Motif ID: SMAD3

Z-value: 0.871


Transcription factors associated with SMAD3:

Gene SymbolEntrez IDGene Name
SMAD3 ENSG00000166949.11 SMAD3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67420441_674206060.154.8e-01Click!


Activity profile for motif SMAD3.

activity profile for motif SMAD3


Sorted Z-values histogram for motif SMAD3

Sorted Z-values for motif SMAD3



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_26240561 1.146 ENST00000377745.2
HIST1H4F
histone cluster 1, H4f
chr4_-_177116772 1.116 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr6_+_116937636 1.059 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr6_+_26217159 0.930 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr7_-_142247606 0.905 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr19_-_11688500 0.903 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_26124138 0.885 ENST00000314332.5
ENST00000396984.1
HIST1H2BC

histone cluster 1, H2bc

chr14_+_96858433 0.861 ENST00000267584.4
AK7
adenylate kinase 7
chr1_-_60539405 0.828 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 0.825 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr1_-_36906474 0.778 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr19_-_55691472 0.732 ENST00000537500.1
SYT5
synaptotagmin V
chr19_-_55691614 0.725 ENST00000592470.1
ENST00000354308.3
SYT5

synaptotagmin V

chr6_+_27100811 0.721 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr2_-_220110187 0.718 ENST00000295759.7
ENST00000392089.2
GLB1L

galactosidase, beta 1-like

chr1_-_9129895 0.717 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_-_220110111 0.717 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L



galactosidase, beta 1-like



chr6_+_26273144 0.706 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr6_-_27775694 0.705 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr6_+_146920097 0.689 ENST00000397944.3
ENST00000522242.1
ADGB

androglobin

chr6_+_146920116 0.683 ENST00000367493.3
ADGB
androglobin
chr18_+_44526786 0.678 ENST00000245121.5
ENST00000356157.7
KATNAL2

katanin p60 subunit A-like 2

chr6_-_26216872 0.659 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr16_-_30773372 0.645 ENST00000545825.1
ENST00000541260.1
C16orf93

chromosome 16 open reading frame 93

chr16_+_699319 0.621 ENST00000549091.1
ENST00000293879.4
WDR90

WD repeat domain 90

chr16_+_618837 0.596 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr3_+_125687987 0.546 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B




rhophilin associated tail protein 1B




chr6_+_27114861 0.497 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr4_+_55524085 0.496 ENST00000412167.2
ENST00000288135.5
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr5_+_52776228 0.479 ENST00000256759.3
FST
follistatin
chr12_+_110906169 0.477 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr6_-_27860956 0.470 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr19_-_11688447 0.468 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr17_-_34195862 0.455 ENST00000592980.1
ENST00000587626.1
C17orf66

chromosome 17 open reading frame 66

chr17_-_34195889 0.447 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chrX_-_48328631 0.439 ENST00000429543.1
ENST00000317669.5
SLC38A5

solute carrier family 38, member 5

chrX_-_48328551 0.437 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chr19_+_51728316 0.425 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33



CD33 molecule



chr6_+_26124373 0.421 ENST00000377791.2
ENST00000602637.1
HIST1H2AC

histone cluster 1, H2ac

chr6_-_27100529 0.419 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ


histone cluster 1, H2bj


chr1_-_226129189 0.414 ENST00000366820.5
LEFTY2
left-right determination factor 2
chr15_+_71184931 0.413 ENST00000560369.1
ENST00000260382.5
LRRC49

leucine rich repeat containing 49

chr1_-_226129083 0.408 ENST00000420304.2
LEFTY2
left-right determination factor 2
chr6_-_27782548 0.399 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr16_+_25228242 0.330 ENST00000219660.5
AQP8
aquaporin 8
chr2_-_49381572 0.330 ENST00000454032.1
ENST00000304421.4
FSHR

follicle stimulating hormone receptor

chr2_-_49381646 0.313 ENST00000346173.3
ENST00000406846.2
FSHR

follicle stimulating hormone receptor

chr6_+_27775899 0.306 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr5_+_79950463 0.291 ENST00000265081.6
MSH3
mutS homolog 3
chr14_-_106494587 0.282 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr2_+_96991033 0.279 ENST00000420176.1
ENST00000536814.1
ENST00000439118.2
ITPRIPL1


inositol 1,4,5-trisphosphate receptor interacting protein-like 1


chr2_-_208031943 0.278 ENST00000421199.1
ENST00000457962.1
KLF7

Kruppel-like factor 7 (ubiquitous)

chr2_-_79313973 0.277 ENST00000454188.1
REG1B
regenerating islet-derived 1 beta
chr1_+_149804218 0.262 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr17_-_56621665 0.260 ENST00000321691.3
C17orf47
chromosome 17 open reading frame 47
chr6_-_26285737 0.255 ENST00000377727.1
ENST00000289352.1
HIST1H4H

histone cluster 1, H4h

chr6_-_27114577 0.245 ENST00000356950.1
ENST00000396891.4
HIST1H2BK

histone cluster 1, H2bk

chr3_+_126243126 0.234 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr11_+_33563821 0.221 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L


KIAA1549-like


chr6_-_52441713 0.211 ENST00000182527.3
TRAM2
translocation associated membrane protein 2
chr4_-_186696425 0.210 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2


sorbin and SH3 domain containing 2


chr6_-_27806117 0.207 ENST00000330180.2
HIST1H2AK
histone cluster 1, H2ak
chr9_+_21967137 0.205 ENST00000441769.2
C9orf53
chromosome 9 open reading frame 53
chr10_-_90712520 0.195 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_59762642 0.195 ENST00000371218.4
ENST00000303721.7
FGGY

FGGY carbohydrate kinase domain containing

chr6_+_27861190 0.191 ENST00000303806.4
HIST1H2BO
histone cluster 1, H2bo
chr9_+_100069933 0.188 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chr3_-_123710893 0.188 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1







rhophilin associated tail protein 1







chr13_-_60738003 0.184 ENST00000400330.1
ENST00000400324.4
DIAPH3

diaphanous-related formin 3

chr16_+_56703737 0.182 ENST00000569155.1
MT1H
metallothionein 1H
chr1_+_153388993 0.170 ENST00000368729.4
S100A7A
S100 calcium binding protein A7A
chr4_+_186990298 0.169 ENST00000296795.3
ENST00000513189.1
TLR3

toll-like receptor 3

chr1_-_44482979 0.166 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr14_-_100625932 0.158 ENST00000553834.1
DEGS2
delta(4)-desaturase, sphingolipid 2
chr3_+_141103634 0.157 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr4_-_90759440 0.153 ENST00000336904.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr6_+_27806319 0.152 ENST00000606613.1
ENST00000396980.3
HIST1H2BN

histone cluster 1, H2bn

chr16_+_56703703 0.151 ENST00000332374.4
MT1H
metallothionein 1H
chr3_-_112565703 0.147 ENST00000488794.1
CD200R1L
CD200 receptor 1-like
chrX_-_46618490 0.145 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr19_+_41594377 0.145 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr14_+_93389425 0.145 ENST00000216492.5
ENST00000334654.4
CHGA

chromogranin A (parathyroid secretory protein 1)

chr6_+_27782788 0.144 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr4_-_39033963 0.139 ENST00000381938.3
TMEM156
transmembrane protein 156
chr1_+_209602771 0.139 ENST00000440276.1
MIR205HG
MIR205 host gene (non-protein coding)
chr1_-_9129631 0.132 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr18_+_77623668 0.131 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr11_+_124824000 0.131 ENST00000529051.1
ENST00000344762.5
CCDC15

coiled-coil domain containing 15

chr22_-_36013368 0.129 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB



myoglobin



chr15_-_83316254 0.128 ENST00000567678.1
ENST00000450751.2
CPEB1

cytoplasmic polyadenylation element binding protein 1

chr19_-_13947099 0.125 ENST00000587762.1
MIR24-2
microRNA 24-2
chr6_-_46922659 0.125 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr19_-_35166604 0.124 ENST00000601241.1
SCGB2B2
secretoglobin, family 2B, member 2
chr18_+_43753974 0.119 ENST00000282059.6
ENST00000321319.6
C18orf25

chromosome 18 open reading frame 25

chr12_+_49212514 0.110 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3


calcium channel, voltage-dependent, beta 3 subunit


chrX_-_62571220 0.110 ENST00000374884.2
SPIN4
spindlin family, member 4
chr8_-_101117847 0.110 ENST00000523287.1
ENST00000519092.1
RGS22

regulator of G-protein signaling 22

chr11_-_133402410 0.108 ENST00000524381.1
OPCML
opioid binding protein/cell adhesion molecule-like
chr4_+_2813946 0.105 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr16_-_3350614 0.104 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr2_-_105030466 0.101 ENST00000449772.1
AC068535.3
AC068535.3
chrX_-_62571187 0.097 ENST00000335144.3
SPIN4
spindlin family, member 4
chr4_-_38666430 0.092 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr18_+_13611763 0.086 ENST00000585931.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr20_+_44036900 0.086 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr6_-_26033796 0.084 ENST00000259791.2
HIST1H2AB
histone cluster 1, H2ab
chr2_+_75061108 0.084 ENST00000290573.2
HK2
hexokinase 2
chr5_-_68628543 0.084 ENST00000396496.2
ENST00000511257.1
ENST00000383374.2
CCDC125


coiled-coil domain containing 125


chr20_+_44036620 0.084 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr3_+_51741072 0.081 ENST00000395052.3
GRM2
glutamate receptor, metabotropic 2
chr4_+_2814011 0.078 ENST00000502260.1
ENST00000435136.2
SH3BP2

SH3-domain binding protein 2

chr9_+_37486005 0.076 ENST00000377792.3
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr9_-_14910990 0.071 ENST00000380881.4
ENST00000422223.2
FREM1

FRAS1 related extracellular matrix 1

chr12_+_50135588 0.071 ENST00000423828.1
ENST00000550445.1
TMBIM6

transmembrane BAX inhibitor motif containing 6

chr17_-_39093672 0.069 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23


keratin 23 (histone deacetylase inducible)


chr7_+_139529040 0.069 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_-_22862406 0.067 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr9_+_37485932 0.067 ENST00000377798.4
ENST00000442009.2
POLR1E

polymerase (RNA) I polypeptide E, 53kDa

chr14_+_24600484 0.066 ENST00000267426.5
FITM1
fat storage-inducing transmembrane protein 1
chr8_-_101118210 0.065 ENST00000360863.6
RGS22
regulator of G-protein signaling 22
chr7_+_139528952 0.063 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr2_+_220110177 0.063 ENST00000409638.3
ENST00000396738.2
ENST00000409516.3
STK16


serine/threonine kinase 16


chr10_+_118350468 0.063 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1


pancreatic lipase-related protein 1


chr12_+_96588143 0.062 ENST00000228741.3
ENST00000547249.1
ELK3

ELK3, ETS-domain protein (SRF accessory protein 2)

chr10_+_118350522 0.059 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1



pancreatic lipase-related protein 1



chr1_+_52682052 0.056 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr20_-_43280361 0.056 ENST00000372874.4
ADA
adenosine deaminase
chr10_+_94451574 0.055 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr4_+_40337340 0.054 ENST00000310169.2
CHRNA9
cholinergic receptor, nicotinic, alpha 9 (neuronal)
chr11_-_46142615 0.054 ENST00000529734.1
ENST00000323180.6
PHF21A

PHD finger protein 21A

chr11_+_35211511 0.054 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr11_-_72145426 0.054 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB


ClpB caseinolytic peptidase B homolog (E. coli)


chr12_+_14927270 0.051 ENST00000544848.1
H2AFJ
H2A histone family, member J
chr19_-_51192661 0.050 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr14_+_96858454 0.049 ENST00000555570.1
AK7
adenylate kinase 7
chr2_-_136594740 0.048 ENST00000264162.2
LCT
lactase
chr7_-_22862448 0.047 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr1_-_160832642 0.047 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr14_-_24551195 0.044 ENST00000560550.1
NRL
neural retina leucine zipper
chr17_+_36452989 0.044 ENST00000312513.5
ENST00000582535.1
MRPL45

mitochondrial ribosomal protein L45

chr13_+_96743093 0.044 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr18_+_13612613 0.040 ENST00000586765.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr12_+_50135351 0.040 ENST00000549445.1
ENST00000550951.1
ENST00000549385.1
ENST00000548713.1
ENST00000548201.1
TMBIM6




transmembrane BAX inhibitor motif containing 6




chr1_-_89357179 0.038 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B


general transcription factor IIB


chr1_+_25757376 0.035 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
TMEM57


transmembrane protein 57


chr12_+_50135327 0.034 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
TMBIM6






transmembrane BAX inhibitor motif containing 6






chr16_+_30483962 0.033 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr13_-_114898016 0.032 ENST00000542651.1
ENST00000334062.7
RASA3

RAS p21 protein activator 3

chr21_+_33031935 0.031 ENST00000270142.6
ENST00000389995.4
SOD1

superoxide dismutase 1, soluble

chrX_-_153523462 0.030 ENST00000361930.3
ENST00000369926.1
TEX28

testis expressed 28

chr20_+_24449821 0.030 ENST00000376862.3
SYNDIG1
synapse differentiation inducing 1
chr19_-_37958086 0.030 ENST00000592490.1
ENST00000392149.2
ZNF569

zinc finger protein 569

chrX_-_101410762 0.029 ENST00000543160.1
ENST00000333643.3
BEX5

brain expressed, X-linked 5

chr6_+_30850697 0.025 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1






discoidin domain receptor tyrosine kinase 1






chr3_-_126277796 0.025 ENST00000318225.2
C3orf22
chromosome 3 open reading frame 22
chr12_+_26111823 0.024 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
RASSF8


Ras association (RalGDS/AF-6) domain family (N-terminal) member 8


chr11_+_55653396 0.022 ENST00000244891.3
TRIM51
tripartite motif-containing 51
chr2_+_16080659 0.021 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr5_-_41870621 0.021 ENST00000196371.5
OXCT1
3-oxoacid CoA transferase 1
chr8_+_38586068 0.019 ENST00000443286.2
ENST00000520340.1
ENST00000518415.1
TACC1


transforming, acidic coiled-coil containing protein 1


chr11_+_72983246 0.018 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr14_-_24551137 0.015 ENST00000396995.1
NRL
neural retina leucine zipper
chr11_+_116700600 0.014 ENST00000227667.3
APOC3
apolipoprotein C-III
chrX_-_110513703 0.013 ENST00000324068.1
CAPN6
calpain 6
chr6_-_11807277 0.012 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr5_+_55147205 0.011 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA



interleukin 31 receptor A



chr9_+_44867571 0.011 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr11_+_116700614 0.010 ENST00000375345.1
APOC3
apolipoprotein C-III
chr11_+_117070037 0.009 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN


transgelin


chr2_-_71062938 0.008 ENST00000410009.3
CD207
CD207 molecule, langerin
chr20_-_60795296 0.007 ENST00000340177.5
HRH3
histamine receptor H3
chr19_+_42724423 0.004 ENST00000301215.3
ENST00000597945.1
ZNF526

zinc finger protein 526

chr14_+_53196872 0.004 ENST00000442123.2
ENST00000354586.4
STYX

serine/threonine/tyrosine interacting protein

chr19_-_42724261 0.001 ENST00000595337.1
DEDD2
death effector domain containing 2
chr1_+_202385953 0.001 ENST00000466968.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr1_+_153190053 0.000 ENST00000368744.3
PRR9
proline rich 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 0.5 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.2 0.6 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 0.6 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 1.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.0 GO:0015816 glycine transport(GO:0015816)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:2000705 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.5 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.3 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 1.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.1 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.1 GO:0061010 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 2.2 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.0 GO:0050894 determination of affect(GO:0050894)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.0 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 0.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.1 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.3 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.3 GO:0006833 water transport(GO:0006833)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0001534 radial spoke(GO:0001534)
0.3 1.5 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.3 GO:0032302 MutSbeta complex(GO:0032302)
0.1 4.9 GO:0000786 nucleosome(GO:0000786)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 1.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.9 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 1.4 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.3 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 1.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 1.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0015250 water channel activity(GO:0015250)
0.0 0.0 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.7 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion