Motif ID: SMAD3

Z-value: 0.871


Transcription factors associated with SMAD3:

Gene SymbolEntrez IDGene Name
SMAD3 ENSG00000166949.11 SMAD3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67420441_674206060.154.8e-01Click!


Activity profile for motif SMAD3.

activity profile for motif SMAD3


Sorted Z-values histogram for motif SMAD3

Sorted Z-values for motif SMAD3



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 176 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_26240561 1.146 ENST00000377745.2
HIST1H4F
histone cluster 1, H4f
chr4_-_177116772 1.116 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr6_+_116937636 1.059 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr6_+_26217159 0.930 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr7_-_142247606 0.905 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr19_-_11688500 0.903 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_26124138 0.885 ENST00000314332.5
ENST00000396984.1
HIST1H2BC

histone cluster 1, H2bc

chr14_+_96858433 0.861 ENST00000267584.4
AK7
adenylate kinase 7
chr1_-_60539405 0.828 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 0.825 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr1_-_36906474 0.778 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr19_-_55691472 0.732 ENST00000537500.1
SYT5
synaptotagmin V
chr19_-_55691614 0.725 ENST00000592470.1
ENST00000354308.3
SYT5

synaptotagmin V

chr6_+_27100811 0.721 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr2_-_220110187 0.718 ENST00000295759.7
ENST00000392089.2
GLB1L

galactosidase, beta 1-like

chr1_-_9129895 0.717 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_-_220110111 0.717 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L



galactosidase, beta 1-like



chr6_+_26273144 0.706 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr6_-_27775694 0.705 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr6_+_146920097 0.689 ENST00000397944.3
ENST00000522242.1
ADGB

androglobin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 1.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.3 1.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.0 GO:0015816 glycine transport(GO:0015816)
0.0 0.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.2 0.6 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 0.6 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.2 0.5 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.5 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.3 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.3 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.3 GO:0006833 water transport(GO:0006833)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0000786 nucleosome(GO:0000786)
0.3 1.5 GO:1990769 proximal neuron projection(GO:1990769)
0.4 1.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 0.3 GO:0032302 MutSbeta complex(GO:0032302)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.4 GO:0008199 ferric iron binding(GO:0008199)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.9 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 0.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0048185 activin binding(GO:0048185)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.3 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.0 0.3 GO:0015250 water channel activity(GO:0015250)
0.0 0.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.7 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters