Motif ID: RUNX1_RUNX2

Z-value: 1.059

Transcription factors associated with RUNX1_RUNX2:

Gene SymbolEntrez IDGene Name
RUNX1 ENSG00000159216.14 RUNX1
RUNX2 ENSG00000124813.16 RUNX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RUNX2hg19_v2_chr6_+_45389893_45389914-0.537.2e-03Click!
RUNX1hg19_v2_chr21_-_36421401_36421462-0.377.5e-02Click!


Activity profile for motif RUNX1_RUNX2.

activity profile for motif RUNX1_RUNX2


Sorted Z-values histogram for motif RUNX1_RUNX2

Sorted Z-values for motif RUNX1_RUNX2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1_RUNX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_180018540 3.923 ENST00000292641.3
 SCGB3A1
secretoglobin, family 3A, member 1
chr20_+_31870927 3.457 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1
chr3_+_100328433 2.965 ENST00000273352.3
 GPR128
G protein-coupled receptor 128
chr1_+_47264711 2.558 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr19_-_41388657 2.024 ENST00000301146.4
ENST00000291764.3
 CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr17_+_1633755 1.658 ENST00000545662.1
 WDR81
WD repeat domain 81
chr15_-_93632421 1.563 ENST00000329082.7
 RGMA
repulsive guidance molecule family member a
chr9_-_130635741 1.452 ENST00000223836.10
 AK1
adenylate kinase 1
chr5_-_35938674 1.429 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr19_+_56989609 1.392 ENST00000601875.1
 ZNF667-AS1
ZNF667 antisense RNA 1 (head to head)
chr2_-_216257849 1.372 ENST00000456923.1
 FN1
fibronectin 1
chr20_-_23967432 1.332 ENST00000286890.4
ENST00000278765.4
 GGTLC1

gamma-glutamyltransferase light chain 1

chr19_-_9092018 1.194 ENST00000397910.4
 MUC16
mucin 16, cell surface associated
chr6_+_32407619 1.171 ENST00000395388.2
ENST00000374982.5
 HLA-DRA

major histocompatibility complex, class II, DR alpha

chr19_+_56989485 1.162 ENST00000585445.1
ENST00000586091.1
ENST00000594783.1
ENST00000592146.1
ENST00000588158.1
ENST00000299997.4
ENST00000591797.1
 ZNF667-AS1






ZNF667 antisense RNA 1 (head to head)






chr17_-_1532106 1.158 ENST00000301335.5
ENST00000382147.4
 SLC43A2

solute carrier family 43 (amino acid system L transporter), member 2

chr19_-_6720686 1.134 ENST00000245907.6
 C3
complement component 3
chr1_+_196621156 1.064 ENST00000359637.2
 CFH
complement factor H
chr4_+_89299994 1.064 ENST00000264346.7
 HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr21_-_36421626 1.013 ENST00000300305.3
 RUNX1
runt-related transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 383 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 4.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 3.5 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.3 3.2 GO:0015889 cobalamin transport(GO:0015889)
0.1 3.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.4 2.6 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 2.6 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 2.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 2.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.7 2.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 1.8 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 1.8 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.4 1.7 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.5 1.6 GO:0070428 negative regulation of interleukin-23 production(GO:0032707) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 1.5 GO:0006768 biotin metabolic process(GO:0006768)
0.1 1.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 1.4 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 1.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)
0.1 3.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 2.5 GO:0036038 MKS complex(GO:0036038)
0.2 2.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 2.1 GO:0031901 early endosome membrane(GO:0031901)
0.3 1.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 1.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.2 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.8 GO:0097433 dense body(GO:0097433)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 233 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0070330 aromatase activity(GO:0070330)
0.2 4.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.3 3.2 GO:0031419 cobalamin binding(GO:0031419)
0.2 2.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 2.3 GO:0016504 peptidase activator activity(GO:0016504)
0.5 2.1 GO:0047708 biotinidase activity(GO:0047708)
0.3 2.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 2.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 1.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 1.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 1.6 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 1.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.3 1.3 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 1.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.3 GO:0042169 SH2 domain binding(GO:0042169)
0.3 1.2 GO:0004031 aldehyde oxidase activity(GO:0004031)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 2.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 3.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.3 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.1 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.2 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.1 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.0 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation