Motif ID: POU5F1_POU2F3
Z-value: 0.938


Transcription factors associated with POU5F1_POU2F3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
POU2F3 | ENSG00000137709.5 | POU2F3 |
POU5F1 | ENSG00000204531.11 | POU5F1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
POU2F3 | hg19_v2_chr11_+_120107344_120107351 | -0.62 | 1.3e-03 | Click! |
POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.42 | 3.9e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 328 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 20.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
0.1 | 13.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.0 | 7.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
0.1 | 4.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.1 | 4.0 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
0.0 | 4.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.1 | 3.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.1 | 3.4 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
1.0 | 3.0 | GO:0060557 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
0.1 | 2.6 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 2.6 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
0.1 | 2.6 | GO:0060325 | face morphogenesis(GO:0060325) |
0.0 | 2.4 | GO:0035307 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
0.4 | 2.2 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
0.0 | 2.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.0 | 2.0 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
0.2 | 1.9 | GO:0036155 | acylglycerol acyl-chain remodeling(GO:0036155) |
0.4 | 1.8 | GO:0003322 | pancreatic A cell development(GO:0003322) |
0.4 | 1.8 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
0.2 | 1.8 | GO:0036486 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 105 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 18.9 | GO:0001533 | cornified envelope(GO:0001533) |
0.0 | 15.4 | GO:0005615 | extracellular space(GO:0005615) |
0.1 | 5.3 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 5.0 | GO:0072562 | blood microparticle(GO:0072562) |
0.0 | 2.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 1.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.2 | 1.7 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 1.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
0.0 | 1.7 | GO:0005811 | lipid particle(GO:0005811) |
0.4 | 1.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.0 | 1.6 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
0.0 | 1.5 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 1.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
0.1 | 1.3 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
0.0 | 1.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 1.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.1 | 1.0 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
0.1 | 1.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
0.1 | 1.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.0 | 1.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 207 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 16.9 | GO:0003823 | antigen binding(GO:0003823) |
0.0 | 15.9 | GO:0005198 | structural molecule activity(GO:0005198) |
0.2 | 4.3 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
0.2 | 3.7 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.2 | 3.7 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.2 | 3.6 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
0.0 | 3.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 3.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 2.9 | GO:0019003 | GDP binding(GO:0019003) |
0.1 | 2.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.3 | 2.4 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
0.2 | 2.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
0.1 | 2.1 | GO:0002162 | dystroglycan binding(GO:0002162) |
0.1 | 2.0 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.4 | 1.8 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
0.0 | 1.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.6 | 1.7 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
0.0 | 1.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 1.6 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
0.0 | 1.5 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 45 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 3.3 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.1 | 3.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.0 | 3.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.0 | 2.4 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 2.3 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 1.9 | PID_IGF1_PATHWAY | IGF1 pathway |
0.0 | 1.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 1.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 1.5 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.0 | 1.4 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
0.0 | 1.3 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 1.3 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
0.0 | 1.2 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 1.2 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
0.0 | 1.0 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.0 | 1.0 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 0.9 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 0.9 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 0.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.1 | 0.8 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 71 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 6.4 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.0 | 4.0 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.3 | 3.8 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.2 | 3.4 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 2.8 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
0.0 | 2.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 2.4 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.1 | 2.3 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
0.0 | 2.2 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.0 | 2.1 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
0.0 | 1.9 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
0.1 | 1.8 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 1.7 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.0 | 1.6 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 1.5 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
0.0 | 1.5 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
0.1 | 1.3 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
0.0 | 1.3 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.0 | 1.3 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
0.0 | 1.2 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |