Motif ID: RELA

Z-value: 1.244


Transcription factors associated with RELA:

Gene SymbolEntrez IDGene Name
RELA ENSG00000173039.14 RELA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RELAhg19_v2_chr11_-_65430251_654303990.555.5e-03Click!


Activity profile for motif RELA.

activity profile for motif RELA


Sorted Z-values histogram for motif RELA

Sorted Z-values for motif RELA



Network of associatons between targets according to the STRING database.



First level regulatory network of RELA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_228678550 4.126 ENST00000409189.3
ENST00000358813.4
CCL20

chemokine (C-C motif) ligand 20

chr1_-_186649543 3.552 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_74864386 3.513 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr19_-_51471362 3.372 ENST00000376853.4
ENST00000424910.2
KLK6

kallikrein-related peptidase 6

chr19_-_51471381 3.333 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr4_-_74964904 3.215 ENST00000508487.2
CXCL2
chemokine (C-X-C motif) ligand 2
chr4_-_74904398 2.851 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chrX_-_73072534 2.291 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr11_+_102188272 2.235 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr11_+_102188224 2.196 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr19_-_51472031 2.096 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr9_+_75263565 1.957 ENST00000396237.3
TMC1
transmembrane channel-like 1
chr9_-_136344197 1.922 ENST00000414172.1
ENST00000371897.4
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr1_-_38100539 1.873 ENST00000401069.1
RSPO1
R-spondin 1
chr10_+_104154229 1.853 ENST00000428099.1
ENST00000369966.3
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr7_-_93520259 1.783 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr6_+_138188551 1.709 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr3_+_101546827 1.679 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ


nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta


chr18_-_31802056 1.657 ENST00000538587.1
NOL4
nucleolar protein 4
chr12_-_76425368 1.640 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.4 GO:0016540 protein autoprocessing(GO:0016540)
0.5 4.4 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
1.4 4.1 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.2 3.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 3.3 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.3 3.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 3.0 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 2.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.6 2.5 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.1 2.4 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 2.1 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.3 2.0 GO:0060005 vestibular reflex(GO:0060005)
0.1 2.0 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 1.9 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.4 1.8 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2 1.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 1.7 GO:0070428 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.6 1.7 GO:0045210 FasL biosynthetic process(GO:0045210)
0.0 1.7 GO:0060113 inner ear receptor cell differentiation(GO:0060113)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.0 GO:0005615 extracellular space(GO:0005615)
0.0 7.8 GO:0045121 membrane raft(GO:0045121)
0.0 4.0 GO:0005884 actin filament(GO:0005884)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.6 2.5 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 2.5 GO:0030478 actin cap(GO:0030478)
0.0 2.4 GO:0002102 podosome(GO:0002102)
0.1 2.1 GO:0045180 basal cortex(GO:0045180)
0.2 1.8 GO:0005610 laminin-5 complex(GO:0005610)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 1.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 1.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 1.4 GO:0000145 exocyst(GO:0000145)
0.4 1.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 1.3 GO:0033643 host cell part(GO:0033643)
0.0 1.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.9 GO:0036449 microtubule minus-end(GO:0036449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 8.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
1.4 4.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.9 3.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 3.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.5 2.4 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 2.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.1 GO:0019003 GDP binding(GO:0019003)
0.0 2.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 2.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 1.6 GO:0008199 ferric iron binding(GO:0008199)
0.0 1.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 1.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 1.4 GO:0001618 virus receptor activity(GO:0001618)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 10.9 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 8.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 3.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.2 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.9 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 2.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.7 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 1.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.5 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.4 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.2 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 7.5 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 5.1 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 3.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 3.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.3 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 1.0 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo