Motif ID: SHOX

Z-value: 0.632


Transcription factors associated with SHOX:

Gene SymbolEntrez IDGene Name
SHOX ENSG00000185960.8 SHOX
SHOX ENSGR0000185960.8 SHOX



Activity profile for motif SHOX.

activity profile for motif SHOX


Sorted Z-values histogram for motif SHOX

Sorted Z-values for motif SHOX



Network of associatons between targets according to the STRING database.



First level regulatory network of SHOX

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_152131703 2.089 ENST00000316073.3
RPTN
repetin
chr1_-_152386732 1.695 ENST00000271835.3
CRNN
cornulin
chr4_+_69313145 1.404 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr3_+_186353756 1.083 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB


fetuin B


chr4_-_69111401 1.001 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr4_-_57547870 0.933 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX



HOP homeobox



chr4_-_57547454 0.928 ENST00000556376.2
HOPX
HOP homeobox
chr12_-_89746173 0.638 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr20_-_21494654 0.631 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr20_+_2276639 0.628 ENST00000381458.5
TGM3
transglutaminase 3
chr7_-_14026063 0.621 ENST00000443608.1
ENST00000438956.1
ETV1

ets variant 1

chr13_-_36050819 0.600 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr11_-_111794446 0.595 ENST00000527950.1
CRYAB
crystallin, alpha B
chr17_+_39261584 0.553 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr2_-_68052694 0.553 ENST00000457448.1
AC010987.6
AC010987.6
chr13_+_78109884 0.516 ENST00000377246.3
ENST00000349847.3
SCEL

sciellin

chr4_+_71458012 0.514 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr7_-_25268104 0.512 ENST00000222674.2
NPVF
neuropeptide VF precursor
chrX_+_99839799 0.504 ENST00000373031.4
TNMD
tenomodulin
chr12_-_57328187 0.501 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0070268 cornification(GO:0070268)
0.0 1.9 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 1.0 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.2 0.6 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.6 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.6 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.6 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.5 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.5 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.5 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.4 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 0.3 GO:0031523 Myb complex(GO:0031523)
0.1 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.7 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.5 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME_OPSINS Genes involved in Opsins
0.0 0.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane