Motif ID: SPI1

Z-value: 0.686


Transcription factors associated with SPI1:

Gene SymbolEntrez IDGene Name
SPI1 ENSG00000066336.7 SPI1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPI1hg19_v2_chr11_-_47400062_47400077-0.145.3e-01Click!


Activity profile for motif SPI1.

activity profile for motif SPI1


Sorted Z-values histogram for motif SPI1

Sorted Z-values for motif SPI1



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_114429997 1.417 ENST00000471267.1
ENST00000393320.3
BCL2L15

BCL2-like 15

chr2_+_233925064 1.373 ENST00000359570.5
ENST00000538935.1
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr10_+_94833642 1.308 ENST00000224356.4
ENST00000394139.1
CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

chr15_-_80263506 1.049 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr6_-_34524049 1.000 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr2_-_161056762 0.834 ENST00000428609.2
ENST00000409967.2
ITGB6

integrin, beta 6

chr6_-_34524093 0.795 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr11_-_102826434 0.768 ENST00000340273.4
ENST00000260302.3
MMP13

matrix metallopeptidase 13 (collagenase 3)

chr2_-_161056802 0.725 ENST00000283249.2
ENST00000409872.1
ITGB6

integrin, beta 6

chr8_+_124194875 0.633 ENST00000522648.1
ENST00000276699.6
FAM83A

family with sequence similarity 83, member A

chr1_-_205419053 0.611 ENST00000367154.1
LEMD1
LEM domain containing 1
chr12_-_51785182 0.610 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
GALNT6



UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)



chr8_-_42065075 0.604 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
PLAT



plasminogen activator, tissue



chr8_-_42065187 0.602 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
PLAT


plasminogen activator, tissue


chr2_+_228678550 0.585 ENST00000409189.3
ENST00000358813.4
CCL20

chemokine (C-C motif) ligand 20

chr2_+_37571717 0.583 ENST00000338415.3
ENST00000404976.1
QPCT

glutaminyl-peptide cyclotransferase

chr2_+_37571845 0.570 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr8_+_124194752 0.559 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr17_+_38171681 0.551 ENST00000225474.2
ENST00000331769.2
ENST00000394148.3
ENST00000577675.1
CSF3



colony stimulating factor 3 (granulocyte)



chr11_+_65408273 0.550 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr17_+_38171614 0.550 ENST00000583218.1
ENST00000394149.3
CSF3

colony stimulating factor 3 (granulocyte)

chr1_-_114430169 0.548 ENST00000393316.3
BCL2L15
BCL2-like 15
chr11_+_65407331 0.529 ENST00000527525.1
SIPA1
signal-induced proliferation-associated 1
chr11_-_58343319 0.492 ENST00000395074.2
LPXN
leupaxin
chr3_-_16555150 0.480 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr7_-_27135591 0.473 ENST00000343060.4
ENST00000355633.5
HOXA1

homeobox A1

chr6_+_33589161 0.457 ENST00000605930.1
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr22_-_37640456 0.456 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr1_+_16083154 0.445 ENST00000375771.1
FBLIM1
filamin binding LIM protein 1
chr7_-_107642348 0.403 ENST00000393561.1
LAMB1
laminin, beta 1
chr12_+_101869096 0.400 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr1_+_43766642 0.397 ENST00000372476.3
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr22_-_37640277 0.394 ENST00000401529.3
ENST00000249071.6
RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr4_+_8201091 0.389 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr9_+_103204553 0.387 ENST00000334943.6
ENST00000502978.1
TMEFF1
MSANTD3-TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
MSANTD3-TMEFF1 readthrough
chr19_+_41257084 0.381 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr14_-_94421923 0.378 ENST00000555507.1
ASB2
ankyrin repeat and SOCS box containing 2
chr17_+_15848231 0.378 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr5_-_39270725 0.373 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB


FYN binding protein


chr16_-_67597789 0.368 ENST00000605277.1
CTD-2012K14.6
CTD-2012K14.6
chr7_+_129847688 0.367 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr19_+_45281118 0.366 ENST00000270279.3
ENST00000341505.4
CBLC

Cbl proto-oncogene C, E3 ubiquitin protein ligase

chr16_-_30393752 0.365 ENST00000566517.1
ENST00000605106.1
SEPT1
SEPT1
septin 1
Uncharacterized protein
chr1_+_209859510 0.348 ENST00000367028.2
ENST00000261465.1
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr1_-_167487758 0.341 ENST00000362089.5
CD247
CD247 molecule
chr2_-_235405168 0.335 ENST00000339728.3
ARL4C
ADP-ribosylation factor-like 4C
chr19_-_14224969 0.334 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr17_+_7461613 0.328 ENST00000438470.1
ENST00000436057.1
TNFSF13

tumor necrosis factor (ligand) superfamily, member 13

chr1_-_167487808 0.327 ENST00000392122.3
CD247
CD247 molecule
chr5_-_39203093 0.326 ENST00000515010.1
FYB
FYN binding protein
chr16_-_30394143 0.325 ENST00000321367.3
ENST00000571393.1
SEPT1

septin 1

chr6_-_43595039 0.322 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr7_+_123241908 0.316 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15


ankyrin repeat and SOCS box containing 15


chr14_-_53417732 0.315 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
FERMT2



fermitin family member 2



chrX_-_153979315 0.314 ENST00000369575.3
ENST00000369568.4
ENST00000424127.2
GAB3


GRB2-associated binding protein 3


chr3_-_50360192 0.312 ENST00000442581.1
ENST00000447092.1
ENST00000357750.4
HYAL2


hyaluronoglucosaminidase 2


chr1_-_110933663 0.307 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4


solute carrier family 16, member 4


chr21_-_40685536 0.307 ENST00000341322.4
BRWD1
bromodomain and WD repeat domain containing 1
chr3_-_112693865 0.306 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200R1


CD200 receptor 1


chr1_-_110933611 0.304 ENST00000472422.2
ENST00000437429.2
SLC16A4

solute carrier family 16, member 4

chr2_-_192711968 0.302 ENST00000304141.4
SDPR
serum deprivation response
chr22_-_17489112 0.297 ENST00000400588.1
GAB4
GRB2-associated binding protein family, member 4
chr14_-_67859422 0.292 ENST00000556532.1
PLEK2
pleckstrin 2
chr4_-_111119804 0.292 ENST00000394607.3
ENST00000302274.3
ELOVL6

ELOVL fatty acid elongase 6

chr6_-_42419649 0.284 ENST00000372922.4
ENST00000541110.1
ENST00000372917.4
TRERF1


transcriptional regulating factor 1


chr16_+_55512742 0.281 ENST00000568715.1
ENST00000219070.4
MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

chr17_+_38599693 0.280 ENST00000542955.1
ENST00000269593.4
IGFBP4

insulin-like growth factor binding protein 4

chr9_-_136242909 0.278 ENST00000371991.3
ENST00000545297.1
SURF4

surfeit 4

chr15_-_56209306 0.275 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4


neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase


chr12_+_53443963 0.273 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr12_+_53443680 0.273 ENST00000314250.6
ENST00000451358.1
TENC1

tensin like C1 domain containing phosphatase (tensin 2)

chr11_+_844406 0.271 ENST00000397404.1
TSPAN4
tetraspanin 4
chr9_+_116327326 0.270 ENST00000342620.5
RGS3
regulator of G-protein signaling 3
chr1_-_109618566 0.269 ENST00000338366.5
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr17_+_7482785 0.268 ENST00000250092.6
ENST00000380498.6
ENST00000584502.1
CD68


CD68 molecule


chr10_+_75532028 0.263 ENST00000372841.3
ENST00000394790.1
FUT11

fucosyltransferase 11 (alpha (1,3) fucosyltransferase)

chr12_+_6493319 0.260 ENST00000536876.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr11_-_75141206 0.260 ENST00000376292.4
KLHL35
kelch-like family member 35
chr1_+_84609944 0.258 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_-_38545799 0.255 ENST00000577541.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr14_+_65171315 0.250 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr3_-_112693759 0.241 ENST00000440122.2
ENST00000490004.1
CD200R1

CD200 receptor 1

chr19_-_45661995 0.239 ENST00000438936.2
NKPD1
NTPase, KAP family P-loop domain containing 1
chr11_+_66624527 0.238 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr5_-_77844974 0.231 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr1_-_155948218 0.231 ENST00000313667.4
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr3_+_25469802 0.229 ENST00000330688.4
RARB
retinoic acid receptor, beta
chr17_-_39211463 0.228 ENST00000542910.1
ENST00000398477.1
KRTAP2-2

keratin associated protein 2-2

chr20_+_35201993 0.225 ENST00000373872.4
TGIF2
TGFB-induced factor homeobox 2
chr2_-_31360887 0.224 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
GALNT14


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)


chr3_+_25469724 0.222 ENST00000437042.2
RARB
retinoic acid receptor, beta
chr7_+_86274145 0.220 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3


glutamate receptor, metabotropic 3


chr19_+_17862274 0.218 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCHO1








FCH domain only 1








chr3_+_47324424 0.215 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
KLHL18


kelch-like family member 18


chr15_-_33360342 0.214 ENST00000558197.1
FMN1
formin 1
chr19_+_41256764 0.213 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA



small nuclear ribonucleoprotein polypeptide A



chr16_-_2908155 0.213 ENST00000571228.1
ENST00000161006.3
PRSS22

protease, serine, 22

chr4_+_37892682 0.212 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1


TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1


chr1_-_118472171 0.211 ENST00000369442.3
GDAP2
ganglioside induced differentiation associated protein 2
chr12_+_96588279 0.209 ENST00000552142.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr8_+_27491572 0.209 ENST00000301904.3
SCARA3
scavenger receptor class A, member 3
chr9_+_116263778 0.208 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr9_+_116263639 0.206 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr13_-_33760216 0.206 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr18_-_59274139 0.205 ENST00000586949.1
RP11-879F14.2
RP11-879F14.2
chrX_+_79591003 0.205 ENST00000538312.1
FAM46D
family with sequence similarity 46, member D
chr3_-_71179988 0.204 ENST00000491238.1
FOXP1
forkhead box P1
chr6_-_11382478 0.204 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9



neural precursor cell expressed, developmentally down-regulated 9



chr18_+_21452964 0.203 ENST00000587184.1
LAMA3
laminin, alpha 3
chr9_+_139557360 0.201 ENST00000308874.7
ENST00000406555.3
ENST00000492862.2
EGFL7


EGF-like-domain, multiple 7


chr8_+_74903580 0.200 ENST00000284818.2
ENST00000518893.1
LY96

lymphocyte antigen 96

chr15_+_90744533 0.198 ENST00000411539.2
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr2_-_64371546 0.198 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1
chr5_-_141060389 0.196 ENST00000504448.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr6_+_20403997 0.195 ENST00000535432.1
E2F3
E2F transcription factor 3
chr12_-_123187890 0.195 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr20_-_23030296 0.194 ENST00000377103.2
THBD
thrombomodulin
chr6_-_32145861 0.189 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr12_-_123201337 0.187 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr7_-_150864635 0.187 ENST00000297537.4
GBX1
gastrulation brain homeobox 1
chr1_-_207095324 0.186 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_+_205682497 0.185 ENST00000598338.1
AC119673.1
AC119673.1
chr18_+_21452804 0.184 ENST00000269217.6
LAMA3
laminin, alpha 3
chr11_+_118403747 0.181 ENST00000526853.1
TMEM25
transmembrane protein 25
chr3_-_27498235 0.180 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7


solute carrier family 4, sodium bicarbonate cotransporter, member 7


chr8_+_15397732 0.180 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
TUSC3



tumor suppressor candidate 3



chr3_-_195808980 0.180 ENST00000360110.4
TFRC
transferrin receptor
chr15_+_55611128 0.179 ENST00000164305.5
ENST00000539642.1
PIGB

phosphatidylinositol glycan anchor biosynthesis, class B

chr2_+_69001913 0.179 ENST00000409030.3
ENST00000409220.1
ARHGAP25

Rho GTPase activating protein 25

chr3_-_71179699 0.178 ENST00000497355.1
FOXP1
forkhead box P1
chr3_-_195808952 0.177 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC



transferrin receptor



chr14_+_102276192 0.175 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr5_-_175388327 0.173 ENST00000432305.2
ENST00000505969.1
THOC3

THO complex 3

chr8_+_86089460 0.173 ENST00000418930.2
E2F5
E2F transcription factor 5, p130-binding
chr2_+_31456874 0.173 ENST00000541626.1
EHD3
EH-domain containing 3
chr14_+_65171099 0.171 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr3_-_46249878 0.171 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr20_+_1875110 0.170 ENST00000400068.3
SIRPA
signal-regulatory protein alpha
chr15_-_59981479 0.170 ENST00000607373.1
BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr11_-_124670273 0.170 ENST00000524950.1
ENST00000374979.3
MSANTD2

Myb/SANT-like DNA-binding domain containing 2

chr1_-_155947951 0.169 ENST00000313695.7
ENST00000497907.1
ARHGEF2

Rho/Rac guanine nucleotide exchange factor (GEF) 2

chr11_-_72433346 0.169 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr3_-_172428959 0.168 ENST00000475381.1
ENST00000538775.1
ENST00000273512.3
ENST00000543711.1
NCEH1



neutral cholesterol ester hydrolase 1



chr11_-_67120974 0.168 ENST00000539074.1
ENST00000312419.3
POLD4

polymerase (DNA-directed), delta 4, accessory subunit

chr8_-_133772794 0.168 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71




transmembrane protein 71




chr6_+_45390222 0.168 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr7_+_99971068 0.167 ENST00000198536.2
ENST00000453419.1
PILRA

paired immunoglobin-like type 2 receptor alpha

chr7_+_74188309 0.167 ENST00000289473.4
ENST00000433458.1
NCF1

neutrophil cytosolic factor 1

chrX_-_132549506 0.167 ENST00000370828.3
GPC4
glypican 4
chr7_+_112063192 0.165 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr12_-_54758251 0.164 ENST00000267015.3
ENST00000551809.1
GPR84

G protein-coupled receptor 84

chr22_-_37545972 0.163 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr19_+_42381173 0.162 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr11_+_47270475 0.162 ENST00000481889.2
ENST00000436778.1
ENST00000531660.1
ENST00000407404.1
NR1H3



nuclear receptor subfamily 1, group H, member 3



chr1_-_212588157 0.162 ENST00000261455.4
ENST00000535273.1
TMEM206

transmembrane protein 206

chr11_-_31832862 0.161 ENST00000379115.4
PAX6
paired box 6
chr2_-_96811170 0.161 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr7_-_75443118 0.159 ENST00000222902.2
CCL24
chemokine (C-C motif) ligand 24
chr10_-_121302195 0.159 ENST00000369103.2
RGS10
regulator of G-protein signaling 10
chr2_+_68961934 0.159 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr12_-_118797475 0.158 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3


TAO kinase 3


chr7_-_115670792 0.158 ENST00000265440.7
ENST00000393485.1
TFEC

transcription factor EC

chr2_+_68961905 0.157 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr7_-_115670804 0.157 ENST00000320239.7
TFEC
transcription factor EC
chr20_-_48747662 0.157 ENST00000371656.2
TMEM189
transmembrane protein 189
chr16_-_2205352 0.156 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr11_-_72432950 0.156 ENST00000426523.1
ENST00000429686.1
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr11_-_31832785 0.156 ENST00000241001.8
PAX6
paired box 6
chr11_-_124670550 0.156 ENST00000239614.4
MSANTD2
Myb/SANT-like DNA-binding domain containing 2
chr15_-_91565743 0.156 ENST00000535843.1
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr8_+_86089619 0.156 ENST00000256117.5
ENST00000416274.2
E2F5

E2F transcription factor 5, p130-binding

chr17_+_7461580 0.156 ENST00000483039.1
ENST00000396542.1
TNFSF13

tumor necrosis factor (ligand) superfamily, member 13

chr20_+_43374421 0.155 ENST00000372861.3
KCNK15
potassium channel, subfamily K, member 15
chr11_-_104034827 0.155 ENST00000393158.2
PDGFD
platelet derived growth factor D
chr1_+_154300217 0.154 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr11_+_47270436 0.153 ENST00000395397.3
ENST00000405576.1
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr19_-_59010565 0.153 ENST00000594786.1
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr2_+_187454749 0.152 ENST00000261023.3
ENST00000374907.3
ITGAV

integrin, alpha V

chr1_-_25256368 0.152 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr17_-_29641104 0.152 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr17_+_7461781 0.151 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_-_71640227 0.151 ENST00000388726.3
ENST00000392650.3
SDK2

sidekick cell adhesion molecule 2

chr16_+_30205225 0.150 ENST00000345535.4
ENST00000251303.6
SLX1A

SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

chr19_+_17530838 0.149 ENST00000528659.1
ENST00000392702.2
ENST00000529939.1
MVB12A


multivesicular body subunit 12A


chr6_-_33548006 0.149 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr6_-_33547975 0.148 ENST00000442998.2
ENST00000360661.5
BAK1

BCL2-antagonist/killer 1

chr2_-_119605253 0.148 ENST00000295206.6
EN1
engrailed homeobox 1
chr4_+_2813946 0.148 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr11_+_102188224 0.147 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr11_-_31832581 0.147 ENST00000379111.2
PAX6
paired box 6
chr21_+_34775181 0.146 ENST00000290219.6
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr2_+_161993412 0.145 ENST00000259075.2
ENST00000432002.1
TANK

TRAF family member-associated NFKB activator

chr20_+_35201857 0.145 ENST00000373874.2
TGIF2
TGFB-induced factor homeobox 2
chr16_+_29465822 0.145 ENST00000330181.5
ENST00000351581.4
SLX1B

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr12_+_12938541 0.145 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr12_+_26274917 0.144 ENST00000538142.1
SSPN
sarcospan
chr9_-_137809718 0.143 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr12_+_48577366 0.143 ENST00000316554.3
C12orf68
chromosome 12 open reading frame 68
chr16_-_29875057 0.143 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr6_-_32143828 0.143 ENST00000412465.2
ENST00000375107.3
AGPAT1

1-acylglycerol-3-phosphate O-acyltransferase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.4 1.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.3 1.3 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.3 1.8 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.2 1.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.2 0.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.2 0.6 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 1.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 1.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.5 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.5 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.3 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.1 0.5 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.1 0.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.3 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1 0.5 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.1 0.3 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 0.3 GO:0019087 transformation of host cell by virus(GO:0019087)
0.1 0.2 GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186)
0.1 0.8 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 0.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.9 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.1 0.4 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.2 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.2 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.3 GO:0070889 platelet alpha granule organization(GO:0070889)
0.1 0.2 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.1 1.3 GO:0003417 growth plate cartilage development(GO:0003417)
0.1 0.4 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.2 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.0 0.0 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.2 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 1.2 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.2 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0 0.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.1 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.0 1.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.3 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.3 GO:0051917 regulation of fibrinolysis(GO:0051917)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0046203 spermidine catabolic process(GO:0046203)
0.0 0.1 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.0 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.1 GO:0019075 virus maturation(GO:0019075)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:0030578 PML body organization(GO:0030578)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.2 GO:2000416 regulation of eosinophil migration(GO:2000416)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.1 GO:0097045 phosphatidylserine exposure on blood platelet(GO:0097045)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.1 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.1 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.5 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.1 GO:0033590 response to cobalamin(GO:0033590)
0.0 0.1 GO:0008355 olfactory learning(GO:0008355)
0.0 0.1 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642) plasma membrane long-chain fatty acid transport(GO:0015911)
0.0 0.1 GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.2 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.1 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.0 0.1 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.0 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 0.1 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.0 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.0 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0007566 embryo implantation(GO:0007566)
0.0 0.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.1 GO:1901804 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0072711 cellular response to hydroxyurea(GO:0072711)
0.0 0.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0046073 dUMP biosynthetic process(GO:0006226) dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.0 0.2 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.7 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.0 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.0 0.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.0 GO:0030728 ovulation(GO:0030728)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.2 GO:0009650 UV protection(GO:0009650)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:1903961 positive regulation of anion channel activity(GO:1901529) positive regulation of anion transmembrane transport(GO:1903961)
0.0 0.1 GO:0030047 actin modification(GO:0030047)
0.0 0.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.1 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.0 0.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.2 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.0 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 0.2 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.2 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0030953 astral microtubule organization(GO:0030953)
0.0 0.1 GO:0070970 interleukin-2 secretion(GO:0070970)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.1 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.0 GO:0097695 establishment of RNA localization to telomere(GO:0097694) establishment of macromolecular complex localization to telomere(GO:0097695)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.4 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.3 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.2 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.4 GO:0030897 HOPS complex(GO:0030897)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.0 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 1.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3 1.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 1.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 0.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.1 1.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.3 GO:0032810 sterol response element binding(GO:0032810)
0.1 0.1 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.2 GO:0030305 heparanase activity(GO:0030305)
0.1 1.3 GO:0051400 BH domain binding(GO:0051400)
0.1 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1 0.2 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.2 GO:0034038 deoxyhypusine synthase activity(GO:0034038)
0.1 0.2 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.0 0.1 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030) nerve growth factor receptor activity(GO:0010465) nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.0 0.2 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.3 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.3 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.1 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:0004132 dCMP deaminase activity(GO:0004132)
0.0 0.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.2 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0097643 amylin receptor activity(GO:0097643)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 1.4 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.0 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 1.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.3 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.3 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.4 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.6 PID_CDC42_PATHWAY CDC42 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 0.5 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 1.7 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 0.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.1 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling