Motif ID: SOX21

Z-value: 0.442


Transcription factors associated with SOX21:

Gene SymbolEntrez IDGene Name
SOX21 ENSG00000125285.4 SOX21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.223.0e-01Click!


Activity profile for motif SOX21.

activity profile for motif SOX21


Sorted Z-values histogram for motif SOX21

Sorted Z-values for motif SOX21



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX21

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_69313145 1.751 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_152881014 1.058 ENST00000368764.3
ENST00000392667.2
IVL

involucrin

chr11_+_35201826 0.768 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr12_-_89746173 0.689 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr1_-_54303934 0.656 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr4_-_39034542 0.650 ENST00000344606.6
TMEM156
transmembrane protein 156
chr19_+_16308659 0.640 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr19_+_16308711 0.613 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr15_-_80263506 0.607 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr6_+_31371337 0.575 ENST00000449934.2
ENST00000421350.1
MICA

MHC class I polypeptide-related sequence A

chr12_+_123011776 0.572 ENST00000450485.2
ENST00000333479.7
KNTC1

kinetochore associated 1

chr11_+_5410607 0.541 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr7_-_73133959 0.520 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A



syntaxin 1A (brain)



chr8_-_143961236 0.376 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1


cytochrome P450, family 11, subfamily B, polypeptide 1


chrX_+_2984874 0.373 ENST00000359361.2
ARSF
arylsulfatase F
chr19_+_7030589 0.367 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr19_-_7040190 0.326 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr1_-_151148492 0.311 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr12_+_1099675 0.299 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr4_-_177190364 0.295 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr1_+_67632083 0.281 ENST00000347310.5
ENST00000371002.1
IL23R

interleukin 23 receptor

chr2_+_3705785 0.254 ENST00000252505.3
ALLC
allantoicase
chr14_-_107170409 0.248 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr3_+_57994127 0.239 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
FLNB





filamin B, beta





chrX_-_39186610 0.228 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2

RP11-265P11.2

chr17_-_71410794 0.222 ENST00000424778.1
SDK2
sidekick cell adhesion molecule 2
chr9_-_14910990 0.221 ENST00000380881.4
ENST00000422223.2
FREM1

FRAS1 related extracellular matrix 1

chr6_-_3195981 0.215 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9

RP1-40E16.9

chr9_+_105757590 0.212 ENST00000374798.3
ENST00000487798.1
CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr12_+_20522179 0.205 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr3_-_164875850 0.188 ENST00000472120.1
RP11-747D18.1
RP11-747D18.1
chr9_-_104249400 0.176 ENST00000374848.3
TMEM246
transmembrane protein 246
chrY_+_14813160 0.175 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr16_-_15149828 0.172 ENST00000566419.1
ENST00000568320.1
NTAN1

N-terminal asparagine amidase

chr6_-_112575912 0.171 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4


laminin, alpha 4


chr6_-_112575838 0.168 ENST00000455073.1
LAMA4
laminin, alpha 4
chr4_-_122854612 0.166 ENST00000264811.5
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr4_-_83931862 0.162 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
LIN54



lin-54 homolog (C. elegans)



chr12_-_10324716 0.161 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1



oxidized low density lipoprotein (lectin-like) receptor 1



chr8_+_26150628 0.161 ENST00000523925.1
ENST00000315985.7
PPP2R2A

protein phosphatase 2, regulatory subunit B, alpha

chr18_+_29769978 0.159 ENST00000269202.6
ENST00000581447.1
MEP1B

meprin A, beta

chr10_+_5005445 0.149 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr19_-_2783363 0.139 ENST00000221566.2
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr10_-_13276329 0.138 ENST00000378681.3
ENST00000463405.2
UCMA

upper zone of growth plate and cartilage matrix associated

chr15_+_58702742 0.129 ENST00000356113.6
ENST00000414170.3
LIPC

lipase, hepatic

chr22_+_23063100 0.127 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr17_+_66245341 0.125 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr7_-_37026108 0.121 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr20_+_43343886 0.121 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chrX_+_36053908 0.118 ENST00000378660.2
CHDC2
calponin homology domain containing 2
chr7_+_2394445 0.106 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
EIF3B


eukaryotic translation initiation factor 3, subunit B


chr12_-_1058685 0.106 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52





RAD52 homolog (S. cerevisiae)





chr3_+_37035289 0.102 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1




mutL homolog 1




chr3_+_37035263 0.099 ENST00000458205.2
ENST00000539477.1
MLH1

mutL homolog 1

chr6_-_112575758 0.098 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4



laminin, alpha 4



chr8_-_19459993 0.098 ENST00000454498.2
ENST00000520003.1
CSGALNACT1

chondroitin sulfate N-acetylgalactosaminyltransferase 1

chr9_+_99691286 0.096 ENST00000372322.3
NUTM2G
NUT family member 2G
chrX_+_65384052 0.093 ENST00000336279.5
ENST00000458621.1
HEPH

hephaestin

chr5_-_179045199 0.088 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr4_-_103746683 0.087 ENST00000504211.1
ENST00000508476.1
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr17_+_60457914 0.083 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3


EF-hand calcium binding domain 3


chr19_+_42381173 0.082 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr4_-_103746924 0.079 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3


ubiquitin-conjugating enzyme E2D 3


chr1_+_158901329 0.077 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1




pyrin and HIN domain family, member 1




chr4_-_103747011 0.076 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr22_+_39353527 0.076 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr1_-_26394114 0.075 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr19_-_54784937 0.070 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2


chr7_+_120702819 0.069 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr17_-_18266660 0.069 ENST00000582653.1
ENST00000352886.6
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr22_-_40929812 0.064 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr3_+_38537960 0.062 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr3_+_37034823 0.051 ENST00000231790.2
ENST00000456676.2
MLH1

mutL homolog 1

chr11_+_114168085 0.045 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr1_+_146714291 0.044 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
CHD1L



chromodomain helicase DNA binding protein 1-like



chr6_+_42531798 0.042 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2


ubiquitin protein ligase E3 component n-recognin 2


chr6_+_140175987 0.041 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1

RP5-899B16.1

chr19_+_18682531 0.040 ENST00000596304.1
ENST00000430157.2
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr14_+_50291993 0.039 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr19_-_45737469 0.039 ENST00000413988.1
EXOC3L2
exocyst complex component 3-like 2
chr1_+_199996733 0.037 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr3_+_141103634 0.035 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr16_-_15982440 0.033 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL






FGFR1OP N-terminal like






chr6_-_121655593 0.031 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chrX_+_52927576 0.030 ENST00000416841.2
FAM156B
family with sequence similarity 156, member B
chr7_-_14942944 0.028 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr10_-_71169031 0.025 ENST00000373307.1
TACR2
tachykinin receptor 2
chr3_+_155838337 0.021 ENST00000490337.1
ENST00000389636.5
KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr5_+_175875349 0.017 ENST00000261942.6
FAF2
Fas associated factor family member 2
chr11_-_8285405 0.013 ENST00000335790.3
ENST00000534484.1
LMO1

LIM domain only 1 (rhombotin 1)

chr5_+_140579162 0.012 ENST00000536699.1
ENST00000354757.3
PCDHB11

protocadherin beta 11

chr3_+_38537763 0.005 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
EXOG


endo/exonuclease (5'-3'), endonuclease G-like


chr5_-_95158644 0.003 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr5_-_95158375 0.002 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX



glutaredoxin (thioltransferase)



chr19_+_42381337 0.000 ENST00000597454.1
ENST00000444740.2
CD79A

CD79a molecule, immunoglobulin-associated alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.7 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.5 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 0.6 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255) cellular amide catabolic process(GO:0043605)
0.1 0.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 1.3 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.4 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.2 GO:0071321 cellular response to cGMP(GO:0071321)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.6 GO:1990423 RZZ complex(GO:1990423)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.3 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.2 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.3 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0047718 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.3 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.6 GO:0051400 BH domain binding(GO:0051400)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.0 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels