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.2 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.1 0.9 GO:0036310 annealing helicase activity(GO:0036310)
0.1 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.2 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.3 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.7 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 3.4 GO:0015026 coreceptor activity(GO:0015026)
0.1 1.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.1 0.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 16.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0015232 heme transporter activity(GO:0015232)
0.0 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.3 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.7 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.4 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.7 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.4 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 1.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 3.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0032357 oxidized purine DNA binding(GO:0032357)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 3.0 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 15.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 5.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.0 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 3.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 2.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 2.1 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.4 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 1.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.6 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.3 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.7 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.1 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.1 0.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 1.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 1.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 2.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis