Motif ID: SOX10_SOX15

Z-value: 0.344

Transcription factors associated with SOX10_SOX15:

Gene SymbolEntrez IDGene Name
SOX10 ENSG00000100146.12 SOX10
SOX15 ENSG00000129194.3 SOX15

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX10hg19_v2_chr22_-_38380543_383805690.174.2e-01Click!
SOX15hg19_v2_chr17_-_7493390_7493488-0.058.3e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of SOX10_SOX15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_86564776 0.406 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1


receptor accessory protein 1


chr2_-_118943930 0.394 ENST00000449075.1
ENST00000414886.1
ENST00000449819.1
AC093901.1


AC093901.1


chr3_-_141747950 0.334 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_-_123339418 0.318 ENST00000583087.1
MYLK
myosin light chain kinase
chr3_-_123339343 0.312 ENST00000578202.1
MYLK
myosin light chain kinase
chr15_+_84115868 0.298 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr3_+_39509163 0.272 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP


myelin-associated oligodendrocyte basic protein


chr3_+_111260856 0.269 ENST00000352690.4
CD96
CD96 molecule
chr4_+_154387480 0.260 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922


KIAA0922


chr2_-_1748214 0.254 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
PXDN


peroxidasin homolog (Drosophila)


chr1_+_47799542 0.246 ENST00000471289.2
ENST00000450808.2
CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

chr5_-_157002775 0.243 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr3_+_39509070 0.213 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP





myelin-associated oligodendrocyte basic protein





chr19_-_51472823 0.211 ENST00000310157.2
KLK6
kallikrein-related peptidase 6
chr11_+_125496619 0.206 ENST00000532669.1
ENST00000278916.3
CHEK1

checkpoint kinase 1

chr2_+_10262857 0.198 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr7_-_121944491 0.197 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr6_-_28411241 0.196 ENST00000289788.4
ZSCAN23
zinc finger and SCAN domain containing 23
chr3_-_167813132 0.193 ENST00000309027.4
GOLIM4
golgi integral membrane protein 4
chr6_-_27880174 0.191 ENST00000303324.2
OR2B2
olfactory receptor, family 2, subfamily B, member 2

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.4 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.4 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.3 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.3 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.2 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.2 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.0 0.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.2 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.2 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.0 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.2 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates