Motif ID: POU5F1_POU2F3

Z-value: 0.938

Transcription factors associated with POU5F1_POU2F3:

Gene SymbolEntrez IDGene Name
POU2F3 ENSG00000137709.5 POU2F3
POU5F1 ENSG00000204531.11 POU5F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU2F3hg19_v2_chr11_+_120107344_120107351-0.621.3e-03Click!
POU5F1hg19_v2_chr6_-_31138439_311384750.423.9e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_POU2F3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153044083 4.511 ENST00000341611.2
SPRR2B
small proline-rich protein 2B
chr1_-_153029980 4.291 ENST00000392653.2
SPRR2A
small proline-rich protein 2A
chr1_-_153066998 3.729 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chr1_-_153013588 3.299 ENST00000360379.3
SPRR2D
small proline-rich protein 2D
chr2_-_113594279 3.046 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B


interleukin 1, beta


chr9_+_132099158 2.957 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr19_-_50143452 2.583 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr6_-_35656685 1.888 ENST00000539068.1
ENST00000540787.1
FKBP5

FK506 binding protein 5

chr1_+_17575584 1.823 ENST00000375460.3
PADI3
peptidyl arginine deiminase, type III
chr20_+_361890 1.771 ENST00000449710.1
ENST00000422053.2
TRIB3

tribbles pseudokinase 3

chr6_-_35656712 1.751 ENST00000357266.4
ENST00000542713.1
FKBP5

FK506 binding protein 5

chr17_+_62461569 1.730 ENST00000603557.1
ENST00000605096.1
MILR1

mast cell immunoglobulin-like receptor 1

chr8_+_7752151 1.707 ENST00000302247.2
DEFB4A
defensin, beta 4A
chr20_+_361261 1.653 ENST00000217233.3
TRIB3
tribbles pseudokinase 3
chr6_+_26183958 1.534 ENST00000356530.3
HIST1H2BE
histone cluster 1, H2be
chr12_+_107712173 1.480 ENST00000280758.5
ENST00000420571.2
BTBD11

BTB (POZ) domain containing 11

chr1_-_153085984 1.435 ENST00000468739.1
SPRR2F
small proline-rich protein 2F
chr2_+_174219548 1.403 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
CDCA7




cell division cycle associated 7




chr3_+_130650738 1.361 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr15_+_45406519 1.358 ENST00000323030.5
DUOXA2
dual oxidase maturation factor 2

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 328 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.1 GO:0018149 peptide cross-linking(GO:0018149)
0.1 13.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 7.4 GO:0002377 immunoglobulin production(GO:0002377)
0.1 4.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 4.0 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 4.0 GO:0006334 nucleosome assembly(GO:0006334)
0.1 3.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 3.4 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
1.0 3.0 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 2.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 2.6 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 2.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 2.4 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.4 2.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 2.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 2.0 GO:0048813 dendrite morphogenesis(GO:0048813)
0.2 1.9 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.4 1.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.4 1.8 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.2 1.8 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.9 GO:0001533 cornified envelope(GO:0001533)
0.0 15.4 GO:0005615 extracellular space(GO:0005615)
0.1 5.3 GO:0000786 nucleosome(GO:0000786)
0.0 5.0 GO:0072562 blood microparticle(GO:0072562)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.7 GO:0042629 mast cell granule(GO:0042629)
0.0 1.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.4 1.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 1.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.0 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 1.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.9 GO:0003823 antigen binding(GO:0003823)
0.0 15.9 GO:0005198 structural molecule activity(GO:0005198)
0.2 4.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 3.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 3.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 3.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.9 GO:0019003 GDP binding(GO:0019003)
0.1 2.7 GO:0070412 R-SMAD binding(GO:0070412)
0.3 2.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.2 2.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 2.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.0 GO:0045499 chemorepellent activity(GO:0045499)
0.4 1.8 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 1.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 1.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 1.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.6 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.5 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 3.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 3.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.9 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 0.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 4.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 3.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 3.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.8 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.3 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.9 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 1.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.7 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.5 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 1.5 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 1.3 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions