Motif ID: SOX4

Z-value: 0.654


Transcription factors associated with SOX4:

Gene SymbolEntrez IDGene Name
SOX4 ENSG00000124766.4 SOX4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX4hg19_v2_chr6_+_21593972_21594071-0.174.2e-01Click!


Activity profile for motif SOX4.

activity profile for motif SOX4


Sorted Z-values histogram for motif SOX4

Sorted Z-values for motif SOX4



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_74495188 1.754 ENST00000563965.1
ENST00000395105.4
STRA6

stimulated by retinoic acid 6

chr10_-_105845674 1.748 ENST00000353479.5
ENST00000369733.3
COL17A1

collagen, type XVII, alpha 1

chr14_+_75746781 1.644 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_208031542 1.413 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_+_134551583 1.342 ENST00000435928.1
CALD1
caldesmon 1
chrX_-_153599578 1.275 ENST00000360319.4
ENST00000344736.4
FLNA

filamin A, alpha

chr4_-_69111401 1.239 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr2_+_33172221 1.212 ENST00000354476.3
LTBP1
latent transforming growth factor beta binding protein 1
chr22_+_31477296 1.192 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
SMTN




smoothelin




chr15_+_63335899 1.128 ENST00000561266.1
TPM1
tropomyosin 1 (alpha)
chr4_+_54966198 1.038 ENST00000326902.2
ENST00000503800.1
GSX2

GS homeobox 2

chr2_-_1748214 1.008 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
PXDN


peroxidasin homolog (Drosophila)


chrX_+_69509927 0.992 ENST00000374403.3
KIF4A
kinesin family member 4A
chr2_-_85641162 0.969 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG


capping protein (actin filament), gelsolin-like


chr2_-_9143786 0.940 ENST00000462696.1
ENST00000305997.3
MBOAT2

membrane bound O-acyltransferase domain containing 2

chr7_+_134464376 0.921 ENST00000454108.1
ENST00000361675.2
CALD1

caldesmon 1

chr7_-_107643674 0.918 ENST00000222399.6
LAMB1
laminin, beta 1
chr7_+_134464414 0.907 ENST00000361901.2
CALD1
caldesmon 1
chr11_-_10829851 0.827 ENST00000532082.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr11_+_125496619 0.764 ENST00000532669.1
ENST00000278916.3
CHEK1

checkpoint kinase 1

chr2_+_33172012 0.736 ENST00000404816.2
LTBP1
latent transforming growth factor beta binding protein 1
chr20_-_56284816 0.728 ENST00000395819.3
ENST00000341744.3
PMEPA1

prostate transmembrane protein, androgen induced 1

chr4_-_140544386 0.722 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr3_-_197024965 0.722 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chr12_-_95611149 0.707 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
FGD6


FYVE, RhoGEF and PH domain containing 6


chr15_-_70390191 0.688 ENST00000559191.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr3_+_50649302 0.687 ENST00000446044.1
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr11_-_10830463 0.674 ENST00000527419.1
ENST00000530211.1
ENST00000530702.1
ENST00000524932.1
ENST00000532570.1
EIF4G2




eukaryotic translation initiation factor 4 gamma, 2




chr13_-_24007815 0.665 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr8_-_42623747 0.653 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr12_-_109915098 0.645 ENST00000542858.1
ENST00000542262.1
ENST00000424763.2
KCTD10


potassium channel tetramerization domain containing 10


chrX_-_15683147 0.626 ENST00000380342.3
TMEM27
transmembrane protein 27
chr14_-_71276211 0.620 ENST00000381250.4
ENST00000555993.2
MAP3K9

mitogen-activated protein kinase kinase kinase 9

chr8_-_6783588 0.619 ENST00000297436.2
DEFA6
defensin, alpha 6, Paneth cell-specific
chr8_-_42623924 0.615 ENST00000276410.2
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr22_-_50524298 0.603 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_76788317 0.602 ENST00000296679.4
WDR41
WD repeat domain 41
chr18_+_56530794 0.602 ENST00000590285.1
ENST00000586085.1
ENST00000589288.1
ZNF532


zinc finger protein 532


chr1_+_244998918 0.602 ENST00000366528.3
COX20
COX20 cytochrome C oxidase assembly factor
chr1_+_42928945 0.594 ENST00000428554.2
CCDC30
coiled-coil domain containing 30
chr10_+_17272608 0.590 ENST00000421459.2
VIM
vimentin
chr3_-_197024394 0.584 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1




discs, large homolog 1 (Drosophila)




chr2_+_223536428 0.567 ENST00000446656.3
MOGAT1
monoacylglycerol O-acyltransferase 1
chr12_+_95611516 0.557 ENST00000436874.1
VEZT
vezatin, adherens junctions transmembrane protein
chr3_+_141105235 0.557 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_+_209602771 0.543 ENST00000440276.1
MIR205HG
MIR205 host gene (non-protein coding)
chr16_+_14980632 0.538 ENST00000565655.1
NOMO1
NODAL modulator 1
chr3_-_197025447 0.534 ENST00000346964.2
ENST00000357674.4
ENST00000314062.3
ENST00000448528.2
ENST00000419553.1
DLG1




discs, large homolog 1 (Drosophila)




chr1_+_68150744 0.529 ENST00000370986.4
ENST00000370985.3
GADD45A

growth arrest and DNA-damage-inducible, alpha

chr20_-_17511962 0.514 ENST00000377873.3
BFSP1
beaded filament structural protein 1, filensin
chr20_-_13971255 0.502 ENST00000284951.5
ENST00000378072.5
SEL1L2

sel-1 suppressor of lin-12-like 2 (C. elegans)

chr5_-_76788024 0.500 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WDR41




WD repeat domain 41




chr1_+_109419596 0.498 ENST00000435987.1
ENST00000264126.3
GPSM2

G-protein signaling modulator 2

chr1_-_93645818 0.493 ENST00000370280.1
ENST00000479918.1
TMED5

transmembrane emp24 protein transport domain containing 5

chr4_+_118955500 0.482 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr22_-_36357671 0.471 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr7_+_139528952 0.471 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr7_+_23146271 0.465 ENST00000545771.1
KLHL7
kelch-like family member 7
chr3_-_50649192 0.457 ENST00000443053.2
ENST00000348721.3
CISH

cytokine inducible SH2-containing protein

chr11_-_67981295 0.456 ENST00000405515.1
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr12_+_95611569 0.453 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
VEZT


vezatin, adherens junctions transmembrane protein


chr5_-_39425290 0.449 ENST00000545653.1
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr6_+_41040678 0.446 ENST00000341376.6
ENST00000353205.5
NFYA

nuclear transcription factor Y, alpha

chr2_+_105050794 0.443 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2


long intergenic non-protein coding RNA 1102


chr10_-_99052382 0.432 ENST00000466484.1
ENST00000358531.4
ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ARHGAP19

ARHGAP19-SLIT1


Rho GTPase activating protein 19

ARHGAP19-SLIT1 readthrough (NMD candidate)


chr7_-_35293740 0.425 ENST00000408931.3
TBX20
T-box 20
chr7_-_99699538 0.409 ENST00000343023.6
ENST00000303887.5
MCM7

minichromosome maintenance complex component 7

chr5_-_39425222 0.407 ENST00000320816.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr4_-_139163491 0.406 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr17_+_25621102 0.401 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1







WD repeat and SOCS box containing 1







chr6_-_127840021 0.395 ENST00000465909.2
SOGA3
SOGA family member 3
chr5_+_140767452 0.387 ENST00000519479.1
PCDHGB4
protocadherin gamma subfamily B, 4
chr1_-_26233423 0.381 ENST00000357865.2
STMN1
stathmin 1
chr1_+_228337553 0.381 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr4_+_2819883 0.373 ENST00000511747.1
ENST00000503393.2
SH3BP2

SH3-domain binding protein 2

chr15_+_78730622 0.367 ENST00000560440.1
IREB2
iron-responsive element binding protein 2
chr10_+_11206925 0.366 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2


CUGBP, Elav-like family member 2


chr15_-_70390213 0.366 ENST00000557997.1
ENST00000317509.8
ENST00000442299.2
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr12_-_48963829 0.364 ENST00000301046.2
ENST00000549817.1
LALBA

lactalbumin, alpha-

chr20_+_30598231 0.360 ENST00000300415.8
ENST00000262659.8
CCM2L

cerebral cavernous malformation 2-like

chr10_+_18948311 0.345 ENST00000377275.3
ARL5B
ADP-ribosylation factor-like 5B
chr3_-_99833333 0.344 ENST00000354552.3
ENST00000331335.5
ENST00000398326.2
FILIP1L


filamin A interacting protein 1-like


chr12_+_70760056 0.339 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_155880672 0.339 ENST00000609492.1
ENST00000368322.3
RIT1

Ras-like without CAAX 1

chr15_+_81293254 0.332 ENST00000267984.2
MESDC1
mesoderm development candidate 1
chr17_-_72358001 0.327 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr7_-_111032971 0.327 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr1_-_152297679 0.324 ENST00000368799.1
FLG
filaggrin
chr5_-_39425068 0.318 ENST00000515700.1
ENST00000339788.6
DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

chr2_-_20425158 0.314 ENST00000381150.1
SDC1
syndecan 1
chr4_+_78079570 0.313 ENST00000509972.1
CCNG2
cyclin G2
chr4_+_78079450 0.301 ENST00000395640.1
ENST00000512918.1
CCNG2

cyclin G2

chr4_-_22444733 0.294 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr1_+_28844778 0.292 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr11_-_94965667 0.289 ENST00000542176.1
ENST00000278499.2
SESN3

sestrin 3

chr22_+_27017921 0.288 ENST00000354760.3
CRYBA4
crystallin, beta A4
chr19_-_59031118 0.285 ENST00000600990.1
ZBTB45
zinc finger and BTB domain containing 45
chrX_+_65384052 0.284 ENST00000336279.5
ENST00000458621.1
HEPH

hephaestin

chr2_+_11679963 0.283 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_243418621 0.282 ENST00000366544.1
ENST00000366543.1
CEP170

centrosomal protein 170kDa

chr1_-_243418344 0.276 ENST00000366542.1
CEP170
centrosomal protein 170kDa
chr17_+_27573875 0.274 ENST00000225387.3
CRYBA1
crystallin, beta A1
chr14_+_32798547 0.274 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6


A kinase (PRKA) anchor protein 6


chr1_-_1243392 0.272 ENST00000354700.5
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr1_+_156052354 0.271 ENST00000368301.2
LMNA
lamin A/C
chr11_-_64013663 0.269 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_-_59030921 0.268 ENST00000354590.3
ENST00000596739.1
ZBTB45

zinc finger and BTB domain containing 45

chr5_-_135701164 0.263 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr14_-_60097297 0.263 ENST00000395090.1
RTN1
reticulon 1
chr14_-_51027838 0.257 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr13_-_110959478 0.255 ENST00000543140.1
ENST00000375820.4
COL4A1

collagen, type IV, alpha 1

chr13_+_34392200 0.252 ENST00000434425.1
RFC3
replication factor C (activator 1) 3, 38kDa
chr4_+_78078304 0.251 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2


cyclin G2


chr17_+_80416050 0.250 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF


nuclear prelamin A recognition factor


chrX_+_65384182 0.245 ENST00000441993.2
ENST00000419594.1
HEPH

hephaestin

chr7_-_148581360 0.245 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr4_-_109089573 0.243 ENST00000265165.1
LEF1
lymphoid enhancer-binding factor 1
chr1_-_1243252 0.243 ENST00000353662.3
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr19_+_9296279 0.242 ENST00000344248.2
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr6_-_89927151 0.242 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr15_-_34502197 0.241 ENST00000557877.1
KATNBL1
katanin p80 subunit B-like 1
chrX_-_128977364 0.241 ENST00000371064.3
ZDHHC9
zinc finger, DHHC-type containing 9
chr8_+_9911778 0.235 ENST00000317173.4
ENST00000441698.2
MSRA

methionine sulfoxide reductase A

chr19_+_56111680 0.229 ENST00000301073.3
ZNF524
zinc finger protein 524
chr3_+_57875711 0.227 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr17_+_9066252 0.226 ENST00000436734.1
NTN1
netrin 1
chr14_+_32798462 0.223 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr16_+_6069072 0.219 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr4_-_109090106 0.216 ENST00000379951.2
LEF1
lymphoid enhancer-binding factor 1
chr16_-_48281305 0.215 ENST00000356608.2
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr10_+_11207438 0.212 ENST00000609692.1
ENST00000354897.3
CELF2

CUGBP, Elav-like family member 2

chr16_+_6069586 0.211 ENST00000547372.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr9_+_77230499 0.207 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr6_-_41040268 0.204 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
OARD1





O-acyl-ADP-ribose deacylase 1





chr7_-_42276612 0.201 ENST00000395925.3
ENST00000437480.1
GLI3

GLI family zinc finger 3

chr8_-_6420759 0.197 ENST00000523120.1
ANGPT2
angiopoietin 2
chr12_+_8666126 0.194 ENST00000299665.2
CLEC4D
C-type lectin domain family 4, member D
chr17_+_27920486 0.194 ENST00000394859.3
ANKRD13B
ankyrin repeat domain 13B
chr7_-_27219849 0.192 ENST00000396344.4
HOXA10
homeobox A10
chr20_-_62610982 0.190 ENST00000369886.3
ENST00000450107.1
SAMD10

sterile alpha motif domain containing 10

chr7_-_148581251 0.186 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2


enhancer of zeste homolog 2 (Drosophila)


chr14_-_73493784 0.186 ENST00000553891.1
ZFYVE1
zinc finger, FYVE domain containing 1
chrX_-_69509738 0.185 ENST00000374454.1
ENST00000239666.4
PDZD11

PDZ domain containing 11

chr10_+_11047259 0.184 ENST00000379261.4
ENST00000416382.2
CELF2

CUGBP, Elav-like family member 2

chr1_+_93645314 0.180 ENST00000343253.7
CCDC18
coiled-coil domain containing 18
chr4_-_164534657 0.178 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr8_-_6420565 0.175 ENST00000338312.6
ANGPT2
angiopoietin 2
chr20_+_58630972 0.174 ENST00000313426.1
C20orf197
chromosome 20 open reading frame 197
chr14_-_73493825 0.173 ENST00000318876.5
ENST00000556143.1
ZFYVE1

zinc finger, FYVE domain containing 1

chr10_-_99393208 0.173 ENST00000307450.6
MORN4
MORN repeat containing 4
chr6_-_123957942 0.171 ENST00000398178.3
TRDN
triadin
chr14_+_24521202 0.170 ENST00000334420.7
ENST00000342740.5
LRRC16B

leucine rich repeat containing 16B

chr4_+_71588372 0.170 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr1_+_47799542 0.168 ENST00000471289.2
ENST00000450808.2
CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

chr14_-_57960545 0.161 ENST00000526336.1
ENST00000216445.3
C14orf105

chromosome 14 open reading frame 105

chr8_-_80993010 0.160 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52




tumor protein D52




chr21_+_30671690 0.160 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chrX_+_12993336 0.160 ENST00000380635.1
TMSB4X
thymosin beta 4, X-linked
chr2_+_172543919 0.159 ENST00000452242.1
ENST00000340296.4
DYNC1I2

dynein, cytoplasmic 1, intermediate chain 2

chr2_-_106015527 0.158 ENST00000344213.4
ENST00000358129.4
FHL2

four and a half LIM domains 2

chr16_-_3068171 0.157 ENST00000572154.1
ENST00000328796.4
CLDN6

claudin 6

chr4_+_54243798 0.157 ENST00000337488.6
ENST00000358575.5
ENST00000507922.1
FIP1L1


factor interacting with PAPOLA and CPSF1


chrX_+_51927919 0.157 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr19_-_55690758 0.153 ENST00000590851.1
SYT5
synaptotagmin V
chr8_-_16043780 0.152 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr10_+_73724123 0.150 ENST00000373115.4
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr6_-_123958141 0.150 ENST00000334268.4
TRDN
triadin
chr1_+_47137445 0.148 ENST00000569393.1
ENST00000334122.4
ENST00000415500.1
TEX38


testis expressed 38


chr15_+_75940218 0.147 ENST00000308527.5
SNX33
sorting nexin 33
chr15_+_78730531 0.147 ENST00000258886.8
IREB2
iron-responsive element binding protein 2
chr2_+_172544294 0.146 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
DYNC1I2



dynein, cytoplasmic 1, intermediate chain 2



chr12_-_99288536 0.146 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr1_+_47137544 0.146 ENST00000564373.1
TEX38
testis expressed 38
chr6_-_41040195 0.144 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
OARD1


O-acyl-ADP-ribose deacylase 1


chr3_+_132757215 0.139 ENST00000321871.6
ENST00000393130.3
ENST00000514894.1
ENST00000512662.1
TMEM108



transmembrane protein 108



chr1_-_115259337 0.134 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr6_+_22146851 0.134 ENST00000606197.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr8_-_8751068 0.133 ENST00000276282.6
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr13_+_39612442 0.129 ENST00000470258.1
ENST00000379600.3
NHLRC3

NHL repeat containing 3

chr5_+_140579162 0.129 ENST00000536699.1
ENST00000354757.3
PCDHB11

protocadherin beta 11

chr10_-_18948156 0.126 ENST00000414939.1
ENST00000449529.1
ENST00000456217.1
ENST00000444660.1
ARL5B-AS1



ARL5B antisense RNA 1



chr7_-_88425025 0.126 ENST00000297203.2
C7orf62
chromosome 7 open reading frame 62
chr4_+_106629929 0.124 ENST00000512828.1
ENST00000394730.3
ENST00000507281.1
ENST00000515279.1
GSTCD



glutathione S-transferase, C-terminal domain containing



chrX_-_110655391 0.118 ENST00000356915.2
ENST00000356220.3
DCX

doublecortin

chr1_-_167883353 0.117 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr8_+_79428539 0.116 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr9_-_117150303 0.115 ENST00000312033.3
AKNA
AT-hook transcription factor
chr3_+_39509070 0.114 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP





myelin-associated oligodendrocyte basic protein





chr14_+_101299520 0.112 ENST00000455531.1
MEG3
maternally expressed 3 (non-protein coding)
chr7_+_115850547 0.110 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES


testis derived transcript (3 LIM domains)


chr3_+_141106643 0.110 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_173572181 0.109 ENST00000536496.1
ENST00000367714.3
SLC9C2

solute carrier family 9, member C2 (putative)

chr3_+_108855558 0.105 ENST00000467240.1
ENST00000477643.1
ENST00000479039.1
ENST00000593799.1
RP11-59E19.1



RP11-59E19.1



chr12_+_32260085 0.102 ENST00000548411.1
ENST00000281474.5
ENST00000551086.1
BICD1


bicaudal D homolog 1 (Drosophila)


chr6_+_13925098 0.097 ENST00000488300.1
ENST00000544682.1
ENST00000420478.2
RNF182


ring finger protein 182


chr1_-_167487758 0.097 ENST00000362089.5
CD247
CD247 molecule
chr14_+_35761580 0.096 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
PSMA6


proteasome (prosome, macropain) subunit, alpha type, 6


chr14_+_69658194 0.095 ENST00000409018.3
ENST00000409014.1
ENST00000409675.1
EXD2


exonuclease 3'-5' domain containing 2


chr6_+_21666633 0.093 ENST00000606851.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr2_+_172543967 0.090 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2




dynein, cytoplasmic 1, intermediate chain 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.3 1.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.3 1.2 GO:0035026 leading edge cell differentiation(GO:0035026)
0.3 3.1 GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905031)
0.2 0.9 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2 1.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 1.9 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.4 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.4 GO:0021524 pulmonary valve formation(GO:0003193) visceral motor neuron differentiation(GO:0021524) foramen ovale closure(GO:0035922)
0.1 1.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.8 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.5 GO:0031291 Ran protein signal transduction(GO:0031291)
0.1 0.4 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 0.4 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.3 GO:0048627 myoblast development(GO:0048627)
0.1 0.6 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.3 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.3 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.1 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.8 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.6 GO:0035542 positive regulation of vesicle fusion(GO:0031340) regulation of SNARE complex assembly(GO:0035542)
0.1 0.2 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 1.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.5 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:1900276 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.0 0.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 1.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.9 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.5 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.3 GO:1904262 TORC2 signaling(GO:0038203) negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.3 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.2 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 1.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.6 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 1.0 GO:0006826 iron ion transport(GO:0006826)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.0 0.3 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0031523 Myb complex(GO:0031523)
0.3 0.9 GO:0005607 laminin-2 complex(GO:0005607)
0.2 1.6 GO:0035976 AP1 complex(GO:0035976)
0.2 3.0 GO:0030478 actin cap(GO:0030478)
0.2 1.8 GO:0043219 lateral loop(GO:0043219)
0.1 1.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.4 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 1.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.7 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.1 1.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.1 0.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0072517 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.0 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 1.1 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0050436 microfibril binding(GO:0050436)
0.3 1.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 1.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.2 1.8 GO:0097016 L27 domain binding(GO:0097016)
0.2 0.5 GO:0030350 iron-responsive element binding(GO:0030350)
0.2 0.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2 0.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.6 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 3.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.4 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.6 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.9 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.4 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.3 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0008198 ferrous iron binding(GO:0008198)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 0.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 1.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.8 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_DEFENSINS Genes involved in Defensins
0.0 0.3 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 1.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.6 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.2 REACTOME_GAP_JUNCTION_TRAFFICKING Genes involved in Gap junction trafficking